EP0365828B1 - Support pour récipients d'échantillons - Google Patents

Support pour récipients d'échantillons Download PDF

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Publication number
EP0365828B1
EP0365828B1 EP89117451A EP89117451A EP0365828B1 EP 0365828 B1 EP0365828 B1 EP 0365828B1 EP 89117451 A EP89117451 A EP 89117451A EP 89117451 A EP89117451 A EP 89117451A EP 0365828 B1 EP0365828 B1 EP 0365828B1
Authority
EP
European Patent Office
Prior art keywords
holders
holder
sample
members
sample containers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP89117451A
Other languages
German (de)
English (en)
Other versions
EP0365828A2 (fr
EP0365828A3 (fr
Inventor
Fritz Dr. Berthold
Willy Lohr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorium Prof Dr Rudolf Berthold GmbH and Co KG
Original Assignee
Laboratorium Prof Dr Rudolf Berthold GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorium Prof Dr Rudolf Berthold GmbH and Co KG filed Critical Laboratorium Prof Dr Rudolf Berthold GmbH and Co KG
Priority to AT89117451T priority Critical patent/ATE93412T1/de
Publication of EP0365828A2 publication Critical patent/EP0365828A2/fr
Publication of EP0365828A3 publication Critical patent/EP0365828A3/fr
Application granted granted Critical
Publication of EP0365828B1 publication Critical patent/EP0365828B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/06—Test-tube stands; Test-tube holders
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/809—Incubators or racks or holders for culture plates or containers

