EP0744189A1 - Appareil pour administrer des médicaments - Google Patents

Appareil pour administrer des médicaments Download PDF

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Publication number
EP0744189A1
EP0744189A1 EP95108135A EP95108135A EP0744189A1 EP 0744189 A1 EP0744189 A1 EP 0744189A1 EP 95108135 A EP95108135 A EP 95108135A EP 95108135 A EP95108135 A EP 95108135A EP 0744189 A1 EP0744189 A1 EP 0744189A1
Authority
EP
European Patent Office
Prior art keywords
medicine
electrode
catheter
applying tool
piezoelectric element
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95108135A
Other languages
German (de)
English (en)
Inventor
Katsuro Tachibana
Shunro Tachibana
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to EP95108135A priority Critical patent/EP0744189A1/fr
Publication of EP0744189A1 publication Critical patent/EP0744189A1/fr
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A61N1/306—Arrangements where at least part of the apparatus is introduced into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body

Definitions

  • the present invention relates to a medicine applying tool that is used while mounted on the tip of a catheter, for the purpose of treating various diseases such as thrombosis and arteriosclerosis, and for the treatment of re-occlusion after, for instance, PTCA.
  • the invention relates to a medicine applying tool that utilizes a combination of ultrasonic waves and electrophoresis.
  • myocardinal infarct is a disease in which blood flow is restricted by a thrombus or due to arteriosclerosis, so that heart muscles are not supplied with sufficient oxygen and may become necrotic.
  • drug thrombolytic therapy which is intended to dissolve a thrombus by means of oral application or intravascular injection of a medicine.
  • drug thrombolytic therapy the medicine is supplied to the affected part by first having the medicine absorbed into the blood and then having the blood circulate through the body. Only a very small amount of the medicine used is absorbed by the affected part.
  • drug thrombolytic therapy has a problem in that the efficiency in applying a medicine to an affected part is very low. It has a further problem in that the increasing of the density of the medicine to obtain its effective concentration in the blood may cause side effects in other organs.
  • artery expanding therapy which is also called PTCA (percutaneous transluminal coronary angioplasty).
  • PTCA percutaneous transluminal coronary angioplasty
  • a guide catheter is percutaneously introduced to the inlet of the coronary arteries of a patient through a portion of his thigh under X-rays, and then a catheter with a balloon at its tip is introduced, guided by the guide wire, to the part including a pathological change.
  • the stricture of the coronary artery is relieved by expanding the balloon, to thereby increase the blood flow there.
  • artery expanding therapy has a problem that the probability of restenosis occurring several months after the operation is as high as 30% to 50%. Therefore, reexamination is performed by coronary angiography a predetermined period after the operation. If restenosis is found in the reexamination, the artery expanding therapy is performed again. If the restenosis is not cured, a coronary artery bypass operation is needed, which is much larger in scale.
  • a mesh-like cylindrical body called a stent is inserted into the stricture portion of the artery to reinforce the artery wall and the diameter of the cylindrical body is increased by expanding the balloon.
  • a stent is inserted into the stricture portion of the artery to reinforce the artery wall and the diameter of the cylindrical body is increased by expanding the balloon.
  • restenosis occurs at a very high frequency.
  • An object of the present invention is to provide a medicine applying tool which can efficiently apply a medicine to an affected part, to thereby enhance the effect of treatment.
  • a medicine applying tool that is provided at the tip of a catheter that is used to inject a medicine, comprises:
  • the medicine is absorbed by the living tissue through an electrophoresis that depends on the density gradient and the voltage difference between the electrodes.
  • ultrasonic waves are applied to the part of the body to which the medicine is to be applied. This vibrates the living tissue of that part, and allows the medicine to enter the body tissue more easily. Further, since ultrasonic waves also affect the medicine, the efficiency of diffusion and penetration for the medicine is improved. Further, since ultrasonic waves also affect the electrode, polarization is prevented from occurring in the vicinity of the electrode, and the electrode function can be properly maintained.
  • Figs. 1(a) and 1(b) are a perspective view and a sectional view of a medicine applying tool utilizing ultrasonic waves according to a first embodiment of the invention.
  • a cylindrical medicine applying tool 1 is to be attached to the tip of a catheter that is made of silicone or Teflon and to be inserted into an organ of a human body, or is integral with the tip of the catheter.
  • the medicine applying tool 1 has an electrode portion 2 and a medicine injecting portion 3.
