EP0444443B1 - Dispositif de lyophilisation - Google Patents

Dispositif de lyophilisation Download PDF

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Publication number
EP0444443B1
EP0444443B1 EP91101553A EP91101553A EP0444443B1 EP 0444443 B1 EP0444443 B1 EP 0444443B1 EP 91101553 A EP91101553 A EP 91101553A EP 91101553 A EP91101553 A EP 91101553A EP 0444443 B1 EP0444443 B1 EP 0444443B1
Authority
EP
European Patent Office
Prior art keywords
fact
disc
accordance
freeze
dish
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP91101553A
Other languages
German (de)
English (en)
Other versions
EP0444443A1 (fr
Inventor
Rainer Rilke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GEA Lyophil GmbH
Original Assignee
Amsco Finn Aqua GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amsco Finn Aqua GmbH filed Critical Amsco Finn Aqua GmbH
Publication of EP0444443A1 publication Critical patent/EP0444443A1/fr
Application granted granted Critical
Publication of EP0444443B1 publication Critical patent/EP0444443B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00—Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/8593—Systems
    • Y10T137/86493—Multi-way valve unit
    • Y10T137/86718—Dividing into parallel flow paths with recombining
    • Y10T137/86743—Rotary

Definitions

  • the invention relates to a freeze-drying device with a freeze-drying chamber, with a condenser chamber and with an intermediate plate which is located between the freeze-drying chamber and the condenser chamber and is equipped with a lockable passage for connecting and separating the two chambers.
  • a freeze dryer of this type is known from US-A-30 77 036.
  • the freeze-drying chamber of this device has shelves on which the product is located while the drying process is being carried out.
  • a condenser with an evacuation connection is provided to generate the required vacuum and to accumulate the vapors generated during the drying process.
  • DE-B-12 76 554 also belongs to the prior art. It discloses a freeze-drying device with a freeze-drying chamber, a condenser and an intermediate plate which is equipped with openings into which the Condenser forming pipes open. The openings in the intermediate plate cannot be locked.
  • the present invention has for its object to provide a freeze-drying device of the type mentioned, which do not have the disadvantages described in the prior art according to US-A-30 77 036.
  • the plate and disk have several (for example four) openings lying on a circle concentric to the axis of rotation. A particularly uniform flow through the passage cross-section in the intermediate plate is thereby achieved.
  • the freeze-drying device 1 shown in FIG. 1 has the freeze-drying chamber 2 and the condenser chamber 3. Both are cylindrical and one above the other.
  • the intermediate plate 4 simultaneously forms the lid of the condenser chamber 3 and the bottom of the freeze-drying chamber 2.
  • the intermediate plate 4 is not shown in detail in FIG. 1 Lockable openings equipped, which allow the chamber 2 and 3 to be connected and separated.
  • the freeze-drying chamber 2 there is a frame 5 with the setting plates 6.
  • a cylindrical hood is provided as the chamber wall 7, which is supported on the intermediate plate 4 and suitably consists of acrylic glass.
  • the capacitor chamber 3 is formed by the intermediate plate 4, the base plate 8 and the cylindrical housing section 9, which preferably also consists of acrylic glass.
  • the condenser 11 is located within the condenser chamber 3.
  • the base plate 8 is supported on a housing, not shown in detail, in which - as indicated schematically - there is a refrigerator 12 for supplying the condenser 11 and a vacuum pump 13 for evacuating the condenser chamber 3 .
  • FIGS. 2 and 3 show that the intermediate plate 4 comprises a plate 15 and a ring 16 of the same diameter placed thereon in a vacuum-tight manner.
  • the center of the plate 15 is equipped with a concentric extension 17 which forms a hub for an annular disk 18.
  • the disc 18 is rotatable about the axis 19.
  • Both the plate 15 and the disc 18 are each equipped with four circular openings 21 and 22 (Figure 3). These openings 21, 22 lie with respect to the axis 19 on a circle 23 (shown in broken lines). The diameter of the openings 21, 22 is smaller than their distance on the circle 23, so that a valve function can be achieved by rotating the disk 18.
  • the passage cross section formed by the openings 21, 22 is continuously adjustable between the complete opening (concentric position of the openings 21, 22 with respect to one another) and a tight seal (non-overlapping position of the openings 21, 22).
  • a carrier 27 for a magnet 28 is fastened to the disk 18.
  • the ring 16 is equipped on part of its circumference with a guide groove 29, in which a metallic or magnetic counterpart 31 is guided to the magnet 28. Moving the counterpart 31 in the guide groove causes the plate 18 to rotate.

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Drying Of Solid Materials (AREA)

Claims (8)

