EP0796605A1 - Feuille de fermeture avec pistes conductrices - Google Patents

Feuille de fermeture avec pistes conductrices Download PDF

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Publication number
EP0796605A1
EP0796605A1 EP96810180A EP96810180A EP0796605A1 EP 0796605 A1 EP0796605 A1 EP 0796605A1 EP 96810180 A EP96810180 A EP 96810180A EP 96810180 A EP96810180 A EP 96810180A EP 0796605 A1 EP0796605 A1 EP 0796605A1
Authority
EP
European Patent Office
Prior art keywords
label
conductor tracks
cover film
layer
cover
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96810180A
Other languages
German (de)
English (en)
Inventor
Markus Lüthi
Patrik Zeiter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
3A Composites International AG
Original Assignee
Alusuisse Lonza Services Ltd
Alusuisse Technology and Management Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alusuisse Lonza Services Ltd, Alusuisse Technology and Management Ltd filed Critical Alusuisse Lonza Services Ltd
Priority to EP96810180A priority Critical patent/EP0796605A1/fr
Publication of EP0796605A1 publication Critical patent/EP0796605A1/fr
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
    • A61J1/035—Blister-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
    • A61J7/0409—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers
    • A61J7/0481—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers working on a schedule basis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J2205/00—General identification or selection means
    • A61J2205/70—Audible labels, e.g. for pre-recorded info or messages