  • the electrode portion 2 is composed of a cylindrical piezoelectric element 4, a cylindrical inner electrode 5 formed on the inner circumferential surface of the piezoelectric element 4, for instance, by silver evaporation, and a cylindrical outer electrode 6 formed on the outer circumferential surface of the piezoelectric element 4 in the similar manner.
  • the inner electrode 5 is coated with an insulative material and is therefore electrically insulated from the exterior.
  • the outer electrode 6 is electrically exposed to the exterior.
  • Leads 7 and 8, which are connected to the inner electrode 5 and the outer electrode 6, respectively, are led to the proximal end of a catheter through its inside and thereby led out from a human body.
  • the tip portion of the medicine applying tool 1 is covered by a lid 9 that is shaped like a circular plate.
  • the electrode portion 2 has a diameter of about 1 mm and an axial length of about 1 mm.
  • the diameter and the axial length of the electrode portion 1 is in no way limited to such specific dimensions, but can be modified in accordance with the kind and state of an affected part to be treated.
  • the medicine injecting portion 3 is provided upstream of the electrode portion 2 in a medicine transporting direction (indicated by arrow A). A medicine is jetted from a circular opening 10 of the medicine applying portion 3 in a direction indicated by arrow B.
  • Fig. 2 shows a circuit for generating signals or voltages to be applied to the respective electrodes.
  • the terminal 12b is connected, via a DC power supply 13, to a body contact electrode 14 serving as an indifferent electrode.
  • the body contact electrode 14 is brought into close contact with the skin of a patient to be treated to electrically connect one electrode of the DC power supply 13 to the patient's body.
  • An ultrasonic wave signal source 15 is connected to a primary winding 11P of the insulation transformer 11, and one terminal of the primary winding 11P is grounded.
  • the DC power supply 13 and the ultrasonic wave signal source 15 are schematically shown in Fig. 2.
  • the DC power supply 13 may be a variable DC voltage supply device in which the polarity, magnitude and application time of the voltage can be set arbitrarily.
  • the ultrasonic wave signal source 15 may be a programmable ultrasonic wave output device that is composed of a variable frequency oscillator, a variable output amplifying circuit, and other circuits.
  • Figs. 3(a) and 3(b) show how a guide member 16 for introducing the medicine applying tool 1 of Figs. 1(a) and 1(b) to an affected part is used.
  • the guide member 16 is a flexible pipe whose inside diameter is somewhat larger than the outside diameter of a catheter 17 that has the medicine applying tool 1 at its tip.
  • force is applied to the guide member 16 to move it through the blood vessels until its tip reaches the vicinity of the affected part.
  • the catheter 17 moves together with the guide member 16.
  • the guide member 16 is moved in the direction of the blood flow to facilitate insertion.
  • the proximal end of the catheter 17 is connected to a medicine supply tank directly or via a detachable coupler.
  • a medicine supply tank directly or via a detachable coupler.
  • an open/close-switchable plug may be provided at the proximal end of the catheter 17.
  • the medicine is injected by use of a syringe or the like with the plug opened. During application of the medicine, the plug is closed.
  • Fig. 4 schematically shows how thrombosis is treated by using the medicine applying tool 1 of Figs. 1(a) and 1(b).
  • reference characters D denotes a blood vessel; E, a wall of the blood vessel D; F, a thrombus formed on the wall E; G, a skin; H, body tissue between the blood vessel D and the skin G; and I, a direction of the blood flow.
  • Fig. 4 shows a state where the electrode portion 2 of the medicine applying tool 1 is moved to a position opposed to the affected part, i.e., the thrombus F.
  • a medicine in the form of a solution for thrombosis treatment is injected into the inside of the catheter 17 from its proximal end, it moves through the catheter 17 and reaches the medicine applying tool 1 attached to the catheter's tip. Since the tip of the medicine applying tool 1 is covered by the lid 9, and the opening 10 is formed in the medicine injecting portion 3, the medicine that has been transported through the catheter 17 in the direction indicated by arrow A is injected into the blood vessel D as indicated by arrow B. The medicine then flows toward the thrombus F being carried by the blood stream, and components of the medicine are brought into contact with the surface of the thrombus F.
  • an electric signal of an ultrasonic frequency is applied to the inner electrode 5 and the outer electrode 6 in between, so that the piezoelectric element 4 vibrates mechanically at the ultrasonic frequency.
  • the ultrasonic vibration is applied to the thrombus F and the medicine in the vicinity thereof. Since the ultrasonic vibration is emitted from the piezoelectric element 4 perpendicularly to its surface, i.e., to the axis of the electrode portion 2 as indicated by arrow J, it acts on the thrombus F efficiently.
  • tissue of the thrombus F is loosened to absorb the medicine more easily.
