EP0760849A4 - Proteines de recombinaison de type augmentant la permeabilite bactericide (bpi) et de type fixant le liposaccharide (lbd), molecules codant pour ces proteines, leurs procedes de production et leurs utilisations - Google Patents

Proteines de recombinaison de type augmentant la permeabilite bactericide (bpi) et de type fixant le liposaccharide (lbd), molecules codant pour ces proteines, leurs procedes de production et leurs utilisations

Info

Publication number
EP0760849A4
EP0760849A4 EP19940917901 EP94917901A EP0760849A4 EP 0760849 A4 EP0760849 A4 EP 0760849A4 EP 19940917901 EP19940917901 EP 19940917901 EP 94917901 A EP94917901 A EP 94917901A EP 0760849 A4 EP0760849 A4 EP 0760849A4
Authority
EP
European Patent Office
Prior art keywords
same
lbp
nucleic acid
methods
acid molecules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19940917901
Other languages
German (de)
English (en)
Other versions
EP0760849A1 (fr
Inventor
Randal W Scott
Marian N Marra
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Incyte Corp
Original Assignee
Incyte Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Pharmaceuticals Inc filed Critical Incyte Pharmaceuticals Inc
Publication of EP0760849A4 publication Critical patent/EP0760849A4/fr
Publication of EP0760849A1 publication Critical patent/EP0760849A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4742—Bactericidal/Permeability-increasing protein [BPI]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP94917901A 1993-04-30 1994-04-29 Proteines de recombinaison de type augmentant la permeabilite bactericide (bpi) et de type fixant le liposaccharide (lbd), molecules codant pour ces proteines, leurs procedes de production et leurs utilisations Withdrawn EP0760849A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5629293A 1993-04-30 1993-04-30
US16571793A 1993-12-10 1993-12-10
US165717 1993-12-10
PCT/US1994/004709 WO1994025476A1 (fr) 1993-04-30 1994-04-29 Proteines de recombinaison de type augmentant la permeabilite bactericide (bpi) et de type fixant le liposaccharide (lbd), molecules codant pour ces proteines, leurs procedes de production et leurs utilisations
US56292 2002-01-24

Publications (2)

Publication Number Publication Date
EP0760849A4 true EP0760849A4 (fr) 1996-12-02
EP0760849A1 EP0760849A1 (fr) 1997-03-12

Family

ID=26735192

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94917901A Withdrawn EP0760849A1 (fr) 1993-04-30 1994-04-29 Proteines de recombinaison de type augmentant la permeabilite bactericide (bpi) et de type fixant le liposaccharide (lbd), molecules codant pour ces proteines, leurs procedes de production et leurs utilisations

Country Status (5)

Country Link
EP (1) EP0760849A1 (fr)
JP (1) JPH08511682A (fr)
AU (1) AU6942994A (fr)
CA (1) CA2161971A1 (fr)
WO (1) WO1994025476A1 (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6265187B1 (en) * 1989-02-14 2001-07-24 Incyte Pharmaceuticals, Inc. Recombinant endotoxin-neutralizing proteins
US5420019A (en) 1993-02-02 1995-05-30 Xoma Corporation Stable bactericidal/permeability-increasing protein muteins
US5652332A (en) * 1993-03-12 1997-07-29 Xoma Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof
US5484705A (en) 1994-01-24 1996-01-16 Xoma Corporation Method for quantifying lipopolysaccharide binding protein
US5891618A (en) 1994-01-24 1999-04-06 Xoma Corporation Method for quantifying LBP in body fluids
US5786324A (en) * 1994-03-24 1998-07-28 Regents Of The University Of Minnesota Synthetic peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use
US5830860A (en) * 1994-03-24 1998-11-03 Regents Of The University Of Minnesota Peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use
WO1997004008A1 (fr) * 1995-07-20 1997-02-06 Xoma Corporation Peptides antifongiques
US5780429A (en) * 1995-12-22 1998-07-14 Marine Biological Laboratory Anti-LPS factor from horseshoe crabs and methods of use
US5741779A (en) * 1996-05-10 1998-04-21 Xoma Corporation Antithrombotic materials and methods
DE69703689T2 (de) 1996-05-10 2001-05-10 Xoma Technology Ltd., Berkeley Therapeutische anwendungen von bpi-protein-produkten zur behandlung von humaner meningococcämia
NZ332954A (en) * 1996-05-23 2000-07-28 Xoma Corp Use of BPI protein products to treat humans with hemorrhage due to trauma
CA2255865C (fr) 1996-05-24 2008-10-14 The Regents Of The University Of Minnesota Synthese de peptides formant des feuillets beta solubles
US5888973A (en) 1996-08-09 1999-03-30 Xoma Corporation Anti-chlamydial uses of BPI protein products
US6482796B2 (en) 1996-11-01 2002-11-19 Xoma Corporation Therapeutic uses of N-terminal BPI protein products in ANCA-positive patients
US5846789A (en) * 1996-12-10 1998-12-08 Council Of Scientific And Industrial Research Process for preparing nontoxic lipopolysaccharides from acidiphilium species
US6093573A (en) * 1997-06-20 2000-07-25 Xoma Three-dimensional structure of bactericidal/permeability-increasing protein (BPI)
DE19729810C2 (de) * 1997-07-11 2000-01-13 Max Delbrueck Centrum Mittel zur Sepsistherapie, seine Herstellung und seine Verwendung
US5990082A (en) 1997-10-22 1999-11-23 Xoma Corporation Uses of lipopolysaccharide binding protein
US6013631A (en) * 1998-06-19 2000-01-11 Xoma Corporation Bactericidal/permeability-increasing protein (BPI) deletion analogs
AU2003211163A1 (en) 2002-02-20 2003-09-09 Regents Of The University Of Minnesota Partial peptide mimetics and methods
US8394379B2 (en) 2003-05-15 2013-03-12 Iogenetics, Llc Targeted cryptosporidium biocides
US8703134B2 (en) 2003-05-15 2014-04-22 Iogenetics, Llc Targeted cryptosporidium biocides

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990009183A1 (fr) * 1989-02-14 1990-08-23 Invitron Corporation Utilisation d'une proteine bactericide/accroissant la permeabilite ou d'analogues biologiquement actifs de cette proteine pour traiter la lipopolysaccharide associee aux infections gram negatives
EP0464533A1 (fr) * 1990-06-28 1992-01-08 BEHRINGWERKE Aktiengesellschaft Protéines fusionnées avec des portions d'immunoglobulines, leurs production et utilisation
WO1992003535A1 (fr) * 1990-08-13 1992-03-05 Incyte Pharmaceuticals, Inc. Proteines bpi recombinees, utilisation et procedes de preparation de ces proteines
WO1993006228A1 (fr) * 1991-09-26 1993-04-01 Incyte Pharmaceuticals, Inc. Nouvelle forme de proteine fixatrice des liposaccharides
WO1993005797A1 (fr) * 1991-09-27 1993-04-01 Incyte Pharmaceuticals, Inc. Compositions comprenant une proteine a action bactericide/accroissant la permeabilite et un excipient lipidique, procedes pour leur production et utilisations
WO1993023434A2 (fr) * 1992-05-19 1993-11-25 Xoma Corporation Proteines de fusion de l'immunoglobuline bactericides augmentant la permeabilite

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990009183A1 (fr) * 1989-02-14 1990-08-23 Invitron Corporation Utilisation d'une proteine bactericide/accroissant la permeabilite ou d'analogues biologiquement actifs de cette proteine pour traiter la lipopolysaccharide associee aux infections gram negatives
EP0464533A1 (fr) * 1990-06-28 1992-01-08 BEHRINGWERKE Aktiengesellschaft Protéines fusionnées avec des portions d'immunoglobulines, leurs production et utilisation
WO1992003535A1 (fr) * 1990-08-13 1992-03-05 Incyte Pharmaceuticals, Inc. Proteines bpi recombinees, utilisation et procedes de preparation de ces proteines
WO1993006228A1 (fr) * 1991-09-26 1993-04-01 Incyte Pharmaceuticals, Inc. Nouvelle forme de proteine fixatrice des liposaccharides
WO1993005797A1 (fr) * 1991-09-27 1993-04-01 Incyte Pharmaceuticals, Inc. Compositions comprenant une proteine a action bactericide/accroissant la permeabilite et un excipient lipidique, procedes pour leur production et utilisations
WO1993023434A2 (fr) * 1992-05-19 1993-11-25 Xoma Corporation Proteines de fusion de l'immunoglobuline bactericides augmentant la permeabilite

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
AU-YOUNG J ET AL.: "A novel LBP-BPI fusion protein with in vivo efficacy and longer half life.", JOURNAL OF ENDOTOXIN RESEARCH, vol. 2, June 1995 (1995-06-01), pages 209 - 212, XP000611392 *
See also references of WO9425476A1 *

Also Published As

Publication number Publication date
JPH08511682A (ja) 1996-12-10
CA2161971A1 (fr) 1994-11-10
EP0760849A1 (fr) 1997-03-12
WO1994025476A1 (fr) 1994-11-10
AU6942994A (en) 1994-11-21

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