EP0455060A1 - Machine à doser avec dispositif pour compacter des produits pharmaceutiques dans des gélules - Google Patents

Machine à doser avec dispositif pour compacter des produits pharmaceutiques dans des gélules Download PDF

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Publication number
EP0455060A1
EP0455060A1 EP91106238A EP91106238A EP0455060A1 EP 0455060 A1 EP0455060 A1 EP 0455060A1 EP 91106238 A EP91106238 A EP 91106238A EP 91106238 A EP91106238 A EP 91106238A EP 0455060 A1 EP0455060 A1 EP 0455060A1
Authority
EP
European Patent Office
Prior art keywords
hole
chamber
fact
pin
container
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP91106238A
Other languages
German (de)
English (en)
Inventor
Ernesto Gamberini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MG 2 SpA
MG2 SpA
Original Assignee
MG 2 SpA
MG2 SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MG 2 SpA, MG2 SpA filed Critical MG 2 SpA
Publication of EP0455060A1 publication Critical patent/EP0455060A1/fr
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A61J3/074—Filling capsules; Related operations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
    • B30B11/005—Control arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
    • B30B15/30—Feeding material to presses
    • B30B15/302—Feeding material in particulate or plastic state to moulding presses

Definitions

  • the present invention relates to a device, installed on a metering machine, for compacting pharmaceutical products, preferably powders, inside preferably hard gelatine capsules.
  • Known metering machines feature a rotary annular container, the bottom of which presents a number of holes which, for each turn of the container, are opened at the bottom for a given period of time.
  • a conveyor belt Beneath the container, a conveyor belt supports a number of bottom capsule portions which, for said period, are arranged coaxial with said holes.
  • the machine also comprises a rotary drum fitted with a number of rods moved axially by a cam and each fitted on the end with a block from which a pin extends inwards of the container.
  • the compacting function is performed by said pin, which presses the powder inside the capsule once or several times for each turn of the machine.
  • the pressure exerted by the pin is counteracted by a spring, the setting of which determines how much pressure is applied.
  • the above compacting system presents several drawbacks. Foremost of these is that, for ensuring the powder is compacted equally in all the capsules, the springs must be set one by one to the same value. Achieving an accurate setting is a painstaking job even in the case of one spring, let alone for several. What is more, the setting of the spring is what determines the extent to which the powder is compacted and, therefore, the amount of powder fed into the capsule. Consequently, any inaccuracy in the setting of the spring results in a corresponding inaccuracy in the amount of powder fed into the capsule. Last but not least is the fact that the springs cannot be set without first stopping the machine.
  • It is an object of the present invention is provide a metering machine device for compacting pharmaceutical products in capsules, designed to overcome the aforementioned drawbacks, i.e. which can be set easily and accurately without having to stop the machine.
  • a device for compacting pharmaceutical products in capsules on a metering machine comprising a first drum type body designed to rotate a container filled with said product, characterised by the fact that it comprises: at least a second body above said container and in which is formed a first airtight chamber; a vertical axially-mobile pin supported on said second body and having a top portion housed in said first chamber, and a bottom portion outside said second body and designed, in at least one operating stage, to engage a first hole formed in the bottom of said container, for compacting said product in a capsule underneath said first hole; a pressurized fluid circuit between a source of said fluid and said first chamber, for exerting downward pressure on said top portion of said pin, and such that the extent to which said product is compacted is a function of the pressure of said fluid inside said first chamber; and a vertical piston supporting said second body and designed to move back and forth along a second vertical hole formed in said first body.
  • Machine 1 indicates a machine for metering powdered pharmaceutical products into bottom capsule portions 2 normally made of hard gelatine.
  • Machine 1 is described in Italian Patent Application n.3750 A/89 entitled “MACHINE FOR METERING POWDERED PHARMACEUTICAL PRODUCTS INTO A CONTAINER", filed on 6 December 1989 by the present Applicant, and the content of which is incorporated herein purely by way of reference as required.
  • machine 1 comprises a device 3 for compacting powder inside capsules and naturally differing from that illustrated in the above Italian patent application.
  • device 3 may also be employed on metering machines other that that described in said application.
  • Machine 1 substantially comprises: a vertical column 4 rotated about its longitudinal axis by an electric motor (not shown); a fixed vertical column 5 housed inside column 4 and extending upwards beyond the top end of the same; a vertical drum type body 6 integral and therefore rotating with column 4; an open-topped annular container 7 integral and therefore rotating with body 6; an intermediate ring of equally-spaced vertical through holes 8 formed in the bottom wall 11 of container 7; a flange 12 integral with body 6, located beneath container 7, and so formed as to engage a belt 13 defined by a number of bushes 14 each housing a capsule 2; and an intermediate ring of equally-spaced vertical through holes 15 equal in number to holes 8 and formed in body 6.
  • belt 13 feeds capsules 2 from one end to the other of the system of which machine 1 forms part, said system presenting a number of machines, each having a flange or similar engaged by belt 13.