  • Iontophoresis is one of the methods for increasing the absorption rate, and is described in, for instance, Morimoto: “Development of TTS derivatives in the U.S.,” Therapeutic Research, Vol. 10, No. 3, pp. 169 (889) - 180 (900), 1989.
  • Iontophoresis which is also called the ion introduction method or ion penetration method, is a kind of electrical therapy in which a certain amount of medicine is introduced into a living body without causing pain, through a skin or a mucous membrane, being aided by a DC current ("Medical Dictionary,” Nanzando Company, Ltd., published April 10, 1974).
  • Iontophoresis provides an advantage of facilitating absorption of medicine, because the absorption is effected by electrophoresis in addition to the density gradient.
  • the application of ultrasonic waves has the effect of reducing the voltage that is necessary for the iontophoresis, eliminating the possibility of inducing irregular pulses even where the treatment is performed near the heart.
  • the invention can provide more effective treatment with a lower dosage of medicine, side effects are reduced accordingly.
  • Fig. 5 is a perspective view of a second embodiment of the invention.
  • This embodiment is different from the first embodiment in that an opening 10a is formed in the tip portion (rather than in the side wall) of the medicine applying tool 1; that is, the tip portion of the medicine applying tool 1 becomes the medicine injecting portion.
  • the medicine applying tool 1 of the second embodiment operates in approximately the same manner as the first embodiment.
  • the catheter 17 can be guided with a guide wire (not shown) passed through it.
  • the guide member 16 of Figs. 3(a) and 3(b) need not be provided outside the catheter 17, the medicine applying tool 1 can be inserted into thinner blood vessels.
  • Fig. 6 is a perspective view showing a third embodiment of the invention.
  • the electrode portion is composed of a flat, annular piezoelectric element 4a, an annular inner electrode 5a that is attached to the inner surface of the piezoelectric element 4a, and an annular outer electrode 6a that is formed on the outer surface of the piezoelectric element 4a.
  • the surface of the inner electrode 5a is covered with an insulating material so that the inner electrode 5a is electrically insulated from the exterior.
  • the outer electrode 6a is electrically exposed to the exterior.
  • an opening 10b is provided inside the piezoelectric element 4a and the electrodes 5a and 5a.
  • a medicine is jetted forward (indicated by arrow L) from the opening 10b. Since the piezoelectric element 4a vibrates in the axial direction of the catheter 17, ultrasonic energy is also emitted in a forward direction (indicated by arrow L).
  • the catheter 17 can be guided by a wire, because the opening 10b is formed inside the piezoelectric element 4a and the electrodes 5a and 6a.
  • Fig. 7 is a perspective view showing a fourth embodiment of the invention.
  • the electrode portion is composed of a disc-shaped piezoelectric element 4b, a disc-shaped inner electrode 5b that is attached to the inner surface of the piezoelectric element 4b, and a disc-shaped outer electrode 5b that is formed on the outer surface of the piezoelectric element 4b.
  • the tip portion of the catheter 17 is covered by the electrode portion.
  • an opening 10c for jetting a medicine is formed in the side wall of the catheter 17. A medicine is jetted sideways while ultrasonic waves are emitted in a forward direction.
  • a plurality of divisional electrode portions 2a may be provided along the axis of the catheters as shown in Fig. 8, or a plurality of electrode portions 2b may be provided along the axis of the catheter at predetermined intervals as shown in Fig. 9.
  • the reason why the divisional electrode portions are provided along the axis of the catheter in the above manner is that, if a long electrode portion having a piezoelectric element that is usually not flexible is provided along the axis of the catheter, the flexibility of the catheter is lost.
  • a long electrode portion can be provided along the axis of the catheter as shown in Fig. 10.
  • the medicine applying tool is inserted into a blood vessel
  • the invention is not limited to this manner. It is applicable to other cases where it may be inserted into a digestive tract or a tumor.
  • Examples of medicines that can be injected by use of the medicine applying tool of the invention are heparin, hirudin, urokinase, and photofrin (ultrasonic-wave-sensitive medicine).
  • a medicine is applied to an affected part being assisted by iontophoresis and application of ultrasonic waves.
  • the efficiency of a medicines application can be greatly improved over the cases where components of a medicine are penetrated only by its osmotic pressure.
  • the tool since one of the electrodes for emission of ultrasonic waves is also used as the electrode for iontophoresis, the tool has a simple configuration.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
EP95108135A 1995-05-26 1995-05-26 Appareil pour administrer des médicaments Withdrawn EP0744189A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP95108135A EP0744189A1 (fr) 1995-05-26 1995-05-26 Appareil pour administrer des médicaments

