EP0354742A2 - Dispositif de perfusion portatif - Google Patents

Dispositif de perfusion portatif Download PDF

Info

Publication number
EP0354742A2
EP0354742A2 EP89307970A EP89307970A EP0354742A2 EP 0354742 A2 EP0354742 A2 EP 0354742A2 EP 89307970 A EP89307970 A EP 89307970A EP 89307970 A EP89307970 A EP 89307970A EP 0354742 A2 EP0354742 A2 EP 0354742A2
Authority
EP
European Patent Office
Prior art keywords
compartment
housing
pump
drug
infusion device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP89307970A
Other languages
German (de)
English (en)
Other versions
EP0354742B1 (fr
EP0354742A3 (en
Inventor
Rolf A. Faste
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Flora Inc
Original Assignee
PharMetrix Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PharMetrix Corp filed Critical PharMetrix Corp
Priority to AT89307970T priority Critical patent/ATE102839T1/de
Publication of EP0354742A2 publication Critical patent/EP0354742A2/fr
Publication of EP0354742A3 publication Critical patent/EP0354742A3/en
Application granted granted Critical
Publication of EP0354742B1 publication Critical patent/EP0354742B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. by means of pistons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. by means of pistons
    • A61M2005/14513—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. by means of pistons with secondary fluid driving or regulating the infusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S128/00—Surgery
    • Y10S128/12—Pressure infusion

Definitions

  • Patent 4,474,048 discloses another modification employing an impermeable elastic wall, and a moveable end wall which can be screwed in to deliver a pulse dose of the contained drug at any time during the operation of the pump.
  • U.S. Patent 4,474,575 is a variant of 4,474,048 where the flow rate of the dispensed agent can be varied by altering the area of semipermeable membrane exposed to the water chamber.
  • U.S. Patent 4,552,561 discloses a pump assembly for use with a small osmotic pump, which can be filled in advance of use with the active agent to be dispensed. The action of the pump is initiated by filling the lower chamber of the housing with a hydrogel.
  • a portable infusion device assembly in accordance with one aspect of the invention comprises a housing having first and second compartments disposed therein adjacent one another, an osmotic pump within the first compartment, a driving liquid for the pump within the second compartment, wick means disposed within the housing in liquid transferring relationship between the first and second compartments, a barrier between the wick means and the driving liquid which separates the driving liquid from the wick means and means for rupturing the barrier.
  • the liquid diffuses through the membrane under a concentration gradient, creating a saturated salt solution, and exerting a pressure on the expandable diaphragm, which in turn forces the agent to be dispensed out of the assembly through a delivery tube.
  • the osmotic pressure developed by this type of pump is much higher than the pressure required to pump the drug from the device; hence the drug delivery rate remains constant as long as some excess undissolved salt remains.
  • the pump is extremely simple, and once activated, is self sustaining, thus problems associated with with mechanical failure, adjustment or monitoring are eliminated.
  • Drug as used herein broadly includes any physiologically or pharmacologically active substance for producing a localized effect at the administration site or a systemic effect at a site remote from the administration site.
  • the wick material may be filter paper, or any porous or spongy material capable of absorbing and transporting the driving liquid.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicinal Preparation (AREA)
EP89307970A 1988-08-09 1989-08-04 Dispositif de perfusion portatif Expired - Lifetime EP0354742B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT89307970T ATE102839T1 (de) 1988-08-09 1989-08-04 Tragbare infusionsvorrichtung.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US230620 1988-08-09
US07/230,620 US4898582A (en) 1988-08-09 1988-08-09 Portable infusion device assembly

Publications (3)

Publication Number Publication Date
EP0354742A2 true EP0354742A2 (fr) 1990-02-14
EP0354742A3 EP0354742A3 (en) 1990-07-25
EP0354742B1 EP0354742B1 (fr) 1994-03-16

Family

ID=22865929

Family Applications (1)

Application Number Title Priority Date Filing Date
EP89307970A Expired - Lifetime EP0354742B1 (fr) 1988-08-09 1989-08-04 Dispositif de perfusion portatif

Country Status (11)

