EP0804208A1 - Polivinylpyrrolydon-jod ebthaltende brausemischung und ihre verwendung zur desinfektion - Google Patents

Polivinylpyrrolydon-jod ebthaltende brausemischung und ihre verwendung zur desinfektion

Info

Publication number: EP0804208A1
Authority: EP; European Patent Office
Prior art keywords: composition according; pvpi; composition; effervescent; polyvinylpyrrolidone
Prior art date: 1995-01-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP96902310A

Other languages

English (en)

French (fr)

Inventor

Jérome Besse

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Galenix Developpement

Original Assignee

Mission SC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-01-30

Filing date

1996-01-30

Publication date

1997-11-05

1996-01-30 Application filed by Mission SC filed Critical Mission SC

1997-11-05 Publication of EP0804208A1 publication Critical patent/EP0804208A1/de

Status Withdrawn legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title claims abstract description 60
229920000036 polyvinylpyrrolidone Polymers 0.000 title claims abstract description 59
239000001267 polyvinylpyrrolidone Substances 0.000 title claims abstract description 59
235000013855 polyvinylpyrrolidone Nutrition 0.000 title claims abstract description 59
238000004659 sterilization and disinfection Methods 0.000 title claims description 7
239000003795 chemical substances by application Substances 0.000 claims abstract description 31
230000002195 synergetic effect Effects 0.000 claims abstract description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 17
239000008187 granular material Substances 0.000 claims description 12
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
239000000126 substance Substances 0.000 claims description 9
238000002360 preparation method Methods 0.000 claims description 8
BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims description 3
210000004400 mucous membrane Anatomy 0.000 claims description 3
239000000843 powder Substances 0.000 claims description 3
239000005871 repellent Substances 0.000 claims description 3
229920002785 Croscarmellose sodium Polymers 0.000 claims description 2
230000003139 buffering effect Effects 0.000 claims description 2
239000003826 tablet Substances 0.000 claims description 2
239000007853 buffer solution Substances 0.000 claims 1
150000004653 carbonic acids Chemical class 0.000 claims 1
239000000243 solution Substances 0.000 claims 1
ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 9
239000011630 iodine Substances 0.000 description 9
229910052740 iodine Inorganic materials 0.000 description 9
239000004094 surface-active agent Substances 0.000 description 8
238000000034 method Methods 0.000 description 6
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
238000007906 compression Methods 0.000 description 5
230000006835 compression Effects 0.000 description 5
238000004519 manufacturing process Methods 0.000 description 5
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
230000000694 effects Effects 0.000 description 4
239000000314 lubricant Substances 0.000 description 4
239000002253 acid Substances 0.000 description 3
229960004543 anhydrous citric acid Drugs 0.000 description 3
239000008119 colloidal silica Substances 0.000 description 3
150000001875 compounds Chemical class 0.000 description 3
238000005469 granulation Methods 0.000 description 3
230000003179 granulation Effects 0.000 description 3
229910002012 Aerosil® Inorganic materials 0.000 description 2
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 2
YASYEJJMZJALEJ-UHFFFAOYSA-N Citric acid monohydrate Chemical compound O.OC(=O)CC(O)(C(O)=O)CC(O)=O YASYEJJMZJALEJ-UHFFFAOYSA-N 0.000 description 2
229920002584 Polyethylene Glycol 6000 Polymers 0.000 description 2
239000012736 aqueous medium Substances 0.000 description 2
229960004106 citric acid Drugs 0.000 description 2
229960002303 citric acid monohydrate Drugs 0.000 description 2
239000000470 constituent Substances 0.000 description 2
239000007884 disintegrant Substances 0.000 description 2
238000004090 dissolution Methods 0.000 description 2
239000006260 foam Substances 0.000 description 2
150000004820 halides Chemical class 0.000 description 2
150000007524 organic acids Chemical class 0.000 description 2
239000007800 oxidant agent Substances 0.000 description 2
229940093429 polyethylene glycol 6000 Drugs 0.000 description 2
239000007787 solid Substances 0.000 description 2
238000011282 treatment Methods 0.000 description 2
