EP0444443A1 - Dispositif de lyophilisation - Google Patents

Dispositif de lyophilisation Download PDF

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Publication number
EP0444443A1
EP0444443A1 EP91101553A EP91101553A EP0444443A1 EP 0444443 A1 EP0444443 A1 EP 0444443A1 EP 91101553 A EP91101553 A EP 91101553A EP 91101553 A EP91101553 A EP 91101553A EP 0444443 A1 EP0444443 A1 EP 0444443A1
Authority
EP
European Patent Office
Prior art keywords
freeze
openings
chamber
passage
disks
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP91101553A
Other languages
German (de)
English (en)
Other versions
EP0444443B1 (fr
Inventor
Rainer Rilke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GEA Lyophil GmbH
Original Assignee
Finn Aqua Santasalo Sohlberg GmbH
Amsco Finn Aqua GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Finn Aqua Santasalo Sohlberg GmbH, Amsco Finn Aqua GmbH filed Critical Finn Aqua Santasalo Sohlberg GmbH
Publication of EP0444443A1 publication Critical patent/EP0444443A1/fr
Application granted granted Critical
Publication of EP0444443B1 publication Critical patent/EP0444443B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00—Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/8593—Systems
    • Y10T137/86493—Multi-way valve unit
    • Y10T137/86718—Dividing into parallel flow paths with recombining
    • Y10T137/86743—Rotary

Definitions

  • the invention relates to a freeze-drying device with a freeze-drying chamber, with a condenser chamber and with an intermediate plate which is located between the freeze-drying chamber and the condenser chamber and is equipped with a lockable passage.
  • a freeze-drying device of this type is known from US Pat. No. 3,077,036.
  • the freeze-drying chamber of this device has shelves on which the product is located while the drying process is being carried out.
  • a condenser with an evacuation connection is provided to generate the required vacuum and to accumulate the vapors generated during the drying process.
  • the present invention has for its object to provide a freeze-drying device of the type mentioned, which do not have the disadvantages described.
  • this object is achieved in that two closable rotatable disks are provided to form the closable opening, that the disks are each equipped with openings remote from the axis of rotation and that these openings are designed such that they are rotated into one another overlapping position, in a non-overlapping position and in intermediate positions are adjustable.
  • the use of a valve designed in this way between the freeze-drying chamber and the condenser chamber has the advantage that the passage cross section can be regulated more easily.
  • the water vapor flowing to the condenser passes through the openings unhindered with respect to its direction, so that a uniform loading of the condenser is always achieved.
  • each of the disks has a plurality (for example four) of openings lying on a circle concentric with the axis of rotation. A particularly uniform flow through the passage cross section in the intermediate plate is achieved.
  • the freeze-drying device 1 shown in FIG. 1 has the freeze-drying chamber 2 and the condenser chamber 3. Both are cylindrical and arranged one above the other.
  • the intermediate plate 4 simultaneously forms the lid of the condenser chamber 3 and the bottom of the freeze-drying chamber 2.
  • the intermediate plate 4 is equipped with closable openings, not shown in detail in FIG. 1, which allow the chambers 2 and 3 to be connected to one another and separated from one another.
  • the freeze-drying chamber 2 there is a frame 5 with the setting plates 6.
  • a cylindrical hood is provided as the chamber wall 7, which is supported on the intermediate plate 4 and suitably consists of acrylic glass.
  • the capacitor chamber 3 is formed by the intermediate plate 4, the base plate 8 and the cylindrical housing section 9, which preferably also consists of acrylic glass.
  • the condenser 11 is located within the condenser chamber 3.
  • the base plate 8 is supported on a housing, not shown in detail, in which - as indicated schematically - there is a refrigerator 12 for supplying the condenser 11 and a vacuum pump 13 for evacuating the condenser chamber 3 .
  • FIGS. 2 and 3 show that the intermediate plate 4 comprises a plate 15 and a ring 16 of the same diameter placed thereon in a vacuum-tight manner.
  • the center of the plate 15 is equipped with a concentric extension 17 which forms a hub for an annular disk 18.
  • the disc 18 is rotatable about the axis 19.
  • Both the plate 15 and the disc 18 are each equipped with four circular openings 21 and 22 (Figure 3). These openings 21, 22 lie with respect to the axis 19 on a circle 23 (shown in broken lines). The diameter of the openings 21, 22 is smaller than their distance on the circle 23, so that a valve function can be achieved by rotating the disk 18.
  • the passage cross section formed by the openings 21, 22 is continuously adjustable between the complete opening (concentric position of the openings 21, 22 with respect to one another) and a tight seal (non-overlapping position of the openings 21, 22).
  • a carrier 27 for a magnet 28 is fastened to the disk 18.
  • the ring 16 is equipped on part of its circumference with a guide groove 29 in which a metallic or magnetic counterpart 31 is guided to the magnet 28. Moving the counterpart 31 in the guide groove causes the plate 18 to rotate.