Definitions

  • the invention relates to a sample holder for sample vessels according to the preamble of patent claim 1.
  • Such measurement methods are generally not carried out “individually” on a laboratory scale, that is to say by successively processing a single sample vessel, but throughput rates of up to several hundred sample vessels are customary.
  • the problem thus arises here that a large number of sample vessels, as a rule test tubes, pass through these process steps quickly and safely, that is to say without interchanging the sequence, with multiple conversion of the sample vessels between the process steps to the respective apparatus and Facilities and possibly in a measuring device may be required.
  • sample rack consists of a plastic substructure with, for example, 5 x 10 bores on its upper side, into which the sample vessels are inserted.
  • each sample tube is generally labeled individually. This label can e.g. as long as the tubes are not yet in the sample rack. However, sometimes the samples are already delivered by the manufacturer in sample racks, then they have to be individually removed from the sample rack, labeled, and then put back into the sample rack. Removal and reinsertion are labor intensive.
  • sample tubes e.g. the frequently used dimension of 12 mm in diameter and 75 mm in height
  • labels namely the radioactive or non-radioactive labeled antigens or antibodies.
  • the sample tubes e.g. the frequently used dimension of 12 mm in diameter and 75 mm in height
  • a sample holder is known from US-A-4 055 396, which allows the frictional reception of M x N sample vessels in a defined spatial association with one another and with the sample holder, but only by means of a single, common, structurally complex holder.
  • the object of the invention is therefore to further develop the generic sample holder so that simplification of the entire process sequence is made possible with the highest possible safety in handling, the holders should be simple but mechanically stable so that they can be disposed of if necessary after the measurements have been carried out .
  • the basic idea of the invention thus consists in the modular design of the sample holder by means of a suitable combination of the components, in that the stand enables several holders to be held securely, whereas the holder in which the sample containers remain during all the work steps is designed as a "lost" cheap plastic part can, the purpose of which is only the linear, unambiguous and fixable spatial assignment of a number of sample vessels, and which, if appropriate, can be thrown away together with the sample vessels after the end of the measurement, with only minimal disposal problems arising due to the minimal design of such a holder.
  • the sample vessels can be used in this holder right from the start and also there remain, so that complex implementation processes, which can be the reason for mix-ups and confusions, are reliably avoided during the verification steps.
  • sample vessels can be labeled easily while they are in the cold, so they do not have to be removed.
  • the user can e.g. 10 samples in one hand e.g. Hold it at an angle of 45 ° to the vertical, insert the pipette with the other hand and add liquids, suspensions, etc., whereby the entire sample container, but especially the lower part, remains completely in the field of view, since only a number of Sample vessels are in the holder.
  • sample holder which is made up of several holders and a stand.
  • the samples are e.g. placed in an incubator / shaker and / or in a washing station.
  • the holders are removed from the stand and inserted into the measuring device only for the external measurement that may be required.
  • FIG. 1 shows the components of the sample holder, a holder 20 for holding several sample vessels 30 and a stand 40 for holding several such holders 20 in parallel (FIG. 3).
  • a holder 20 consists of a plastic part 21 with side faces 24A, 24B pulled down on both sides on its longitudinal sides and vertical lugs 23A, 23B bent downwards on both sides on its end faces, so that the holder 20 has an approximately trough-shaped shape.
  • Vertical slots 25A, 25B are cut out at the corner regions, that is to say in the transition region between the side surfaces 24A, 24B and the vertical projections 23A, 23B.
  • a grip strip 28 is also attached to an end face.
  • each vertical extension 23A, 23B has an inward thickening 26A, 26B in its lower middle region, a depression 27A, 27B is provided on both sides of this thickening (27B on the right side of the holder 20 in the figures not shown).
  • the two vertical lugs 23A, 23B are of equal length; the thickenings 26A, 26B extending to the lower edge of the lugs are of different widths (lugs 26B narrower than lugs 26A).
  • the stand 40 is U-shaped, with a base part 40C and two parallel side parts 40A, 40B, the upper region of which is specially adapted to accommodate the holders 20:
  • rectangular cutouts 40D, 40E are provided at the upper end, in each case lugs 41 on either side thereof.
  • the cutouts 40E in the side part 40B are less wide than the cutouts 40D in the left side part 40A.
  • a horizontal handle 48 is attached to the right side part 40B.
  • the shape of the cutouts 40D, 40E is matched to the rear thickenings 26A, 26B of the holder 20 such that when a holder 20 is placed on the stand 40, the vertical projections 23A, 23B overlap the side parts 40A, 40B on the outside, the thickenings 26A, 26B are then inserted in a drawer-like manner and essentially in a form-fitting manner into an opposing pair of cutouts 40D, 40E and plunge into the remaining, uncut upper ends of the side parts in the slots 25A, 25B, the latter being particularly clear from FIG. 3.
  • the lugs 41 also snap into the associated depressions 27A, B (snap connection between the holder 20 and the stand 40).
  • the above-described different configuration of the thickenings and associated cutouts on the two sides of the carrier and the holder serve to cancel the symmetry of the holder 20 with respect to a central plane parallel to the side parts 40A, 40B of the stand 40, so that the holder 20 only in one defined position absolutely horizontal, ie can be placed parallel to the floor 40C on the stand 40, whereas if the holder 20 is mixed up (i.e. rotated by 180 °), the holder 20 is inclined slightly noticeably on the stand 40, since the (wider) inside thickening 26A on the left side of a holder 20 cannot be inserted into a (narrower) cutout 40E in the right side part 40B of the stand 40.