238000005550 wet granulation Methods 0.000 description 2
238000009736 wetting Methods 0.000 description 2
CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 description 1
208000002874 Acne Vulgaris Diseases 0.000 description 1
241001480043 Arthrodermataceae Species 0.000 description 1
241000894006 Bacteria Species 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
241000222120 Candida <Saccharomycetales> Species 0.000 description 1
241001185363 Chlamydiae Species 0.000 description 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
241001430197 Mollicutes Species 0.000 description 1
208000031888 Mycoses Diseases 0.000 description 1
239000008118 PEG 6000 Substances 0.000 description 1
208000004210 Pressure Ulcer Diseases 0.000 description 1
208000006311 Pyoderma Diseases 0.000 description 1
241000347391 Umbrina cirrosa Species 0.000 description 1
206010046914 Vaginal infection Diseases 0.000 description 1
201000008100 Vaginitis Diseases 0.000 description 1
208000000558 Varicose Ulcer Diseases 0.000 description 1
206010052428 Wound Diseases 0.000 description 1
208000027418 Wounds and injury Diseases 0.000 description 1
206010000496 acne Diseases 0.000 description 1
238000013019 agitation Methods 0.000 description 1
230000000844 anti-bacterial effect Effects 0.000 description 1
230000000843 anti-fungal effect Effects 0.000 description 1
230000003260 anti-sepsis Effects 0.000 description 1
230000002421 anti-septic effect Effects 0.000 description 1
229940121375 antifungal agent Drugs 0.000 description 1
239000003716 antitrichomonal agent Substances 0.000 description 1
239000003899 bactericide agent Substances 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
150000004649 carbonic acid derivatives Chemical class 0.000 description 1
230000015556 catabolic process Effects 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
229910052801 chlorine Inorganic materials 0.000 description 1
239000000460 chlorine Substances 0.000 description 1
150000001860 citric acid derivatives Chemical class 0.000 description 1
238000005056 compaction Methods 0.000 description 1
238000010668 complexation reaction Methods 0.000 description 1
238000006731 degradation reaction Methods 0.000 description 1
230000037304 dermatophytes Effects 0.000 description 1
238000007907 direct compression Methods 0.000 description 1
239000003814 drug Substances 0.000 description 1
238000001035 drying Methods 0.000 description 1
230000002500 effect on skin Effects 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
238000005187 foaming Methods 0.000 description 1
235000013355 food flavoring agent Nutrition 0.000 description 1
238000009472 formulation Methods 0.000 description 1
XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
150000002497 iodine compounds Chemical class 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
239000008101 lactose Substances 0.000 description 1
239000000463 material Substances 0.000 description 1
HWPKGOGLCKPRLZ-UHFFFAOYSA-M monosodium citrate Chemical compound [Na+].OC(=O)CC(O)(C([O-])=O)CC(O)=O HWPKGOGLCKPRLZ-UHFFFAOYSA-M 0.000 description 1
235000018342 monosodium citrate Nutrition 0.000 description 1
239000002524 monosodium citrate Substances 0.000 description 1
230000003232 mucoadhesive effect Effects 0.000 description 1
LNOPIUAQISRISI-UHFFFAOYSA-N n'-hydroxy-2-propan-2-ylsulfonylethanimidamide Chemical compound CC(C)S(=O)(=O)CC(N)=NO LNOPIUAQISRISI-UHFFFAOYSA-N 0.000 description 1
229920000847 nonoxynol Polymers 0.000 description 1
239000002674 ointment Substances 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
239000008389 polyethoxylated castor oil Substances 0.000 description 1
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
229920000053 polysorbate 80 Polymers 0.000 description 1
238000011321 prophylaxis Methods 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
235000010234 sodium benzoate Nutrition 0.000 description 1
239000004299 sodium benzoate Substances 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
235000011083 sodium citrates Nutrition 0.000 description 1
238000003860 storage Methods 0.000 description 1
238000001356 surgical procedure Methods 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
229940098465 tincture Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
- A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
- A61K31/79—Polymers of vinyl pyrrolidone
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/12—Iodine, e.g. iodophors; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders

Definitions

Effervescent composition based on iodized polyvinylpyrrolidone and use for disinfection
the present invention relates to an effervescent composition based on iodized polyvinylpyrrolidone.
Iodine has long been used in various pharmaceutical forms (solution, tincture) for the fine disinfection of small wounds. Despite the good effectiveness of the product, its application is limited because it has a number of side effects.
PVPI Iodized polyvinylpyrrolidone
PVP polyvinylpyrrolidone
iodine contained in the complex is released slowly and gradually.
PVPI is characterized by a wide range of applications. The main areas of use are in the field of prophylaxis: - hand disinfection, in particular in surgery,
This compound is a broad spectrum antiseptic: - bactericide on all bacteria including chlamydiae and mycoplasmas,
PVPI polyvinylpyrrolidone
PVPI tablets have already been described, but specifically for mucoadhesive and local use.
PVPI tablets have the significant drawback of dissolving very slowly in aqueous media.
compositions containing in particular an iodine carrier which can be polyvinylpyrrolidone, an iodide or an iodine compound, an oxidizing agent, an acid and a base in the form of powders. These last two compounds form an effervescent couple.
this composition does not include iodized polyvinylpyrrolidone, which is a complex which it is necessary to form before integrating it into a composition.
this composition does not contain a disintegrating agent, and therefore is not susceptible to be used to make PVPI solutions extemporaneously, but only to form foams, as indicated in these abstracts.
Patent GB-A-2,108,386 (AUCHINCLOSS) describes compositions in dry form containing an iodine source, such as a polyvinylpyrrolidone and iodine complex, a non-reducing acid and a surfactant capable of combine with iodine to form an iodophore.
an iodine source such as a polyvinylpyrrolidone and iodine complex
a non-reducing acid such as sodium bicarbonate
a surfactant capable of combine with iodine to form an iodophore.
PCT / GB 90 01 423 discloses a composition comprising an inorganic water-soluble halide, a strong oxidizing agent, which will react with the halide in order to generate hypohalogenic ions, sulfamic acid, and a water-soluble carbonate or bicarbonate in order to produce, in reaction with the acid, an effervescent effect.
a disintegrating agent is not mentioned in this application, which preferably relates to chlorine-based tablets.
compositions containing PVPI While allowing extemporaneous, reproducible preparation, and easy to use solutions of PVPI.
the present invention therefore relates to an effervescent composition for the extemporaneous preparation of PVPI solutions comprising in synergistic amounts:
compositions object of the present invention have the advantage of dissolving in less than 10 minutes, and generally in three to five minutes, which allows an extemporaneous preparation of PVPI solution unlike the compositions described in the state of the art. which do not contain a disintegrating agent. They also make it possible to obtain reproducible levels of iodine in solution.
effervescent agent and disintegrating agent are meant substances meeting the definitions given by Le Hir in "Pharmacy Abstract Galenic "(Masson Editions; 5th edition).
Such a composition advantageously comprises by weight, from 0.1 to 99%, preferably from 10% to 90%, and even more preferably from 20% to 60% of PVPI relative to the total weight of the composition.
Said effervescent agent is advantageously a pair comprising on the one hand citric acid and on the other hand carbonic acid, or their derivatives. It can nevertheless be any combination of organic acid / carbonate substances, making it possible to obtain an effervescence.
