EP0344476A2 - Ampoule - Google Patents
Ampoule Download PDFInfo
- Publication number
- EP0344476A2 EP0344476A2 EP19890107869 EP89107869A EP0344476A2 EP 0344476 A2 EP0344476 A2 EP 0344476A2 EP 19890107869 EP19890107869 EP 19890107869 EP 89107869 A EP89107869 A EP 89107869A EP 0344476 A2 EP0344476 A2 EP 0344476A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- ampoule
- neck
- ampoule neck
- application device
- container
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/06—Ampoules or carpules
- A61J1/067—Flexible ampoules, the contents of which are expelled by squeezing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1468—Containers characterised by specific material properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2068—Venting means
- A61J1/2075—Venting means for external venting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J2205/00—General identification or selection means
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S215/00—Bottles and jars
- Y10S215/902—Vent
Definitions
- Ampoule for receiving a dose of a liquid agent to be taken into an application device, preferably an injection syringe, on the ampoule vessel of which an ampoule neck with a predetermined breaking point and handle for opening the, for example, conical head of the application device is provided.
- an application device preferably an injection syringe
- ampoules of this type have mostly been made of glass, with the ampoule neck being sealed at its free end after the ampoule has been filled in order to seal it tightly.
- the user has to prearrange the wall of the ampoule neck at a suitable point with an ampoule saw and break off the sealed portion of the ampoule neck in order to insert a pull-on cannula into the opened one, which is placed on the head of an application device, for example the cone for the injection needle of an injection syringe Insert the neck of the ampoule and transfer the contents of the ampoule to the application device, for example to be able to pull it into the injection syringe.
- an application device for example the cone for the injection needle of an injection syringe
- Glass ampoules are also already known in which a predetermined breaking point is pre-formed by scratching the wall of the ampoule neck and secured by a marking strip.
- a predetermined breaking point is formed on the ampoule neck in that an annular wall area of the ampoule neck is provided with internal stresses in the glass by means of special heat treatment.
- the scoring by the user is not necessary. It is only necessary to break off the part of the ampoule neck which is closed by melting, this part of the ampoule neck serving as a handle.
- the phenomenon occurs that when a part of the ampoule neck breaks off, glass particles enter the Get ampoule content.
- the syringe cylinder with a receiving cone for a cannula is made of a plastic ampoule and is closed at the end opposite the ampoule neck to the plunger of the syringe .
- the ampoule neck has a predetermined breaking point in order to break off the closed part at a defined point and to be able to use the remaining part as a receiving cone for the cannula.
- Dose containers made of plastic are also known, for example from US Pat. No. 4,643,309, the container neck of which is conical in order to be able to insert the conical head of an injection syringe after removal of a closure cap.
- the container neck of which is conical in order to be able to insert the conical head of an injection syringe after removal of a closure cap.
- there are no facilities for admitting air so that when the contents of the container are transferred to the injection syringe, either the seat of the head in the container neck must be loosened or the container wall must be pressed together. Both make it difficult to transfer the contents of the container and make the activity of the user unsafe during the transfer.
- ampoules which are used to hold liquid agents to be taken up in application devices, for example injection syringes, in such a way that the transfer of the ampoule content into the application device, for example the drawing up of the ampoule content onto an injection syringe, is made considerably easier and safer becomes.
- the ampoule neck is made of elastically stretchable material, and is designed as an insertion and holding ring for the preferably conical head of the application device designed to attach the actual applicator (injection needle) and that a ventilation device leading into the interior of the ampoule is provided.
- the ampoule with its ampoule neck can be securely and sufficiently firmly taken over for the ampoule contents and - apart from the air inlet - can be plugged together tightly with the respective application device.
- the user no longer has to hold the ampoule during the transfer of the ampoule contents into the application device, but can instead safely insert the application device into the open ampoule neck. and hold the application device, for example an injection syringe, with one hand and actuate it with the other hand to open the contents of the ampoule.