  • the two grip strips 28, 48 are provided on the same side, in the exemplary embodiment on the right side, so that the correct assignment of the holder 20 in the stand 40 can be recognized immediately, even without great user attention is.
  • a marking strip for example a bar code, is applied to the side surface 24A of the holder 20.
  • the openings 22 on the top of the holder 20 are provided with elastic plastic tongues 22A pointing downwards, which in the unloaded state (ie without the inserted sample vessel 30) point inwards, ie lie on a truncated cone jacket. whose axis is perpendicular to the top of the plastic part 21.
  • these elastic plastic tongues 22A are more or less spread outwards, so that a frictional connection between these tongues 22A on the one hand and the sample vessel 30 on the other hand is strong enough that the holder 20 with the inserted sample vessels 30 can be transported without changing their vertical position in the holder 20.
  • these plastic tongues 22A also have a centering effect on the sample vessels 30 insofar as they ensure a precise vertical alignment of the sample vessels.
  • the bottom 40C has a number of depressions or bores 49 such that when the stand 40 is completely covered with holders 20 (FIG. 3), a bore 49 comes to lie vertically below each opening 22.
  • the diameter of the bores 49 and their inner wall design is selected so that the sample vessels are laterally fixed; This can be achieved, for example, by a cross section of the bores 49 tapering downward, as a result of which sample vessels of different diameters can also be accommodated.
  • FIG. 4 schematically shows a process sequence using the sample holder (holder 20, stand 40) according to the invention described in detail above, as is typical, for example, for carrying out an immunoassay:
  • a test tube 60 contains, for example, the blood sample taken from a patient in which the substance of interest is to be detected (A).
  • the serum used for the measurement which contains the analyte, is separated from the blood cells (B) and the serum is removed (C).
  • the serum sample is usually stored temporarily as a primary sample (61) for distribution over several sample vessels for different tests.
  • the relevant data such as the name of the patient, type of examination, etc., are recorded on a data carrier (Documentation D).
  • sample vessels 30 are used, which are provided with a short identification in accordance with the documentation (E).
  • the sample vessels 30 used here can already be provided with an antibody inner coating which is specific for the analyte to be detected.
  • sample vessels are then inserted one after the other into the holders 20 placed on a stand 40 and pushed through to the bottom of the stand 40 (F), where their bottom dips into the holes 49 in the bottom 40.
  • sample tubes can be placed in the holder at the manufacturer of the diagnostics. In this case, the tubes can be labeled very easily without having to remove them from the holder and readjust them after labeling.
  • the serum taken from the primary sample and containing the analyte is poured into one of the sample vessels (G), then the next patient sample, etc., until, for example, all sample tubes contain the patient sample.
  • the reagents in the case of the immunoassay the labeled antibodies or antigens, are then pipetted in (H). This can either be done while the samples are in the rack or you take one holder after the other to add reagents and then put it back in the rack.
  • the stand 40 which is appropriately covered with holders, is then inserted into an incubator, in which the desired antigen-antibody reaction takes place, if appropriate at elevated temperature (I). For this it may be necessary to shake the stand with the holders to accelerate this run.
  • the stands and the holders are then placed in a washing machine (K). If this is not available in the laboratory, the sample vessels can be filled with cleaning reagent and the entire sample rack (rack + glasses) decanted. This operation can also be required several times under certain circumstances.
  • sample vessels thus prepared are then inserted holder by holder into a carrier element rotating in the actual measuring device 50 and then pass the measuring point, where the substances initiating chemiluminescence are added and the resulting light output is measured, the intensity of which is a measure of the amount of the substance to be detected in the analyte (L).
  • the holders with the measured sample vessels are then removed from their associated carrier element and thrown away (M).
  • the fixed holding of the sample vessels in the sample rack also enables safe joint handling, for example when shaking or decanting, without having to remove individual sample vessels or holders.
  • sample tubes for example with a coating
  • the sample tubes are already supplied by the diagnostics manufacturer in holders, since they can then remain in the holders from sample preparation to measurement and disposal.
  • the concept of the sample holder according to the invention can also be advantageously used when using magnetic particles. It only has to be provided that the sample vessels must be in the area of influence of magnetic fields for effecting the separation and during the actual separation step, while on the other hand, e.g. B. during incubation phases, the magnetic field should not act.
  • the stand can therefore also be designed in a known manner or with an open bottom surface so that it can be placed on a substructure which contains magnets which, after the modular rack has been placed on it, the magnetic field required for separation on the magnetic particles in the suspension exercise.
  • the magnets generally permanent magnets, are arranged so that they either pull the magnetic particles to the bottom or, in the lower area, to the sides of the sample vessels.
  • the combination of holder, stand and base is then tipped over as a unit for decanting.
  • the combination of holder and stand can then be detached from the base and, for example, washing liquid added. Then the combination holder and stand can be placed on the substructure again, waiting for the magnetic particles to settle on the wall and then decanted again.

