EP0786454A4 - Derive thioquinolone - Google Patents

Derive thioquinolone

Info

Publication number
EP0786454A4
EP0786454A4 EP95933632A EP95933632A EP0786454A4 EP 0786454 A4 EP0786454 A4 EP 0786454A4 EP 95933632 A EP95933632 A EP 95933632A EP 95933632 A EP95933632 A EP 95933632A EP 0786454 A4 EP0786454 A4 EP 0786454A4
Authority
EP
European Patent Office
Prior art keywords
thioquinolone
derivative
represent
combined together
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95933632A
Other languages
German (de)
English (en)
Other versions
EP0786454A1 (fr
Inventor
Masataka Konishi
Naoki Fukuda
Yukio Oku
Hiroaki Yamazaki
Kazuhiro Imaizumi
Hideshi Kobayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zenyaku Kogyo KK
Original Assignee
Zenyaku Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zenyaku Kogyo KK filed Critical Zenyaku Kogyo KK
Publication of EP0786454A1 publication Critical patent/EP0786454A1/fr
Publication of EP0786454A4 publication Critical patent/EP0786454A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/08—Aza-anthracenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

On décrit un dérivé thioquinolone représenté par la formule générale (I), qui possède une sélectivité élevée ainsi qu'une puissante activité antibactérienne contre Helicobacter pylori. Dans cette formule, R1 et R2 représentent chacun hydrogène, ou bien combinés ensemble ils représentent -O-(CH2)2-; R3 représente halogène, alkyle C1-C12, alcoxy C1-C12, alkylsulfonyloxy inférieur, etc.; et R4 représente hydrogène ou alkyle inférieur, ou bien R4 et R3 sont combinés ensemble pour former un noyau cyclohexène, benzène ou pyridine.
EP95933632A 1994-10-07 1995-10-06 Derive thioquinolone Withdrawn EP0786454A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP24434894 1994-10-07
JP244348/94 1994-10-07
PCT/JP1995/002052 WO1996011187A1 (fr) 1994-10-07 1995-10-06 Derive thioquinolone

Publications (2)

Publication Number Publication Date
EP0786454A1 EP0786454A1 (fr) 1997-07-30
EP0786454A4 true EP0786454A4 (fr) 1998-01-07

Family

ID=17117370

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95933632A Withdrawn EP0786454A4 (fr) 1994-10-07 1995-10-06 Derive thioquinolone

Country Status (5)

Country Link
US (1) US5773449A (fr)
EP (1) EP0786454A4 (fr)
AU (1) AU3619695A (fr)
CA (1) CA2201866A1 (fr)
WO (1) WO1996011187A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998004529A1 (fr) * 1996-07-30 1998-02-05 Zenyaku Kogyo Kabushiki Kaisha Derives de sulfure de quinoleine
PT1154774E (pt) 1999-02-10 2005-10-31 Astrazeneca Ab Derivados de quinazolina como inibidores de angiogenese
WO2008046085A2 (fr) 2006-10-12 2008-04-17 Supergen, Inc. Dérivés de quinoline pour la modulation de la méthylation de l'adn
US20130225581A1 (en) 2010-07-16 2013-08-29 Kyowa Hakko Kirin Co., Ltd Nitrogen-containing aromatic heterocyclic derivative
CN105037266B (zh) * 2012-12-12 2017-07-28 王子厚 用于抗菌的氯氧喹衍生物
CN103864680B (zh) * 2012-12-12 2015-09-02 王子厚 具有抗肿瘤活性的氯氧喹衍生物
WO2018085348A1 (fr) * 2016-11-03 2018-05-11 Actavalon, Inc. Quinoléines substituées et procédés pour traiter le cancer

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06271556A (ja) * 1993-03-23 1994-09-27 Pola Chem Ind Inc 薬剤に対する感受性回復剤

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4619994A (en) * 1983-04-26 1986-10-28 Douglas Shortridge Benzeneazo polynuclear aromatic or heteroaromatic amidine compounds containing amidine substituents
JPS6461461A (en) * 1987-09-01 1989-03-08 Otsuka Pharma Co Ltd Benzohetero ring derivative
JPH02288864A (ja) * 1988-05-24 1990-11-28 Kirin Brewery Co Ltd ４（１ｈ）キノロン誘導体
EP0343574B1 (fr) * 1988-05-24 1994-07-27 Kirin Beer Kabushiki Kaisha Dérivés de la 4(1H)-quinoléione
US5189210A (en) * 1992-04-30 1993-02-23 Dowelanco Process for the preparation of 3- and/or 5-substituted anthranilic acids

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06271556A (ja) * 1993-03-23 1994-09-27 Pola Chem Ind Inc 薬剤に対する感受性回復剤

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Foye, W.O. et al, Phosphorous and Sulfur, 1980, vol.8, pp.205-207 *
No further relevant documents disclosed *
See also references of WO9611187A1 *

Also Published As

Publication number Publication date
EP0786454A1 (fr) 1997-07-30
WO1996011187A1 (fr) 1996-04-18
CA2201866A1 (fr) 1996-04-18
AU3619695A (en) 1996-05-02
US5773449A (en) 1998-06-30

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