EP0365828A2 - Support pour récipients d'échantillons - Google Patents

Support pour récipients d'échantillons Download PDF

Info

Publication number
EP0365828A2
EP0365828A2 EP89117451A EP89117451A EP0365828A2 EP 0365828 A2 EP0365828 A2 EP 0365828A2 EP 89117451 A EP89117451 A EP 89117451A EP 89117451 A EP89117451 A EP 89117451A EP 0365828 A2 EP0365828 A2 EP 0365828A2
Authority
EP
European Patent Office
Prior art keywords
sample
holder
sample rack
stand
rack according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP89117451A
Other languages
German (de)
English (en)
Other versions
EP0365828A3 (fr
EP0365828B1 (fr
Inventor
Fritz Dr. Berthold
Willy Lohr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorium Prof Dr Rudolf Berthold GmbH and Co KG
Original Assignee
Laboratorium Prof Dr Rudolf Berthold GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorium Prof Dr Rudolf Berthold GmbH and Co KG filed Critical Laboratorium Prof Dr Rudolf Berthold GmbH and Co KG
Priority to AT89117451T priority Critical patent/ATE93412T1/de
Publication of EP0365828A2 publication Critical patent/EP0365828A2/fr
Publication of EP0365828A3 publication Critical patent/EP0365828A3/fr
Application granted granted Critical
Publication of EP0365828B1 publication Critical patent/EP0365828B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/06—Test-tube stands; Test-tube holders
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/809—Incubators or racks or holders for culture plates or containers

Definitions

  • the invention relates to a sample rack for sample vessels such as e.g. Test tubes with M x N openings on the top for holding M x N sample tubes.
  • Such measurement methods are generally not carried out “individually” on a laboratory scale, that is to say by successively processing a single sample vessel, but throughput rates of up to several hundred sample vessels are customary.
  • the problem thus arises here that a large number of sample vessels, as a rule test tubes, pass through these process steps quickly and safely, that is to say without interchanging the sequence, with multiple conversion of the sample vessels between the process steps to the respective apparatus and Facilities and may be required in a measuring device.
  • sample rack consists of a plastic substructure with, for example, 5 x 10 bores on its upper side, into which the sample vessels are inserted.
  • each sample tube is generally labeled individually. This label can e.g. as long as the tubes are not yet in the sample rack. However, sometimes the samples are already delivered by the manufacturer in sample racks, then they have to be individually removed from the sample rack, labeled, and then put back into the sample rack. Removal and reinsertion are labor intensive.
  • sample tubes e.g. the frequently used dimension of 12 mm in diameter and 75 mm in height
  • labels namely the radioactive or non-radioactive labeled antigens or antibodies.
  • the basic idea of the invention thus consists in the modular design of the sample rack by a suitable combination of two components, in that the stand enables several holders to be securely accommodated, whereas the holder, in which the sample vessels remain during all operations, can be designed as a "lost" cheap plastic part can, the purpose of which is merely the linear spatial assignment of a number of sample vessels, and which, if appropriate, can be thrown away together with the sample vessels after the end of the measurement, the minimal design of such a holder also resulting in only minor disposal problems.
  • the sample vessels can be used from the beginning and also remain there, so that complex conversion processes, which can give rise to confusions and mix-ups, are reliably avoided during the detection steps.
  • sample vessels can be labeled easily while they are in the holder, so they do not have to be removed.
  • the user can hold the holder with, for example, 10 samples in one hand, for example at an angle of 45 ° to the vertical, insert the pipette with the other hand and add liquids, suspensions, etc., whereby the entire sample vessel, but especially the the lower part remains in the field of vision, since there is only one row of sample vessels in the holder.
  • sample rack consisting of several holders and a stand results.
  • the samples are e.g. placed in an incubator / shaker and / or in a washing station.
  • the holders are removed from the stand and inserted into the measuring device only for the external measurement that may be required.
  • FIG. 1 The components of the sample rack are shown in FIG. 1, a holder 20 for holding a plurality of sample vessels 30 and a stand 40 for the parallel exception of several such holders 20 (FIG. 3).
  • a holder 20 consists of a plastic part 21 with side faces 24A, 24B pulled down on both sides on its long sides and vertical projections 23A, 23B bent downwards on both sides on its end faces, so that the holder 20 has an approximately trough-shaped shape. At the corner areas, that is in the transition area between the side surfaces 24A, 24B and the vertical lugs 23A, 23B, vertical slots 25A, 25B are left free.
  • a grip strip 28 is also attached to an end face.
  • each vertical extension 23A, 23B has an inward thickening 26A, 26B in its lower middle region, a depression 27A, 27B is provided on both sides of this thickening (27B on the right side of the holder 20 in the figures not shown).
  • the two vertical lugs 23A, 23B are of equal length; the thickenings 26A, 26B extending to the lower edge of the lugs are of different widths (lugs 26B narrower than lugs 26A).
  • the stand 40 is U-shaped, with a base part 40C and two parallel side parts 40A, 40B, the upper region of which is specially adapted to accommodate the holders 20:
  • rectangular cutouts 40D, 40E are provided at the upper end, in each case lugs 41 on either side thereof.
  • the cutouts 40E in the side part 40B are less wide than the cutouts 40D in the left side part 40A.
  • a horizontal handle 48 is attached to the right side part 40B.
  • the shape of the cutouts 40D, 40E is matched to the rear thickenings 26A, 26B of the holder 20 such that when a holder 20 is placed on the stand 40, the vertical projections 23A, 23B overlap the side parts 40A, 40B on the outside, the thickenings 26A, 26B are then inserted in a drawer-like manner and essentially in a form-fitting manner into an opposing pair of cutouts 40D, 40E and plunge into the remaining, uncut upper ends of the side parts in the slots 25A, 25B, the latter being particularly clear from FIG. 3.
  • the lugs 41 also snap into the associated depressions 27A, B (snap connection between the holder 20 and the stand 40).
  • the above-described different configuration of the thickenings and associated cutouts on the two sides of the carrier and the holder serve to cancel the symmetry of the holder 20 with respect to a central plane parallel to the side parts 40A, 40B of the stand 40, so that the holder 20 only in one defined position absolutely horizontal, ie can be placed parallel to the floor 40C on the stand 40, whereas if the holder 20 is mixed up (i.e. rotated by 180 °), the holder 20 is inclined slightly noticeably on the stand 40, since the (wider) inside thickening 26A on the left side of a holder 20 cannot be inserted into a (narrower) cutout 40E in the right side part 40B of the stand 40.
  • the two grip strips 28, 48 are provided on the same side, in the exemplary embodiment on the right side, so that the correct assignment of the holder 20 in the stand 40 can be recognized immediately even without great user attention is.
