Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K9/00—Medicinal preparations characterised by special physical form
  • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
  • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release

Definitions

• the devices of this invention combine or utilise this release profile with the controlled release of active material over the' period before and/or after the sharp pulsed release.
• the device of the present Invention may also be combined with another dosage form in a single capsule which will qombine the release profile of the device of this invention with that of the other dosage form.
• two separate devices of this invention designed to have different delay times before the release of the active material may be joined end to end so that the active materials are separated by an impermeable wall.
• a device of this invention may be joined to or combined with any other suitable controlled release device (of appropriate dimensions).
• N-vinylpyrrol1dones cross-linked cellulosic derivatives especially those known to be useful as tablet dislntegrants
• cross-linked dextrans especially those known to * be use' ul for column separations and wound healing
• cross-linked hydroxyethyl ethacrylates especially those known to be useful in contact lenses
• cross-linked gelatins and starches hydrogels comprising cross-linked (meth)acrylic acid copolymers and their salts
• cross-linked polyacrylamides and cross-linked poly(ethylene glycols) cross-linked polyacrylamides and cross-linked poly(ethylene glycols).
• Specific classes of drug which may be utilised in a device of the invention include hypnotics, sedatives, tranquiUsers, anti-pyretics, anti-Inflammatory agents, anti-histamines, anti-tussives, anti-convulsants, anti-asthmatics, muscle relaxants, anti-tumour agents, for example those for the treatment of malignant neoplasia, local anaesthetics, anti-Parkinson agents, topical or dermatological agents, diuretics, for example those containing potassium, such as potassium iodide, preparations for the treatment of mental illness, for example preparations containing lithium for use in the treatment of manic depression or containing prostaglandlns for the treatment of schizophrenia, anti-spasmodics, anti-ulcer agents, ⁇ l blockers such as atenolol and metoprolol; calcium antagonists such as nifedlpine and nitrendipine, ACE . ⁇ inhibitors such
• the devices of this invention are suited to treatment, both prophylactic and therapeutic, of tropical diseases; for example malaria, leprosy, schistoso lasis and clonorchiasis.
• drugs which can be used as biologically active substance in pulsed release devices of this invention for the treatment of these and other tropical diseases include quinine, sulphonamides, rlfamycin, clofazimine, thiambutasine, chlorphenyl derivatives, chlorguamide, cycloguanil, pyr1metham1ne, sulphadiazine, trimethoprlm, quinoline derivatives such as pa aquine, chloroqulne, pentaquine, primaquine and a odiquine, pararosaniUne, sulphamethizole, quinacrine, dapsone, sodium sulphoxone, sulphetrone, sodium hydnocarpate and sodium chaulmoograte
• Any conventional enteric coating agent may be employed, for " " ex ' ample cellulose acetate phthalate, polyvinylacetate phthalate hydroxypropylmethylcellulose phthalate and pH sensitive polyacrylate and polymethacrylate derivates.
• hydrogels may also be employed as- the water swellable material which is contained within the capsule. Those hydrogels which exhibit a higher degree of swelling are preferably used for this purpose. They may readily be prepared in the form of moulded monoliths or in particulate form. In the preferred devices the water swellable material and the plug may be constructed from the same material.
• the hydrophilic polymer for example, polyethylene oxide, may also be foamed in a manner known jjer ⁇ e_.
• suitable materials which may be used to coat the surface of the capsule include nitrocellulose, cellulose esters, ethers and acetals, polymethacr late copolymers, polyurethanes, air curing coatings " such as alkyd resins and moisture curing coatings such as polyurethanes containing an excess of isocyanate groups.

Landscapes

• Health & Medical Sciences (AREA)
• Public Health (AREA)
• Animal Behavior & Ethology (AREA)
• Chemical & Material Sciences (AREA)
• Medicinal Chemistry (AREA)
• Pharmacology & Pharmacy (AREA)
• Epidemiology (AREA)
• Life Sciences & Earth Sciences (AREA)
• Engineering & Computer Science (AREA)
• General Health & Medical Sciences (AREA)
• Veterinary Medicine (AREA)
• Bioinformatics & Cheminformatics (AREA)
• Medicinal Preparation (AREA)
• Sampling And Sample Adjustment (AREA)
• Encapsulation Of And Coatings For Semiconductor Or Solid State Devices (AREA)
• Formation And Processing Of Food Products (AREA)
• Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
• Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
• Refuse Collection And Transfer (AREA)
• Seal Device For Vehicle (AREA)
• Nozzles (AREA)
• Molding Of Porous Articles (AREA)
• Medical Preparation Storing Or Oral Administration Devices (AREA)

Applications Claiming Priority (2)

Publications (1)

Family

ID=10651816

Family Applications (2)

Family Applications Before (1)

Country Status (13)

Families Citing this family (25)

Family Cites Families (6)

• 1989
  • 1989-02-16 GB GB898903564A patent/GB8903564D0/en active Pending
• 1990
  • 1990-02-15 ZA ZA901156A patent/ZA901156B/xx unknown
  • 1990-02-15 JP JP2503361A patent/JPH0735327B2/ja not_active Expired - Lifetime
  • 1990-02-15 DK DK90301608.7T patent/DK0384642T3/da active
  • 1990-02-15 NZ NZ232558A patent/NZ232558A/xx unknown
  • 1990-02-15 GB GB9003502A patent/GB2230441B/en not_active Expired - Lifetime
  • 1990-02-15 PT PT93168A patent/PT93168B/pt not_active IP Right Cessation
  • 1990-02-15 ES ES90301608T patent/ES2049414T3/es not_active Expired - Lifetime
  • 1990-02-15 DE DE90301608T patent/DE69005149T2/de not_active Expired - Fee Related
  • 1990-02-15 EP EP90301608A patent/EP0384642B1/de not_active Expired - Lifetime
  • 1990-02-15 EP EP90903196A patent/EP0458835A1/de active Pending
  • 1990-02-15 AT AT90301608T patent/ATE98483T1/de not_active IP Right Cessation
  • 1990-02-15 AU AU50966/90A patent/AU5096690A/en not_active Abandoned
  • 1990-02-15 WO PCT/GB1990/000250 patent/WO1990009169A1/en not_active Ceased
  • 1990-02-15 IE IE55490A patent/IE64154B1/en not_active IP Right Cessation

Non-Patent Citations (1)

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