  • Capsules 2 are of course arranged coaxial with respective holes 8.
  • device 3 comprises: a number of vertical pistons 16 housed in respective holes 15, rotated by and about the longitudinal axis of body 6, and moved axially back and forth by a cam (not shown); a number of blocks 17 fitted integral with the top ends, outside hole 15, of respective pistons 16; a number of vertical pins 18, one for each block 17, extending from blocks 17 inwards of container 7 and coaxially with respective holes 8, for tamping the product once or repeatedly inside respective capsules 2; a chamber 21 formed in each block 17 and containing pressurized fluid, preferably air, for counteracting upward travel of respective pin 18; an annular chamber 22 formed in a body 23 integral with body 6; a number of conduits 24 for constantly connecting chamber 22 to all of chambers 21; and a member 25 for connecting chamber 22 to a pressurized fluid source 26.
  • Block 17 comprises a vertical body 27 in which is formed a vertical cylindrical through hole 28 having a top portion sealed by a cap 31, and a bottom portion smaller in diameter than said top portion and defining with the same an annular shoulder 32.
  • Pin 18 comprises a wide head 33 housed in the top portion of hole 28 and supporting an annular seal; a central portion 34 housed in the bottom portion of hole 28; and a bottom portion 35 smaller in diameter than portion 34 and extending downwards outside hole 28.
  • Chamber 21 is defined inside the top portion of hole 28, between head 33 and cap 31. Pin 18 is free to travel axially along hole 28 between cap 31 and shoulder 32, but is pressed constantly downwards by said pressurized fluid so that head 33 rests on shoulder 32. When compacting the product, the fluid in chamber 21 counteracts upward travel of pin 18 caused by the reaction of the product to the tamping operation.
  • a horizontal plate 36, extending from block 17, presents a vertical through hole engaged by the threaded top end 37 of respective piston 16, to which is screwed a nut 38.
  • Each block 17 is centered quite simply in relation to respective hole 8.
  • piston 16 is fitted, in adjustable manner in relation to hole 8, with a plate 41 having a hole 42 engaged by a pin 43 extending downwards from plate 36.
  • an integral cylindrical coupling 44 extends upwards, coaxially with column 4, and is fitted integrally on the top end with body 23, which presents a top annular wall 45, a cylindrical lateral wall 46 and an annular bottom wall 47.
  • Chamber 22 is defined between said walls 45, 46 and 47, and by the outer surface of coupling 44, which thus constitutes the inner lateral wall of chamber 22.
  • body 23 is fitted on to coupling 44 and secured firmly to the same by threaded pins 48 fitted inside through holes formed in wall 47.
  • threaded pins 48 fitted inside through holes formed in wall 47.
  • Coupling 44 is closed at the top by a cap 52 having an axial hole 53 engaged by the top end of fixed column 5.
  • Column 5 supports a known rotary coupling 54, such as that produced by ATLAS COPCO ITALIA S.p.A. and marketed by AUTOMAZIONE EMILIANA s.r.l. of Castenaso (Bologna) under catalogue number 303.
  • the inlet of coupling 54 is fitted inside fixed column 5 and connected to source 26 by a conduit 55 extending along the whole of column 5 and coming out underneath a surface of machine 1 (not shown).
  • a portion of conduit 55 outside machine 1 is fitted with a pressure regulator 56 having a knob 57 for manually regulating the pressure inside chamber 22 and, consequently, inside chambers 21.
  • the outlet of coupling 54 presents a conduit 58 extending through cap 52 and connected to a fitting 61 supported on coupling 44 next to chamber 22.
  • Wall 45 presents a number of equally-spaced holes 62, each housing a fitting 63 from which extends a respective conduit 24 connected to a second fitting 64 on cap 31 of respective block 17.
  • While hole 8 is open, provision may be made on machine 1 for tamping the product once or several times inside capsule 2 via reciprocating motion of pistons 16 and respective blocks 17, at each downstroke of which, portion 35 of pin 18 moves down through respective hole 8 into capsule 2.
  • the pressure exerted on the product by pin 18 depends on the pressure of the fluid inside chamber 21. Consequently, a variation in the fluid pressure results in a corresponding variation in the pressure exerted on the product and, therefore, the amount of product fed into capsule 2.
  • capsule 2 is preferably raised, by a piston 66 operated by a cam (not shown), so as to contact the edge of respective hole 8 and prevent spillage of the product from container 7.
  • a final tamping operation is also performed at a recess formed in body 65 and so designed as to prevent the product from being fed into the recess from container 7, and to enable entry of pin 18 which moves down through hole 8 into capsule 2 for performing the final tamping operation.
  • the conduits mentioned above preferably consist of hoses.
  • the extent to which the product is compacted inside capsules 2 depends on the pressure of a fluid which, as is known, may be regulated to a high degree of accuracy, which accuracy is also reflected in the amount of product fed into capsules 2.
  • said fluid pressure may be regulated easily with no need for arresting operation of machine 1.
  • a manual pressure regulating control is shown in Fig.1
  • the protective scope of the present invention obviously also extends to an electrically controlled pressure regulating system.
  • the fluid pressure, and consequently also adjustment thereof, is the same for all of blocks 17, so that the same amount of product is fed into all of capsules 2.
  • compacting device 3 is of straightforward design; presents no components subject to wear, or springs or other components requiring periodic adjustment; and involves no fluid consumption.
  • source 26 will consist of a straightforward compressor. Also, changes may be made to the design of chamber 22 and connection of the same to chambers 21.

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  • Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Basic Packing Technique (AREA)
  • Supply Of Fluid Materials To The Packaging Location (AREA)
  • Filling Of Jars Or Cans And Processes For Cleaning And Sealing Jars (AREA)
EP91106238A 1990-05-02 1991-04-18 Machine à doser avec dispositif pour compacter des produits pharmaceutiques dans des gélules Ceased EP0455060A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT3469A IT1238915B (it) 1990-05-02 1990-05-02 Dispositivo per il compattamento di prodotti farmaceutici in capsule per una macchina di dosaggio di tali prodotti.
IT346990 1990-05-02

Publications (1)

Publication Number Publication Date
EP0455060A1 true EP0455060A1 (fr) 1991-11-06

Family

ID=11107966

Family Applications (1)

Application Number Title Priority Date Filing Date
EP91106238A Ceased EP0455060A1 (fr) 1990-05-02 1991-04-18 Machine à doser avec dispositif pour compacter des produits pharmaceutiques dans des gélules

Country Status (4)

Country Link
EP (1) EP0455060A1 (fr)
JP (1) JPH04242588A (fr)
BR (1) BR9101759A (fr)
IT (1) IT1238915B (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3425221A1 (de) * 1983-07-12 1985-01-24 Aktiebolaget Bofors, Bofors Regelkreis fuer eine materialbearbeitungsmaschine
DE3432992A1 (de) * 1983-09-08 1985-03-28 MG 2 S.p.A., Pian di Macina-Pianoro, Bologna Vorrichtung zum zumessen einer vorgegebenen pulvermenge
EP0344790A2 (fr) * 1988-06-02 1989-12-06 Warner-Lambert Company Instrumentation d'une machine à remplir des capsules avec disque de dosage

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3425221A1 (de) * 1983-07-12 1985-01-24 Aktiebolaget Bofors, Bofors Regelkreis fuer eine materialbearbeitungsmaschine
DE3432992A1 (de) * 1983-09-08 1985-03-28 MG 2 S.p.A., Pian di Macina-Pianoro, Bologna Vorrichtung zum zumessen einer vorgegebenen pulvermenge
EP0344790A2 (fr) * 1988-06-02 1989-12-06 Warner-Lambert Company Instrumentation d'une machine à remplir des capsules avec disque de dosage

Also Published As

Publication number Publication date
JPH04242588A (ja) 1992-08-31
ITBO903469A1 (it) 1991-11-02
IT9003469A0 (it) 1990-05-02
IT1238915B (it) 1993-09-07
BR9101759A (pt) 1991-12-17

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