  • a marking strip for example a bar code, is applied to the side surface 24A of the holder 20.
  • the openings 22 on the top of the holder 20 are provided with elastic plastic tongues 22A pointing downwards, which in the unloaded state (ie without the inserted sample vessel 30) point inwards, ie lie on a truncated cone jacket. whose axis is perpendicular to the top of the plastic part 21.
  • these elastic plastic tongues 22A are more or less spread outwards, so that a frictional connection between these tongues 22A on the one hand and the sample vessel 30 on the other hand is strong enough that the holder 20 with the inserted sample vessels 30 can be transported without changing their vertical position in the holder 20.
  • these plastic tongues 22A also have a centering effect on the sample vessels 30 insofar as they ensure a precise vertical alignment of the sample vessels.
  • the bottom 40C has a number of depressions or bores 49 such that when the stand 40 is completely covered with holders 20 (FIG. 3), a bore 49 comes to lie vertically below each opening 22.
  • the diameter of the bores 49 and their inner wall design is selected so that the sample vessels are laterally fixed; This can be achieved, for example, by a cross section of the bores 49 tapering downward, as a result of which sample vessels of different diameters can also be accommodated.
  • FIG. 4 schematically shows a process sequence using the sample racks (holder 20, stand 40) according to the invention described in detail above, as is typical, for example, for carrying out an immunoassay:
  • a test tube 60 contains, for example, the blood sample taken from a patient in which the substance of interest is to be detected (A).
  • the serum used for the measurement which contains the analyte, is separated from the blood cells (B) and the serum is removed (C).
  • the serum sample is usually stored temporarily as a primary sample (61) for distribution over several sample vessels for different tests.
  • the relevant data such as the name of the patient, type of examination, etc., are recorded on a data carrier (Documentation D).
  • sample vessels 30 are used, which are provided with a short identification in accordance with the documentation (F).
  • the sample vessels 30 used here can already be provided with an antibody inner coating which is specific for the analyte to be detected.
  • sample vessels are then inserted one after the other into the holders 20 placed on a stand 40 and pushed through to the bottom of the stand 40 (G), where their bottom dips into the holes 49 in the bottom 40.
  • sample tubes can be placed in the holder at the manufacturer of the diagnostics. In this case, the tubes can be labeled very easily without having to remove them from the holder and readjust them after labeling.
  • the serum taken from the primary sample and containing the analyte is poured into one of the sample vessels (H), then the next patient sample etc., until, for example, all sample tubes contain the patient sample.
  • the reagents that is to say the labeled antibodies or antigens in the case of the immunoassay, are then pipetted in (I). This can either be done while the samples are in the rack or you take one holder after the other to add the reagents and then put it back in the rack.
  • the stand 40 which is appropriately covered with holders, is then inserted into an incubator, in which the desired antigen-antibody reaction takes place, if appropriate, at elevated temperature (K). For this purpose, it may be necessary to shake the stand with the holders to accelerate this process.
  • the stands and the holders are then placed in a washing machine (L). If this is not available in the laboratory, the sample vessels can be filled with cleaning reagent and the entire sample rack (rack + glasses) decanted. This operation can also be required several times under certain circumstances.
  • sample vessels thus prepared are then inserted holder by holder into a carrier element rotating in the ordinary measuring device 50 and then pass the measuring point, where the substances initiating chemiluminescence are added and the resulting light output is measured, the intensity of which is a measure of the amount of the substance to be detected in the analyte (M).
  • the holders with the measured sample vessels are then removed from their associated carrier element and thrown away (N).
  • the fixed holding of the sample vessels in the sample rack also enables safe joint handling, for example when shaking or decanting, without having to remove individual sample vessels or holders.
  • sample tubes for example with a coating
  • the sample tubes are already supplied by the diagnostics manufacturer in holders, since they can then remain in the holders from sample preparation through measurement to disposal.
  • the concept of the modular rack can also be advantageously used when using magnetic particles. It only has to be provided that the sample vessels must be in the area of influence of magnetic fields to effect the separation and during the actual separation step, while on the other hand, e.g. B. during incubation phases, the magnetic field should not act.
  • the stand can therefore be designed in a known manner or with an open bottom surface that it can be placed on a substructure that contains magnets that, after placing the modular rack, the magnetic field required for separation on the magnetic particles in the suspension exercise.
  • the magnets generally permanent magnets, are arranged so that they either pull the magnetic particles to the bottom or, in the lower area, to the sides of the sample vessels.
  • the combination of holder, stand and substructure is then tipped over as a unit for decanting.
  • the combination of holder and stand can then be detached from the base and, for example, washing liquid added. Then the combination holder and stand can be placed on the substructure again, waiting for the magnetic particles to settle on the wall and then decanted again.