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP95108135A EP0744189A1 (fr) 1995-05-26 1995-05-26 Appareil pour administrer des médicaments

Publications (1)

Publication Number Publication Date
EP0744189A1 true EP0744189A1 (fr) 1996-11-27

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Family Applications (1)

Application Number Title Priority Date Filing Date
EP95108135A Withdrawn EP0744189A1 (fr) 1995-05-26 1995-05-26 Appareil pour administrer des médicaments

Country Status (1)

Country Link
EP (1) EP0744189A1 (fr)

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000007508A1 (fr) * 1998-08-05 2000-02-17 Ekos Corporation Ensemble a ultrasons a utiliser avec un catheter
US6575956B1 (en) 1997-12-31 2003-06-10 Pharmasonics, Inc. Methods and apparatus for uniform transcutaneous therapeutic ultrasound
US7186246B2 (en) 1997-05-01 2007-03-06 Ekos Corporation Ultrasound catheter with utility lumen
US7618434B2 (en) 2003-05-12 2009-11-17 University Of Florida Research Foundation, Inc. Devices and methods for disruption and removal of luminal occlusions
US7976483B2 (en) 1997-05-01 2011-07-12 Ekos Corporation Ultrasound assembly with increased efficacy
US8167831B2 (en) 2001-12-03 2012-05-01 Ekos Corporation Catheter with multiple ultrasound radiating members
US8192363B2 (en) 2006-10-27 2012-06-05 Ekos Corporation Catheter with multiple ultrasound radiating members
US8192391B2 (en) 2009-07-03 2012-06-05 Ekos Corporation Power parameters for ultrasonic catheter
US8226629B1 (en) 2002-04-01 2012-07-24 Ekos Corporation Ultrasonic catheter power control
US8740835B2 (en) 2010-02-17 2014-06-03 Ekos Corporation Treatment of vascular occlusions using ultrasonic energy and microbubbles
US8764700B2 (en) 1998-06-29 2014-07-01 Ekos Corporation Sheath for use with an ultrasound element
US9044568B2 (en) 2007-06-22 2015-06-02 Ekos Corporation Method and apparatus for treatment of intracranial hemorrhages
US9107590B2 (en) 2004-01-29 2015-08-18 Ekos Corporation Method and apparatus for detecting vascular conditions with a catheter
US9579494B2 (en) 2013-03-14 2017-02-28 Ekos Corporation Method and apparatus for drug delivery to a target site
US10092742B2 (en) 2014-09-22 2018-10-09 Ekos Corporation Catheter system
CN109042460A (zh) * 2018-09-06 2018-12-21 安徽冠禅生物科技有限公司 一种用于水蛭养殖池施药装置
US10182833B2 (en) 2007-01-08 2019-01-22 Ekos Corporation Power parameters for ultrasonic catheter
US10188410B2 (en) 2007-01-08 2019-01-29 Ekos Corporation Power parameters for ultrasonic catheter
US10232196B2 (en) 2006-04-24 2019-03-19 Ekos Corporation Ultrasound therapy system
US10656025B2 (en) 2015-06-10 2020-05-19 Ekos Corporation Ultrasound catheter
US10888657B2 (en) 2010-08-27 2021-01-12 Ekos Corporation Method and apparatus for treatment of intracranial hemorrhages
US11458290B2 (en) 2011-05-11 2022-10-04 Ekos Corporation Ultrasound system
US12458379B2 (en) 2017-01-24 2025-11-04 Boston Scientific Scimed, Inc. Method for the treatment of thromboembolism

