EP0576688A1 - Element insere pour tube collecteur de bellini - Google Patents

Element insere pour tube collecteur de bellini Download PDF

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Publication number
EP0576688A1
EP0576688A1 EP93902517A EP93902517A EP0576688A1 EP 0576688 A1 EP0576688 A1 EP 0576688A1 EP 93902517 A EP93902517 A EP 93902517A EP 93902517 A EP93902517 A EP 93902517A EP 0576688 A1 EP0576688 A1 EP 0576688A1
Authority
EP
European Patent Office
Prior art keywords
chitin
insert
papillary
papillary duct
duct
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP93902517A
Other languages
German (de)
English (en)
Other versions
EP0576688A4 (fr
Inventor
Yoshihiro Shigemasa
Akira Tottori Daigaku Shirahama Matsuhashi
Saburo Godoshukusha Koyamajyutaku Rck3-401 Minami
Shin-Ichiro Sunfive Corporation Tanioka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SUNFIVE Corp
Original Assignee
SUNFIVE Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SUNFIVE Corp filed Critical SUNFIVE Corp
Publication of EP0576688A1 publication Critical patent/EP0576688A1/fr
Publication of EP0576688A4 publication Critical patent/EP0576688A4/xx
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D1/00—Surgical instruments for veterinary use
    • A61D1/02—Trocars or cannulas for teats; Vaccination appliances

