EP0771185A1 - Preparations cosmetiques ou dermatologiques finement dispersees, exemptes d'emulsifiants, du type huile dans eau - Google Patents

Preparations cosmetiques ou dermatologiques finement dispersees, exemptes d'emulsifiants, du type huile dans eau

Info

Publication number
EP0771185A1
EP0771185A1 EP95925830A EP95925830A EP0771185A1 EP 0771185 A1 EP0771185 A1 EP 0771185A1 EP 95925830 A EP95925830 A EP 95925830A EP 95925830 A EP95925830 A EP 95925830A EP 0771185 A1 EP0771185 A1 EP 0771185A1
Authority
EP
European Patent Office
Prior art keywords
weight
preparations according
water
cosmetic
additives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP95925830A
Other languages
German (de)
English (en)
Inventor
Dorte Artz
Michael Christiansen
Uwe SCHÖNROCK
Sigrid Steinke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beiersdorf AG
Original Assignee
Beiersdorf AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beiersdorf AG filed Critical Beiersdorf AG
Publication of EP0771185A1 publication Critical patent/EP0771185A1/fr
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/044—Suspensions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/062—Oil-in-water emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/678—Tocopherol, i.e. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8105—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
    • A61K8/8111—Homopolymers or copolymers of aliphatic olefines, e.g. polyethylene, polyisobutene; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/30—Characterized by the absence of a particular group of ingredients
    • A61K2800/33—Free of surfactant

