EP0343231A4 - Production of animal lysozyme c via secretion from pichia pastoris and composition therefor - Google Patents

Production of animal lysozyme c via secretion from pichia pastoris and composition therefor

Info

Publication number: EP0343231A4
Authority: EP; European Patent Office
Prior art keywords: production; pichia pastoris; composition therefor; via secretion; animal lysozyme
Prior art date: 1987-11-02
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP19890900706

Other languages

English (en)

Other versions

EP0343231A1 (fr

Inventor

Mary Ellen Digan

Michael Miller Harpold

Stephen Vernon Lair

Gregory Patrick Thill

Robert Steven Siegel

Steven Bradley Ellis

Mark Edward Williams

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

SIBIA Neurosciences Inc

Original Assignee

Salk Institute Biotechnology Industrial Associates Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-11-02

Filing date

1988-11-02

Publication date

1990-09-05

1988-11-02 Application filed by Salk Institute Biotechnology Industrial Associates Inc filed Critical Salk Institute Biotechnology Industrial Associates Inc

1989-11-29 Publication of EP0343231A1 publication Critical patent/EP0343231A1/fr

1990-09-05 Publication of EP0343231A4 publication Critical patent/EP0343231A4/en

Status Withdrawn legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2462—Lysozyme (3.2.1.17)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Mycology (AREA)
Microbiology (AREA)
Medicinal Chemistry (AREA)
Communicable Diseases (AREA)
Physics & Mathematics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Crystallography & Structural Chemistry (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

EP19890900706 1987-11-02 1988-11-02 Production of animal lysozyme c via secretion from pichia pastoris and composition therefor Withdrawn EP0343231A4 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US11594087A	1987-11-02	1987-11-02
US115940		1987-11-02

Publications (2)

Publication Number	Publication Date
EP0343231A1 EP0343231A1 (fr)	1989-11-29
EP0343231A4 true EP0343231A4 (en)	1990-09-05

Family

ID=22364276

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP19890900706 Withdrawn EP0343231A4 (en)	1987-11-02	1988-11-02	Production of animal lysozyme c via secretion from pichia pastoris and composition therefor

Country Status (8)

Country	Link
EP (1)	EP0343231A4 (fr)
JP (1)	JPH02501976A (fr)
KR (1)	KR890701606A (fr)
AU (1)	AU2825489A (fr)
CA (1)	CA1340063C (fr)
DK (1)	DK327589A (fr)
FI (1)	FI893207L (fr)
WO (1)	WO1989004320A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL91765A0 (en) *	1988-09-26	1990-06-10	Salk Inst Biotech Ind	Mixed feed recombinant yeast fermentation
US5122465A (en) *	1989-06-12	1992-06-16	Phillips Petroleum Company	Strains of pichia pastoris created by interlocus recombination
US5612198A (en) *	1990-09-04	1997-03-18	The Salk Institute	Production of insulin-like growth factor-1 in methylotrophic yeast cells
ATE220105T1 (de) *	1991-04-01	2002-07-15	Merck & Co Inc	Gene, die die proteolytische aktivitaet von pichia beeinflussen und deren verwendung
US5850025A (en) *	1991-09-19	1998-12-15	Sibia Neurosciences, Inc.	Protection of plants against plant pathogens
US5422108A (en) *	1991-09-19	1995-06-06	Smart Plants International Inc.	Protection of plants against plant pathogens
CN109810963B (zh) *	2017-11-22	2021-09-28	上海复华兴生物技术有限公司	一种新的牛肠源溶菌酶蛋白的dna序列及其生产工艺和应用
CN110903991A (zh) *	2019-11-13	2020-03-24	浙江新银象生物工程有限公司	一种含高拷贝数人源溶菌酶基因的重组毕赤酵母工程菌及其应用
CN112029783B (zh) *	2020-09-15	2022-05-27	西南民族大学	利用毕赤酵母异源表达反刍动物胃溶菌酶的方法
CN115873733B (zh) *	2022-07-20	2024-06-25	青岛蔚蓝生物集团有限公司	一种高产溶菌酶的毕赤酵母菌株及其应用