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0438078A2 (fr) * 1990-01-15 1991-07-24 Cino Rossi Appareil d'iontophorèse
US5273525A (en) * 1992-08-13 1993-12-28 Btx Inc. Injection and electroporation apparatus for drug and gene delivery
WO1994005361A1 (fr) * 1992-08-28 1994-03-17 Cortrak Medical, Inc. Appareil a matrice polymere d'administration de medicament et procede
US5304120A (en) * 1992-07-01 1994-04-19 Btx Inc. Electroporation method and apparatus for insertion of drugs and genes into endothelial cells
EP0625360A1 (fr) * 1992-08-28 1994-11-23 Katsuro Tachibana Appareil a elements de dosage de medicaments et de collecte de fluides corporels

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0438078A2 (fr) * 1990-01-15 1991-07-24 Cino Rossi Appareil d'iontophorèse
US5304120A (en) * 1992-07-01 1994-04-19 Btx Inc. Electroporation method and apparatus for insertion of drugs and genes into endothelial cells
US5273525A (en) * 1992-08-13 1993-12-28 Btx Inc. Injection and electroporation apparatus for drug and gene delivery
WO1994005361A1 (fr) * 1992-08-28 1994-03-17 Cortrak Medical, Inc. Appareil a matrice polymere d'administration de medicament et procede
EP0625360A1 (fr) * 1992-08-28 1994-11-23 Katsuro Tachibana Appareil a elements de dosage de medicaments et de collecte de fluides corporels

Cited By (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7976483B2 (en) 1997-05-01 2011-07-12 Ekos Corporation Ultrasound assembly with increased efficacy
US7186246B2 (en) 1997-05-01 2007-03-06 Ekos Corporation Ultrasound catheter with utility lumen
US7914509B2 (en) 1997-05-01 2011-03-29 Ekos Corporation Ultrasound catheter
US8690818B2 (en) 1997-05-01 2014-04-08 Ekos Corporation Ultrasound catheter for providing a therapeutic effect to a vessel of a body
US6575956B1 (en) 1997-12-31 2003-06-10 Pharmasonics, Inc. Methods and apparatus for uniform transcutaneous therapeutic ultrasound
US8764700B2 (en) 1998-06-29 2014-07-01 Ekos Corporation Sheath for use with an ultrasound element
US6210356B1 (en) 1998-08-05 2001-04-03 Ekos Corporation Ultrasound assembly for use with a catheter
WO2000007508A1 (fr) * 1998-08-05 2000-02-17 Ekos Corporation Ensemble a ultrasons a utiliser avec un catheter
US10080878B2 (en) 2001-12-03 2018-09-25 Ekos Corporation Catheter with multiple ultrasound radiating members
US8167831B2 (en) 2001-12-03 2012-05-01 Ekos Corporation Catheter with multiple ultrasound radiating members
US10926074B2 (en) 2001-12-03 2021-02-23 Ekos Corporation Catheter with multiple ultrasound radiating members
US9415242B2 (en) 2001-12-03 2016-08-16 Ekos Corporation Catheter with multiple ultrasound radiating members
US8696612B2 (en) 2001-12-03 2014-04-15 Ekos Corporation Catheter with multiple ultrasound radiating members
US8226629B1 (en) 2002-04-01 2012-07-24 Ekos Corporation Ultrasonic catheter power control
US8852166B1 (en) 2002-04-01 2014-10-07 Ekos Corporation Ultrasonic catheter power control
US9943675B1 (en) 2002-04-01 2018-04-17 Ekos Corporation Ultrasonic catheter power control
US7618434B2 (en) 2003-05-12 2009-11-17 University Of Florida Research Foundation, Inc. Devices and methods for disruption and removal of luminal occlusions
US9107590B2 (en) 2004-01-29 2015-08-18 Ekos Corporation Method and apparatus for detecting vascular conditions with a catheter
US10232196B2 (en) 2006-04-24 2019-03-19 Ekos Corporation Ultrasound therapy system
US12064650B2 (en) 2006-04-24 2024-08-20 Ekos Corporation Ultrasound therapy system
US12186595B2 (en) 2006-04-24 2025-01-07 Boston Scientific Scimed, Inc. Ultrasound therapy system
US11058901B2 (en) 2006-04-24 2021-07-13 Ekos Corporation Ultrasound therapy system
US8192363B2 (en) 2006-10-27 2012-06-05 Ekos Corporation Catheter with multiple ultrasound radiating members
US10182833B2 (en) 2007-01-08 2019-01-22 Ekos Corporation Power parameters for ultrasonic catheter
US10188410B2 (en) 2007-01-08 2019-01-29 Ekos Corporation Power parameters for ultrasonic catheter
US11925367B2 (en) 2007-01-08 2024-03-12 Ekos Corporation Power parameters for ultrasonic catheter
US9044568B2 (en) 2007-06-22 2015-06-02 Ekos Corporation Method and apparatus for treatment of intracranial hemorrhages
US11672553B2 (en) 2007-06-22 2023-06-13 Ekos Corporation Method and apparatus for treatment of intracranial hemorrhages
US9849273B2 (en) 2009-07-03 2017-12-26 Ekos Corporation Power parameters for ultrasonic catheter
US8192391B2 (en) 2009-07-03 2012-06-05 Ekos Corporation Power parameters for ultrasonic catheter
US9192566B2 (en) 2010-02-17 2015-11-24 Ekos Corporation Treatment of vascular occlusions using ultrasonic energy and microbubbles
US8740835B2 (en) 2010-02-17 2014-06-03 Ekos Corporation Treatment of vascular occlusions using ultrasonic energy and microbubbles
US10888657B2 (en) 2010-08-27 2021-01-12 Ekos Corporation Method and apparatus for treatment of intracranial hemorrhages
US11458290B2 (en) 2011-05-11 2022-10-04 Ekos Corporation Ultrasound system
US9579494B2 (en) 2013-03-14 2017-02-28 Ekos Corporation Method and apparatus for drug delivery to a target site
US10507320B2 (en) 2014-09-22 2019-12-17 Ekos Corporation Catheter system
US10092742B2 (en) 2014-09-22 2018-10-09 Ekos Corporation Catheter system
US10656025B2 (en) 2015-06-10 2020-05-19 Ekos Corporation Ultrasound catheter
US11740138B2 (en) 2015-06-10 2023-08-29 Ekos Corporation Ultrasound catheter
US12458379B2 (en) 2017-01-24 2025-11-04 Boston Scientific Scimed, Inc. Method for the treatment of thromboembolism
CN109042460A (zh) * 2018-09-06 2018-12-21 安徽冠禅生物科技有限公司 一种用于水蛭养殖池施药装置

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