EP0683671A4 - Modulationen des immunsystems mittels psoralene, die durch sichtbares licht aktiviert würden. - Google Patents

Modulationen des immunsystems mittels psoralene, die durch sichtbares licht aktiviert würden.

Info

Publication number: EP0683671A4
Authority: EP; European Patent Office
Prior art keywords: visible light; psoralenes; modulation; active; immune system
Prior art date: 1993-02-04
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

EP94907939A

Other languages

English (en)

French (fr)

Other versions

EP0683671A1 (de

EP0683671B1 (de

Inventor

Richard L Edelson

Francis P Gasparro

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Yale University

Original Assignee

Yale University

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-02-04

Filing date

1994-02-01

Publication date

1996-10-30

1994-02-01 Application filed by Yale University filed Critical Yale University

1995-11-29 Publication of EP0683671A1 publication Critical patent/EP0683671A1/de

1996-10-30 Publication of EP0683671A4 publication Critical patent/EP0683671A4/de

2002-01-09 Application granted granted Critical

2002-01-09 Publication of EP0683671B1 publication Critical patent/EP0683671B1/de

2014-02-01 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0066—Psoralene-activated UV-A photochemotherapy (PUVA-therapy), e.g. for treatment of psoriasis or eczema, extracorporeal photopheresis with psoralens or fucocoumarins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Immunology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Pharmacology & Pharmacy (AREA)
Cell Biology (AREA)
Developmental Biology & Embryology (AREA)
Molecular Biology (AREA)
Virology (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Engineering & Computer Science (AREA)
Hematology (AREA)
Dermatology (AREA)
Biochemistry (AREA)
Zoology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Microbiology (AREA)
Mycology (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Circuit Arrangement For Electric Light Sources In General (AREA)
Optical Communication System (AREA)
Prostheses (AREA)

EP94907939A 1993-02-04 1994-02-01 Modulationen des immunsystems mittels psoralene, die durch sichtbares licht aktiviert werden Expired - Lifetime EP0683671B1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US08/013,831 US5462733A (en)	1993-02-04	1993-02-04	Immune system modulation using psoralens activated with visible light
US13831		1993-02-04
PCT/US1994/001142 WO1994017812A1 (en)	1993-02-04	1994-02-01	Immune system modulation using psoralens activated with visible light

Publications (3)

Publication Number	Publication Date
EP0683671A1 EP0683671A1 (de)	1995-11-29
EP0683671A4 true EP0683671A4 (de)	1996-10-30
EP0683671B1 EP0683671B1 (de)	2002-01-09

Family

ID=21761984

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP94907939A Expired - Lifetime EP0683671B1 (de)	1993-02-04	1994-02-01	Modulationen des immunsystems mittels psoralene, die durch sichtbares licht aktiviert werden

Country Status (7)