- the elastically stretchable design of the ampoule neck does not represent a significant increase in effort, particularly not if the entire ampoule is made in one piece from elastically stretchable material, for example plastic such as polypropylene.
- the ampoule neck carries at its free end a closure piece which is connected in one piece to the mouth edge region of the impulse neck via an annular predetermined breaking point, the actual mouth edge of the ampoule neck being designed as a funnel-shaped introduction for the head or cone of the application device.
- the actual mouth edge of the neck of the ampoule can preferably be designed with a rounded curvature to form the funnel-shaped introduction.
- the closure piece can have a substantially disc-shaped part arranged within the mouth edge region, the predetermined breaking point surrounding the closure piece being arranged so as to be recessed around the funnel-shaped insertion relative to the actual mouth edge of the ampoule neck.
- the head of the application device for example the receiving cone of an injection syringe
- the head of the application device can be inserted particularly safely and simply into the mouth edge region of the ampoule neck after the closure piece has been removed.
- the residues of the predetermined breaking point remaining when the closure piece is removed reach the outer surface of the head or the receiving cone and are thereby pressed against the peripheral wall of the ampoule neck, so that the detachment of plastic particles from these residues the predetermined breaking point is impossible or made harmless for the transfer of the ampoule content into the application device because particles adhering to the remnants of the predetermined breaking point are displaced radially outward from the peripheral surface of the head or receiving cone and are prevented from penetrating into the interior of the ampoule.
- a ventilation device on the ampoule which is closed during transport of the ampoule and is closed when the ampoule is in use and which can be opened simultaneously with the ampoule neck when the ampoule is in use, ensures that when the liquid ampoule contents are sucked in by the application device, for example an injection syringe, air flows into the ampoule container. This avoids the formation of a vacuum inside the ampoule container, which would resist the aspiration of the liquid ampoule contents by the application device.
- the ampoule neck can have a ventilation channel on its inside, which can extend essentially axially to the ampoule neck. However, it is preferred to provide a separate ventilation opening in addition to the ampoule neck to form the ventilation device.
- this ventilation opening can be formed on a ventilation tube which extends parallel to the ampoule neck and which has a closure element which can be broken off together with the closure piece of the ampoule neck.
- the ampoule tube can be made longer than the ampoule neck after the interior of the ampoule.
- the separate ventilation opening to be provided next to the ampoule neck can also be a thinned, penetrable wall area of the ampoule shoulder. It is also possible to separate and form a ventilation tube into the ampoule shoulder or another wall part of the ampoule at a distance from the ampoule neck.
- the ampoule according to the invention is preferably intended for use in conjunction with conventional injection syringes which are designed for multiple use for drawing in the liquid to be administered and with a receiving cone for applying an injection needle.
- the ampoule neck is preferably designed with a greater axial length than the receiving cone of conventional injection syringes. This ensures that the receiving cone of an injection syringe pressed into the mouth of the ampoule neck is positively surrounded by the ampoule neck. It is achieved in this way that the entire amount of liquid contained in the ampoule can be sucked into the injection syringe.
- the ampoule container together with the ampoule neck, is formed in one piece from thermoplastic material, preferably polypropylene, and is sealed at its end opposite the ampoule neck after filling.
- the ampoule can be designed similarly to a dose container known from DE-PS 26 53 993 or 19 65 761.
- the ampoule vessel can be particularly advantageously thicker on its part adjacent to the ampoule neck than on its part opposite the ampoule neck.
- the ampoule container on its part adjacent to the ampoule neck is designed to be significantly less flexible than on the part opposite the ampoule neck. This has the advantage that when the ampoule is touched on the part adjacent to the ampoule neck, undesired compression and thus inadvertent pressing out of ampoule contents avoided and the ampoule can still be firmly gripped.
- the container wall is sufficiently thin and flexible that it can be compressed and welded after the ampoule has been filled.
- the ampoule container with a cylindrical outer shape and the open end opposite the ampoule neck can be produced in one piece with the ampoule neck and its closure piece by hand by injection molding.