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Drying Of Solid Materials (AREA)
EP91101553A 1990-02-26 1991-02-06 Dispositif de lyophilisation Expired - Lifetime EP0444443B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4006015 1990-02-26
DE4006015A DE4006015A1 (de) 1990-02-26 1990-02-26 Gefriertrocknungseinrichtung

Publications (2)

Publication Number Publication Date
EP0444443A1 true EP0444443A1 (fr) 1991-09-04
EP0444443B1 EP0444443B1 (fr) 1994-07-06

Family

ID=6400989

Family Applications (1)

Application Number Title Priority Date Filing Date
EP91101553A Expired - Lifetime EP0444443B1 (fr) 1990-02-26 1991-02-06 Dispositif de lyophilisation

Country Status (4)

Country Link
US (1) US5131170A (fr)
EP (1) EP0444443B1 (fr)
JP (1) JPH05231767A (fr)
DE (2) DE4006015A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7354514B2 (en) 2000-09-21 2008-04-08 Ethypharm S.A. Method for isolating and drying microparticles (microspheres or microcapsules) initially dispersed or suspensed in liquid phase
CN105222576A (zh) * 2015-10-27 2016-01-06 江苏楷益智能科技有限公司 冷冻干燥装置的干燥箱与隔板连接机构

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT1399U1 (de) 1995-11-29 1997-04-25 Immuno Ag Verfahren und einrichtung zum lyophilisieren
US6945264B1 (en) 2004-07-09 2005-09-20 Zurn Industries, Inc. Flow control valve and method for using the same
US7073775B2 (en) * 2004-09-13 2006-07-11 Cameron International Corporation Rotating check valve for compression equipment
CN100357687C (zh) * 2005-04-01 2007-12-26 南通冷冻设备有限公司 一种真空冷冻干燥装置
US9739395B2 (en) * 2014-01-09 2017-08-22 Dresser-Rand Company Grid valve apparatus
EP3303958B1 (fr) * 2015-06-01 2019-10-09 IMA Life North America Inc. Lyophilisation en vrac utilisant la congélation par pulvérisation et le séchage avec agitation et chauffage
CN107588601A (zh) * 2017-09-19 2018-01-16 上海东富龙科技股份有限公司 液体直接灌装无托盘冻干机
CN109737713B (zh) * 2018-12-12 2020-09-22 泰州市扬帆车件有限公司 一种磁动自旋转烤架

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1185544B (de) * 1963-05-10 1965-01-14 Leybold Hockvakuum Anlagen G M Mit gasfoermigem Kuehlmittel betriebene Gefriertrocknungskammer
DE1276554B (de) * 1965-08-04 1968-08-29 Paul Stein Dipl Ing Dr Gefriertrocknungsanlage fuer biologische Praeparate
US3997978A (en) * 1975-09-08 1976-12-21 Stuckey Alfred R Rope conditioning apparatus

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3077036A (en) * 1959-01-10 1963-02-12 Leybold Hochvakuum Anlagen Temperature responsive freeze drying method and apparatus
DE1160290B (de) * 1959-10-30 1963-12-27 Schwermaschb Iakarl Liebknecht Sammelstueck fuer den wahlweisen Anschluss der Ausblaseleitungen mehrerer Zellstoffkocher an einem gemeinsamen Ausblasebehaelter
US3271874A (en) * 1965-01-28 1966-09-13 Oppenheimer Suzanne Bohnen Infra-red sublimation method and apparatus for freeze drying techniques
DK117688B (da) * 1965-03-18 1970-05-19 Atlas As Apparat til frysetørring af vandholdige produkter under vakuum.
DK126720B (da) * 1968-05-11 1973-08-13 Leybold Heraeus Verwaltung Apparat til kontinuerlig frysettørring.
DK137287B (da) * 1970-08-25 1978-02-13 Atlas As Frysetørringsapparat.
US4395019A (en) * 1981-04-24 1983-07-26 Mobil Oil Corporation Seal for wear resistant inserts
AT374206B (de) * 1982-11-15 1984-03-26 Hirsch Kurt Verfahren und vorrichtung zum vorschaeumen von kunststoffen
US4516606A (en) * 1983-02-16 1985-05-14 Exxon Research And Engineering Co. Variable orifice valve assembly
US4776104A (en) * 1987-04-27 1988-10-11 Kuboyama Nobuyoshi Balanced extraction system

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1185544B (de) * 1963-05-10 1965-01-14 Leybold Hockvakuum Anlagen G M Mit gasfoermigem Kuehlmittel betriebene Gefriertrocknungskammer
DE1276554B (de) * 1965-08-04 1968-08-29 Paul Stein Dipl Ing Dr Gefriertrocknungsanlage fuer biologische Praeparate
US3997978A (en) * 1975-09-08 1976-12-21 Stuckey Alfred R Rope conditioning apparatus

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7354514B2 (en) 2000-09-21 2008-04-08 Ethypharm S.A. Method for isolating and drying microparticles (microspheres or microcapsules) initially dispersed or suspensed in liquid phase
CN105222576A (zh) * 2015-10-27 2016-01-06 江苏楷益智能科技有限公司 冷冻干燥装置的干燥箱与隔板连接机构

Also Published As

Publication number Publication date
EP0444443B1 (fr) 1994-07-06
DE59102090D1 (de) 1994-08-11
US5131170A (en) 1992-07-21
DE4006015A1 (de) 1991-09-05
JPH05231767A (ja) 1993-09-07

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