EP0458903A4 - Soluble analogs of thrombomodulin - Google Patents

Soluble analogs of thrombomodulin

Info

Publication number: EP0458903A4
Authority: EP; European Patent Office
Prior art keywords: thrombomodulin; soluble analogs; analogs; soluble
Prior art date: 1989-02-17
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP19900904135

Other languages

English (en)

Other versions

EP0458903A1 (fr

Inventor

Michael John Morser

Charles Glaser

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bayer Healthcare Pharmaceuticals Inc

Original Assignee

Codon

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-02-17

Filing date

1990-02-16

Publication date

1992-06-17

1990-02-16 Application filed by Codon filed Critical Codon

1991-12-04 Publication of EP0458903A1 publication Critical patent/EP0458903A1/fr

1992-06-17 Publication of EP0458903A4 publication Critical patent/EP0458903A4/en

Status Withdrawn legal-status Critical Current

Links

102000012607 Thrombomodulin Human genes 0.000 title 1
108010079274 Thrombomodulin Proteins 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
- C07K14/3153—Streptokinase
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/7455—Thrombomodulin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/90—Fusion polypeptide containing a motif for post-translational modification
- C07K2319/91—Fusion polypeptide containing a motif for post-translational modification containing a motif for glycosylation

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Biochemistry (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Toxicology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

EP19900904135 1989-02-17 1990-02-16 Soluble analogs of thrombomodulin Withdrawn EP0458903A4 (en)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date
US31214189A	1989-02-17	1989-02-17
US312141		1989-02-17
US34537289A	1989-04-28	1989-04-28
US345372		1989-04-28
US40694189A	1989-09-13	1989-09-13
US406941		1989-09-13

Publications (2)

Publication Number	Publication Date
EP0458903A1 EP0458903A1 (fr)	1991-12-04
EP0458903A4 true EP0458903A4 (en)	1992-06-17

Family

ID=27405562

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP19900904135 Withdrawn EP0458903A4 (en)	1989-02-17	1990-02-16	Soluble analogs of thrombomodulin

Country Status (6)

Country	Link
EP (1)	EP0458903A4 (fr)
JP (1)	JPH04505554A (fr)
KR (1)	KR920701459A (fr)
AU (1)	AU646633B2 (fr)
CA (1)	CA2046906A1 (fr)
WO (1)	WO1990010081A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6063763A (en) *	1989-04-28	2000-05-16	Schering Aktiengesellschaft	Protease-resistant thrombomodulin analogs
GB8927722D0 (en) *	1989-12-07	1990-02-07	British Bio Technology	Proteins and nucleic acids
DK0544826T3 (da) *	1990-08-15	2002-04-22	Paion Gmbh	Overlegne trombomodulinanaloger til farmaceutisk anvendelse
EP0641215B1 (fr) *	1992-02-05	2004-04-21	Paion GmbH	Analogues de thrombomoduline resistant a la protease
AU4533093A (en) *	1992-06-10	1994-01-04	Michael John Morser	Mutants of the epidermal growth factor domains of human thrombomodulin
US5585095A (en) *	1993-09-14	1996-12-17	Regents Of The University Of Minnesota	Method to enhance thrombomodulin APC generation using cationic proteins
US5830448A (en) *	1994-06-16	1998-11-03	Genentech, Inc.	Compositions and methods for the treatment of tumors
US7579000B2 (en)	2002-05-01	2009-08-25	Bayer Schering Pharma Ag	Tissue factor targeted antibodies as anticoagulants
CN100412090C (zh) *	2002-05-01	2008-08-20	舍林股份公司	作为抗凝剂的新的靶向组织因子的血栓调节蛋白融合蛋白
CA2609262A1 (fr)	2005-06-03	2006-12-07	Mochida Pharmaceutical Co., Ltd.	Proteine fusionnee possedant un anticorps anti-cd14
BR112013002739A2 (pt) *	2010-08-05	2019-09-24	Council Scient Ind Res	constructos de proteínas de fusão que possuem propriedades trombolíticas e anticoagulantes
CN119798451B (zh) *	2025-01-06	2025-08-12	印月生物技术(杭州)有限公司	抗人凝血酶调节蛋白的单克隆抗体及应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4849403A (en) *	1985-05-29	1989-07-18	Pentapharm Ag	Protein C activator, methods of preparation and use thereof
JPH0689014B2 (ja) *	1986-01-21	1994-11-09	興和株式会社	トロンビン結合性物質およびその製法
US4912207A (en) *	1987-05-06	1990-03-27	Washington University	DNA clone of human thrombomodulin and portions thereof
DK299087D0 (da) *	1987-06-12	1987-06-12	Novo Industri As	Proteins and derivatives thereof
US5256770A (en) *	1990-04-09	1993-10-26	Schering Ag	Oxidation resistant thrombomodulin analogs
CA2022713A1 (fr) *	1989-08-11	1991-02-12	Nils U. Bang	Derives de thrombomoduline humaine

1990
- 1990-02-16 AU AU51917/90A patent/AU646633B2/en not_active Ceased
- 1990-02-16 JP JP2504399A patent/JPH04505554A/ja active Pending
- 1990-02-16 KR KR1019910700941A patent/KR920701459A/ko not_active Withdrawn
- 1990-02-16 CA CA002046906A patent/CA2046906A1/fr not_active Abandoned
- 1990-02-16 EP EP19900904135 patent/EP0458903A4/en not_active Withdrawn
- 1990-02-16 WO PCT/US1990/000955 patent/WO1990010081A1/fr not_active Ceased

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
No further relevant documents have been disclosed. *
See also references of WO9010081A1 *

Also Published As

Publication number	Publication date
KR920701459A (ko)	1992-08-11
WO1990010081A1 (fr)	1990-09-07
AU5191790A (en)	1990-09-26
EP0458903A1 (fr)	1991-12-04
JPH04505554A (ja)	1992-10-01
AU646633B2 (en)	1994-03-03
CA2046906A1 (fr)	1990-08-18

Legal Events

Date	Code	Title	Description
1991-10-18	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1991-12-04	17P	Request for examination filed	Effective date: 19910726
1991-12-04	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB IT LI LU NL SE
1992-06-17	A4	Supplementary search report drawn up and despatched	Effective date: 19920428
1992-06-17	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB IT LI LU NL SE
1994-08-17	17Q	First examination report despatched	Effective date: 19940705
1995-03-29	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
1995-05-17	18D	Application deemed to be withdrawn	Effective date: 19941116

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