Country	Link
US (1)	US5462733A (de)
EP (1)	EP0683671B1 (de)
JP (1)	JPH08506585A (de)
AT (1)	ATE211652T1 (de)
DE (1)	DE69429615T2 (de)
ES (1)	ES2165872T3 (de)
WO (1)	WO1994017812A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5651993A (en)	1992-11-18	1997-07-29	Yale University	Specific immune system modulation
US5820872A (en) *	1992-11-18	1998-10-13	Yale University	Methods and compositions for improving the effectiveness of X-irradiation therapy for the treatment of an internal solid tumor
US7186543B1 (en) *	1998-07-21	2007-03-06	Gambro Inc.	Preparation of vaccines using a photosensitizer and light
RU2145500C1 (ru) *	1998-11-23	2000-02-20	Ковальчук Леонид Васильевич	Средство для иммуностимуляции
EP1176986B1 (de)	1999-04-20	2018-07-04	Yale University	Differenzierung von monozyten in funktionale dentritische zellen
US20050084966A1 (en) *	1999-04-20	2005-04-21	Edelson Richard L.	Methods for inducing the differentiation of blood monocytes into functional dendritic cells
US7109031B2 (en) *	1999-04-20	2006-09-19	Yale University	Methods for inducing the differentiation of monocytes into functional dendritic cells and immunotherapeutic compositions including such dendritic cells
US20080241815A1 (en) *	1999-04-20	2008-10-02	Edelson Richard L	Methods for Inducing the Differentiation of Blood Monocytes into Functional Dendritic Cells
US20050158856A1 (en) *	1999-04-20	2005-07-21	Edelson Richard L.	Methods for producing functional antigen presenting dendritic cells using biodegradable microparticles for delivery of antigenic materials
US6565802B1 (en)	1999-06-03	2003-05-20	Baxter International Inc.	Apparatus, systems and methods for processing and treating a biological fluid with light
US7068361B2 (en)	1999-06-03	2006-06-27	Baxter International	Apparatus, systems and methods for processing and treating a biological fluid with light
US6719778B1 (en)	2000-03-24	2004-04-13	Endovascular Technologies, Inc.	Methods for treatment of aneurysms
ATE369442T1 (de) *	2000-05-19	2007-08-15	Richard B Williams	In vitro evolution von nukleinsäuren und kodierten polypeptiden
US7410761B2 (en) *	2000-05-19	2008-08-12	Proteonova, Inc.	System for rapid identification and selection of nucleic acids and polypeptides, and method thereof
US20040229271A1 (en) *	2000-05-19	2004-11-18	Williams Richard B.	Compositions and methods for the identification and selection of nucleic acids and polypeptides
US6962781B1 (en) *	2000-05-19	2005-11-08	Proteonova, Inc.	In vitro evolution of nucleic acids and encoded polypeptide
JP2006306743A (ja) *	2005-04-26	2006-11-09	Hamamatsu Photonics Kk	体液処理方法
US8835104B2 (en)	2007-12-20	2014-09-16	Fenwal, Inc.	Medium and methods for the storage of platelets
EP3662750A1 (de)	2011-04-07	2020-06-10	Fenwal, Inc.	Automatisierte verfahren und systeme zur bereitstellung von thrombozytenkonzentraten mit reduziertem restplasmavolumen und medien zur lagerung solcher thrombozytenkonzentrate
US20130131423A1 (en) *	2011-04-12	2013-05-23	Tianxin Wang	Methods to detect and treat diseases
US20190134095A1 (en) *	2016-05-02	2019-05-09	Cerus Corporation	Compositions and methods for improved nk cell therapies
US20240197852A1 (en) *	2021-04-23	2024-06-20	Wake Forest University Health Sciences	Psoralen-inactivated neisseria gonorrhoeae vaccines and methods thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0392429A1 (de) *	1989-04-11	1990-10-17	F. Hoffmann-La Roche Ag	Psoralen-Reagens
WO1995003814A1 (en) *	1993-07-30	1995-02-09	Yale University	Cellular vaccine and methods of use for the treatment of solid tumor malignancies

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4684521A (en) *	1982-12-08	1987-08-04	Frederic A. Bourke, Jr.	Method and system for externally treating the blood
US4838852A (en) *	1987-03-27	1989-06-13	Therakos, Inc.	Active specific immune suppression
US5256648A (en) *	1988-01-21	1993-10-26	Yale University	Selective inhibition of gene expression by photoactivatable oligonucleotides
IL85746A (en) *	1988-03-15	1994-05-30	Yeda Res & Dev	Preparations comprising t-lymphocyte cells treated with 8-methoxypsoralen or cell membranes separated therefrom for preventing or treating autoimmune diseases
US5147289A (en) *	1990-03-29	1992-09-15	Therakos, Inc	Non-specific immune system enhancement
US5116864A (en) *	1991-04-09	1992-05-26	Indiana University Foundation	Method for preventing restenosis following reconfiguration of body vessels

1993
- 1993-02-04 US US08/013,831 patent/US5462733A/en not_active Expired - Lifetime
1994
- 1994-02-01 EP EP94907939A patent/EP0683671B1/de not_active Expired - Lifetime
- 1994-02-01 WO PCT/US1994/001142 patent/WO1994017812A1/en not_active Ceased
- 1994-02-01 AT AT94907939T patent/ATE211652T1/de not_active IP Right Cessation
- 1994-02-01 JP JP6518157A patent/JPH08506585A/ja not_active Ceased
- 1994-02-01 DE DE69429615T patent/DE69429615T2/de not_active Expired - Lifetime
- 1994-02-01 ES ES94907939T patent/ES2165872T3/es not_active Expired - Lifetime

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0392429A1 (de) *	1989-04-11	1990-10-17	F. Hoffmann-La Roche Ag	Psoralen-Reagens
WO1995003814A1 (en) *	1993-07-30	1995-02-09	Yale University	Cellular vaccine and methods of use for the treatment of solid tumor malignancies