1988
- 1988-11-02 WO PCT/US1988/003907 patent/WO1989004320A1/fr not_active Ceased
- 1988-11-02 FI FI893207A patent/FI893207L/fi not_active Application Discontinuation
- 1988-11-02 JP JP1500523A patent/JPH02501976A/ja active Pending
- 1988-11-02 AU AU28254/89A patent/AU2825489A/en not_active Abandoned
- 1988-11-02 KR KR1019890701253A patent/KR890701606A/ko not_active Withdrawn
- 1988-11-02 CA CA000581993A patent/CA1340063C/fr not_active Expired - Fee Related
- 1988-11-02 EP EP19890900706 patent/EP0343231A4/en not_active Withdrawn
1989
- 1989-06-30 DK DK327589A patent/DK327589A/da not_active Application Discontinuation

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Bio/Technology, Vol. 7, No. 2, February 1989, pages 160-164, New York, US; M.E. DIGAN et al.: "Continuous via secretion from the yeast, pichia pastoris", the whole article. *
Developments in Industrial Microbiology, Proceedings of the 44th General Meeting SIM, August 10-14, 1987, Baltimore, MD, US, Vol. 29, pages 59-65, Society for Industrial Microbiology, Washington, D.C. US; M.E. DIGAN et al.: "Secretion of heterologous proteins from the methylotrophic yeast, pichia pastoris", the whole article. *
Gene, Vol. 43, No. 3, 1986, pages 273-279, Elsevier Science Publishers B.V., Amsterdam, NL; Y. JIGAMI et al.: "Expression of synthetic human-lysozyme gene in saccharomyces cerevisiae: use of a synthetic chicken-lysozyme signal sequence for secretion and processing". *
Molecular and Cellular Biochemistry, Vol. 63, 1984, pages 165-189, Martinus Nijhoff Publishers, Boston, The Hague, NL; P. JOLLES et al.: "What's new in lysozyme research", the whole article. *
See also references of WO8904320A1 *
The Journal of Biological Chemistry, Vol. 259, No. 18, September 25, 1984, pages 11617-11625, The American Society of Biological Chemists Inc., Washington, D.C, US; P. JOLLES et al.: "Stomach lysozymes of ruminants". *

Also Published As

Publication number	Publication date
AU2825489A (en)	1989-06-01
JPH02501976A (ja)	1990-07-05
EP0343231A1 (fr)	1989-11-29
FI893207A0 (fi)	1989-06-30
DK327589D0 (da)	1989-06-30
WO1989004320A1 (fr)	1989-05-18
KR890701606A (ko)	1989-12-21
FI893207A7 (fi)	1989-06-30
DK327589A (da)	1989-06-30
FI893207L (fi)	1989-06-30
CA1340063C (fr)	1998-09-29

Legal Events

Date	Code	Title	Description
1989-10-14	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1989-11-29	17P	Request for examination filed	Effective date: 19890703
1989-11-29	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE FR GB IT LI LU NL SE
1990-09-05	A4	Supplementary search report drawn up and despatched	Effective date: 19900718
1990-09-05	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE FR GB IT LI LU NL SE
1991-07-31	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: THE SALK INSTITUTE BIOTECHNOLOGY INDUSTRIAL ASSOCI
1993-05-05	17Q	First examination report despatched	Effective date: 19930318
1994-02-14	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
1994-04-06	18D	Application deemed to be withdrawn	Effective date: 19930929

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GB8806463D0 (en)	1988-04-20	Wire bonded microfuse & method of making same
JPS6471895A (en)	1989-03-16	Manufacture of alkyloligoglycoside
HU903813D0 (en)	1990-11-28	Process for breeding new stocks of pichia pastoris
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IL67637A0 (en)	1983-05-15	Preparation of 1'-ethoxycarbonyl-oxyethyl esters of penicillins and novel intermediates
EP0321158A3 (en)	1990-08-29	Production of m-aminophenol
CS810187A2 (en)	1989-07-12	Method of 2-guanidinothiazole's derivative production
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