Definitions

  • Cover film with liter webs for pharmaceutical packaging that can be connected to a computer, the pharmaceutical packaging containing a plurality of depressions which are filled with filling material.
  • a device for storing and reminding a patient of the need to take medication consisting of a medication packaging and a signal transmitter.
  • a start pulse is fed to the signal generator via a pulse line.
  • the impulse line is cast in a push-through second film and the coated tablets in the pharmaceutical packaging are cast in a first film provided with depressions and the push-through second film.
  • This known medicament container represents a medicament packaging, which is also known to the experts as a blister pack.
  • the impulse lines are attached in the cover film of this known pharmaceutical container.
  • Pharmaceutical packaging of this type i.e. Blister packs in general are continuously produced in large numbers on packaging machines.
  • a plastic monofoil or plastic composite film is provided with recesses or cells by means of depths.
  • the filler such as the coated tablets or tablets, capsules, ampoules and the like, are filled into the depressions and the cover film is then sealed.
  • the blister packs are generally produced continuously from tape-like foils and only cut to size after filling in the contents and covering and, if necessary, are filled into an outer packaging.
  • push-through second film must already contain the impulse lines in the case of EP-B 0 129 785 and it must be ensured that the impulse lines are positioned exactly over the intended trough.
  • the cover film, as well as the base parts, can shift against each other to a greater or lesser extent at the given processing speed. In the case of cover materials without pulse lines, this has no further effect, since, for example, product information is printed on the strip material in a regular sequence in such a way that at least one complete information block can always be recognized on a blister pack.
  • the object of the present invention is to propose a cover film with conductor tracks which does not have the disadvantages described and the conductor tracks can be arranged exactly in accordance with the depressions without positioning problems during the filling and closing process.
  • the cover film consists of at least two layers, the one layer being the cover material fixed on the pharmaceutical packaging and the second layer being a label containing the conductor tracks and the label covering at least the depressions containing the filling material.
  • the label according to the invention can, for example, have a carrier material and, applied to the carrier material, the conductor tracks.
  • a further material can be applied to the carrier material and lying over the conductor tracks.
  • a carrier film for example a plastic film of high brittleness, such as e.g. a polyolefin film, a polyethylene film or a polyvinyl chloride film can be used.
  • the brittleness can be increased, for example, by the addition of fillers, e.g. Talk, mica, etc. can be achieved.
  • Other plastic films can be acrylonitrile-styrene-containing films.
  • papers or semi-cardboard can also be used as carrier materials.
  • Further carrier materials are metal foils or metal foils which are coated on one or both sides with further layers, such as lacquer layers or plastic foils and the like.
  • the films and papers mentioned as carrier materials can be used as a further material for protecting the conductor tracks.
  • These protective materials can be fixed on the carrier material, covering the conductor tracks.
  • the labels are advantageously constructed from the same materials for the carrier material and protective material.
  • the material for protecting the conductor tracks can also be a protective layer sprayed on, sprayed on, rolled up or spread on in the form of a protective lacquer or can be vapor-deposited, vacuum-vapor-deposited or sputtered-on layers.
  • the conductor tracks can be made of an electrically conductive film or of wires or an electrically conductive lacquer or powder coating or an evaporated or vacuum-deposited electrically conductive layer.
  • the electrically conductive paint can contain electrically conductive substances and paint carriers, solvents, etc.
  • the electrically conductive lacquer can also be solvent-free.
  • the electrical conductivity in paints can be increased by inorganic compounds such as metals or semimetals, e.g. Metal powder or dust, in particular platelet-shaped nickel, silver-coated platelet-shaped nickel, nickel, iron, copper, silver powder etc. or by carbon, for example in the form of carbon black, coke and preferably graphite or by oxide mixtures.
  • Preferred as conductor tracks in the context of the present invention are conductor tracks containing an SnO 2 / Sb 2 O 3 hydroxide mixture on a mica substrate.
  • the SnO 2 / Sb 2 O 3 hydroxide mixture advantageously has a layer thickness on the mica particles of 8 to 20, advantageously 16 to 20 nanometers.
  • the SnO 2 / Sb 2 O 3 hydroxide mixture on the mica particles represents a conductive pigment.
  • the ratio Sn / Sb is expediently 95: 5 to 75:25, a ratio of 85:15 being preferred.
  • the grain size of the mica can be, for example, from 10 to 100 ⁇ m and the grain size of the mica is expediently less than 15 ⁇ m.
  • a lacquer can contain the electrically conductive pigment, for example the SnO 2 / Sb 2 O 3 hydroxide mixture on the mica substrate, and a binder.
  • Melamine resins, acrylic melamine resins, polyurethane lacquers, nitrocellulose lacquers, acrylonitrocellulose lacquers etc. are used as binders in such lacquers.
  • the proportion of binder in the lacquer can be, for example, from 10 to 60% by weight and advantageously from 10 to 25% by weight.
  • the proportion of electrically conductive pigment can be 40 to 90% by weight and advantageously 75 to 90% by weight in the lacquer.
  • a filler such as TiO 2 can be used , for example in a grain size equal to or less than 15 ⁇ m and in a ratio of electrically conductive pigment to filler of 1: 1, or fillers in the form of porous spherical particles a grain size of greater than 30 ⁇ m and known under the brand name LiChrospher from Merck, in a ratio of 1: 1 of electrically conductive pigment to filler.
  • Varnishes for producing conductor tracks can be applied to the carrier material by brushing, brushing, spraying, etc., if necessary using a stencil, or by printing using offset, gravure, letterpress or screen printing, etc.
  • Other methods for producing conductor tracks on the carrier material are electrostatic methods, methods according to the Decal principle, photochemical reproduction processes or photochemical printing processes, such as by applying a full-surface lacquer film, fixing the conductor pattern and removing the unnecessary lacquer surfaces.
  • Another method for producing conductor tracks is the generation of layers by vapor deposition, for example in a vacuum (chemical vapor deposition, physical vapor deposition, sputtering).
  • the structuring of vapor-deposited electrically conductive layers can take place, for example, by locally applying a layer upstream of the vapor deposition process, which layer either prevents the adhesion of the electrically conductive layer or the condensation of the vapor.
  • a layer upstream of the vapor deposition process which layer either prevents the adhesion of the electrically conductive layer or the condensation of the vapor.
  • As liable or Anti-condensation layers are applied, for example, silicone oils in a vacuum.
  • a vapor-deposited layer can also be masked after vapor deposition and then structured using etching processes. Structuring is also possible by local evaporation of the layer using laser or electron beams.
  • Another form of structuring of the vapor-deposited electrically conductive layer lies in a method according to which a varnish which is soluble in a solvent is applied to the carrier before the vapor-deposition process, for example by a deep, sieve or high-pressure method. After the coated support has been evaporated, the paint is removed again using a solvent. The vapor-deposited layers are inevitably removed with the lacquer. The vapor-deposited layer and thus the desired conductor pattern remains on the unpainted areas of the carrier surface.
  • detection and distance marks or circuits for mechanically applying the labels to the blister pack can be provided.
  • circuits which contain information which can be evaluated by the computer such as e.g. about the contents of the pack, the composition, the dosage of the product, the intake cycle, the expiry date, etc.