- the cylindrical outer shape of the wall of the ampoule container has the advantage on the one hand that any further processing, in particular printing, and the feeding within the filling and welding machine is made considerably easier.
- the cylindrical outer shape has the advantage that the expansion of shape at the weld, which is unavoidable during welding, is noticeably less than that of ampoules, in which the conical shape of the ampoule container is assumed.
- the production of ampoules according to the invention with a cylindrical outer shape of the ampoule container by injection molding may initially appear difficult.
- the ampoule container can be made with a slightly conically tapering interior from the open end to the ampoule neck and correspondingly with a wall thickness increasing conically from the open end to the ampoule neck.
- the demolding of the ampoule according to the invention during manufacture by injection molding is considerably facilitated and, on the other hand, a desired wall formation of the ampoule vessel is achieved with less flexibility in the part adjacent to the ampoule neck and greater flexibility in the part remote from the ampoule neck.
- the transition from the ampoule container to the ampoule neck can also be designed as an ampoule shoulder in which blind embossments are provided, for example for information about the volume and content of the respective ampoule.
- This blind embossing on the ampoule shoulder inevitably falls into the user's field of vision when touching the ampoule to open it and when attaching the ampoule to an application device, so that additional security can be given that an ampoule before opening and before applying the application device to the correct content and correct amount is checked.
- the empty ampoule can also be kept as a control piece.
- the ampoule 10 is made in one piece from thermoplastic, namely polypropylene by injection molding. It has an ampoule container 11 which merges into an ampoule neck 13 via an ampoule shoulder 12. At the free end of the ampoule neck 13, a closure piece 14 is formed, which can be removed by twisting it off at the same time as breaking off and tearing it off. At the end remote from the ampoule neck 13, the peripheral wall of the ampoule container 11 is compressed flat after filling and welded tightly at a closure seam 15.
- the ampoule neck 13 is elastically stretchable due to the production of the entire ampoule 10 from polypropylene and as an insertion and retaining ring for the head of one Application device, for example the receiving cone 17, an injection syringe 16, wherein this conical head or receiving cone 17 is used to attach the actual applicator, for example a conventional injection needle.
- the closure piece 14 has a disk-shaped part 18 and an actuating part 19.
- the disc-shaped part 18 of the closure piece 14 is arranged in the interior of the mouth edge region 20 of the container neck 13 and is connected in one piece to the mouth edge region 20 of the ampoule neck 13 via an annular predetermined breaking point 21 surrounding the periphery of the disc-shaped part 18.
- the container neck 13 is sealed at its free end by the disk-shaped part 18 of the closure piece 14 and the predetermined breaking point 21.
- the predetermined breaking point 21 is destroyed by unscrewing, breaking off and tearing off the closure piece 13.
- the mouth of the ampoule neck 13 is exposed.
- the head of an application device for example the receiving cone 17 of an injection syringe, 16 can now be inserted into the open end of the ampoule neck 13.
- the rim area 20 of the ampoule neck is essentially funnel-shaped towards the inside.
- the different embodiments shown in the drawing show variations in the design of this funnel-shaped introduction. In the example in FIG.
- the actual mouth edge 22 of the ampoule neck 13 is curved with an approximately semicircular cross section.
- the actual mouth edge 23 of the ampoule neck 13 is designed with an outer rounding and an inner conical bevel, while in the example in FIG that instead of the conical funnel inlet provided in the example of FIGS. 3 and 4, there is a reinforced funnel inlet that is stronger than the example of FIG. As FIGS.
- the predetermined breaking point 21 is recessed in the mouth edge region 20 of the ampoule neck 13, so that the head of the application device or the receiving cone 17 of an injection syringe 16 has already been inserted into the ordinary mouth rim 22, 23, 25 of the ampoule neck 13 before it reaches the remnants of the predetermined breaking point 21.
- an axially extending ventilation channel 26 is formed in the interior of the ampoule neck 13, which has an arcuate profile with a depth 27 of for example 0.4 mm and a width 28 of 1.0 mm can.