Country Link
US (1) US4898582A (fr)
EP (1) EP0354742B1 (fr)
JP (1) JPH02119871A (fr)
AT (1) ATE102839T1 (fr)
AU (1) AU634481B2 (fr)
CA (1) CA1316063C (fr)
DE (1) DE68913854T2 (fr)
ES (1) ES2050243T3 (fr)
MX (1) MX166422B (fr)
NO (1) NO172326C (fr)
NZ (1) NZ230182A (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2670387A1 (fr) * 1990-12-18 1992-06-19 Scras Pompe osmotique.
EP0732113A1 (fr) * 1995-03-17 1996-09-18 Fresenius AG Pompe de perfusion implantable
FR2836520A1 (fr) * 2002-02-28 2003-08-29 Univ Joseph Fourier Actionneur et moteur osmotiques
CN112601565A (zh) * 2018-06-18 2021-04-02 萨博库杰克特有限公司 注射装置的渗透致动器和包括渗透致动器的注射装置

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* Cited by examiner, † Cited by third party
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DE3915251A1 (de) * 1989-05-10 1990-11-22 Annemarie Schloegl Ges M B H Implantierbare vorrichtung zur dosierten abgabe von medikamenten in den menschlichen koerper
US5336188A (en) * 1989-06-16 1994-08-09 Science Incorporated Fluid delivery apparatus having a stored energy source
US5135498A (en) * 1990-04-02 1992-08-04 Kam Robert J Controlled release infusion device
US5085644A (en) * 1990-04-02 1992-02-04 Pudenz-Schulte Medical Research Corporation Sterilizable medication infusion device with dose recharge restriction
US5152753A (en) * 1990-04-02 1992-10-06 Pudenz-Schulte Medical Research Corporation Medication infusion device with dose recharge restriction
US5257987A (en) * 1990-05-21 1993-11-02 Pharmetrix Corporation Controlled release osmotic infusion system
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US5672167A (en) * 1990-05-21 1997-09-30 Recordati Corporation Controlled release osmotic pump
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US8550119B2 (en) * 1999-06-28 2013-10-08 California Institute Of Technology Microfabricated elastomeric valve and pump systems
CN100402850C (zh) * 1999-06-28 2008-07-16 加利福尼亚技术学院 微型制造的弹性体的阀和泵系统
US7144616B1 (en) 1999-06-28 2006-12-05 California Institute Of Technology Microfabricated elastomeric valve and pump systems
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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2670387A1 (fr) * 1990-12-18 1992-06-19 Scras Pompe osmotique.
BE1004788A4 (fr) * 1990-12-18 1993-01-26 Sod Conseils Rech Applic Pompe osmotique.
EP0732113A1 (fr) * 1995-03-17 1996-09-18 Fresenius AG Pompe de perfusion implantable
FR2836520A1 (fr) * 2002-02-28 2003-08-29 Univ Joseph Fourier Actionneur et moteur osmotiques
WO2003072941A3 (fr) * 2002-02-28 2004-03-04 Univ Joseph Fourier Actionneur et moteur osmotiques
CN112601565A (zh) * 2018-06-18 2021-04-02 萨博库杰克特有限公司 注射装置的渗透致动器和包括渗透致动器的注射装置
CN112601565B (zh) * 2018-06-18 2023-02-28 萨博库杰克特有限公司 注射装置的渗透致动器和包括渗透致动器的注射装置

Also Published As

Publication number Publication date
NO893199D0 (no) 1989-08-08
US4898582A (en) 1990-02-06
JPH02119871A (ja) 1990-05-07
DE68913854T2 (de) 1994-08-11
DE68913854D1 (de) 1994-04-21
EP0354742B1 (fr) 1994-03-16
NZ230182A (en) 1994-07-26
ES2050243T3 (es) 1994-05-16
EP0354742A3 (en) 1990-07-25
CA1316063C (fr) 1993-04-13
ATE102839T1 (de) 1994-04-15
MX166422B (es) 1993-01-07
NO172326C (no) 1993-07-07
NO172326B (no) 1993-03-29
AU3902189A (en) 1990-02-15
AU634481B2 (en) 1993-02-25
NO893199L (no) 1990-02-12

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