EP0481003A2 - Process for producing antibacterial intermediates via enzyme hydrolysis of racemic substrates. - Google Patents

Process for producing antibacterial intermediates via enzyme hydrolysis of racemic substrates.

Info

Publication number
EP0481003A2
EP0481003A2 EP90911357A EP90911357A EP0481003A2 EP 0481003 A2 EP0481003 A2 EP 0481003A2 EP 90911357 A EP90911357 A EP 90911357A EP 90911357 A EP90911357 A EP 90911357A EP 0481003 A2 EP0481003 A2 EP 0481003A2
Authority
EP
European Patent Office
Prior art keywords
enzyme hydrolysis
via enzyme
producing antibacterial
intermediates via
racemic substrates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP90911357A
Other languages
French (fr)
Inventor
Jon E Clark
Doris P Schumacher
Derek Walker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of EP0481003A2 publication Critical patent/EP0481003A2/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • C12P41/007—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving acyl derivatives of racemic amines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Selon un nouveau procédé de préparation d'intermédiaires bactéricides, par exemple de préparation du composé bactéricide thiamphénicol, on utilise une hydrolase de gamma-glutamyle afin d'hydrolyser sélectivement un mélange racémique de D-thréophénylsérines et de L-thréophénylsérines.According to a new process for the preparation of bactericidal intermediates, for example of the preparation of the bactericidal compound thiamphenicol, a gamma-glutamyl hydrolase is used in order to selectively hydrolyze a racemic mixture of D-threophenylserines and L-threophenylserines.

EP90911357A 1989-07-07 1990-07-05 Process for producing antibacterial intermediates via enzyme hydrolysis of racemic substrates. Pending EP0481003A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37644889A 1989-07-07 1989-07-07

Publications (1)

Publication Number Publication Date
EP0481003A2 true EP0481003A2 (en) 1992-04-22

Family

ID=23485070

Family Applications (2)

Application Number Title Priority Date Filing Date
EP90911357A Pending EP0481003A2 (en) 1989-07-07 1990-07-05 Process for producing antibacterial intermediates via enzyme hydrolysis of racemic substrates.
EP19900307347 Withdrawn EP0407190A3 (en) 1989-07-07 1990-07-05 Process for producing antibacterial intermediates via enzyme hydrolysis of racemic substrates

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP19900307347 Withdrawn EP0407190A3 (en) 1989-07-07 1990-07-05 Process for producing antibacterial intermediates via enzyme hydrolysis of racemic substrates

Country Status (4)

Country Link
EP (2) EP0481003A2 (en)
KR (1) KR920701470A (en)
AU (1) AU6052090A (en)
WO (1) WO1991000923A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5346828A (en) * 1991-03-27 1994-09-13 Celgene Corporation Stereoisomeric enrichment of 2-amino-3-hydroxy-3-phenylpropionic acids using d-threonine aldolase
TW397866B (en) * 1993-07-14 2000-07-11 Bristol Myers Squibb Co Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes
JPH09506610A (en) * 1993-12-17 1997-06-30 ディーエスエム エヌ．ブイ． Preparation of phenylserine amide and phenylserine / phenylserine amide
US6686296B1 (en) 2000-11-28 2004-02-03 International Business Machines Corp. Nitrogen-based highly polymerizing plasma process for etching of organic materials in semiconductor manufacturing

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3347752A (en) * 1965-03-26 1967-10-17 Merck & Co Inc Microbiological cleavage process for resolving racemic alpha-methyl-beta-(3, 4,-dihydroxyphenyl)-alanine
US3733352A (en) * 1969-07-29 1973-05-15 Sumitomo Chemical Co Preparation of d-threo-1-p-methyl-sulfonylphenyl-2-dichloro-acet-amidopropane-1,3-diol
JPS5133550B2 (en) * 1974-05-01 1976-09-20
EP0677511A3 (en) * 1983-06-02 1996-07-24 Zambon Spa Intermediates for the preparation of 1-phenyl-1-hydroxy-2-amino-3-fluoropropane derivatives.
JPS6098995A (en) * 1983-11-04 1985-06-01 Microbial Chem Res Found Production of optically active 3-(3,4-dihydroxyphenyl) serine and its derivative
JPS60248192A (en) * 1984-05-23 1985-12-07 Sumitomo Chem Co Ltd Preparation of optically active threo-3-phenylserine derivative

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9100923A2 *

Also Published As

Publication number Publication date
EP0407190A2 (en) 1991-01-09
EP0407190A3 (en) 1991-03-13
WO1991000923A3 (en) 1991-03-07
KR920701470A (en) 1992-08-11
AU6052090A (en) 1991-02-06
WO1991000923A2 (en) 1991-01-24

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