EP0792170A4 - Radionuklid-chelatverbindungen zur radiomarkierung von liganden, antiliganden oder verschiedenen proteinen - Google Patents

Radionuklid-chelatverbindungen zur radiomarkierung von liganden, antiliganden oder verschiedenen proteinen

Info

Publication number
EP0792170A4
EP0792170A4 EP94924458A EP94924458A EP0792170A4 EP 0792170 A4 EP0792170 A4 EP 0792170A4 EP 94924458 A EP94924458 A EP 94924458A EP 94924458 A EP94924458 A EP 94924458A EP 0792170 A4 EP0792170 A4 EP 0792170A4
Authority
EP
European Patent Office
Prior art keywords
ligands
radiotarking
proteins
metal chelates
radionuclides used
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94924458A
Other languages
English (en)
French (fr)
Other versions
EP0792170A1 (de
Inventor
Linda M Gustavson
Sudhakar Kasina
Alan R Fritzberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Poniard Pharmaceuticals Inc
Original Assignee
Poniard Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Poniard Pharmaceuticals Inc filed Critical Poniard Pharmaceuticals Inc
Publication of EP0792170A1 publication Critical patent/EP0792170A1/de
Publication of EP0792170A4 publication Critical patent/EP0792170A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A61K51/1054—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from lung
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EP94924458A 1993-07-12 1994-07-12 Radionuklid-chelatverbindungen zur radiomarkierung von liganden, antiliganden oder verschiedenen proteinen Withdrawn EP0792170A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9042193A 1993-07-12 1993-07-12
US90421 1993-07-12
PCT/US1994/007733 WO1995002418A1 (en) 1993-07-12 1994-07-12 Radionuclide metal chelates for the radiolabeling of ligands, anti-ligands or other proteins

Publications (2)

Publication Number Publication Date
EP0792170A1 EP0792170A1 (de) 1997-09-03
EP0792170A4 true EP0792170A4 (de) 2000-03-15

Family

ID=22222702

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94924458A Withdrawn EP0792170A4 (de) 1993-07-12 1994-07-12 Radionuklid-chelatverbindungen zur radiomarkierung von liganden, antiliganden oder verschiedenen proteinen

Country Status (3)

Country Link
EP (1) EP0792170A4 (de)
CA (1) CA2165052A1 (de)
WO (1) WO1995002418A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5556982A (en) * 1985-01-14 1996-09-17 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
WO1995005398A1 (en) * 1993-08-17 1995-02-23 Neorx Corporation S3n chelating compounds for the radiolabeling of ligands, anti-ligands or other proteins
US20090286875A1 (en) * 2005-11-17 2009-11-19 Pfizer, Inc. Isocystene derivatives for the treatment of pain

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0300431A2 (de) * 1987-07-22 1989-01-25 Neorx Corporation Methode zur Bindung von radionukliden Anschwefel enthaltende Chelate
WO1990015808A1 (en) * 1989-06-16 1990-12-27 Neorx Corporation Radionuclide metal chelates for the radiolabeling of proteins
WO1991009876A1 (en) * 1989-12-29 1991-07-11 Neorx Corporation Radiolabeled proteins for diagnostic or therapeutic use
WO1995002423A1 (en) * 1993-07-12 1995-01-26 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5164176A (en) * 1989-06-16 1992-11-17 Neorx Corporation Radionuclide metal chelates for the radiolabeling of proteins

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0300431A2 (de) * 1987-07-22 1989-01-25 Neorx Corporation Methode zur Bindung von radionukliden Anschwefel enthaltende Chelate
WO1990015808A1 (en) * 1989-06-16 1990-12-27 Neorx Corporation Radionuclide metal chelates for the radiolabeling of proteins
WO1991009876A1 (en) * 1989-12-29 1991-07-11 Neorx Corporation Radiolabeled proteins for diagnostic or therapeutic use
WO1995002423A1 (en) * 1993-07-12 1995-01-26 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9502418A1 *

Also Published As

Publication number Publication date
CA2165052A1 (en) 1995-01-26
EP0792170A1 (de) 1997-09-03
WO1995002418A1 (en) 1995-01-26

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