- the inner diameter 29 of the container neck 13 can be approximately 4 mm and the outer diameter 30 approximately 6 mm.
- the actuating part 19 of the closure piece 14 can be approximately plate-shaped or tab-shaped in order to ensure secure gripping for twisting, breaking off and tearing off the closure piece 14.
- axially extending grip ribs 31 can be formed on the actuating part 19.
- the ampoule container 11 is initially open at its end opposite the ampoule neck 13 in order to fill it from this end.
- the peripheral wall of the ampoule container 11 has a greater thickness in the vicinity of the ampoule neck 13 and the ampoule shoulder 12 than at its open end.
- the peripheral wall of the ampoule housing 11 has a slightly conical shape after the open one End widening shape and a portion 32 of greater thickness 33 adjacent to the ampoule shoulder 12, for example of approximately 0.5 mm.
- a part 34 of the peripheral wall with a thickness 35 of approximately 0.35 mm is formed in the vicinity of the open end.
- the outer wall of the ampoule container 11 is cylindrical on the outside and has a decreasing wall thickness from the ampoule shoulder 12 to the open end, namely a thickness 36 adjacent to the ampoule shoulder 12, for example 0.55 mm and a thickness 37 of, for example, 0.35 mm at the open end.
- a thickness 36 adjacent to the ampoule shoulder 12 for example 0.55 mm
- a thickness 37 of, for example, 0.35 mm at the open end the interior formed in the ampoule container 11 before the closure tapers conically from the open end to the ampoule shoulder 12.
- the ampoule neck 13 is elastically widened from the free end when the conical head of an application device, for example the receiving cone 17 of an injection syringe 16, is inserted, so that the ampoule neck 13 with its inner surface firmly on the outer surface of the conical head or the receiving cone 17 sets.
- the application device for example the injection syringe 16 and the attached ampoule 10, then form a firmly held unit, in which the opening of the ampoule contents onto the application device is made considerably easier.
- Only the ventilation channel 26 leaves an axially extending channel between the receiving cone 17 and the inner surface of the ampoule neck 13 in order to admit air during the aspiration of the liquid ampoule contents.
- the ampoule neck 13 has an axial length 38 which is somewhat larger than the axial length 39 of the head of the application device or the Recording cone 17 is.
- the head or the receiving cone when plugged in, ends within the ampoule neck 13, so that - as can be seen from FIG. 10 - the entire liquid content of the ampoule 10 can be aspirated into the application device or the injection syringe 16.
- blind embossments 40 are provided on the ampoule shoulder, which provide information about the content and volume of the ampoule 10. These blind embossments 40 cannot be overlooked when opening the ampoule 10 and when inserting the receiving cone 17. They are also indelible and are therefore suitable for the emptied ampoule 10, possibly as evidence of administered medicine and the like. repeal.
- the ventilation device is formed by a separate, but integrally molded, ventilation tube 41 on the ampoule neck 13 '.
- a common closure piece 14' is formed so that when the closure piece 14 'is broken, the container neck 13' and the ventilation tube 41 are opened at the same time.
- the ventilation tube 41 extends parallel to the ampoule neck 13 'and opens a distance 42 deeper in the interior of the ampoule than the ampoule neck 13, so that the partition wall 43 formed between the ampoule neck 13 and the ventilation tube 41 is still at the mouth of the ampoule neck 13 extends into the interior of the ampoule. In this way, the direct passage of air from the ventilation tube 41 into the ampoule neck 13 'and from there into the application device is prevented when the contents of the ampoule are drawn up.
- the parallel ventilation tube 41 'formed on the ampoule neck 13' can also extend over a larger distance 42 'beyond the ampoule neck 13' into the interior of the ampoule.
- the ventilation tube 41 is preferably formed with a much smaller clear cross section than the ampoule neck 13 '.
- the passage of the ampoule neck 13 ' may have approximately twice the diameter 44 as the corresponding diameter 45 of the ventilation tube 41.
- the ampoule according to FIGS. 11 to 15 can have features corresponding to those of the ampoule according to FIGS. 1 to 10.
