ATE369442T1 - In vitro evolution von nukleinsäuren und kodierten polypeptiden - Google Patents

In vitro evolution von nukleinsäuren und kodierten polypeptiden

Info

Publication number
ATE369442T1
ATE369442T1 AT01935701T AT01935701T ATE369442T1 AT E369442 T1 ATE369442 T1 AT E369442T1 AT 01935701 T AT01935701 T AT 01935701T AT 01935701 T AT01935701 T AT 01935701T AT E369442 T1 ATE369442 T1 AT E369442T1
Authority
AT
Austria
Prior art keywords
nucleic acid
protein
cognate pair
nucleic acids
encoded polypeptides
Prior art date
Application number
AT01935701T
Other languages
English (en)
Inventor
Richard B Williams
Original Assignee
Richard B Williams
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richard B Williams filed Critical Richard B Williams
Application granted granted Critical
Publication of ATE369442T1 publication Critical patent/ATE369442T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1062—Isolating an individual clone by screening libraries mRNA-Display, e.g. polypeptide and encoding template are connected covalently

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT01935701T 2000-05-19 2001-05-18 In vitro evolution von nukleinsäuren und kodierten polypeptiden ATE369442T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20601600P 2000-05-19 2000-05-19

Publications (1)

Publication Number Publication Date
ATE369442T1 true ATE369442T1 (de) 2007-08-15

Family

ID=22764634

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01935701T ATE369442T1 (de) 2000-05-19 2001-05-18 In vitro evolution von nukleinsäuren und kodierten polypeptiden

Country Status (8)

Country Link
EP (1) EP1290222B1 (de)
JP (1) JP2003533995A (de)
AT (1) ATE369442T1 (de)
AU (2) AU2001261771B2 (de)
CA (1) CA2409305C (de)
DE (1) DE60129809T2 (de)
HK (1) HK1054410B (de)
WO (1) WO2001090414A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005072087A2 (en) * 2003-12-12 2005-08-11 Proteonova, Inc. System and methods for nucleic acid and polypeptide selection
EP1401850A1 (de) 2001-06-20 2004-03-31 Nuevolution A/S Nukleosidderivate zur herstellung einer verbindungsbibliothek
US10731151B2 (en) 2002-03-15 2020-08-04 Nuevolution A/S Method for synthesising templated molecules
WO2004013070A2 (en) 2002-08-01 2004-02-12 Nuevolution A/S Multi-step synthesis of templated molecules
DK3299463T3 (da) 2002-10-30 2020-12-07 Nuevolution As Enzymatisk kodning
ATE450609T1 (de) 2002-12-19 2009-12-15 Nuevolution As Durch quasizufallsstrukturen und funktionen geführte synthesemethode
US20070026397A1 (en) 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
WO2005026387A1 (en) 2003-09-18 2005-03-24 Nuevolution A/S A method for obtaining structural information concerning an encoded molecule and method for selecting compounds
EP2261257B1 (de) * 2005-01-12 2018-07-11 Proteonova, Inc. Verfahren zur Herstellung zielgerichteter Therapeutika
US10206998B2 (en) 2005-01-12 2019-02-19 Proteonova, Inc. Modular targeted therapeutic agents and methods of making same
LT2336315T (lt) 2005-12-01 2017-11-10 Nuevolution A/S Fermentiniai kodavimo būdai, skirti efektyviai didelių bibliotekų sintezei
EP2118344B1 (de) * 2007-02-12 2014-07-23 Proteonova, Inc. Erzeugung von bibliotheken aus mit mrna verknüpften löslichen zufallspeptiden
CA2832672A1 (en) 2010-04-16 2011-10-20 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes
GB2500243A (en) * 2012-03-15 2013-09-18 Isogenica Ltd Identifying members of immobilised peptide libraries comprising protein-DNA complexes