the citric acid derivatives which can be used in such a couple are in particular monosodium citrate, or citric acid monohydrate or anhydrous.
a derivative of carbonic acid can be monosodium carbonate.
the citric acid and carbonic acid, or their derivatives are advantageously contained in substantially identical amounts.
the disintegrating agent may be a substance having a structural similarity to PVPI, in particular a crosslinked polyvinylpyrrolidone (PVP), or a crosslinked carboxymethylcellulose. It can nevertheless be any other substance or mixture of substances having a disintegrating effect as defined above.
a composition according to the present invention comprises by weight from 40 to 60% of effervescent agent and from 2 to 10%, preferably from 4 to 6% of disintegrating agent.
the composition is in the form of powder, granules, or tablets.
the present invention may also contain, without being essential, a system buffer at a pH close to 6, in order to limit the degradation of PVPI.
a buffering effect is produced by salts such as KH 9 PO4 or by sodium hydroxide.
a water-repellent substance can also be contained in the composition, in order to prevent it from being degraded by moisture.
Such a water-repellent substance may for example be colloidal silica.
the composition according to the invention can also contain one or more surfactants.
composition is in the form of granules formed:
the present invention also relates to the use of a composition as described above for the disinfection of the skin and mucous membranes.
compositions also have the advantage of having an industrial cost price much lower than the cost price of the PVPI. It has been estimated that their cost price is at least 30% lower than that of the solutions.
the tablets according to the present invention can be obtained by a process in which the PVPI and the effervescent agent are mixed, then the disintegrating agent and the other constituents of the tablet are introduced.
the tablet is then shaped using a tablet press. The whole process must be carried out in a dry place.
Granules according to the present invention can be obtained by a process similar to that of tablets, the step of compressing the tablets being replaced by a step of compaction then of granulation, for example on an ERWEKA AR 400 machine.
Granules with internal and external phases according to the invention can be obtained by a wet granulation process in which:
the internal phase consists of PVPI with possibly a surfactant and an effervescent couple
step (3) Add to the mixture of step (2) the previously sieved colloidal silica plus the disintegrant.
Humidity 3 g of water per m 3 of dry air, i.e. 20% relative humidity at 20 * C.
PVPI PVPI (PVP iodine) 30/06 46.70
anhydrous citric acid is replaced, for equivalent weight, by citric acid monohydrate.
wetting solution (1) In a suitable container pour the surfactant.
step (3) Pour the grain from step (3) in a thin layer on an oven tray.
step (5) Granulate the grain of step (5) using an oscillating granulator type ERWEKA AR 400 or equivalent on a grid with a diameter of 800 ⁇ m.
step (8) Calibrate the grain obtained in step (7) on an 800 ⁇ m sieve.
step (11) Mix 5 minutes at 50 RPM. (12) Introduce the lubricant previously sieved to the mixture of step (11) and mix for 3 minutes.
Nonoxymol can be replaced by Cremophor, Tween 80 or any other equivalent surfactant.
lactose can be added to the components of this layer.
compositions Two types of compositions, one containing a disintegrating agent, crosslinked PVP (polyplasdone XL), and the other devoid of this agent, called respectively GAL 01.16 and GAL 01.17 were produced by direct compression as described in Example 1 .
PVP polyplasdone XL