- the ampoule according to Figure 3. This applies, for example, to the closure piece 14 ', which can have a tab-like actuating part 19 with grip ribs 31 in a corresponding manner as in Figures 5 and 6.
- an easily penetrable thinned point could be formed at a distance from the ampoule neck 13. This could be, for example, at a point indicated by arrow 46 in FIG. It could also be molded into the ampoule shoulder 12 at point 46, a ventilation tube completely separate from the ampoule neck 13 and carry a breakable closure piece separate from the ampoule neck 13.
Landscapes
- Health & Medical Sciences (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Closures For Containers (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3818682 | 1988-06-01 | ||
| DE19883818682 DE3818682A1 (de) | 1988-06-01 | 1988-06-01 | Ampulle |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| EP0344476A2 true EP0344476A2 (fr) | 1989-12-06 |
| EP0344476A3 EP0344476A3 (en) | 1990-03-28 |
| EP0344476B1 EP0344476B1 (fr) | 1992-09-02 |
Family
ID=6355641
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP89107869A Expired - Lifetime EP0344476B1 (fr) | 1988-06-01 | 1989-04-29 | Ampoule |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4926915A (fr) |
| EP (1) | EP0344476B1 (fr) |
| JP (1) | JPH0245056A (fr) |
| AU (1) | AU3597689A (fr) |
| BR (1) | BR8902517A (fr) |
| DE (2) | DE3818682A1 (fr) |
| ES (1) | ES2034471T3 (fr) |
| SU (1) | SU1727518A3 (fr) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0399234A1 (fr) * | 1989-05-24 | 1990-11-28 | Bernd Dipl.-Ing. Hansen | Ampoule |
| EP1918214A1 (fr) * | 2006-11-03 | 2008-05-07 | Seriplast | Ampoule comportant un corps creux et une tête avec possibilité de rupture entre le corps et la tête |
| EP3498126A1 (fr) * | 2017-12-18 | 2019-06-19 | L&P Cosmetic Co., Ltd. | Ampoule pour stocker un liquide cosmétique |
| CN111132647A (zh) * | 2017-09-26 | 2020-05-08 | 科赫尔塑料机械制造有限公司 | 容器以及连接和制造装置 |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5409125A (en) * | 1989-12-11 | 1995-04-25 | Aktiebolaget Astra | Unit dose container |
| AU622740B2 (en) * | 1989-12-11 | 1992-04-16 | Astra Aktiebolag | Unit dose container |
| ES2090339T3 (es) | 1990-06-08 | 1996-10-16 | Astra Ab | Dispositivo de usar y tirar, previamente llenado, para introducir una sustancia farmacologicamente activa en una cavidad del cuerpo de un paciente, metodo para fabricar dicho dispositivo y aparato de moldeo para fabricar dicho dispositivo. |
| US7628339B2 (en) | 1991-04-24 | 2009-12-08 | Novartis Pharma Ag | Systems and methods for controlling fluid feed to an aerosol generator |
| US6540154B1 (en) | 1991-04-24 | 2003-04-01 | Aerogen, Inc. | Systems and methods for controlling fluid feed to an aerosol generator |
| US5224937A (en) * | 1991-06-21 | 1993-07-06 | Npbi Nederlands Produktielaboratorium Voor Bloedtransfusieapparatuur En Infusievloeistoffen B.V. | Closed syringe-filling system |
| FR2682088B1 (fr) * | 1991-10-04 | 1994-06-10 | Emballages Conditionnement | Conditionnement pour la preparation extemporanee de produits medicamenteux. |