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599303A (en) * 1983-12-12 1986-07-08 Hri Associates, Inc. Nucleic acid hybridization assay employing probes crosslinkable to target sequences
US5843701A (en) * 1990-08-02 1998-12-01 Nexstar Pharmaceticals, Inc. Systematic polypeptide evolution by reverse translation
WO1992002536A1 (en) * 1990-08-02 1992-02-20 The Regents Of The University Of Colorado Systematic polypeptide evolution by reverse translation
US5462733A (en) * 1993-02-04 1995-10-31 Yale University Immune system modulation using psoralens activated with visible light
DK0971946T3 (da) * 1997-01-21 2006-10-30 Gen Hospital Corp Selektion af proteiner ved anvendelse af RNA-protein-fusioner
EP1068356B8 (de) * 1998-04-03 2007-01-03 Adnexus Therapeutics, Inc. Adressierbare protein arrays

Also Published As

Publication number Publication date
EP1290222A4 (de) 2005-12-14
HK1054410B (en) 2008-03-07
JP2003533995A (ja) 2003-11-18
EP1290222A1 (de) 2003-03-12
HK1054410A1 (en) 2003-11-28
AU2001261771B2 (en) 2005-06-09
WO2001090414A1 (en) 2001-11-29
CA2409305A1 (en) 2001-11-29
DE60129809D1 (de) 2007-09-20
EP1290222B1 (de) 2007-08-08
AU6177101A (en) 2001-12-03
DE60129809T2 (de) 2008-04-30
CA2409305C (en) 2011-01-11

Similar Documents

Publication Publication Date Title
DE60129809D1 (de) In vitro evolution von nukleinsäuren und kodierten polypeptiden
DE60142254D1 (de) Zusammensetzungen, methoden und reagentien zur nukleinsäureisolierung mittels oberflächenaktiven substanzen und proteasen
DE60230672D1 (de) Nukleinsäureanreicherung
DE69835143D1 (de) Selektion von proteinen mittels rns-protein fusionen
ATE500323T1 (de) Subtilisin-variante
CY1112101T1 (el) Νευροτροφικοι παραγοντες
DE69834032D1 (de) Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagieren
ATE469911T1 (de) Isolierte nukleinsäuremoleküle die t-zellen induzierbare faktoren kodieren (tif), kodierte proteine und ihre anwendung
ATE418609T1 (de) Verfahren für die kontinuierliche zielgerichtete evolution von proteinen in vitro
ATE319814T1 (de) Luciferase, fluoreszenzproteine, für luciferase und fluoreszenzproteine kodierend nukleinsaüre und ihre verwendung in der diagnose, hoch- durchsatz screeningsverfahren
ATE439441T1 (de) Veränderte, fluoreszierende proteine
WO2001096373A3 (en) Fluorescent timer proteins and methods for their use
DE60114804D1 (de) Konstruierte fluoreszenzproteine mit langen wellenlängen
DK1082423T3 (da) Cyclin E2-gener og -proteiner
DE60140139D1 (de) Auf nukleinsäurenamplifizierung basierendes verfahren zur bestimmung von methylierungsprofil und reagenzien dafür
ATE360065T1 (de) Verfahren zur herstellung von matrizen-dna und verfahren zur proteinherstellung in einem zellfreien proteinsynthesesystem unter verwendung davon
DE69728897D1 (de) Saeugetierchemokine
ATE383418T1 (de) Verfahren und zusammensetzungen zur bestimmung glycierter proteine
WO2001066752A3 (en) Reproduction-specific genes
CY1108038T1 (el) Παρασκευη βαθμονομων και εφαρμογη αυτων στη ποσοστωση νουκλεοτιδικων αλληλουχιων που ενδιαφερουν
ATE414905T1 (de) Diabetesmodell
WO2005072087A3 (en) System and methods for nucleic acid and polypeptide selection
DE69937453D1 (de) Verfahren zur isolierung und charakterisierung potentieller funktionen ausgehend von einer biologischen probe, welche nukleinsäuren enthält
WO2002063009A3 (en) Lp mammalian proteins; related reagents
ATE339523T1 (de) Verfahren zur herstellung von rekombinanten nukleinsäuremolekülen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties