EP0760849A4 - Rekombinante, aud bpi und lbp basierende proteine, die für sie kodierenden nukleinsäuren, verfahren zu ihrer herstellung und ihre verwendung - Google Patents

Rekombinante, aud bpi und lbp basierende proteine, die für sie kodierenden nukleinsäuren, verfahren zu ihrer herstellung und ihre verwendung

Info

Publication number
EP0760849A4
EP0760849A4 EP19940917901 EP94917901A EP0760849A4 EP 0760849 A4 EP0760849 A4 EP 0760849A4 EP 19940917901 EP19940917901 EP 19940917901 EP 94917901 A EP94917901 A EP 94917901A EP 0760849 A4 EP0760849 A4 EP 0760849A4
Authority
EP
European Patent Office
Prior art keywords
same
lbp
nucleic acid
methods
acid molecules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19940917901
Other languages
English (en)
French (fr)
Other versions
EP0760849A1 (de
Inventor
Randal W Scott
Marian N Marra
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Incyte Corp
Original Assignee
Incyte Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Pharmaceuticals Inc filed Critical Incyte Pharmaceuticals Inc
Publication of EP0760849A4 publication Critical patent/EP0760849A4/de
Publication of EP0760849A1 publication Critical patent/EP0760849A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4742—Bactericidal/Permeability-increasing protein [BPI]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP94917901A 1993-04-30 1994-04-29 Rekombinante, aud bpi und lbp basierende proteine, die für sie kodierenden nukleinsäuren, verfahren zu ihrer herstellung und ihre verwendung Withdrawn EP0760849A1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5629293A 1993-04-30 1993-04-30
US16571793A 1993-12-10 1993-12-10
US165717 1993-12-10
PCT/US1994/004709 WO1994025476A1 (en) 1993-04-30 1994-04-29 Recombinant bpi-based and lbp-based proteins, nucleic acid molecules encoding same, methods of producing same, and uses thereof
US56292 2002-01-24

Publications (2)

Publication Number Publication Date
EP0760849A4 true EP0760849A4 (de) 1996-12-02
EP0760849A1 EP0760849A1 (de) 1997-03-12

Family

ID=26735192

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94917901A Withdrawn EP0760849A1 (de) 1993-04-30 1994-04-29 Rekombinante, aud bpi und lbp basierende proteine, die für sie kodierenden nukleinsäuren, verfahren zu ihrer herstellung und ihre verwendung

Country Status (5)

Country Link
EP (1) EP0760849A1 (de)
JP (1) JPH08511682A (de)
AU (1) AU6942994A (de)
CA (1) CA2161971A1 (de)
WO (1) WO1994025476A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6265187B1 (en) * 1989-02-14 2001-07-24 Incyte Pharmaceuticals, Inc. Recombinant endotoxin-neutralizing proteins
US5420019A (en) * 1993-02-02 1995-05-30 Xoma Corporation Stable bactericidal/permeability-increasing protein muteins
US5652332A (en) * 1993-03-12 1997-07-29 Xoma Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof
US5891618A (en) * 1994-01-24 1999-04-06 Xoma Corporation Method for quantifying LBP in body fluids
US5484705A (en) 1994-01-24 1996-01-16 Xoma Corporation Method for quantifying lipopolysaccharide binding protein
US5786324A (en) * 1994-03-24 1998-07-28 Regents Of The University Of Minnesota Synthetic peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use
US5830860A (en) * 1994-03-24 1998-11-03 Regents Of The University Of Minnesota Peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use
WO1997004008A1 (en) * 1995-07-20 1997-02-06 Xoma Corporation Anti-fungal peptides
US5780429A (en) * 1995-12-22 1998-07-14 Marine Biological Laboratory Anti-LPS factor from horseshoe crabs and methods of use
US5741779A (en) * 1996-05-10 1998-04-21 Xoma Corporation Antithrombotic materials and methods
PT914144E (pt) * 1996-05-10 2001-05-31 Univ Texas Utilizacoes terapeuticas de produtos de proteinas bip contra a meningococcemia humana
CA2255539C (en) * 1996-05-23 2005-09-27 Xoma Corporation Therapeutic uses of bpi protein products in humans with hemorrhage due to trauma
JP2000511892A (ja) 1996-05-24 2000-09-12 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ 可溶性ベーターシート形成性ペプチドの合成
US5888973A (en) 1996-08-09 1999-03-30 Xoma Corporation Anti-chlamydial uses of BPI protein products
US6482796B2 (en) 1996-11-01 2002-11-19 Xoma Corporation Therapeutic uses of N-terminal BPI protein products in ANCA-positive patients
US5846789A (en) * 1996-12-10 1998-12-08 Council Of Scientific And Industrial Research Process for preparing nontoxic lipopolysaccharides from acidiphilium species
US6093573A (en) * 1997-06-20 2000-07-25 Xoma Three-dimensional structure of bactericidal/permeability-increasing protein (BPI)
DE19729810C2 (de) * 1997-07-11 2000-01-13 Max Delbrueck Centrum Mittel zur Sepsistherapie, seine Herstellung und seine Verwendung
US5990082A (en) * 1997-10-22 1999-11-23 Xoma Corporation Uses of lipopolysaccharide binding protein
US6013631A (en) * 1998-06-19 2000-01-11 Xoma Corporation Bactericidal/permeability-increasing protein (BPI) deletion analogs
CA2476427A1 (en) 2002-02-20 2003-08-28 Regents Of The University Of Minnesota Partial peptide mimetics and methods
US8394379B2 (en) 2003-05-15 2013-03-12 Iogenetics, Llc Targeted cryptosporidium biocides
US8703134B2 (en) 2003-05-15 2014-04-22 Iogenetics, Llc Targeted cryptosporidium biocides

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990009183A1 (en) * 1989-02-14 1990-08-23 Invitron Corporation Use of bactericidal/permeability increasing protein or biologically active analogs thereof to treat lipopolysaccharide associated gram negative infections
EP0464533A1 (de) * 1990-06-28 1992-01-08 BEHRINGWERKE Aktiengesellschaft Fusionsproteine mit immunglobulinanteilen, ihre Herstellung und Verwendung
WO1992003535A1 (en) * 1990-08-13 1992-03-05 Incyte Pharmaceuticals, Inc. Recombinant bpi proteins, uses of bpi proteins, and methods of preparing same
WO1993006228A1 (en) * 1991-09-26 1993-04-01 Incyte Pharmaceuticals, Inc. A new form of liposaccharide binding protein (lbp)
WO1993005797A1 (en) * 1991-09-27 1993-04-01 Incyte Pharmaceuticals, Inc. Compositions comprising a bactericidal/permeability increasing protein and a lipid carrier, methods of making same, and uses thereof
WO1993023434A2 (en) * 1992-05-19 1993-11-25 Xoma Corporation Bpi-immunoglobulin fusion proteins

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990009183A1 (en) * 1989-02-14 1990-08-23 Invitron Corporation Use of bactericidal/permeability increasing protein or biologically active analogs thereof to treat lipopolysaccharide associated gram negative infections
EP0464533A1 (de) * 1990-06-28 1992-01-08 BEHRINGWERKE Aktiengesellschaft Fusionsproteine mit immunglobulinanteilen, ihre Herstellung und Verwendung
WO1992003535A1 (en) * 1990-08-13 1992-03-05 Incyte Pharmaceuticals, Inc. Recombinant bpi proteins, uses of bpi proteins, and methods of preparing same
WO1993006228A1 (en) * 1991-09-26 1993-04-01 Incyte Pharmaceuticals, Inc. A new form of liposaccharide binding protein (lbp)
WO1993005797A1 (en) * 1991-09-27 1993-04-01 Incyte Pharmaceuticals, Inc. Compositions comprising a bactericidal/permeability increasing protein and a lipid carrier, methods of making same, and uses thereof
WO1993023434A2 (en) * 1992-05-19 1993-11-25 Xoma Corporation Bpi-immunoglobulin fusion proteins

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
AU-YOUNG J ET AL.: "A novel LBP-BPI fusion protein with in vivo efficacy and longer half life.", JOURNAL OF ENDOTOXIN RESEARCH, vol. 2, June 1995 (1995-06-01), pages 209 - 212, XP000611392 *
See also references of WO9425476A1 *

Also Published As

Publication number Publication date
WO1994025476A1 (en) 1994-11-10
AU6942994A (en) 1994-11-21
EP0760849A1 (de) 1997-03-12
JPH08511682A (ja) 1996-12-10
CA2161971A1 (en) 1994-11-10

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