| US5807359A (en) | 1993-06-08 | 1998-09-15 | Bemis Manufacturing Company | Medical suction system |
| DK0771184T3 (da) * | 1994-06-24 | 2002-12-23 | Icu Medical Inc | Fluidoverførselsindretning og fremgangsmåde til anvendelse |
| US5620428A (en) * | 1994-12-29 | 1997-04-15 | Bemis Manufacturing Company | Suction canister apparatus and method |
| US6358232B1 (en) | 1994-12-29 | 2002-03-19 | Bemis Manufacturing Company | Method and apparatus for removing and disposing of body fluids |
| US5688255A (en) * | 1994-12-29 | 1997-11-18 | Bemis Manufacturing Company | Method and apparatus for removing and disposing of body fluids |
| US5683371A (en) * | 1994-12-29 | 1997-11-04 | Bemis Manufacturing Company | Suction canister apparatus and method |
| US6244311B1 (en) | 1994-12-29 | 2001-06-12 | Bemis Manufacturing Company | Method and apparatus for removing and disposing of body fluids |
| US6085740A (en) | 1996-02-21 | 2000-07-11 | Aerogen, Inc. | Liquid dispensing apparatus and methods |
| US5758637A (en) | 1995-08-31 | 1998-06-02 | Aerogen, Inc. | Liquid dispensing apparatus and methods |
| DE29602173U1 (de) * | 1996-02-08 | 1997-06-26 | B. Braun Melsungen Ag, 34212 Melsungen | Applikationsvorrichtung für medizinische Flüssigkeiten |
| SE9702636D0 (sv) * | 1997-07-08 | 1997-07-08 | Pharmacia & Upjohn Ab | Improvements related to medical containers |
| US6082575A (en) * | 1998-03-09 | 2000-07-04 | Pepsico, Inc. | Hybrid beverage container |
| US6235177B1 (en) | 1999-09-09 | 2001-05-22 | Aerogen, Inc. | Method for the construction of an aperture plate for dispensing liquid droplets |
| US7674248B2 (en) * | 2000-03-28 | 2010-03-09 | Bemis Manufacturing Company | Medical suction apparatus and methods for draining same |
| WO2001072350A1 (fr) * | 2000-03-28 | 2001-10-04 | Bemis Manufacturing Company | Instrument d'aspiration medical et procedes de vidange de l'instrument |
| US7585292B2 (en) * | 2000-03-28 | 2009-09-08 | Bemis Manufacturing Company | Medical suction apparatus and draining of same |
| US7600511B2 (en) | 2001-11-01 | 2009-10-13 | Novartis Pharma Ag | Apparatus and methods for delivery of medicament to a respiratory system |
| US6948491B2 (en) | 2001-03-20 | 2005-09-27 | Aerogen, Inc. | Convertible fluid feed system with comformable reservoir and methods |
| US7971588B2 (en) | 2000-05-05 | 2011-07-05 | Novartis Ag | Methods and systems for operating an aerosol generator |
| MXPA02010884A (es) | 2000-05-05 | 2003-03-27 | Aerogen Ireland Ltd | Aparato y metodo para el suministro de medicamentos al sistema respiratorio. |
| US7100600B2 (en) * | 2001-03-20 | 2006-09-05 | Aerogen, Inc. | Fluid filled ampoules and methods for their use in aerosolizers |
| US8336545B2 (en) | 2000-05-05 | 2012-12-25 | Novartis Pharma Ag | Methods and systems for operating an aerosol generator |
| US6434913B1 (en) * | 2000-09-15 | 2002-08-20 | Thomas Hatch | Single-use syringe |
| WO2002055134A2 (fr) | 2001-01-12 | 2002-07-18 | Bemis Mfg Co | Procede et appareil destines a l'elimination de liquides organiques contenus dans un recipient |
| US6732944B2 (en) | 2001-05-02 | 2004-05-11 | Aerogen, Inc. | Base isolated nebulizing device and methods |
| US7677467B2 (en) | 2002-01-07 | 2010-03-16 | Novartis Pharma Ag | Methods and devices for aerosolizing medicament |
| US7360536B2 (en) | 2002-01-07 | 2008-04-22 | Aerogen, Inc. | Devices and methods for nebulizing fluids for inhalation |
| AU2003203043A1 (en) | 2002-01-15 | 2003-07-30 | Aerogen, Inc. | Methods and systems for operating an aerosol generator |
| DE10209990B4 (de) * | 2002-03-07 | 2007-02-08 | Rudolf Gantenbrink | Flasche und Verfahren zu deren Herstellung |
| EP1509259B1 (fr) | 2002-05-20 | 2016-04-20 | Novartis AG | Appareil de realisation d'aerosol pour traitement medical et procedes correspondants |
| DE10226591B4 (de) * | 2002-06-14 | 2004-10-28 | Rudolf Gantenbrink | Verfahren zum Verschließen eines Hohlkörpers aus Glas, Hohlkörper aus Glas sowie Bausatz |
| USD493526S1 (en) | 2003-04-22 | 2004-07-27 | Becton, Dickinson And Company | Syringe tip cap |
| US8616195B2 (en) | 2003-07-18 | 2013-12-31 | Novartis Ag | Nebuliser for the production of aerosolized medication |
| US20050101922A1 (en) * | 2003-11-07 | 2005-05-12 | Bemis Manufacturing Company | Suction canister and drainage of same |
| US7946291B2 (en) | 2004-04-20 | 2011-05-24 | Novartis Ag | Ventilation systems and methods employing aerosol generators |
| US7267121B2 (en) | 2004-04-20 | 2007-09-11 | Aerogen, Inc. | Aerosol delivery apparatus and method for pressure-assisted breathing systems |
| US7290541B2 (en) | 2004-04-20 | 2007-11-06 | Aerogen, Inc. | Aerosol delivery apparatus and method for pressure-assisted breathing systems |
| EP1726285A1 (fr) * | 2005-05-24 | 2006-11-29 | Vifor (International) Ag | Réceptacle distributeur pour médicaments et dispositif d'administration associé |
| EA012656B1 (ru) | 2005-05-25 | 2009-12-30 | Аэроджен, Инк. | Вибрационные системы и их применение |
| US20070260691A1 (en) * | 2006-05-02 | 2007-11-08 | Kallqvist Claes M | Wireless local area network capacity triggered upload and download |
| MX2009000081A (es) * | 2006-07-04 | 2009-01-23 | Yoshio Oyama | Porcion de extremo de recipiente hermeticamente sellado que tiene una superficie de abertura fina obtenida facilmente por segmentacion. |
| JP5452882B2 (ja) * | 2008-04-30 | 2014-03-26 | 株式会社吉野工業所 | 樹脂製アンプル |
| US8337108B2 (en) * | 2008-06-26 | 2012-12-25 | Elc Management Llc | Single-use cosmetic sampler |
| JP6189951B2 (ja) | 2012-07-13 | 2017-08-30 | ベクトン ディキンソン アンド カンパニー リミテッド | 均圧化を有する医療用バイアルアクセス器具、および、閉鎖式薬物移送システム |
| JP6452026B2 (ja) * | 2014-07-08 | 2019-01-16 | 大日本印刷株式会社 | 注射剤収納容器、注射剤入り容器、注射剤入り容器の使用方法、および、注射剤収納容器に注射剤を収納する方法 |
| US10179678B2 (en) * | 2017-04-26 | 2019-01-15 | The Hartz Mountain Corporation | Applicator with breakaway cap |
| DE102017007443A1 (de) * | 2017-08-05 | 2019-02-07 | Kocher-Plastik Maschinenbau Gmbh | Blasform-, Füll- und Schließverfahren sowie danach hergestelltes Behältererzeugnis, insbesondere Ampullenerzeugnis |
| EP3769745B1 (fr) * | 2018-03-23 | 2024-05-01 | TERUMO Kabushiki Kaisha | Ampoule en résine synthétique remplie de médicament et corps d'ampoule en résine synthétique utilisé dans celle-ci |
| JP7140615B2 (ja) * | 2018-09-19 | 2022-09-21 | 賢志 根占 | 自動分注装置、自動分注装置の制御方法およびプログラム |