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Pest Control & Pesticides (AREA)
Zoology (AREA)
Plant Pathology (AREA)
Inorganic Chemistry (AREA)
Dentistry (AREA)
Agronomy & Crop Science (AREA)
Environmental Sciences (AREA)
Dermatology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

EP96902310A 1995-01-30 1996-01-30 Polivinylpyrrolydon-jod ebthaltende brausemischung und ihre verwendung zur desinfektion Withdrawn EP0804208A1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR9501047		1995-01-30
FR9501047A FR2729858B1 (fr)	1995-01-30	1995-01-30	Composition effervescente a base de polyvinylpyrrolidone iodee et utilisation pour la desinfection
PCT/FR1996/000157 WO1996023510A1 (fr)	1995-01-30	1996-01-30	Composition effervescente a base de polyvinylpyrrolidone iodee et utilisation pour la desinfection

Publications (1)

Publication Number	Publication Date
EP0804208A1 true EP0804208A1 (de)	1997-11-05

Family

ID=9475639

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP96902310A Withdrawn EP0804208A1 (de)	1995-01-30	1996-01-30	Polivinylpyrrolydon-jod ebthaltende brausemischung und ihre verwendung zur desinfektion

Country Status (7)

Country	Link
US (1)	US5846564A (de)
EP (1)	EP0804208A1 (de)
JP (1)	JPH10513170A (de)
AU (1)	AU4667396A (de)
CA (1)	CA2211586A1 (de)
FR (1)	FR2729858B1 (de)
WO (1)	WO1996023510A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0872544A1 (de) *	1997-04-14	1998-10-21	The Procter & Gamble Company	Trockene Brausegranulate und dessen Verwendung in granulierten Zusammensetzungen
US6974590B2 (en)	1998-03-27	2005-12-13	Cima Labs Inc.	Sublingual buccal effervescent
US20030091629A1 (en)	1998-03-27	2003-05-15	Cima Labs Inc.	Sublingual buccal effervescent
RU2145860C1 (ru) *	1999-08-16	2000-02-27	Хозяйственное общество с ограниченной ответственностью Намус	Способ получения йодовидона
US7147873B2 (en) *	2002-01-16	2006-12-12	3M Innovative Properties Company	Antiseptic compositions and methods
US7858121B2 (en)	2003-12-31	2010-12-28	Cima Labs, Inc.	Effervescent oral fentanyl dosage form and methods of administering fentanyl
CA2549642C (en)	2003-12-31	2012-10-30	Cima Labs Inc.	Effervescent oral opiate dosage forms and methods of administering opiates
DE602004031462D1 (de)	2003-12-31	2011-03-31	Cima Labs Inc	Allgemein lineare brauseform von fentanyl zur oralen anwendung und verfahren zur verabreichung
US20060246027A1 (en) *	2005-05-02	2006-11-02	Tanner Paul R	Personal care composition
FR2900795B1 (fr) *	2006-05-15	2011-04-29	Solutio Lab	Formulation detergente et desinfectante sous forme solide divisee contenant a titre de principe actif une association pvp iodee/iodure de potassium
WO2011089584A1 (en) *	2010-01-25	2011-07-28	Modi-Mundipharma Pvt. Ltd	Process for the preparation of a granular oral composition
WO2016015691A1 (en)	2014-07-30	2016-02-04	Albert SARKESSYAN	A pharmaceutical composition having antibacterial and virucidal effects
JP6955784B2 (ja) *	2017-07-04	2021-10-27	フルケムリミテッドＦｌｕｃｈｅｍＬｔｄ	水溶解性が向上されたヨード剤及び塩化ナトリウムを含む固体組成物及びその水溶液を含む目、口腔用、鼻腔用又は吸入用抗ウイルス及び抗菌組成物
IT202100003764A1 (it) *	2021-02-18	2022-08-18	Diego Zito	Detergente biocida

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3136692A (en) *	1961-06-30	1964-06-09	Strong Cobb Arner Inc	Effervescent composition containing polyvinylpyrrolidone
GB2108386B (en) *	1981-10-26	1985-11-27	Auchincloss Thomas R	Iodine-containing disinfectant compositions
JPS63225308A (ja) *	1986-04-03	1988-09-20	Sanyo Chem Ind Ltd	固形ヨ−ドホ−ル組成物
US5089606A (en) *	1989-01-24	1992-02-18	Minnesota Mining And Manufacturing Company	Water-insoluble polysaccharide hydrogel foam for medical applications
GB8920973D0 (en) *	1989-09-15	1989-11-01	Auchincloss Thomas R	Effervescent tablets

1995
- 1995-01-30 FR FR9501047A patent/FR2729858B1/fr not_active Expired - Fee Related
1996
- 1996-01-30 JP JP8523313A patent/JPH10513170A/ja active Pending
- 1996-01-30 EP EP96902310A patent/EP0804208A1/de not_active Withdrawn
- 1996-01-30 AU AU46673/96A patent/AU4667396A/en not_active Abandoned
- 1996-01-30 WO PCT/FR1996/000157 patent/WO1996023510A1/fr not_active Ceased
- 1996-01-30 CA CA002211586A patent/CA2211586A1/fr not_active Abandoned
- 1996-01-30 US US08/875,632 patent/US5846564A/en not_active Expired - Fee Related

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9623510A1 *

Also Published As

Publication number	Publication date
AU4667396A (en)	1996-08-21
JPH10513170A (ja)	1998-12-15
FR2729858A1 (fr)	1996-08-02
WO1996023510A1 (fr)	1996-08-08
US5846564A (en)	1998-12-08
FR2729858B1 (fr)	1997-04-18
CA2211586A1 (fr)	1996-08-08

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