Definitions

  • This invention relates to an insert to be inserted into a papillary duct of dairy cattle.
  • Milking disorders are sometimes caused by thickening or stricture of the opening or the inner wall of a papilla due to an injury by trample under a hoof, misapplication of a milking cannula, misuse of a milker, stimulation by a teat cup liner, and the like. Further, milk leakage is caused by damage of papillary constrictor muscles.
  • Such milking disorders have been treated by inserting an insert into the papillary duct to dilate the duct or to stop a milk leak.
  • Conventional inserts for this use include a bar-shaped bundle of twisted strands having a diameter of about 3 mm and a length of about 7 cm with its one end obliquely cut and the other end tied up with a ring band having a width of about 5 mm, the bundle being impregnated with an antibiotic and hardened by a binder ("Teat plug B" produced by Denka Seiyaku Co., Ltd. or "TEATOR POINT” produced by Nihon Eiken Co., Ltd.).
  • An object of the present invention is to provide a measure for papillary duct lesions or for the papillary duct after having a surgical treatment for stricture, consisting of simple insertion of a bar-shaped insert into the affected papillary duct.
  • the present invention relates to a papillary duct insert formed of chitin or a chitin derivative or a papillary duct insert comprising a support having coated thereon or impregnated therein chitin or a derivative thereof.
  • Chitin is a polysaccharide represented by formula: comprising N-acetyl-D-glucosamine polycondensed through ⁇ (1 ⁇ 4) linkages which is present in crustaceans (e.g., shrimps and crabs), insects (e.g., grasshoppers and beatles), a cuttlebone, etc.
  • Chitin which can be used in the present invention can be obtained by purifying naturally occurring crude chitin from these sources by referring to, for example, Chitin Chitosan Kenkyukai (ed.), Chitin Chitosan Jikken Manual , Ch. 1 (Preparation of Chitin), pp. 1-7, Gihodo Shuppan K.K. (1991).
  • Chitin derivatives which can be used in the present invention include chemically modified chitin derivatives, such as deacetylated chitin, Chitosan (especially those having a degree of deacylation of 80% or more), carboxymethylated chitin, hydroxyethylated chitin, and sulfonated chitin.
  • chemically modified chitin derivatives such as deacetylated chitin, Chitosan (especially those having a degree of deacylation of 80% or more), carboxymethylated chitin, hydroxyethylated chitin, and sulfonated chitin.
  • deacetylated chitin especially those having a degree of deacylation of 80% or more
  • carboxymethylated chitin hydroxyethylated chitin
  • sulfonated chitin sulfonated chitin.
  • Supports on or in which chitin or a derivative thereof is coated or impregnated include yarn, sponge, cloth, etc. made of soft and biologically harmless materials, such as silk, collagen, cellulose, nylon, polyethylene, polypropylene, polyester, Teflon, etc.
  • the papillary duct insert according to the present invention formed of chitin or a derivative thereof or comprising a support coated or impregnated with chitin or a derivative thereof may further be coated with starch, polyvinyl alcohol, sodium carboxymethyl cellulose, alginic acid or a salt thereof, and so on as a binder so as to have increased hardness.
  • the insert formed of chitin or a chitin derivative according to the present invention can be produced, for example, as follows. Yarn, sponge, cloth, etc. made of chitin or a chitin derivative is shaped into a string or bar having a diameter of from 1 to 5 mm, preferably from 2 to 3 mm. A 1 to 50 w/v%, preferably 1 to 10 w/v%, solution of a binder is coated thereon and dried to obtain a stock bar of about 3 mm in diameter, which is then cut to a length of from 1 to 10 cm, preferably from 3 to 7 cm. The tip of one end of the resulting bar is cut off at right angle or obliquely.
  • the insert comprising a support coated or impregnated with chitin or a chitin derivative according to the present invention can be produced, for example, as follows.
  • a support such as a bar, a filament; sponge, cloth, etc. is shaped into a string or bar having a diameter of from 1 to 5 mm, preferably from 2 to 3 mm, and a solution or dispersion containing 1 to 50 w/v%, preferably 1 to 10 w/v%, of chitin or a chitin derivative is coated thereon or impregnated therein.
  • a 1 to 50 w/v%, preferably 10 to 30 w/v%, binder solution is further coated thereon and dried to prepare a stock bar having a diameter of 1 to 5 mm, preferably 2 to 3 mm.
  • a support is first coated with chitin or a chitin derivative and then shaped into a string or bar, and a binder solution is coated thereon followed by drying.
  • the resulting stock bar is cut at right angle or obliquely to a length of from 1 to 10 cm, preferably from 3 to 7 cm.
  • Chitin and derivatives thereof may be used either individually or in combination of two or more thereof.
  • the support may be prepared by mixing yarn, sponge, cloth, etc. made from the above-described soft and harmless material (e.g., silk, collagen, cellulose, nylon, polyethylene, polypropylene, polyester or Teflon) with yarn, sponge, cloth, etc. made from chitin or a chitin derivative and shaping the mixture to the above-mentioned dimensions.
  • soft and harmless material e.g., silk, collagen, cellulose, nylon, polyethylene, polypropylene, polyester or Teflon
  • the insert according to the present invention heals papillary duct stricture or papillary duct lesions after a surgical treatment of stricture and also prevents mastitis has not yet been made clear.
  • various cells participating in healing mechanism of a wound are made to wander without inducing antixenic reaction to markedly accelerate vascularization and formation of granulations.
  • the insert of the invention is believed to exert direct accelerating effects on postoperative treatment after a surgical measure for papillary duct stricture and to accelerate regeneration of the epithelium while preventing invasion of bacteria.
  • the dope was spun from a nozzole having 500 orifices of 0.1 mm in diameter into a 1.5 m long first coagulating-bath containing 10 l of ethylene glycol, 1.5 kg of water, and 1.8 kg of potassium hydroxide and passed through a 0.9 m long second coagulating bath containing a 50 v/v% aqueous solution of methanol at a speed of 12 m/sec to complete coagulation.
  • the spun filament was drawn at a draw ratio of 1.17, wound around a bobbin, washed with running water as wound for 12 hours, immersed in hot water at 70 to 80°C for 4 hours and then in ethanol for 24 hours, re-wounded around a reel, and spontaneously dried to obtain a hank.
  • the hank was wetted with water, and 18 filaments out of the hank were intertwined to obtain twisted yarn having a diameter of 5 mm.
  • the twisted yarn was dipped in a 7 w/v% aqueous solution of polyvinyl alcohol (a product of Wako Pure Chemical Co., Ltd.; degree of polymerization: about 1500) to coat 1 ml of the polyvinyl alcohol per 10 cm, followed by drying under reduced pressure to obtain a stock bar having a diameter of 3 mm.
  • the stock bar was cut to lengths of 6.5 cm, and the tip at one end of each cut bar was cut off at about 45° or at right angle with the longitudinal direction.
  • the other end of the twisted yarn bar was fitted into a silicone tube of 5 mm in diameter and 5 mm in width to prepare a papillary duct insert.
  • the resulting insert was designated A.
  • Papillary duct insert B having a diameter of 3 mm and a length of 6.5 m was prepared in the same manner as in Example 1, except that the twisted yarn was dipped in a 2 w/v% aqueous solution of sodium carboxymethyl cellulose (a first grade reagent produced by Nakarai Tesuku Co., Ltd.) in place of polyvinyl alcohol to pick up 0.5 ml of sodium carboxymethyl cellulose per 10 cm.
  • sodium carboxymethyl cellulose a first grade reagent produced by Nakarai Tesuku Co., Ltd.
  • the cloth was washed with running water for 1 hour, soaked in hot water at 70 to 80°C for 30 minutes, and spontaneously dried to obtain chitosan-impregnated nonwoven cloth containing 0.2 g of chitosan per gram. After wetted with water, the cloth was folded in four in the width direction and twisted in the longitudinal direction. A 2 w/v% aqueous solution of sodium carboxymethyl cellulose (a first grade reagent produced by Nakarai Tesuku Co., Ltd.) was coated on the resulting bar-shaped twisted cloth at a spread of 2.0 ml/10 cm and dried under reduced pressure to obtain a stock bar of 3 mm in diameter.
  • sodium carboxymethyl cellulose a first grade reagent produced by Nakarai Tesuku Co., Ltd.
  • the stock bar was cut to lengths of 6.5 cm, and the tip was cut at an angle of about 45° or at right angles with the longitudinal direction.
  • the other end of the bar was fitted into a silicone tube of 5 mm in diameter and 5 mm in width to prepare a papillary duct insert designated C.
  • Each of the inserts prepared in Examples 1 to 3 was inserted to the papillary duct of a female Holstein suffering from papillary duct stricture or a female Holstein having undergone stricturotomy for dilating the opening of the papillary duct.
  • the cows were milked twice a day, and a fresh insert was inserted after every milking. Any change of the papilla was observed everyday.
  • the prognostic symptoms and the state of mastitis are shown in Table 1 below.
  • Case 2 showed a sign of improvement on the stricture. While no further effects could be observed because of shortage of the period of treatment, 7-day application of the insert of the present invention resulted in healing of mastitis. No influence on other mammae (any changes of milk of other normal mammae of the same animal) was noted at all. Development into mastitis due to the use of the insert was not observed.
  • TEATOR POINT a commercially available insert for a papillary duct

