EP0453561A4 - Chimeric mouse human antibodies with specificity to hiv antigens - Google Patents

Chimeric mouse human antibodies with specificity to hiv antigens

Info

Publication number
EP0453561A4
EP0453561A4 EP19910901136 EP91901136A EP0453561A4 EP 0453561 A4 EP0453561 A4 EP 0453561A4 EP 19910901136 EP19910901136 EP 19910901136 EP 91901136 A EP91901136 A EP 91901136A EP 0453561 A4 EP0453561 A4 EP 0453561A4
Authority
EP
European Patent Office
Prior art keywords
specificity
human antibodies
chimeric mouse
hiv antigens
mouse human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19910901136
Other languages
English (en)
Other versions
EP0453561A1 (fr
Inventor
Marc D. Better
Arnold H. Horwitz
Pradip Ghosh-Dastidar
Randy R. Robinson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xoma Royalty Corp
Original Assignee
Xoma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xoma Corp filed Critical Xoma Corp
Publication of EP0453561A1 publication Critical patent/EP0453561A1/fr
Publication of EP0453561A4 publication Critical patent/EP0453561A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/112—Retroviridae (F), e.g. leukemia viruses
    • C07K16/114—Lentivirus (G), e.g. human immunodeficiency virus [HIV], feline immunodeficiency virus [FIV] or simian immunodeficiency virus [SIV]
    • C07K16/1145—Env proteins, e.g. gp41, gp110/120, gp160, V3, principal neutralising domain [PND] or CD4-binding site
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/112—Retroviridae (F), e.g. leukemia viruses
    • C07K16/114—Lentivirus (G), e.g. human immunodeficiency virus [HIV], feline immunodeficiency virus [FIV] or simian immunodeficiency virus [SIV]
    • C07K16/1143—Gag-pol proteins, e.g. p17or p24
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/112—Retroviridae (F), e.g. leukemia viruses
    • C07K16/114—Lentivirus (G), e.g. human immunodeficiency virus [HIV], feline immunodeficiency virus [FIV] or simian immunodeficiency virus [SIV]
    • C07K16/1147—Regulatory proteins, e.g. trans-activator of transcription [TAT], rev or vacuolar protein targeting [VPT]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plant Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Compositions Of Oxide Ceramics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EP19910901136 1989-11-13 1990-11-13 Chimeric mouse human antibodies with specificity to hiv antigens Withdrawn EP0453561A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43370389A 1989-11-13 1989-11-13
US433703 1989-11-13

Publications (2)

Publication Number Publication Date
EP0453561A1 EP0453561A1 (fr) 1991-10-30
EP0453561A4 true EP0453561A4 (en) 1993-02-10

Family

ID=23721227

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19910901136 Withdrawn EP0453561A4 (en) 1989-11-13 1990-11-13 Chimeric mouse human antibodies with specificity to hiv antigens

Country Status (6)

Country Link
EP (1) EP0453561A4 (fr)
JP (2) JPH03206888A (fr)
KR (2) KR910009285A (fr)
AU (2) AU6663990A (fr)
CA (2) CA2044609A1 (fr)
WO (1) WO1991007494A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0519866A1 (fr) * 1991-06-18 1992-12-23 Ciba-Geigy Ag Anticorps contre V.I.H.
US5558865A (en) * 1991-08-22 1996-09-24 Nissin Shokuhin Kabushiki Kaisha HIV immunotherapeutics
EP0581353A1 (fr) * 1992-07-03 1994-02-02 De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezondheid En Cultuur Anticorps monoclonaux dirigés contre HIV-1 gp120, lignées cellulaires les produisant et structures epitopiques correspondantes
WO1998001476A1 (fr) * 1996-07-10 1998-01-15 Nabi Neutralisation hautement synergique du vih par des combinaisons d'anticorps monoclonaux et polyclonaux
WO1998043995A1 (fr) * 1997-03-28 1998-10-08 Seikagaku Corporation Nouveaux complexes anti-vih et compositions medicamenteuses
US20030035798A1 (en) 2000-08-16 2003-02-20 Fang Fang Humanized antibodies
JP2005522192A (ja) 2001-07-19 2005-07-28 パーラン セラピューティクス， インコーポレイテッド マルチマータンパク質およびマルチマータンパク質を作製および使用する方法
EP1960435A1 (fr) * 2005-12-15 2008-08-27 Micromet AG Anticorps à domaines greffés
CN105980405A (zh) * 2013-12-08 2016-09-28 派特塞尔有限公司 Hiv抗原和抗体及其组合物、方法和用途
CN116143909B (zh) * 2021-11-20 2023-10-31 东莞市朋志生物科技有限公司 一种抗hiv-1 p24的抗体及其制备方法和用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0248534A2 (fr) * 1986-05-06 1987-12-09 Epitope, Inc. Méthode pour détecter une infection provoquée par le virus SIDA
EP0327000A2 (fr) * 1988-01-30 1989-08-09 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Fragments de gènes codant pour la région variable d'un anticorps anti-HIV, anticorps chimériques anti-HIV exprimés lors de leur utilisation et procédé pour leur préparation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1339857C (fr) * 1987-05-29 1998-05-05 Cecily Rou-Yun Sun Anticorps monoclonaux qui peuvent se fixer a la proteine gp120 et qui neutralisent le vih-1
WO1989005820A1 (fr) * 1987-12-21 1989-06-29 Arch Development Corporation Antigenes et anticorps associes au virus d'immunodeficience humaine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0248534A2 (fr) * 1986-05-06 1987-12-09 Epitope, Inc. Méthode pour détecter une infection provoquée par le virus SIDA
EP0327000A2 (fr) * 1988-01-30 1989-08-09 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Fragments de gènes codant pour la région variable d'un anticorps anti-HIV, anticorps chimériques anti-HIV exprimés lors de leur utilisation et procédé pour leur préparation

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS vol. 160, no. 3, 15 May 1989, DULUTH, MINNESOTA US pages 1250 - 1256 LARRICK ET AL. 'Rapid cloning of rearranged immunoglobulin genes from human hybridoma cells' *
BIOCHIMICA ET BIOPHYSICA ACTA vol. 949, 1988, AMSTERDAM, NL pages 213 - 223 MARCUS-SEKURA ET AL. 'Reactivity of an HIV gag gene polypeptide expressed in E.coli with sera from AIDS patients and monoclonal antibodies to gag' *
BIOTECHNOLOGY vol. 7, no. 9, September 1989, NEW YORK US pages 934 - 938 LARRICK ET AL. 'Polymerase chain reaction using mixed primers: cloning of human monoclonal antibody variable region genes from single hybridoma cells' *
PROCEEDINGS OF THE 4TH INTERNATIONAL CONFERENCE ON AIDS June 1988, page 237 YOSHIHARA ET AL. 'HIV neutralization studies using anti-core and anti-envelope protein monoclonal antibodies' *
See also references of WO9107494A1 *

Also Published As

Publication number Publication date
KR910009285A (ko) 1991-06-28
CA2044627A1 (fr) 1991-05-14
EP0453561A1 (fr) 1991-10-30
AU6953091A (en) 1991-06-13
JPH03206888A (ja) 1991-09-10
KR920701441A (ko) 1992-08-11
AU6663990A (en) 1991-05-16
JPH04503609A (ja) 1992-07-02
WO1991007494A1 (fr) 1991-05-30
CA2044609A1 (fr) 1991-05-14

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Effective date: 19940601