Definitions

  • the present invention relates to cosmetic and dermatological preparations of the oil-in-water type, processes for their preparation and their use for cosmetic and medical purposes.
  • Cosmetic skin care is understood primarily to mean that the natural function of the skin as a barrier against environmental influences (eg dirt, chemicals, microorganisms) and against the loss of the body's own substances (eg water, natural fats, electrolytes) is strengthened or is restored.
  • environmental influences eg dirt, chemicals, microorganisms
  • body's own substances eg water, natural fats, electrolytes
  • the aim of skin care is also to compensate for the loss of fat and water in the skin caused by daily washing. This is especially important when the natural regeneration ability is insufficient.
  • skin care products are intended to protect against environmental influences, in particular from the sun and wind, and to delay skin aging.
  • Medical topical compositions usually contain one or more drugs in effective concentration.
  • drugs in effective concentration.
  • a clear distinction between cosmetic and medical use and corresponding products is based on the statutory requirements.
  • ERSAI7BLATT Sentiments of the Federal Republic of Germany referenced (eg cosmetics regulation, food and drug law).
  • Emulsifier-free sunscreen preparations based on so-called hydrodispersions have been accessible to the consumer for some time.
  • Hydrodispersions are dispersions of a liquid, semi-solid or solid inner (discontinuous) epidase in an outer aqueous (continuous) phase.
  • hydrodispersions are essentially free of emulsifiers. Like emulsions, hydrodispersions are metastable systems and tend to change into a state of two interrelated discrete phases. In emulsions, the choice of a suitable emulsifier prevents phase separation.
  • the stability of such a system can, for example,
  • SPARE BLADE (RULE 26) by ensuring that a gel structure is built up in the aqueous phase in which the lipid droplets are stably suspended.
  • compositions of the prior art generally have the disadvantage that they are either unstable, restricted to a narrow range of use or limited in the choice of starting materials.
  • compositions of the prior art contain little or no skin-care fats or oils.
  • An object of the present invention was to provide emulsifier-free, finely dispersed oil-in-water preparations which do not have the disadvantages of the prior art. Another object of the invention was to enrich the limited supply of emulsifier-free finely dispersed preparations of the oil-in-water type of the prior art. It was also an object of the present invention to provide stable, emulsifier-free preparations with a high fat and / or oil content.
  • an oil phase containing one or more non-polar oils, fats and / or waxes as the main constituent a water phase one or more thickeners selected from the group of acrylic acid copolymers, polysaccharides and their alkyl ethers, these thickeners not being allowed to have any emulsifier properties and if desired containing customary cosmetic or dermatological herbal, additives and / or active ingredients.
  • An advantageous thickener according to the invention is Carbomer 980, an acrylic acid polymer.
  • Carbomer 980 is available under the trade name Synthalen M (Sigma), among others.
  • EP-OS 328 355 describes a finely dispersed cosmetic preparation of the oil-in-water type, containing 3 to 40% by weight of an oil phase, 0.02 to 2.0% by weight of an amphipathic emulsifier and water.
  • the amphipathic emulsifier can be selected from the group of acrylic acid copolymers (called carbomers or carbopols) with emulsifier properties, namely Carbopol 934, Carbopol 940, Carbopol 941, Carbopol 1342 and other amphipathic emulsifiers.
  • the thickeners are acrylic acid polymers without emulsifier properties, for example carbomer 980.
  • carbomer 980 In soap-oil-fat waxes 113. Volume 5/1987, p. 149 ff., It is expressly pointed out that carbomer 980, in contrast to the other aforementioned carbomer or carbopol types has no emulsifier properties.
  • thickeners are polysaccharides and their alkyl ethers, it is advantageous to choose them from the group consisting of xanthan gum, methyl cellulose, hydroxymethyl cellulose, ethyl cellulose, hydroxyethyl cellulose, propyl cellulose and hydroxypropyl cellulose.
  • nonpolar fats, waxes or oils according to the invention are advantageously selected from the group consisting of petroleum jelly (petrolatum), paraffin oil and polyolefins.
  • petroleum jelly petrolatum
  • paraffin oil paraffin oil
  • polyolefins polydecenes are the preferred substances.
  • REPLACEMENT SHEET (REGR 26) Furthermore, it is possible and advantageous, although not absolutely necessary, to dispense with an additional content of silicone oils.
  • Preparations according to the invention advantageously contain 0.5-50% by weight of one or more nonpolar oils, 0.005-10% by weight of thickeners, if appropriate auxiliaries, additives or active ingredients and water.
  • Preparations according to the invention particularly advantageously comprise 0.5-50% by weight of petrolatum, 0.005-10% by weight of thickener, optionally auxiliaries, additives or active substances and water.
  • Preparations according to the invention also particularly advantageously comprise 0.5-50% by weight of paraffin oil, 0.005-10% by weight of thickener, optionally auxiliaries, additives or active substances and water.
  • Preparations according to the invention very particularly advantageously comprise 0.5-30% by weight of petrolatum, 0.5-30% by weight of paraffin oil, 0.005-10% by weight of thickener, if appropriate auxiliaries, additives or active substances and water.
  • Preparations according to the invention preferably contain 1.5-20% by weight of petrolatum, 3-18% by weight of paraffin oil, 0.1-2% by weight of thickener, if appropriate auxiliaries, additives or active substances and water.
