EP0654084A4 - Molekulare klonierung der für die kollagennaseproduktion in clostridium histolyticum verantwortlichen gene. - Google Patents

Molekulare klonierung der für die kollagennaseproduktion in clostridium histolyticum verantwortlichen gene.

Info

Publication number
EP0654084A4
EP0654084A4 EP93916670A EP93916670A EP0654084A4 EP 0654084 A4 EP0654084 A4 EP 0654084A4 EP 93916670 A EP93916670 A EP 93916670A EP 93916670 A EP93916670 A EP 93916670A EP 0654084 A4 EP0654084 A4 EP 0654084A4
Authority
EP
European Patent Office
Prior art keywords
reponsible
genes
molecular cloning
clostridium histolyticum
collagenase production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP93916670A
Other languages
English (en)
French (fr)
Other versions
EP0654084A1 (de
Inventor
Hun-Chi Lin
Shau-Ping Lei
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Trigen Inc
Original Assignee
Trigen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trigen Inc filed Critical Trigen Inc
Publication of EP0654084A1 publication Critical patent/EP0654084A1/de
Publication of EP0654084A4 publication Critical patent/EP0654084A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP93916670A 1992-06-22 1993-06-22 Molekulare klonierung der für die kollagennaseproduktion in clostridium histolyticum verantwortlichen gene. Withdrawn EP0654084A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US90212992A 1992-06-22 1992-06-22
US902129 1992-06-22
PCT/US1993/005944 WO1994000580A1 (en) 1992-06-22 1993-06-22 Molecular cloning of the genes reponsible for collagenase production from clostridium histolyticum

Publications (2)

Publication Number Publication Date
EP0654084A1 EP0654084A1 (de) 1995-05-24
EP0654084A4 true EP0654084A4 (de) 1996-07-03

Family

ID=25415339

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93916670A Withdrawn EP0654084A4 (de) 1992-06-22 1993-06-22 Molekulare klonierung der für die kollagennaseproduktion in clostridium histolyticum verantwortlichen gene.

Country Status (5)

Country Link
EP (1) EP0654084A4 (de)
JP (1) JPH08500970A (de)
AU (1) AU4644793A (de)
CA (1) CA2138948A1 (de)
WO (1) WO1994000580A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995005477A1 (en) * 1993-08-12 1995-02-23 University Of Maryland Thermostable alkaline metalloprotease produced by a hyphomonas, and preparation thereof
DE4408940A1 (de) * 1994-03-16 1995-10-05 Boehringer Mannheim Gmbh Rekombinante Collagenase Typ II aus Clostridium histolyticum und ihre Verwendung zur Isolierung von Zellen und Zellverbänden
BR9607143A (pt) * 1995-03-16 1997-11-25 Knoll Ag Enzima ibtenível de clostridium histolyticum mistura de enzimas uso da mistura uso de enzimas colagenase hp na forma pura colagenase az na forma pura e elastase na forma pura
JPH10508205A (ja) * 1995-04-25 1998-08-18 バクスター インターナショナル インコーポレイテッド 肝細胞および膵臓ランゲルハンス島細胞を単離するためのコラーゲナーゼおよびキモパパインを含有する組成物
US5670358A (en) * 1995-10-19 1997-09-23 Baxter International Inc. Method for inhibiting chymopapain and papain enzyme activity with polysaccharides of animal origin
WO1998022574A2 (de) * 1996-11-19 1998-05-28 Roche Diagnostics Gmbh Rekombinante collagenase typ i aus clostridium histolyticum und ihre verwendung zur isolierung von zellen und zellverbänden
US6280993B1 (en) * 1999-08-24 2001-08-28 Ichiro Yamato Gene encoding class I collagenase
US7811560B2 (en) * 2006-01-30 2010-10-12 Auxilium Us Holdings, Llc Compositions and methods for treating collagen-mediated diseases
US20090191608A1 (en) * 2008-01-22 2009-07-30 Baylor Research Institute Pancreatic Islet Cell Preparation and Transplantation
IT1397646B1 (it) 2009-12-15 2013-01-18 Seidita Collagenasi ricombinanti di c. histolyticum e metodo per la loro produzione.
CN102174548B (zh) * 2011-03-01 2012-07-11 山东大学 一种深海适冷耐盐胶原蛋白酶及其编码基因myr02与应用
EP4772625A2 (de) * 2012-01-12 2026-07-08 Endo Biologics Limited Clostridium histolyticum enzym
DK3589204T3 (da) 2017-03-01 2025-06-30 Endo Operations Ltd Apparat og fremgangsmåde til vurdering og behandling af cellulitis
KR20250171475A (ko) 2017-03-28 2025-12-08 엔도 오퍼레이션즈 리미티드 개선된 콜라게나제 생성 방법
CN115058443B (zh) * 2022-06-22 2023-03-24 广州市乾相生物科技有限公司 转录抑制质粒pCRISPR-nadG及其在提高产溶剂梭菌胞内还原力中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991014447A1 (en) * 1990-03-22 1991-10-03 Lin Hun Chi MOLECULAR CLONING OF THE GENES RESPONSIBLE FOR COLLAGENASE PRODUCTION FROM $i(CLOSTRIDIUM HISTOLYTICUM)

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991014447A1 (en) * 1990-03-22 1991-10-03 Lin Hun Chi MOLECULAR CLONING OF THE GENES RESPONSIBLE FOR COLLAGENASE PRODUCTION FROM $i(CLOSTRIDIUM HISTOLYTICUM)

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9400580A1 *

Also Published As

Publication number Publication date
EP0654084A1 (de) 1995-05-24
AU4644793A (en) 1994-01-24
WO1994000580A1 (en) 1994-01-06
JPH08500970A (ja) 1996-02-06
CA2138948A1 (en) 1994-01-06

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Legal Events

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Effective date: 19970106