EP0806190B1 - Un stent pour angioplastie - Google Patents

Un stent pour angioplastie Download PDF

Info

Publication number
EP0806190B1
EP0806190B1 EP97107423A EP97107423A EP0806190B1 EP 0806190 B1 EP0806190 B1 EP 0806190B1 EP 97107423 A EP97107423 A EP 97107423A EP 97107423 A EP97107423 A EP 97107423A EP 0806190 B1 EP0806190 B1 EP 0806190B1
Authority
EP
European Patent Office
Prior art keywords
stent
segments
wall
arms
radial expansion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP97107423A
Other languages
German (de)
English (en)
Other versions
EP0806190A1 (fr
Inventor
Giovanni Rolando
Paolo Gaschino
Franco Vallana
Osvaldo Cerise
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sorin Biomedica Cardio SpA
Original Assignee
Sorin Biomedica Cardio SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITTO960374 external-priority patent/IT1285089B1/it
Priority claimed from IT96TO000376 external-priority patent/IT1285091B1/it
Priority claimed from ITTO960373 external-priority patent/IT1285088B1/it
Priority claimed from IT96TO000377 external-priority patent/IT1285092B1/it
Priority claimed from ITTO960375 external-priority patent/IT1285090B1/it
Application filed by Sorin Biomedica Cardio SpA filed Critical Sorin Biomedica Cardio SpA
Priority to EP03016995A priority Critical patent/EP1354569B1/fr
Publication of EP0806190A1 publication Critical patent/EP0806190A1/fr
Application granted granted Critical
Publication of EP0806190B1 publication Critical patent/EP0806190B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/89—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure the wire-like elements comprising two or more adjacent rings flexibly connected by separate members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/3011—Cross-sections or two-dimensional shapes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/9155—Adjacent bands being connected to each other
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/9155—Adjacent bands being connected to each other
    • A61F2002/91566—Adjacent bands being connected to each other connected trough to trough
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/9155—Adjacent bands being connected to each other
    • A61F2002/91575—Adjacent bands being connected to each other connected peak to trough
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002—Two-dimensional shapes, e.g. cross-sections