  • Preparations according to the invention particularly preferably contain 5-10% by weight petrolatum, 8-18% by weight paraffin oil, 0.1-2% by weight thickener, optionally auxiliaries, additives or active ingredients and water.
  • compositions are also obtained if antioxidants are used as additives or active ingredients.
  • the preparations advantageously contain one or more antioxidants. All of the antioxidants suitable or customary for cosmetic and / or dermatological applications can be used as inexpensive, but nevertheless optional antioxidants.
  • REPLACEMENT SHEET REGR 26
  • the antioxidants are particularly advantageously selected from the group consisting of
  • Amino acids e.g. glycine, histidine, tyrosine, tryptophan
  • imidazoles e.g. urocanic acid
  • peptides such as D, L-carnosine, D-carnosine, L-carnosine and their derivatives (e.g. anserine)
  • caro - Tinoids e.g. ⁇ -carotene, ß-carotene, lycopene
  • lipoic acid and their derivatives e.g. dihydroliponic acid
  • aurothioglucose propylthiouracil and other thiols
  • thioredoxin glutathione, cysteine, cystine, cystamine and their glycosyl- , N-acetyl, methyl, ethyl, propyl, amyl, butyl and lauryl, palmitoyl, oleyl, gamma-linoleyl, cholesteryl and glyceryl esters) and their salts, dilauryl thiodipropionate, distearylthio dipropionate, Thiodipropionic acid and its derivatives (esters, ethers, peptides, lipids, nucleotides, nucleosides and salts) as well as sulfoximine compounds (e.g.
  • buthioninsurfoximines in very low tolerable doses (e.g.
  • far he (metal) chelators for example ⁇ -hydroxy fatty acids, palmitic acid, phytic acid, lactoferrin), ⁇ -hydroxy acids (for example citric acid, lactic acid, malic acid), humic acid, bile acid, bile extracts, bilirubin, biliverdin, EDTA, EGTA and their derivatives, unsaturated fatty acids and their derivatives (eg gamma-lininoic acid, linoleic acid, oleic acid), folic acid and their derivatives, ubiquinone and ubiquinol their derivatives, vitamin C and derivatives (eg ascorbyl palmitates, Mg - ascorbyl phosphates, ascorbylacetates), Tocopherols and derivatives (e.g.
  • vitamin E acetate
  • vitamin A and derivatives vitamin A palmitate
  • REPLACEMENT SHEET Oil-soluble antioxidants can be used particularly advantageously for the purposes of the present invention.
  • preparations according to the invention are very good vehicles for cosmetic or dermatological active ingredients in the skin, preferred active ingredients being anti-oxidants which can protect the skin against oxidative stress.
  • preferred active ingredients being anti-oxidants which can protect the skin against oxidative stress.
  • Preferred antioxidants are vitamin E and its derivatives and vitamin A and its derivatives.
  • the amount of the antioxidants (one or more compounds) in the preparations is preferably 0.001 to 30% by weight, particularly preferably 0.05-20% by weight, in particular 1-10% by weight, based on the total weight of the preparation.
  • vitamin E and / or its derivatives represent the antioxidant (s)
  • vitamin A or vitamin A derivatives or carotenes or their derivatives represent the antioxidant or antioxidants, it is advantageous to have their respective concentrations in the range from 0.001-10% by weight, based on the Total weight of the formulation to choose.
  • the preparations according to the invention can be used, for example, as a skin protection cream, cleansing milk, sunscreen lotion, nutritional cream, day or night cream, etc. It may be possible and advantageous to use the preparations according to the invention as the basis for pharmaceutical formulations ⁇ the.
  • Cosmetic and dermatological preparations which are in the form of a sunscreen are also favorable.
  • these preferably additionally contain at least one UVA filter substance and / or at least one UVB filter substance and / or at least one inorganic pigment.
  • UV-A or UV-B filter substances are usually incorporated into day creams.
  • UV protection substances like antioxidants and, if desired, preservatives, also provide effective protection of the preparations themselves against spoilage.
  • Preparations according to the invention can advantageously contain substances which absorb UV radiation in the UVB range, the total amount of filter substances being, for example, 0.1% by weight to 30% by weight, preferably 0.5 to 10% by weight, in particular 1 is up to 6% by weight, based on the total weight of the preparations in order to provide cosmetic and / or dermatological preparations which protect the skin from the entire range of ultraviolet radiation. They can also serve as sunscreens.
  • the UVB filters can be oil-soluble or water-soluble. Examples of ole-soluble substances are to call:
  • 3-benzylidene camphor derivatives preferably 3- (4-methylbenzylidene) camphor, 3-benzylidene camphor;
  • 4-aminobenzoic acid derivatives preferably 4- (dimethylamino) benzoic acid (2-ethylhexyl) ester, 4- (dimethylamino) benzoic acid amyl ester;
  • Esters of cinnamic acid preferably 4-methoxycinnamic acid (2-ethylhexyl) ester, 4-methoxycinnamic acid isopentyl ester;
  • esters of salicylic acid preferably salicylic acid (2-ethylhexyl) ester, salicylic acid (4-isopropylbenzyl) ester, salicylic acid homomethyl ester;
  • benzophenone preferably 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone;
  • 3-benzyiide camphor e.g. 4- (2-oxo-3-bornylidenemethyl) benzenesuffonic acid, 2-methyl-5- (2-oxo-3-bornylidenemethyl) sulfonic acid and their salts.
  • UVB filters mentioned which can be used according to the invention is of course not intended to be limiting.
  • the invention also relates to the combination of a UVA filter according to the invention with a UVB filter or a cosmetic or dermatological preparation according to the invention which also contains a UVB filter.
  • UVA filters in preparations according to the invention, which are usually contained in cosmetic and / or dermatological preparations.