  • the conductor tracks can be run in series or in parallel over the depressions and accordingly a conductor track can be placed over all depressions or one conductor track can be placed over one of several series of depressions or each depression can be covered by a single conductor track and each conductor track has its own connection to the computer. These stretchers can pass their information via a connection to the computer.
  • the computer can start a time interval program, which is predetermined in the computer or triggered by a circuit on the label, with the display of the correct intake time for the next tablet and that Show taking times according to the program.
  • the time of withdrawal can also be registered by the computer and based on this the computer can determine and indicate the next due time of taking.
  • the time of removal can be specified by various control commands, such as a display with time indication, by colored light-emitting diodes, acoustically by a warning tone and the like, or by a combination of the control commands.
  • the computer can determine whether the package has not yet opened or can calculate the medication level due to conductor tracks partially interrupted by medication and continue with the appropriate intake interval.
  • the label can be flush with the drug packaging on at least one side or can protrude at least one side of the drug packaging and on this side the conductor tracks can be brought together and arranged so that the computer can be fixed there on the drug packaging and / or on the label and the conductor tracks and the computer connections can come into contact.
  • the label can be the same size as the underlying blister pack or can be larger or smaller than the underlying blister pack, the label advantageously covers all filled depressions and a side edge ensures connection to the computer.
  • the labels can be produced independently of the pharmaceutical packaging and applied to the pharmaceutical packaging by a manufacturing company, a bottling company, a distributor, in the pharmacy, or by the self-dispensing doctor.
  • the label can contain an adhesive layer and can be applied directly or indirectly to the lid material with the adhesive layer directed against the lid material.
  • the lid material can directly or indirectly contain an outwardly directed adhesive layer and the label can then be attached to the adhesive layer.
  • An adhesive film or an adhesive can be used as the adhesive layer.
  • Mainly organic adhesives such as physically setting or chemically reacting adhesives or combined adhesives thereof, are used.
  • pressure sensitive adhesives for example, pressure sensitive adhesives, adhesive solutions, contact adhesives, hot melt adhesives, polymers and polyadducts or polycondensates, latex or synthetic resins, such as polyvinyl acetates.
  • the labels can be attached, for example, by means of pressure-sensitive adhesives or by heat-sealable adhesives.
  • the label can, for example, be attached directly to the adhesive on the outside of the lid material, i.e. be glued.
  • the outside of the lid material is understood to mean the side of the lid material facing outwards on the packaging, in contrast to the inside, the side of the lid film directed towards the contents of the packaging.
  • the lid material can, for example, be a metal foil, such as an aluminum foil.
  • the metal foil can contain sealing layers on one or both sides or the metal foil can be part of a laminate, such as e.g. a sealing layer metal foil-plastic foil laminate.
  • the base and cover materials known from blister packs can be used as cover and base part materials.
  • the label can easily be adapted to the further requirements that are placed on the medication pack.
  • the label can also be provided with weaknesses in the carrier material and / or in the protective layer during the manufacturing process.
  • the weakenings are advantageously in the area of an indentation underneath and enable the medicinal product to be easily removed from the pack by piercing the cover film and the label.
  • the label may not only contain the conductor tracks, but may also serve as a child lock due to its design.
  • the labels can be opaque, translucent or transparent and can have a print, counterprint or embossing.
  • Cover materials with embedded conductor tracks are more complex and therefore more expensive to manufacture than the usual cover films for blister packs. While it can be expected of one patient to pay attention to the correct medication, it can be expected of other patients It is of the utmost importance that the time-accurate medication is displayed and therefore contains a computer with an optical or acoustic signal generator and possibly also a callable memory for registering the circuit breakage, ie the medication intake. It is therefore not always absolutely necessary to have the conductor tracks attached to a medication pack.
  • the label which is independent of the drug pack, proves to be extremely advantageous, since the label can be attached to the drug pack in accordance with the patient and the pattern of use of the medication.
  • the mechanical processing into pharmaceutical packaging remains unaffected and accordingly known and already operating devices can produce the pharmaceutical packaging and the labels on the pharmaceutical packaging can be set on the assembly line or individually.
  • the present invention therefore also relates to a method for producing cover films with conductor tracks for pharmaceutical packaging which can be connected to a computer, the pharmaceutical packaging containing a plurality of depressions which are filled with filling material and then the filled pharmaceutical packaging are closed with a cover film, at least one above the cover film the label covering the contents containing the product to be filled is defined and the label contains the conductor tracks.
  • a method is preferred in which the cover film and the label are connected to one another indirectly or directly by adhesive bonding.
  • the present invention also relates to the use of a label containing conductor tracks as a layer of an at least two-layer cover film, the cover film closing a pharmaceutical packaging with a plurality of depressions which are filled with filling material.
  • the present label can also be used to close or cover a lid material, which in turn closes packs of small parts.
  • a lid material which in turn closes packs of small parts.
  • small parts of a technical nature can be housed in blister packs and labels can blister packs resp. cover the attached lid material.
  • the track in the label is interrupted and e.g. a security system against unauthorized removal can be activated or the pulse can be fed to a computer for inventory control or the like.
  • FIGS. 1 and 2 explain the present invention in more detail by way of example.
  • FIG. 1 shows a top view of a pharmaceutical packaging, such as a blister pack 1 with its depressions 2.
  • a computer 5 is connected to the blister pack 1 by means of a push-in connection or by means of a clamp, snap-in, snap-in or other contact connection.
  • the clamp connection can be activated and the conductor tracks 3 (see FIG. 2) ending at the side edge 9 of the blister pack 1 are connected to counter contacts on the computer.
  • the computer 5 has, for example, a time display 6 and / or a display for the time of the next medication intake and / or a sound generator.
  • the memory process for the patient can be made recognizable or optically enhanced by light-emitting diodes 7.
  • the computer can be used several times and can be reset to zero, for example, using a key 8.
  • FIG. 2 shows the back of the blister pack 1.
  • the label 10 is fixed over the lid material, for example by sticking it on.
  • the label 10 with the conductor tracks 3 completely covers the blister pack 1 and provides the connections to the computer 5 on the side edge 9.
  • the conductor tracks 3, which are attached to the label 10, lie, by appropriate positioning during the gluing process, precisely over the recesses 2 of the blister pack 1.
  • Each recess 2 is covered by a conductor track 3, so that when medication has been removed and the conductor track 3 has broken, a pulse can be sent to the computer 3, respectively. that the computer 3 recognizes on the basis of emitted pulses that the medication has been withdrawn or is due or overdue.
  • the computer 5 is designed such that the contacts can be removed along the side edge 9 of the blister pack 1.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Packages (AREA)
EP96810180A 1996-03-21 1996-03-21 Feuille de fermeture avec pistes conductrices Withdrawn EP0796605A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP96810180A EP0796605A1 (fr) 1996-03-21 1996-03-21 Feuille de fermeture avec pistes conductrices