Definitions

  • the present invention relates in general to so-called stents for angioplasty.
  • This term is intended to indicate in general a device to be fitted in a lumen (for example, inside a blood vessel), usually by catheterization, and subsequently spread out in situ in order to support the lumen locally. This has the main purpose of preventing the re-establishment of a stenotic site in the location treated. It should, however, be pointed out that it has already been proposed in the art to use substantially similar structures for spreading-out and anchoring vascular grafts in situ; naturally this possible extension of the field of application is also intended to be included in the scope of the invention.
  • a stent according to the preamble of claim 1 is known from EP-A-0 540 290.
  • the object of the present invention which has the specific characteristics claimed in the following claims, is to solve at least some of the problems outlined above.
  • the reference numeral 1 is used for generally indicating a so-called angioplasty stent Figures 1, 2, 7 and 8.
  • the stent 1 is usually produced in the form of a body with a tubular envelope having an overall length of between a few millimetres and a few tenths of a millimetre, a wall thickness (the wall usually having a mesh or loop structure with openings, as will be explained further below) of the order, for example, of a few hundredths of a millimetre, in view of its possible insertion in a lumen (such as a blood vessel) in a site in which a stenosis is to be remedied.
  • a lumen such as a blood vessel
  • the stent is normally put in position by catheterization, after which radial expansion from an insertion diameter of the order, for example of 1.5-1.8 mm to an expanded diameter, for example, of the order of 3-4 mm takes place in a manner such that, in the expanded condition, the stent supports the lumen, preventing the recurrence of a stenosis.
  • the outside diameter in the radially contracted condition is selected so as to allow the stent to be introduced into the lumen being treated, whereas the expanded diameter corresponds in general to the diameter to be maintained and established in the lumen once the stenosis has been eliminated.
  • the solution which is currently most widespread is that of the use of a so-called balloon catheter, the stent being disposed around the balloon of the catheter in the contracted condition and the balloon then being expanded once the stent has been brought to the site in which it is to be positioned.
  • the use of superelastic materials which cause the stent to expand once the restraining elements, which are intended to keep the stent in the contracted condition until the implant site has been reached are removed.
  • the use of materials having so-called "shape memory" to form the stent so as to achieve the radial expansion in the implant position has also been proposed.
  • the stent is made of metal which can reconcile two basic requirements for the application, that is, plastic deformability during the expansion stage and the ability to withstand any stresses which would tend to cause the stent to close up, preserving the expanded shape.
  • the material known by the trade name of "Nitinol” is well known and also has super-elasticity and shape-memory properties which may be required in the expansion stage.
  • the first solution described is that which is currently preferred by the Applicant for producing stents according to the embodiments described below, with the exception of the solution to which Figure 4 relates which intrinsically involves the use of a metal wire.
  • laser-beam cutting has been found the most flexible solution with regard to the ability to modify the characteristics of the stents quickly during production according to specific requirements of use.
  • the body of the stent 1 extends in a longitudinal direction generally identified by an axis z.
  • the stent is intended to be bent, possibly significantly, during use, easy flexibility actually being one of the characteristics sought.
  • the body of the stent 1 is constituted by a series of successive, generally annular segments, indicated 2 in the drawings.
  • the stent 1 of Figures 1 and 2 comprises seven of these segments, whereas the stent of Figures 7 and 8 comprises six.
  • the length of the segments 2 measured longitudinally of the stent 1, and hence along the axis z is of the order of about 2 mm. In other words, for reasons which will become clearer from the following, the segments 2 are quite "short" lengthwise.
  • the various segments of the stent 1 shown therein are connected to one another by pairs of bridges 3, 4 (actually constituting integral parts of the stent wall, as will be explained further below, for example, with reference to Figure 3) the essential characteristic of which (this applies both to the stent of Figures 1 and 2 and to the stent of Figures 7 and 8) is to articulate the segments 2 connected respectively thereby in an alternating sequence about mutually perpendicular flexing or bending axes.
  • the longitudinal flexibility of the stent 1 which is necessary to facilitate its location at the implantation site, is demanded essentially of the bridges 3, 4, whereas the structural strength and hence the support for the lumen is demanded of the actual structures of the segments 2; all of this is achieved with a capability to optimize the desired characteristics by precise adaptation of the sections of the various component elements.
  • the arrangement of the bridges in a sequence (usually, but not necessarily, alternating), in combination with the fact that, as stated, the segments 2 are quite short, enables a bend to be formed easily, in practice, at any point along the length of the stent 1 in any direction in space, and with very small radii of curvature.
  • the bridges 4 which are also arranged at 180° to one another in a plane perpendicular to that of the bridges 3, allow the stent 1 to bend locally about a second axis y transverse the longitudinal axis z and, in the embodiment shown, perpendicular to the above-mentioned axis x.
  • the segments 2 are quite short, the aforesaid axes x and y are arranged in close proximity to one another in alternating sequence along the length of the stent 1, however many segments 2 there may be.
  • alternating sequence described above that is: axis x, axis y, axis x, axis y may, at least in principle, be replaced by a different sequence, for example, axis x, axis x, axis y, axis y, axis x, axis x, etc.