Landscapes

  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
EP89117451A 1988-10-24 1989-09-21 Support pour récipients d'échantillons Expired - Lifetime EP0365828B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT89117451T ATE93412T1 (de) 1988-10-24 1989-09-21 Probenhalterung fuer probengefaesse.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE8813340U 1988-10-24
DE8813340U DE8813340U1 (de) 1988-10-24 1988-10-24 Probenrack für Probengefäße

Publications (3)

Publication Number Publication Date
EP0365828A2 true EP0365828A2 (fr) 1990-05-02
EP0365828A3 EP0365828A3 (fr) 1991-01-30
EP0365828B1 EP0365828B1 (fr) 1993-08-25

Family

ID=6829192

Family Applications (1)

Application Number Title Priority Date Filing Date
EP89117451A Expired - Lifetime EP0365828B1 (fr) 1988-10-24 1989-09-21 Support pour récipients d'échantillons

Country Status (4)

Country Link
US (1) US5098663A (fr)
EP (1) EP0365828B1 (fr)
AT (1) ATE93412T1 (fr)
DE (2) DE8813340U1 (fr)

Cited By (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5074505A (en) * 1990-06-01 1991-12-24 Akzo N.V. Support attachment for holding bottles within a bottle block
CN103695291A (zh) * 2007-07-13 2014-04-02 汉迪实验室公司 用于在多个生物样品上进行核酸提取和诊断测试的集成装置
US9028773B2 (en) 2001-09-12 2015-05-12 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US9051604B2 (en) 2001-02-14 2015-06-09 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
USD742027S1 (en) 2011-09-30 2015-10-27 Becton, Dickinson And Company Single piece reagent holder
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9217143B2 (en) 2007-07-13 2015-12-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US9222954B2 (en) 2011-09-30 2015-12-29 Becton, Dickinson And Company Unitized reagent strip
US9238223B2 (en) 2007-07-13 2016-01-19 Handylab, Inc. Microfluidic cartridge
US9259735B2 (en) 2001-03-28 2016-02-16 Handylab, Inc. Methods and systems for control of microfluidic devices
US9259734B2 (en) 2007-07-13 2016-02-16 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9347586B2 (en) 2007-07-13 2016-05-24 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
US9670528B2 (en) 2003-07-31 2017-06-06 Handylab, Inc. Processing particle-containing samples
US9677121B2 (en) 2001-03-28 2017-06-13 Handylab, Inc. Systems and methods for thermal actuation of microfluidic devices
US9765389B2 (en) 2011-04-15 2017-09-19 Becton, Dickinson And Company Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection
US9802199B2 (en) 2006-03-24 2017-10-31 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US9815057B2 (en) 2006-11-14 2017-11-14 Handylab, Inc. Microfluidic cartridge and method of making same
USD814653S1 (en) 2014-08-07 2018-04-03 Becton, Dickinson And Company Sample tube holder and components thereof
CN107971059A (zh) * 2018-01-12 2018-05-01 田艳 一种便携式血液检验试管架
US10179910B2 (en) 2007-07-13 2019-01-15 Handylab, Inc. Rack for sample tubes and reagent holders
US10364456B2 (en) 2004-05-03 2019-07-30 Handylab, Inc. Method for processing polynucleotide-containing samples
US10571935B2 (en) 2001-03-28 2020-02-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US10799862B2 (en) 2006-03-24 2020-10-13 Handylab, Inc. Integrated system for processing microfluidic samples, and method of using same
US10822644B2 (en) 2012-02-03 2020-11-03 Becton, Dickinson And Company External files for distribution of molecular diagnostic tests and determination of compatibility between tests
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US11453906B2 (en) 2011-11-04 2022-09-27 Handylab, Inc. Multiplexed diagnostic detection apparatus and methods
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USD340838S (en) 1991-07-12 1993-11-02 Lingo John L Drinking glass
US5575978A (en) 1992-03-27 1996-11-19 Abbott Laboratories Sample container segment assembly
DE4212471A1 (de) * 1992-04-14 1993-10-28 Ostma Maschinenbau Gmbh In einen Verpackungskarton einzusetzender Träger für zu verpackende Gegenstände
US5324482A (en) * 1992-08-27 1994-06-28 David A. White Pipette tip packaging system
US5571481A (en) * 1995-02-17 1996-11-05 Vicam, L.P. Magnetic capture rack with slidable magnetic member