  • Such substances are preferably derivatives of dibenzoylmethane, in particular 1- (4'-tert-butylphenyl) -3- (4'-methoxyphenyl) propane-1, 3-dione and 1-phenyl-3- (4 '-isopropylphenyl) propane-1,3-dione. Preparations containing these combinations are also the subject of the invention.
  • the same amounts of UVA filter substances that were mentioned for UVB filter substances can be used.
  • Cosmetic and / or dermatological preparations according to the invention can also contain inorganic pigments which are usually used in cosmetics to protect the skin from UV rays. These are oxides of titanium, zinc, iron, zirconium, silicon, manganese, aluminum, cerium and mixtures thereof, as well as modifications in which the oxides are the active agents. Acts particularly preferred are pigments based on titanium dioxide. The amounts given for the above combinations can be used.
  • the cosmetic and dermatological preparations according to the invention can contain cosmetic auxiliaries as are usually used in such preparations, e.g. Preservatives, bactericides, virucides, perfumes, substances to prevent foaming, dyes, pigments which have a coloring effect, thickeners, surface-active substances, emulsifiers, softening, moisturizing and / or moisturizing substances, anti-inflammatory substances, medicaments, fats, Oils, waxes or other usual components of a cosmetic or dermatological formulation such as alcohols, polyols, polymers, foam stabilizers, electrolytes, organic solvents.
  • cosmetic auxiliaries e.g. Preservatives, bactericides, virucides, perfumes, substances to prevent foaming, dyes, pigments which have a coloring effect, thickeners, surface-active substances, emulsifiers, softening, moisturizing and / or moisturizing substances, anti-inflammatory substances, medicaments, fats, Oils, waxes or other usual components
  • Fats, waxes and other natural and synthetic fat bodies preferably esters of fatty acids with alcohols of low C number, e.g. with isopropanol, propylene glycol or glycerin, or esters of fatty alcohols with low C number alkanoic acids or with fatty acids;
  • ethers preferably ethanol, isopropanol, propylene glycol, glycerin, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl ether, diethylene glycol monomethyl or monoethyl ether and analog products.
  • Phases (a) and (c) are heated separately to 75 ° C. Then phases (a) and (c) are combined and cooled to about 65 ° C. with stirring. The mixture is then homogenized and cooled to about 35 ° C. with stirring. Phase (b) is added, then the mixture is homogenized again and cooled to room temperature.
  • Phases (a) and (c) are heated separately to 75 ° C. Then phases (a) and (c) are combined and cooled to about 65 ° C. with stirring. The mixture is then homogenized and cooled to about 35 ° C. with stirring. Phase (b) is added, then the mixture is homogenized again and cooled to room temperature.
  • Phases (a) and (c) are heated separately to 75 ° C. Then phases (a) and (c) are combined and cooled to about 65 ° C. with stirring. The mixture is then homogenized and cooled to about 35 ° C. with stirring. Phase (b) is added, then the mixture is homogenized again and cooled to room temperature.
  • Phases (a) and (c) are heated separately to 75 ° C. Then phases (a) and (c) are combined and cooled to about 65 ° C. with stirring. The mixture is then homogenized and cooled to about 35 ° C. with stirring. Phase (b) is added, then the mixture is homogenized again and cooled to room temperature.
  • Phases (a) and (c) are heated separately to 75 ° C. Then phases (a) and (c) are combined and cooled to about 65 ° C. with stirring. The mixture is then homogenized and cooled to about 35 ° C. with stirring. Phase (b) is added, then the mixture is homogenized again and cooled to room temperature.
  • Carbopol 980 (Goodrich) 0.40 ⁇ -tocopheryl acetate 1.00
  • Phases (a) and (c) are heated separately to 75 ° C. Then phases (a) and (c) are combined and cooled to about 65 ° C. with stirring. The mixture is then homogenized and cooled to about 35 ° C. with stirring. Phase (b) is added, then the mixture is homogenized again and cooled to room temperature.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne des préparations cosmétiques ou dermatologiques finement dispersées, exemptes d'émulsifiants, du type huile dans eau, comprenant: une phase huileuse, contenant, comme constituant essentiel, une ou plusieurs huiles, substances grasses et/ou cires non polaires; une phase aqueuse; un ou plusieurs épaississants choisis dans le groupe comprenant des polymères d'acide acrylique, des polysaccharides et leurs alkyléthers, lesdits épaississants ne devant présenter aucune propriété émulsifiante; et, le cas échéant, des substances auxiliaires, adjuvants et/ou principes actifs cosmétiques ou dermatologiques de type courant.
EP95925830A 1994-07-16 1995-07-05 Preparations cosmetiques ou dermatologiques finement dispersees, exemptes d'emulsifiants, du type huile dans eau Ceased EP0771185A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4425268 1994-07-16
DE4425268A DE4425268C2 (de) 1994-07-16 1994-07-16 Emulgatorfreie, feindisperse kosmetische oder dermatologische Zubereitungen vom Typ Öl-in-Wasser
PCT/EP1995/002599 WO1996002223A1 (fr) 1994-07-16 1995-07-05 Preparations cosmetiques ou dermatologiques finement dispersees, exemptes d'emulsifiants, du type huile dans eau

Publications (1)

Publication Number Publication Date
EP0771185A1 true EP0771185A1 (fr) 1997-05-07

Family

ID=6523416

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95925830A Ceased EP0771185A1 (fr) 1994-07-16 1995-07-05 Preparations cosmetiques ou dermatologiques finement dispersees, exemptes d'emulsifiants, du type huile dans eau

Country Status (4)

Country Link
US (1) US5833951A (fr)
EP (1) EP0771185A1 (fr)
DE (1) DE4425268C2 (fr)
WO (1) WO1996002223A1 (fr)

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US5833951A (en) 1998-11-10
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DE4425268A1 (de) 1996-01-18

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