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  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Sampling And Sample Adjustment (AREA)

Claims (9)

  1. Support pour récipients d'échantillons (30), par exemple des tubes à essai, avec M x N ouvertures sur sa face supérieure pour la réception de M x N récipients d'échantillons (30), composé de M supports (20) identiques pour la réception linéaire de respectivement N récipients d'échantillons (30) et d'un châssis (40) pour la réception de M supports (20), chaque support étant constitué d'un élément (21) en matièrs plastique muni d'ouvertures (22) pour la réception des récipients d'échantillons (30) dans son axe longitudinal (Y-Y), et le châssis (40) présentant des éléments latéraux verticaux (40A, 40B) sur lesquels peuvent être déposés plusieurs supports (20), caractérisé en ce que les éléments (21) en matière plastique sont conformés pour la réception par adhérence des récipients d'échantillons (30), que l'élément (21) en matière plastique en forme d'étrier présente à chacune de ses extrémités frontales un rebord vertical (23A, 23B) et, dans le plan perpendiculaire à son axe longitudinal (Y-Y), une section transversale en U, entre les rebords verticaux (23A, 23B) et les surfaces latérales (24A, 24B) de l'élément (21) en matière plastique étant conformée une fente verticale (25A à D), que le rebord vertical (23A, B) présente dans sa région centrale inférieure un épaississement (26A, 26B) dirigé vers l'intérieur, que des deux côtés de l'épaississement (26A, 26B) est prévu à chaque fois un creux (27A, 27B), que les éléments latéraux verticaux (40A, 40B) du châssis (40) sont munis à leur extrémité supérieure de découpures rectangulaires (40D, E) dont l'écartement et la section transversale sont dimensionnés de telle façon que plusieurs supports (20) peuvent être posés parallèlement sur le châssis (40), leurs épaississements (26A, 26B) sur les rebords verticaux (23A, 23B) s'engageant dans les découpures (40D, E) lorsque les rebords verticaux (23A, 23B) coiffent extérieurement les éléments latéraux (40A, 40B) et que les éléments latéraux (40A, 40B) pénètrent dans les fentes (25A, B), et que de manière conjuguée avec les creux (27A, 27B) dans les rebords verticaux (23A, 23B) des supports (20), des saillies (41) sont conformées dans les éléments latéraux (40A, 40B), des deux côtés des découpures (40D, E), de manière à réaliser un verrouillage à crans entre les supports (20) et le châssis (40).
  2. Support pour récipients d'échantillons selon la revendication 1, caractérisé en ce que pour la réception par adhérence, les ouvertures (22) sont munies de languettes élastiques (22A) en matière plastique dirigées vers le bas qui, à l'état non chargé (sans récipient d'échantillons), se situent sur une aire latérale d'un tronc de cône dont l'axe est perpendiculaire à la face supérieure de l'élément (21) en matière plastique et qui s'écartent lors de l'introduction d'un récipient d'échantillons (30).
  3. Support pour récipients d'échantillons selon la revendication 1, caractérisé en ce que le support (20) comporte au moins sur l'un des côtés une baguette de préhension (28).
  4. Support pour récipient d'échantillons selon la revendication 1, caractérisé en ce que le châssis (40) comporte au moins sur l'un des côtés une baguette de préhension (48).
  5. Support pour récipients d'échantillons selon l'une des revendications précédentes, caractérisé en ce que les parties coopérantes du support (20) et du châssis (40) sont conformées de manière asymétrique par rapport au plan médian parallèle aux éléments latéraux, de sorte qu'un positionnement parallèle d'un support (20) par rapport au fond (40C) du châssis (40) n'est obtenu que dans une position d'introduction.
  6. Support pour récipients d'échantillons selon la revendication 5, caractérisé en ce que les épaississements (26A, 26B) et les découpures (40D, 40E) associées sont conformés de façon à être conjugués par paires (26A, 40D et respectivement 26B, 40E).
  7. Support pour récipients d'échantillons selon la revendication 1, caractérisé en ce que sur les surfaces latérales (24A, 24B) est appliqué un élément d'identification (29), par exemple sous la forme d'une bande code barres.
  8. Support pour récipients d'échantillons selon la revendication 1, caractérisé en ce que le fond (40C) du châssis (40) présente M x N alésages (49) qui se situent respectivement au-dessous d'une ouverture (22) des supports (20) montés.
  9. Support pour récipients d'échantillons selon la revendication 8, caractérisé en ce que la section transversale des alésages (49) diminue vers le bas.
EP89117451A 1988-10-24 1989-09-21 Support pour récipients d'échantillons Expired - Lifetime EP0365828B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT89117451T ATE93412T1 (de) 1988-10-24 1989-09-21 Probenhalterung fuer probengefaesse.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE8813340U 1988-10-24
DE8813340U DE8813340U1 (de) 1988-10-24 1988-10-24 Probenrack für Probengefäße

Publications (3)

Publication Number Publication Date
EP0365828A2 EP0365828A2 (fr) 1990-05-02
EP0365828A3 EP0365828A3 (fr) 1991-01-30
EP0365828B1 true EP0365828B1 (fr) 1993-08-25

Family

ID=6829192

Family Applications (1)

Application Number Title Priority Date Filing Date
EP89117451A Expired - Lifetime EP0365828B1 (fr) 1988-10-24 1989-09-21 Support pour récipients d'échantillons

Country Status (4)

Country Link
US (1) US5098663A (fr)
EP (1) EP0365828B1 (fr)
AT (1) ATE93412T1 (fr)
DE (2) DE8813340U1 (fr)

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US5098663A (en) 1992-03-24
DE8813340U1 (de) 1988-12-08
EP0365828A2 (fr) 1990-05-02
ATE93412T1 (de) 1993-09-15
EP0365828A3 (fr) 1991-01-30
DE58905378D1 (de) 1993-09-30

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