US5795784A (en) 1996-09-19 1998-08-18 Abbott Laboratories Method of performing a process for determining an item of interest in a sample
US5856194A (en) 1996-09-19 1999-01-05 Abbott Laboratories Method for determination of item of interest in a sample
DE69821302T2 (de) * 1997-09-29 2004-11-25 F. Hoffmann-La Roche Ag System zur Handhabung von Verbindungen, bestehend aus Gefässen und Trägern
US7060226B1 (en) 1997-11-24 2006-06-13 Medax International, Inc. Pipette tip packaging and transfer system
US6193892B1 (en) 1999-03-03 2001-02-27 Promega Corporation Magnetic separation assembly and method
USD446311S1 (en) 1999-06-18 2001-08-07 Wescott, Iii Harvey M. Test tube receptacle
CN1113686C (zh) * 2001-06-04 2003-07-09 易荣大 三维运动式旋混装置
EP1409138B1 (fr) * 2001-07-20 2010-09-01 Gen-Probe Incorporated Patent Dept Support pour echantillons et protection anti-egouttement utilisable avec ce support
US20030087447A1 (en) * 2001-11-08 2003-05-08 Blouin Matthew R Sample well strip
USD481133S1 (en) 2002-04-18 2003-10-21 Instrumentation Laboratory Company Sample well-strip for an automated sample analyzer
WO2003097239A1 (fr) * 2002-05-17 2003-11-27 Gen-Probe Incorporated Porte-echantillons dote d'un mecanisme de blocage reversible
AU2003239485B2 (en) 2002-05-17 2008-11-20 Gen-Probe Incorporated Sample carrier having sample tube blocking means and drip shield for use therewith
WO2004105951A1 (fr) * 2003-05-28 2004-12-09 Hte Aktiengesellschaft The High Throughput Experimentation Company Systeme porte-echantillons modulaire
ATE372168T1 (de) * 2004-07-06 2007-09-15 Hoffmann La Roche Ständersystem mit adapter
US7910067B2 (en) 2005-04-19 2011-03-22 Gen-Probe Incorporated Sample tube holder
ES2340289T3 (es) * 2005-09-21 2010-06-01 F. Hoffmann-La Roche Ltd. Soporte para cubetas, disposicion de cubetas y analizador que comprende estos elementos.
EP1850136A1 (fr) * 2006-04-28 2007-10-31 F.Hoffmann-La Roche Ag Dispositif mélangeur d'appareil d'analyse et analyseur comprenant un tel dispositif
US7731899B2 (en) 2007-02-08 2010-06-08 Biokit, S.A. Apparatus and methods for dispensing sample holders
USD563171S1 (en) 2007-03-05 2008-03-04 Mansfield Bryan D Drinking vessel
USD572976S1 (en) 2007-03-27 2008-07-15 Mansfield Bryan D Drinking vessel
MX2010004419A (es) 2007-10-23 2010-05-05 Becton Dickinson Co Kit cerrado para la contencion y estabilizacion tisular para diagnosticos moleculares e histopatologicos.
WO2009055603A2 (fr) 2007-10-23 2009-04-30 Becton, Dickinson And Company Système multicompartiment pour le confinement de tissus à des fins de diagnostics moléculaires et histologiques
CN113145297B (zh) 2009-05-15 2023-09-29 简·探针公司 用于在执行磁性分离工序的仪器中实现磁体的自动移动的方法和设备
US9144801B2 (en) 2010-08-31 2015-09-29 Abbott Laboratories Sample tube racks having retention bars
EP2732878B1 (fr) * 2012-11-20 2018-09-12 QIAGEN GmbH Système de grille magnétique et procédé d'utilisation d'un système de grille magnétique
US10634584B2 (en) * 2015-12-17 2020-04-28 Roku, Inc. Device for microscopic sample collection
US10392183B2 (en) * 2016-06-06 2019-08-27 Christopher Joseph-Paul Link Funnel storage systems
TWI626992B (zh) * 2017-08-08 2018-06-21 元昌生技醫療私人股份有限公司 試管準直檢驗裝置
IT201700116211A1 (it) 2017-10-16 2019-04-16 Inpeco Holding Ltd Sistema di tracciabilità del trasporto di contenitori di campioni biologici
EP3705565A4 (fr) * 2017-10-30 2021-07-21 Nanjing GenScript Biotech Co., Ltd. Support magnétique incliné
US10694922B1 (en) * 2018-04-25 2020-06-30 4 R Oceans, LLC Drinking straw cleaning caddy
US10932647B1 (en) 2018-04-25 2021-03-02 4 R Oceans, LLC Drinking straw cleaning caddy
US20210325416A1 (en) * 2020-04-11 2021-10-21 Mitchell Olin Setzer, SR. Vial grabber inspection apparatus
USD981005S1 (en) * 2020-04-14 2023-03-14 Aesculap Ag Sterile container labelling plate
CN111774123B (zh) * 2020-07-31 2021-08-31 中国人民解放军陆军军医大学第一附属医院 标本放置架
WO2022231665A1 (fr) * 2021-04-27 2022-11-03 Micro Lab Solutions, Llc Ensemble de collecte de sang et son procédé d'utilisation
CN113198560B (zh) * 2021-05-06 2022-06-17 佳木斯大学 一种血标本试管架及识别报警方法
USD1052257S1 (en) * 2024-06-29 2024-11-26 Nanjing Langs Electronics Technology Co., Ltd Capsule holder

