EP0732921A4 - C-glykosidanologe von n-(4-hydroxyphenyl)retinamid-o-glukuronid - Google Patents

C-glykosidanologe von n-(4-hydroxyphenyl)retinamid-o-glukuronid

Info

Publication number
EP0732921A4
EP0732921A4 EP95935115A EP95935115A EP0732921A4 EP 0732921 A4 EP0732921 A4 EP 0732921A4 EP 95935115 A EP95935115 A EP 95935115A EP 95935115 A EP95935115 A EP 95935115A EP 0732921 A4 EP0732921 A4 EP 0732921A4
Authority
EP
European Patent Office
Prior art keywords
retinamide
glucuronide
hydroxyphenyl
glycoside analogues
glycoside
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95935115A
Other languages
English (en)
French (fr)
Other versions
EP0732921A1 (de
Inventor
Robert W Curley Jr
Michael J Robarge
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ohio State University Research Foundation
Original Assignee
Ohio State University Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/316,140 external-priority patent/US5516792A/en
Application filed by Ohio State University Research Foundation filed Critical Ohio State University Research Foundation
Publication of EP0732921A1 publication Critical patent/EP0732921A1/de
Publication of EP0732921A4 publication Critical patent/EP0732921A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06—Fatty acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP95935115A 1994-09-30 1995-09-26 C-glykosidanologe von n-(4-hydroxyphenyl)retinamid-o-glukuronid Withdrawn EP0732921A4 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US316140 1994-09-30
US08/316,140 US5516792A (en) 1992-11-13 1994-09-30 C-glycoside analogues of N-(4-hydroxyphenyl)retinamide-O-glucuronide
US321207 1994-10-07
US08/321,207 US5574177A (en) 1992-11-13 1994-10-07 Arylamide analogues of N-(4-hydroxyphenyl) retinamide-o-glucuronide
PCT/US1995/012258 WO1996013258A1 (en) 1994-09-30 1995-09-26 C-glycoside analogues of n-(4-hydroxyphenyl)retinamide-o-glucuronide

Publications (2)

Publication Number Publication Date
EP0732921A1 EP0732921A1 (de) 1996-09-25
EP0732921A4 true EP0732921A4 (de) 1998-09-02

Family

ID=26980259

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95935115A Withdrawn EP0732921A4 (de) 1994-09-30 1995-09-26 C-glykosidanologe von n-(4-hydroxyphenyl)retinamid-o-glukuronid

Country Status (3)

Country Link
EP (1) EP0732921A4 (de)
JP (1) JPH09509680A (de)
WO (1) WO1996013258A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6117845A (en) * 1999-06-11 2000-09-12 Ohio State University Research Foundation C-linked analogs of N-(4-hydroxyphenyl) retinamide
WO2003018598A2 (en) * 2001-08-30 2003-03-06 University College Dublin Monosaccharide derivatives
AR056195A1 (es) * 2005-09-15 2007-09-26 Boehringer Ingelheim Int Procedimientos para preparar derivados de (etinil-bencil)-benceno sustituidos de glucopiranosilo y compuestos intermedios de los mismos
MX2010002695A (es) 2007-09-10 2010-04-01 Janssen Pharmaceutica Nv Proceso para la preparacion de compuestos utiles como inhibidores de transportador de glucosa dependiente de sodio (sglt).
US9056850B2 (en) 2008-10-17 2015-06-16 Janssen Pharmaceutica N.V. Process for the preparation of compounds useful as inhibitors of SGLT
US20110009347A1 (en) 2009-07-08 2011-01-13 Yin Liang Combination therapy for the treatment of diabetes
SI2488515T1 (sl) 2009-10-14 2017-04-26 Janssen Pharmaceutica Nv Postopek za pripravo spojin, ki so uporabne kot inhibitorji SGLT2
TWI599360B (zh) 2010-05-11 2017-09-21 健生藥品公司 醫藥調配物
RS55056B1 (sr) 2011-04-13 2016-12-30 Janssen Pharmaceutica Nv Proces za pripremu jedinjenja koja su korisna kao inhibitori sglt2
TWI542596B (zh) 2011-05-09 2016-07-21 健生藥品公司 （２ｓ,３ｒ,４ｒ,５ｓ,６ｒ）－２－（３－（（５－（４－氟苯基）噻吩－２－基）甲基）－４－甲基苯基）－６－（羥甲基）四氫－２ｈ－哌喃－３,４,５－三醇之ｌ－脯胺酸及檸檬酸共晶體

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994011030A1 (en) * 1992-11-13 1994-05-26 The Ohio State University Research Foundation C-glycoside analogues of n-(4-hydroxyphenyl)retinamide-o-glucuronide

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994011030A1 (en) * 1992-11-13 1994-05-26 The Ohio State University Research Foundation C-glycoside analogues of n-(4-hydroxyphenyl)retinamide-o-glucuronide

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
PANIGOT M J ET AL: "PREPARATION OF 4-RETINAMIDOPHENYL- AND 4-RETINAMIDOBENZYL-C- GLYCOSYL AND C-GLUCURONOSYL ANALOGUES OF THE GLUCURONIDE OF 4-HYDROXYPHENYL-RETINAMIDE AS POTENTIAL STABLE CANCER CHEMOPREVENTIVE AGENTS", JOURNAL OF CARBOHYDRATE CHEMISTRY, vol. 13, no. 2, 1 January 1994 (1994-01-01), pages 303 - 321, XP000562292 *
ROBARGE M J ET AL: "N-LINKED ANALOGS OF RETINOID O-FLUCURONIDES: POTENTIAL CANCER CHEMOPREVENTIVE/CHEMOTHERAPEUTIC AGENTS", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 4, no. 17, 8 September 1994 (1994-09-08), pages 2117 - 2122, XP000561553 *
See also references of WO9613258A1 *

Also Published As

Publication number Publication date
EP0732921A1 (de) 1996-09-25
JPH09509680A (ja) 1997-09-30
WO1996013258A1 (en) 1996-05-09

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