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PEREZ M I ET AL: "DNA ASSOCIATED WITH THE CELL MEMBRANE IS INVOLVED IN THE INHIBITION OF THE SKIN REJECTION RESPONSE INDUCED BY INFUSIONS OF PHOTODAMAGED ALLOREACTIVE CELLS THAT MEDIATE REJECTION OF SKIN ALLOGRAFT.", PHOTOCHEM PHOTOBIOL 55 (6). 1992. 839-849, XP000573069 *

Also Published As

Publication number	Publication date
EP0683671A1 (de)	1995-11-29
ATE211652T1 (de)	2002-01-15
DE69429615D1 (de)	2002-02-14
ES2165872T3 (es)	2002-04-01
DE69429615T2 (de)	2002-07-18
EP0683671B1 (de)	2002-01-09
JPH08506585A (ja)	1996-07-16
US5462733A (en)	1995-10-31
WO1994017812A1 (en)	1994-08-18

Legal Events

Date	Code	Title	Description
1995-10-13	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1995-11-29	17P	Request for examination filed	Effective date: 19950803
1995-11-29	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
1996-10-30	A4	Supplementary search report drawn up and despatched	Effective date: 19960909
1996-10-30	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
1996-12-04	RIN1	Information on inventor provided before grant (corrected)	Inventor name: GASPARRO, FRANCIS P. Inventor name: EDELSON, RICHARD L.
1999-03-10	17Q	First examination report despatched	Effective date: 19990120
2001-01-24	RIC1	Information provided on ipc code assigned before grant	Free format text: 7A 61K 35/14 A, 7A 61K 41/00 B
2001-01-29	GRAG	Despatch of communication of intention to grant	Free format text: ORIGINAL CODE: EPIDOS AGRA
2001-01-31	RIC1	Information provided on ipc code assigned before grant	Free format text: 7A 61K 35/14 A, 7A 61K 45/00 B
2001-02-28	RIC1	Information provided on ipc code assigned before grant	Free format text: 7A 61K 35/14 A, 7A 61K 45/00 B
2001-05-09	GRAG	Despatch of communication of intention to grant	Free format text: ORIGINAL CODE: EPIDOS AGRA
2001-06-28	GRAG	Despatch of communication of intention to grant	Free format text: ORIGINAL CODE: EPIDOS AGRA
2001-06-28	GRAH	Despatch of communication of intention to grant a patent	Free format text: ORIGINAL CODE: EPIDOS IGRA
2001-08-08	GRAH	Despatch of communication of intention to grant a patent	Free format text: ORIGINAL CODE: EPIDOS IGRA
2001-11-23	GRAA	(expected) grant	Free format text: ORIGINAL CODE: 0009210
2002-01-01	REG	Reference to a national code	Ref country code: GB Ref legal event code: IF02
2002-01-09	AK	Designated contracting states	Kind code of ref document: B1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
2002-01-09	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: GR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20020109
2002-01-09	REF	Corresponds to:	Ref document number: 211652 Country of ref document: AT Date of ref document: 20020115 Kind code of ref document: T
2002-01-15	REG	Reference to a national code	Ref country code: CH Ref legal event code: EP
2002-02-01	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: LU Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20020201
2002-02-06	REG	Reference to a national code	Ref country code: IE Ref legal event code: FG4D
2002-02-14	REF	Corresponds to:	Ref document number: 69429615 Country of ref document: DE Date of ref document: 20020214
2002-03-28	REG	Reference to a national code	Ref country code: CH Ref legal event code: NV Representative=s name: MOINAS & SAVOYE SA
2002-04-01	REG	Reference to a national code	Ref country code: ES Ref legal event code: FG2A Ref document number: 2165872 Country of ref document: ES Kind code of ref document: T3
2002-04-09	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: SE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20020409 Ref country code: PT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20020409 Ref country code: DK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20020409
2002-09-01	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: MC Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20020901
2002-11-15	PLBE	No opposition filed within time limit	Free format text: ORIGINAL CODE: 0009261
2002-11-15	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT
2003-01-02	26N	No opposition filed
2010-04-30	PGFP	Annual fee paid to national office [announced via postgrant information from national office to epo]	Ref country code: IE Payment date: 20100224 Year of fee payment: 17 Ref country code: ES Payment date: 20100225 Year of fee payment: 17 Ref country code: CH Payment date: 20100224 Year of fee payment: 17
2010-05-31	PGFP	Annual fee paid to national office [announced via postgrant information from national office to epo]	Ref country code: IT Payment date: 20100225 Year of fee payment: 17 Ref country code: FR Payment date: 20100303 Year of fee payment: 17
2010-06-30	PGFP	Annual fee paid to national office [announced via postgrant information from national office to epo]	Ref country code: GB Payment date: 20100224 Year of fee payment: 17 Ref country code: DE Payment date: 20100226 Year of fee payment: 17 Ref country code: BE Payment date: 20100223 Year of fee payment: 17 Ref country code: AT Payment date: 20100120 Year of fee payment: 17
2010-08-31	PGFP	Annual fee paid to national office [announced via postgrant information from national office to epo]	Ref country code: NL Payment date: 20100223 Year of fee payment: 17
2011-08-31	BERE	Be: lapsed	Owner name: YALE UNIVERSITY Effective date*: 20110228
2011-09-14	REG	Reference to a national code	Ref country code: NL Ref legal event code: V1 Effective date: 20110901
2011-09-30	REG	Reference to a national code	Ref country code: CH Ref legal event code: PL
2011-10-26	GBPC	Gb: european patent ceased through non-payment of renewal fee	Effective date: 20110201
2011-10-31	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: CH Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20110228 Ref country code: LI Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20110228
2011-11-18	REG	Reference to a national code	Ref country code: FR Ref legal event code: ST Effective date: 20111102
2011-11-23	REG	Reference to a national code	Ref country code: IE Ref legal event code: MM4A
2011-11-30	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: AT Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20110201 Ref country code: BE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20110228
2011-12-30	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: NL Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20110901 Ref country code: IT Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20110201
2012-01-12	REG	Reference to a national code	Ref country code: DE Ref legal event code: R119 Ref document number: 69429615 Country of ref document: DE Effective date: 20110901
2012-01-31	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: IE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20110201 Ref country code: FR Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20110228
2012-02-29	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: GB Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20110201
2012-04-11	REG	Reference to a national code	Ref country code: ES Ref legal event code: FD2A Effective date: 20120411
2012-04-30	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: ES Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20110202
2013-06-28	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: DE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20110901

Publication	Publication Date	Title
EP0683671A4 (de)	1996-10-30	Modulationen des immunsystems mittels psoralene, die durch sichtbares licht aktiviert würden.
ATE218884T1 (de)	2002-06-15	Impfstoffpräparate
ES2149254T3 (es)	2000-11-01	Modulacion especifica del sistema inmunitario.
ATE226085T1 (de)	2002-11-15	Pharmazeutische formulierungen enthaltend nervenwachstumsfaktor
GR890100838A (el)	1991-03-15	Νέα ?εραπευτικώς δραστική ένωσις και μέ?οδος για την παραγωγή της.
ES2098029T5 (es)	2002-03-16	Vacunas de hepatitis que contienen monofosforil lipido a 3-o-desacilado.
ES552985A0 (es)	1987-05-16	Procedimiento fotodinamico de inactivacion de virus
ES2033259T3 (es)	1993-03-16	Bases de liberacion controlada de productos farmaceuticos.
DE69433532D1 (de)	2004-03-11	Amphiphile imidazolinium-derivate
ES2191979T3 (es)	2003-09-16	Sistema de administracion de acido linoleico conjugado en preparaciones cosmeticas.
DE69328492D1 (de)	2000-05-31	Fettsäure-derivate und diese enthaltende pharmazeutische präparationen
IL103920A0 (en)	1993-04-04	Method and pharmaceutical preparations for inhibiting the growth of cancer cells
ES2063326T3 (es)	1995-01-01	Conjugados de polimixina.
IT8822979A0 (it)	1988-12-16	Stativo per irradiazione di raggi di luce
GB8709315D0 (en)	1987-05-28	Light source & detector package
ES2120962T3 (es)	1998-11-16	Composicion antivirica.
ES2127263T3 (es)	1999-04-16	Nuevos trien-derivados cromenicos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
AR246930A1 (es)	1994-10-31	Carrete portador de elementos filiformes y similares.
FI893149L (fi)	1990-01-02	Ljusbestraolningsstativ.
DK0804927T3 (da)	2002-02-25	Multiantioxidantholdigt medikament
FR2694628B1 (fr)	1995-06-16	Cellule photo-electrique, notamment submersible, et attache rapide pour sa fixation sur une source de lumiere ultraviolette.
ITMI911367A1 (it)	1992-11-17	Struttura di supporto avente una sorgente di luce incorporata
MX9304133A (es)	1994-04-29	Nuevos derivados de los fosfolipidos.
RU95116687A (ru)	1998-01-10	Способ лечения перинатального поражения центральной нервной системы у новорожденных
侯建敏 et al.	1996	The photodamage and protective role of pheophytin a in the photosystem Ⅱ reaction center against light-induced damage