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3713771A (en) * 1971-05-13 1973-01-30 B Taylor Method for organized assay and bendable test tube rack therefor
DE2265055B2 (de) * 1971-10-14 1979-08-23 Coulter Electronics Inc., Hialeah, Fla. (V.St.A.) Einrichtung zur Abmessung der Menge einer Probe
US3785773A (en) * 1972-03-02 1974-01-15 Beckman Instruments Inc Chemical analysis tube module
GB1486210A (en) * 1973-11-14 1977-09-21 Suovaniemi Osmo Antero Cuvette assembly for use in automatic reading and recording of reaction results
FR2277013A1 (fr) * 1974-07-05 1976-01-30 Intertechnique Sa Perfectionnements aux convoyeurs d'echantillons pour appareil de mesure
US4055396A (en) * 1975-07-11 1977-10-25 G. D. Searle & Co. Tray and carrier assembly
DE2730214A1 (de) * 1977-07-04 1979-01-11 Franz Liebl Mehrfachprobenstaender fuer labor- untersuchungen
SE8004687L (sv) * 1980-06-25 1981-12-26 Clinicon Ab Automatisk analysapparat
US4495150A (en) * 1983-07-25 1985-01-22 Beckman Instruments, Inc. Multiple object capturing and processing device
DE3405292A1 (de) * 1984-02-15 1985-09-05 Eppendorf Gerätebau Netheler + Hinz GmbH, 2000 Hamburg Verfahren zum durchfuehren von probenanalysen sowie rack zur durchfuehrung des verfahrens
IT209233Z2 (it) * 1985-10-14 1988-09-20 Alfi Srl Struttura di stativo per il supporto ed il contenimento di provette e simili.
US4895650A (en) * 1988-02-25 1990-01-23 Gen-Probe Incorporated Magnetic separation rack for diagnostic assays