| JP7293185B2 (ja) * | 2019-06-05 | 2023-06-19 | 大日本印刷株式会社 | 注射剤収納用容器、注射剤入り容器、注射剤入り容器の使用方法、および、注射剤収納用容器に注射剤を収納する方法 |
| CN112976543B (zh) * | 2021-02-05 | 2023-01-10 | 抚州市医宝城医疗器械有限公司 | 一种用于生产连排塑料安剖瓶的生产工艺、模具及产品 |
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| US1254655A (en) * | 1917-06-14 | 1918-01-29 | Paul Carpenter | Ampul. |
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| US1651963A (en) * | 1926-05-18 | 1927-12-06 | Mooney Jerome Henry | Funnel |
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| FR1066799A (fr) * | 1952-11-25 | 1954-06-09 | Tube pour matières pâteuses ou autres, procédé de fabrication de ce tube et moule pour la mise en oeuvre du procédé ou procédé similaire | |
| US2798488A (en) * | 1954-09-15 | 1957-07-09 | Merck & Co Inc | Syringe unit |
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| DE1966623B2 (de) * | 1969-01-02 | 1976-08-26 | Ausscheidung aus: 19 65 761 Arias, Marcelo Chiquiar, Dr., Mexiko | Zur einmaligen benutzung bestimmte vorrichtung fuer die ausgabe einer dosis von verunreinigungsempfindlichen behandlungsfluessigkeiten |
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| GB8802349D0 (en) * | 1988-02-03 | 1988-03-02 | Waverley Pharma Ltd | Ampoule with luer |
-
1988
- 1988-06-01 DE DE19883818682 patent/DE3818682A1/de not_active Withdrawn
- 1988-07-18 US US07/220,593 patent/US4926915A/en not_active Expired - Fee Related
-
1989
- 1989-04-29 ES ES89107869T patent/ES2034471T3/es not_active Expired - Lifetime
- 1989-04-29 EP EP89107869A patent/EP0344476B1/fr not_active Expired - Lifetime
- 1989-04-29 DE DE8989107869T patent/DE58902185D1/de not_active Expired - Fee Related
- 1989-05-30 SU SU894614233A patent/SU1727518A3/ru active
- 1989-05-31 AU AU35976/89A patent/AU3597689A/en not_active Abandoned
- 1989-06-01 BR BR8902517A patent/BR8902517A/pt unknown
- 1989-06-01 JP JP1137591A patent/JPH0245056A/ja active Granted
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0399234A1 (fr) * | 1989-05-24 | 1990-11-28 | Bernd Dipl.-Ing. Hansen | Ampoule |
| EP1918214A1 (fr) * | 2006-11-03 | 2008-05-07 | Seriplast | Ampoule comportant un corps creux et une tête avec possibilité de rupture entre le corps et la tête |
| FR2908110A1 (fr) * | 2006-11-03 | 2008-05-09 | Seriplast Soc Par Actions Simp | Ampoule comportant un corps creux et une tete avec possibilite de rupture entre le corps et la tete. |
| CN111132647A (zh) * | 2017-09-26 | 2020-05-08 | 科赫尔塑料机械制造有限公司 | 容器以及连接和制造装置 |
| CN111132647B (zh) * | 2017-09-26 | 2023-12-22 | 科赫尔塑料机械制造有限公司 | 容器以及连接和制造装置 |
| EP3498126A1 (fr) * | 2017-12-18 | 2019-06-19 | L&P Cosmetic Co., Ltd. | Ampoule pour stocker un liquide cosmétique |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0588619B2 (fr) | 1993-12-22 |
| AU3597689A (en) | 1989-12-07 |
| SU1727518A3 (ru) | 1992-04-15 |
| US4926915A (en) | 1990-05-22 |
| JPH0245056A (ja) | 1990-02-15 |
| DE3818682A1 (de) | 1989-12-21 |
| EP0344476A3 (en) | 1990-03-28 |
| BR8902517A (pt) | 1990-01-23 |
| EP0344476B1 (fr) | 1992-09-02 |
| DE58902185D1 (de) | 1992-10-08 |
| ES2034471T3 (es) | 1993-04-01 |
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