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Materials For Medical Uses (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

Element inséré pour tubes collecteurs de Bellini, réalisé par moulage de chitine ou de son dérivé, ou par revêtement ou imprégnation d'une matière de base avec de la chitine ou son dérivé. On utilise cet élément pour traiter le rétrécissement des tubes collecteurs de Bellini ou pour le traitement de l'ouverture après une intervention, simplement en l'introduisant dans un tube collecteur de Bellini.
EP93902517A 1992-01-22 1993-01-21 Element insere pour tube collecteur de bellini Withdrawn EP0576688A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP4008829A JPH0654633A (ja) 1992-01-22 1992-01-22 乳頭管挿入材
JP8829/92 1992-01-22

Publications (2)

Publication Number Publication Date
EP0576688A1 true EP0576688A1 (fr) 1994-01-05
EP0576688A4 EP0576688A4 (fr) 1994-03-16

Family

ID=11703683

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93902517A Withdrawn EP0576688A1 (fr) 1992-01-22 1993-01-21 Element insere pour tube collecteur de bellini

Country Status (5)

Country Link
EP (1) EP0576688A1 (fr)
JP (1) JPH0654633A (fr)
AU (1) AU3366993A (fr)
CA (1) CA2106667A1 (fr)
WO (1) WO1993014716A1 (fr)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2244027A (en) * 1938-10-31 1941-06-03 Benjamin D Smith Teat dilator
JPS449492Y1 (fr) * 1966-04-09 1969-04-17
US3938517A (en) * 1975-03-14 1976-02-17 Anderson Carsten D Teat cautery bullet

Also Published As

Publication number Publication date
AU3366993A (en) 1993-09-01
EP0576688A4 (fr) 1994-03-16
CA2106667A1 (fr) 1993-07-23
JPH0654633A (ja) 1994-03-01
WO1993014716A1 (fr) 1993-08-05

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