Cited By (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5074505A (en) * 1990-06-01 1991-12-24 Akzo N.V. Support attachment for holding bottles within a bottle block
US9051604B2 (en) 2001-02-14 2015-06-09 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US9528142B2 (en) 2001-02-14 2016-12-27 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US9259735B2 (en) 2001-03-28 2016-02-16 Handylab, Inc. Methods and systems for control of microfluidic devices
US10571935B2 (en) 2001-03-28 2020-02-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US10619191B2 (en) 2001-03-28 2020-04-14 Handylab, Inc. Systems and methods for thermal actuation of microfluidic devices
US9677121B2 (en) 2001-03-28 2017-06-13 Handylab, Inc. Systems and methods for thermal actuation of microfluidic devices
US10351901B2 (en) 2001-03-28 2019-07-16 Handylab, Inc. Systems and methods for thermal actuation of microfluidic devices
US9028773B2 (en) 2001-09-12 2015-05-12 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US12139745B2 (en) 2003-07-31 2024-11-12 Handylab, Inc. Processing particle-containing samples
US11078523B2 (en) 2003-07-31 2021-08-03 Handylab, Inc. Processing particle-containing samples
US10865437B2 (en) 2003-07-31 2020-12-15 Handylab, Inc. Processing particle-containing samples
US9670528B2 (en) 2003-07-31 2017-06-06 Handylab, Inc. Processing particle-containing samples
US10731201B2 (en) 2003-07-31 2020-08-04 Handylab, Inc. Processing particle-containing samples
US10494663B1 (en) 2004-05-03 2019-12-03 Handylab, Inc. Method for processing polynucleotide-containing samples
US11441171B2 (en) 2004-05-03 2022-09-13 Handylab, Inc. Method for processing polynucleotide-containing samples
US10604788B2 (en) 2004-05-03 2020-03-31 Handylab, Inc. System for processing polynucleotide-containing samples
US10364456B2 (en) 2004-05-03 2019-07-30 Handylab, Inc. Method for processing polynucleotide-containing samples
US10443088B1 (en) 2004-05-03 2019-10-15 Handylab, Inc. Method for processing polynucleotide-containing samples
US11666903B2 (en) 2006-03-24 2023-06-06 Handylab, Inc. Integrated system for processing microfluidic samples, and method of using same
US9802199B2 (en) 2006-03-24 2017-10-31 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US10913061B2 (en) 2006-03-24 2021-02-09 Handylab, Inc. Integrated system for processing microfluidic samples, and method of using the same
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US11085069B2 (en) 2006-03-24 2021-08-10 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US10857535B2 (en) 2006-03-24 2020-12-08 Handylab, Inc. Integrated system for processing microfluidic samples, and method of using same
US10843188B2 (en) 2006-03-24 2020-11-24 Handylab, Inc. Integrated system for processing microfluidic samples, and method of using the same
US10821446B1 (en) 2006-03-24 2020-11-03 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US10821436B2 (en) 2006-03-24 2020-11-03 Handylab, Inc. Integrated system for processing microfluidic samples, and method of using the same
US10799862B2 (en) 2006-03-24 2020-10-13 Handylab, Inc. Integrated system for processing microfluidic samples, and method of using same
US11141734B2 (en) 2006-03-24 2021-10-12 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US10695764B2 (en) 2006-03-24 2020-06-30 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US11142785B2 (en) 2006-03-24 2021-10-12 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US11959126B2 (en) 2006-03-24 2024-04-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US12162007B2 (en) 2006-03-24 2024-12-10 Handylab, Inc. Integrated system for processing microfluidic samples, and method of using same
US9080207B2 (en) 2006-03-24 2015-07-14 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US12458972B2 (en) 2006-03-24 2025-11-04 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US9815057B2 (en) 2006-11-14 2017-11-14 Handylab, Inc. Microfluidic cartridge and method of making same
US10710069B2 (en) 2006-11-14 2020-07-14 Handylab, Inc. Microfluidic valve and method of making same
US12128405B2 (en) 2006-11-14 2024-10-29 Handylab, Inc. Microfluidic valve and method of making same
US12030050B2 (en) 2006-11-14 2024-07-09 Handylab, Inc. Microfluidic cartridge and method of making same
US9238223B2 (en) 2007-07-13 2016-01-19 Handylab, Inc. Microfluidic cartridge
US10065185B2 (en) 2007-07-13 2018-09-04 Handylab, Inc. Microfluidic cartridge
US10234474B2 (en) 2007-07-13 2019-03-19 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US10625261B2 (en) 2007-07-13 2020-04-21 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US10717085B2 (en) 2007-07-13 2020-07-21 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US10179910B2 (en) 2007-07-13 2019-01-15 Handylab, Inc. Rack for sample tubes and reagent holders
CN103695291A (zh) * 2007-07-13 2014-04-02 汉迪实验室公司 用于在多个生物样品上进行核酸提取和诊断测试的集成装置
US10139012B2 (en) 2007-07-13 2018-11-27 Handylab, Inc. Integrated heater and magnetic separator
US12397295B2 (en) 2007-07-13 2025-08-26 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US12128402B2 (en) 2007-07-13 2024-10-29 Handylab, Inc. Microfluidic cartridge
US10844368B2 (en) 2007-07-13 2020-11-24 Handylab, Inc. Diagnostic apparatus to extract nucleic acids including a magnetic assembly and a heater assembly
US10071376B2 (en) 2007-07-13 2018-09-11 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US11466263B2 (en) 2007-07-13 2022-10-11 Handylab, Inc. Diagnostic apparatus to extract nucleic acids including a magnetic assembly and a heater assembly
US10625262B2 (en) 2007-07-13 2020-04-21 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9217143B2 (en) 2007-07-13 2015-12-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US10875022B2 (en) 2007-07-13 2020-12-29 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US11845081B2 (en) 2007-07-13 2023-12-19 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US11060082B2 (en) 2007-07-13 2021-07-13 Handy Lab, Inc. Polynucleotide capture materials, and systems using same
US10632466B1 (en) 2007-07-13 2020-04-28 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US11549959B2 (en) 2007-07-13 2023-01-10 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US10590410B2 (en) 2007-07-13 2020-03-17 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US9347586B2 (en) 2007-07-13 2016-05-24 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US11254927B2 (en) 2007-07-13 2022-02-22 Handylab, Inc. Polynucleotide capture materials, and systems using same
US11266987B2 (en) 2007-07-13 2022-03-08 Handylab, Inc. Microfluidic cartridge
US9259734B2 (en) 2007-07-13 2016-02-16 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
US11788127B2 (en) 2011-04-15 2023-10-17 Becton, Dickinson And Company Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection
US9765389B2 (en) 2011-04-15 2017-09-19 Becton, Dickinson And Company Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection
US10781482B2 (en) 2011-04-15 2020-09-22 Becton, Dickinson And Company Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection
USD1029291S1 (en) 2011-09-30 2024-05-28 Becton, Dickinson And Company Single piece reagent holder
US9222954B2 (en) 2011-09-30 2015-12-29 Becton, Dickinson And Company Unitized reagent strip
US9480983B2 (en) 2011-09-30 2016-11-01 Becton, Dickinson And Company Unitized reagent strip
USD905269S1 (en) 2011-09-30 2020-12-15 Becton, Dickinson And Company Single piece reagent holder
US10076754B2 (en) 2011-09-30 2018-09-18 Becton, Dickinson And Company Unitized reagent strip
USD742027S1 (en) 2011-09-30 2015-10-27 Becton, Dickinson And Company Single piece reagent holder
USD831843S1 (en) 2011-09-30 2018-10-23 Becton, Dickinson And Company Single piece reagent holder
US11453906B2 (en) 2011-11-04 2022-09-27 Handylab, Inc. Multiplexed diagnostic detection apparatus and methods
US10822644B2 (en) 2012-02-03 2020-11-03 Becton, Dickinson And Company External files for distribution of molecular diagnostic tests and determination of compatibility between tests
USD814653S1 (en) 2014-08-07 2018-04-03 Becton, Dickinson And Company Sample tube holder and components thereof
CN107971059A (zh) * 2018-01-12 2018-05-01 田艳 一种便携式血液检验试管架
CN107971059B (zh) * 2018-01-12 2019-11-12 田艳 一种便携式血液检验试管架

Also Published As

Publication number Publication date
EP0365828A3 (fr) 1991-01-30
DE58905378D1 (de) 1993-09-30
US5098663A (en) 1992-03-24
DE8813340U1 (de) 1988-12-08
EP0365828B1 (fr) 1993-08-25
ATE93412T1 (de) 1993-09-15

Similar Documents

Publication Publication Date Title
EP0365828B1 (fr) Support pour récipients d'échantillons
EP0365827B1 (fr) Dispositif de réception pour plusieurs récipients d'échantillons en vue de mesures radiométriques
EP2927163B1 (fr) Dispositif de transport vertical, système de distribution d'échantillons et système d'automatisation de laboratoire
EP0849584B1 (fr) Dispositif (cuvette) pour recevoir et stocker des liquides et pour effecteur des mesures optiques
DE69429840T2 (de) Transportsystem für ein Analysengerät für Flüssigkeiten
DE68911628T2 (de) Verfahren zur automatischen Bearbeitung von magnetischen Festphasen-Reagenzien.
DE2349901C3 (de) Vorrichtung zum reihenweisen Transport von geradlinig hintereinander angeordneten Probengefäßen
EP0774123B1 (fr) Procede et agencement de mesure permettant d'effectuer des analyses luminometriques en serie et cuve multiple de reception d'echantillons liquides
DE69904726T2 (de) Automatisches immunoassay-gerät mit flexiblem hebearm
DE69833846T2 (de) Vorrichtung zum Befördern von Komponenten innerhalb eines automatischen Analysesystems
EP0644426A1 (fr) Analyseur comprenant un dispositif pour la suspension de particules, et méthode de suspension
DE4313807A1 (de) Reagenzbehaelter fuer ein automatisches analysiergeraet
DE112010000822T5 (de) Automatische Analysevorrichtung und automatisches Analyseverfahren
DE2103841A1 (de) Blutuntersuchungsvorrichtung
DE3841961A1 (de) Geraet zur analyse von physiologischen oder anderen fluessigkeiten in den vertiefungen einer mikrotestplatte
WO1985003886A1 (fr) Procede et installation pour amener simultanement une pluralite d'echantillons de liquides sur une lame porte-objets
EP3666381B1 (fr) Appareil automatique de laboratoire destiné au traitement automatique des échantillons de laboratoire
DE69413643T2 (de) Probentraeger
DE3313127A1 (de) Vorrichtung zum faerben von biologischen proben
DE19512430A1 (de) Mikrotiterplatte
DE4329791A1 (de) Verfahren und Einrichtung zur automatischen Verteilung von Mikrofilterscheiben
EP1310303B1 (fr) Reservoir pour plusieurs reactifs differents necessaires a un systeme de dosage
DE202022103803U1 (de) Mikroplatten-Adapter
DE102020134318A1 (de) Handhabung von Laborelementen
EP3608676B1 (fr) Mettre l'échantillon dans le récipient de pointe de pipette pour un posttraitement

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT CH DE ES FR GB IT LI NL SE

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): AT CH DE ES FR GB IT LI NL SE

17P Request for examination filed

Effective date: 19910702

17Q First examination report despatched

Effective date: 19920602

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: LABORATORIUM PROF. DR. RUDOLF BERTHOLD GMBH & CO.

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT CH DE ES FR GB IT LI NL SE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRE;WARNING: LAPSES OF ITALIAN PATENTS WITH EFFECTIVE DATE BEFORE 2007 MAY HAVE OCCURRED AT ANY TIME BEFORE 2007. THE CORRECT EFFECTIVE DATE MAY BE DIFFERENT FROM THE ONE RECORDED.SCRIBED TIME-LIMIT

Effective date: 19930825

Ref country code: NL

Effective date: 19930825

Ref country code: SE

Effective date: 19930825

Ref country code: ES

Free format text: THE PATENT HAS BEEN ANNULLED BY A DECISION OF A NATIONAL AUTHORITY

Effective date: 19930825

REF Corresponds to:

Ref document number: 93412

Country of ref document: AT

Date of ref document: 19930915

Kind code of ref document: T

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AT

Effective date: 19930921

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CH

Effective date: 19930930

Ref country code: LI

Effective date: 19930930

REF Corresponds to:

Ref document number: 58905378

Country of ref document: DE

Date of ref document: 19930930

ET Fr: translation filed
GBT Gb: translation of ep patent filed (gb section 77(6)(a)/1977)

Effective date: 19931123

NLV1 Nl: lapsed or annulled due to failure to fulfill the requirements of art. 29p and 29m of the patents act
REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 19940714

Year of fee payment: 6

26N No opposition filed
PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 19940905

Year of fee payment: 6

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 19940919

Year of fee payment: 6

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Effective date: 19950921

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 19950921

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FR

Effective date: 19960531

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DE

Effective date: 19960601

REG Reference to a national code

Ref country code: FR

Ref legal event code: ST