  1. Installation de lyophilisation avec chambre de lyophilisation (2), un condenseur (3) et une plaque intermédiaire(4), laquelle se trouve entre la chambre de lyophilisation et le condenseur et qui est équipée d'un passage pouvant être fermé pour relier ou séparer les deux enceintes (2,3), caractérisée en ce que la plaque intermédiaire (4) est constituée d'une rondelle fixe (15) et d'un disque (18) pouvant tourner autour de l'axe (19) de la rondelle (15), que pour former le passage pouvant être verrouillé, la rondelle (15) et le disque (18) sont munis d'orifices (21, 22) se trouvant chacun à distance de l'axe de rotation, lesquels orifices (21, 22) sont conçus de telle sorte qu'ils puissent être réglables par un mouvement rotatif dans une situation de superposition, de non superposition et dans des positions intermédiaires.
  2. Installation selon la revendication 1, caractérisée en ce que la rondelle (15) et le disque (18) présentent plusieurs, de préférence quatre, orifices (21 et 22) se trouvant sur un cercle (23) concentrique à l'axe de rotation.
  3. Installation selon la revendication 1 ou 2, caractérisée en ce que les orifices (21 et 22) sont en forme de cercle, que leur taille est identique et que leur diamètre est inférieur à leur distance sur le cercle concentrique (23).
  4. Installation selon l'une des revendications 1 à 3, caractérisée en ce que la rondelle (15) fixe est équipée d'un rebord (17) central et que le disque (18) a la forme d'un cercle, de telle sorte qu'il s'adapte sur le rebord central (17).
  5. Installation selon la revendication 4, caractérisée en ce qu'au centre de la rondelle (15), un positionnement (25) est prévu pour la butée d'un dispositif de rotation.
  6. Installation selon la revendication 4 ou 5, caractérisée en ce que des aimants auxiliaires (28, 31) sont prévus pour permettre une transmission pour faire tourner le disque (18) sans traversée.
  7. Installation selon la revendication 6, caractérisée en ce que le disque (18) est équipé d'un support (27) d'aimant (28).
  8. Installation selon la revendication 7, caractérisée en ce qu'il existe un anneau (16) entourant la rondelle, anneau équipé d'une rainure extérieure, dans laquelle un pendant (31) est déplacé vers l'aimant (28).
EP91101553A 1990-02-26 1991-02-06 Dispositif de lyophilisation Expired - Lifetime EP0444443B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4006015A DE4006015A1 (de) 1990-02-26 1990-02-26 Gefriertrocknungseinrichtung
DE4006015 1990-02-26

Publications (2)

Publication Number Publication Date
EP0444443A1 EP0444443A1 (fr) 1991-09-04
EP0444443B1 true EP0444443B1 (fr) 1994-07-06

Family

ID=6400989

Family Applications (1)

Application Number Title Priority Date Filing Date
EP91101553A Expired - Lifetime EP0444443B1 (fr) 1990-02-26 1991-02-06 Dispositif de lyophilisation

Country Status (4)

Country Link
US (1) US5131170A (fr)
EP (1) EP0444443B1 (fr)
JP (1) JPH05231767A (fr)
DE (2) DE4006015A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT1399U1 (de) 1995-11-29 1997-04-25 Immuno Ag Verfahren und einrichtung zum lyophilisieren
FR2814089B1 (fr) 2000-09-21 2003-07-04 Ethypharm Lab Prod Ethiques Procede pour isoler et secher des microparticules (microspheres ou microcapsules) initialement dispersees ou suspendues en phase liquide
US6945264B1 (en) 2004-07-09 2005-09-20 Zurn Industries, Inc. Flow control valve and method for using the same
US7073775B2 (en) * 2004-09-13 2006-07-11 Cameron International Corporation Rotating check valve for compression equipment
CN100357687C (zh) * 2005-04-01 2007-12-26 南通冷冻设备有限公司 一种真空冷冻干燥装置
US9739395B2 (en) * 2014-01-09 2017-08-22 Dresser-Rand Company Grid valve apparatus
EP3303958B1 (fr) * 2015-06-01 2019-10-09 IMA Life North America Inc. Lyophilisation en vrac utilisant la congélation par pulvérisation et le séchage avec agitation et chauffage
CN105222576A (zh) * 2015-10-27 2016-01-06 江苏楷益智能科技有限公司 冷冻干燥装置的干燥箱与隔板连接机构
CN107588601A (zh) * 2017-09-19 2018-01-16 上海东富龙科技股份有限公司 液体直接灌装无托盘冻干机
CN109737713B (zh) * 2018-12-12 2020-09-22 泰州市扬帆车件有限公司 一种磁动自旋转烤架

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3077036A (en) * 1959-01-10 1963-02-12 Leybold Hochvakuum Anlagen Temperature responsive freeze drying method and apparatus
DE1160290B (de) * 1959-10-30 1963-12-27 Schwermaschb Iakarl Liebknecht Sammelstueck fuer den wahlweisen Anschluss der Ausblaseleitungen mehrerer Zellstoffkocher an einem gemeinsamen Ausblasebehaelter
DE1185544B (de) * 1963-05-10 1965-01-14 Leybold Hockvakuum Anlagen G M Mit gasfoermigem Kuehlmittel betriebene Gefriertrocknungskammer
US3271874A (en) * 1965-01-28 1966-09-13 Oppenheimer Suzanne Bohnen Infra-red sublimation method and apparatus for freeze drying techniques
DK117688B (da) * 1965-03-18 1970-05-19 Atlas As Apparat til frysetørring af vandholdige produkter under vakuum.
DE1276554B (de) * 1965-08-04 1968-08-29 Paul Stein Dipl Ing Dr Gefriertrocknungsanlage fuer biologische Praeparate
DK126720B (da) * 1968-05-11 1973-08-13 Leybold Heraeus Verwaltung Apparat til kontinuerlig frysettørring.
DK137287B (da) * 1970-08-25 1978-02-13 Atlas As Frysetørringsapparat.
US3997978A (en) * 1975-09-08 1976-12-21 Stuckey Alfred R Rope conditioning apparatus
US4395019A (en) * 1981-04-24 1983-07-26 Mobil Oil Corporation Seal for wear resistant inserts
AT374206B (de) * 1982-11-15 1984-03-26 Hirsch Kurt Verfahren und vorrichtung zum vorschaeumen von kunststoffen
US4516606A (en) * 1983-02-16 1985-05-14 Exxon Research And Engineering Co. Variable orifice valve assembly
US4776104A (en) * 1987-04-27 1988-10-11 Kuboyama Nobuyoshi Balanced extraction system

Also Published As

Publication number Publication date
DE4006015A1 (de) 1991-09-05
JPH05231767A (ja) 1993-09-07
EP0444443A1 (fr) 1991-09-04
US5131170A (en) 1992-07-21
DE59102090D1 (de) 1994-08-11

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