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96810180A EP0796605A1 (fr) 1996-03-21 1996-03-21 Feuille de fermeture avec pistes conductrices

Publications (1)

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EP0796605A1 true EP0796605A1 (fr) 1997-09-24

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EP96810180A Withdrawn EP0796605A1 (fr) 1996-03-21 1996-03-21 Feuille de fermeture avec pistes conductrices

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EP (1) EP0796605A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0972507A1 (fr) 1998-05-29 2000-01-19 Alusuisse Technology & Management AG Feuille de fermeture avec pistes conductrices
EP1559742A1 (fr) * 2004-01-15 2005-08-03 Illochroma Etiquettes en plastique transparents

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0129785A2 (fr) * 1983-06-25 1985-01-02 Udo Simon Conteneur pour médicaments
EP0191168A2 (fr) * 1985-02-09 1986-08-20 Udo Simon Dispositif pour le stockage de médicaments et leur absorption provoquée en fonction du temps
US4617557A (en) * 1984-11-08 1986-10-14 National Patent Development Corporation Medication compliance aid for unit dose packaging

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0129785A2 (fr) * 1983-06-25 1985-01-02 Udo Simon Conteneur pour médicaments
US4617557A (en) * 1984-11-08 1986-10-14 National Patent Development Corporation Medication compliance aid for unit dose packaging
EP0191168A2 (fr) * 1985-02-09 1986-08-20 Udo Simon Dispositif pour le stockage de médicaments et leur absorption provoquée en fonction du temps

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0972507A1 (fr) 1998-05-29 2000-01-19 Alusuisse Technology & Management AG Feuille de fermeture avec pistes conductrices
EP1559742A1 (fr) * 2004-01-15 2005-08-03 Illochroma Etiquettes en plastique transparents

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