  • Provision for a capability to bend about the axis x in two adjacent segments 2 followed by a capability to bend about the axis y repeated for two adjacent segments 2, as in the latter example mentioned may, in fact, be advantageous in applications in which an ability to achieve very small radii of curvature is to be given preference.
  • the stent 2 can thus also be bent in the location of each connection between adjacent segments 2 about a generic axis d defined by an equation such as equation (I) introduced above.
  • each segment 2 is constituted, in the embodiments shown, by a set of approximately sinusoidal loops of substantially uniform size (measured circumferentially relative to the element 2) which is doubled in the region of the loops from which the bridges 3, 4 extend, in the manner explained further below.
  • each segment 2 is constituted by a sequence of loops, each loop (approximately comparable to half of a sinusoidal wave) defining a respective concave portion 5 the concave side of which faces towards the median plane X2, and which is connected to two approximately straight arms 6.
  • the radial expansion of the stent 1 takes place substantially as a result of an opening-out of the aforementioned loops; by way of indication, with reference to the development in a plane of Figure 3, the radial expansion of the stent corresponds to a stretching of the development in a plane shown in Figure 3 in the sense of an increase in height and hence a vertical expansion of Figure 3.
  • this radial expansion corresponds to an opening-out of the concave portions 5, whereas the lateral arms 6 of each loop remain substantially straight.
  • the localization of the plastic deformation of the stent 2 in the concave portions of the loops 5 may be favoured (as will be explained further below with reference to Figure 4) by means of the cross-sections and/or the cross-sectional areas of the portions of each loop.
  • the radial expansion (vertical stretching of the development in a plane of Figure 3) affects essentially the concave portions 5 of the loops of the elements 2 and in no way affects the bridges 3, 4 which extend longitudinally (axis z).
  • connection to the relative segments 2 is formed in the region of the concave (or inside) portion of a respective loop, it can easily be appreciated that the radial expansion of the segments 2 is accompanied, so to speak, by a thrust exerted on the bridges 3, 4 (and on the respective spine portions 30). This thrust corresponds, so to speak, to an expulsion of the bridges or of the spine portions in question from the corresponding segment 2.
  • the bridges 4' indicated above are extremely short (it will be remembered, by way of reference, that the axial length of the segments 2 may be of the order of 2 mm). Even during radial expansion, the concave portions (and consequently the convex portions) of all of the loops of each segment in any case retain their alignment with a plane parallel to the median plane X2 at each end of each segment 2. This alignment is thus also retained by the concave or convex portions connected between two adjacent segments 2 by the same bridge 3, the length of which is not changed during the radial expansion.
  • each of the segments 2 constitutes a section which is intended to contract longitudinally as a result of the radial expansion.
  • a corresponding connection of bridges 3, 4 is therefore provided in each of these segments according to the criteria described above.
  • each set of two segments 2 interconnected by respective bridges 3 constitutes, precisely for the reasons described above, a section of stent which does not contract substantially longitudinally during radial expansion.
  • the connection between these sections can take place by means of bridges such as those which are indicated 4' and shown in broken outline in the drawing and which are not connected to a concave (or inside) loop portion.
  • Figure 4 shows how a stent wall structure having the geometry described with reference to Figure 3 can also be formed from one or more pieces of wire bent so as to form a set of loops which is substantially similar to that shown in Figure 3, and in which the bridges 3 and 4 are constituted by wire portions which are coupled (that is, placed side by side parallel to one another) and connected, for example, by welding or other joining methods (for example, brazing, gluing, crimping, etc.).
  • a wire enables different cross-sections and/or cross-sectional areas to be attributed (for example, by a mechanical operation to shape the wire) to the concave portions 5 of the loops and to the straight arms 6 which extend therefrom.
  • the cross-section of Figure 5 is in fact the cross section of a concave portion taken in its tip portion, whereas the cross-section of Figure 6 corresponds to the connection region of two straight arms extending generally longitudinally relative to the stent (axis z).
  • the wire constituting the stent wall may retain a round cross-section, but in the straight portions 6 may adopt a cross-section which is generally flattened in the plane of the wall (and hence along the imaginary cylindrical envelope) of the stent 1.
  • the straight portions 6 are intrinsically more resistant to bending in the plane in which they are generally flattened so that the a force opening out the two arms 6 connected to a common concave portion 5 brings about a deformation of the loop in the concave portion 5.
  • the arms 6 are opened out, they retain a generally straight shape; in this connection, it will be noted that the arms which are coupled to form the bridges 3 and 4 nevertheless retain a straight orientation along the longitudinal axis z of the stent 1.
  • the arms 6 expose a wider surface to the wall of the lumen supported by the stent in its radially expanded condition.
  • the wall of the lumen is therefore subjected to a distributed load preventing the formation of concentrated stress regions.
  • the dimensions of the wire can be optimized in the concave portions 5 in order to achieve optimal characteristics of plastic deformability when the stent is expanded radially and, at the same time, resistance to subsequent stresses which may tend to close up the stent 1.
  • the wall structure of Figure 9 differs from that shown in Figures 3 and 4 essentially in that the bridges which interconnect the various segments 2 are constituted by the two spines 30 extending with a generally sinusoidal shape along two diametrally opposed generatrices of the structure of the stent 1.
  • a structure with spines of the type described can also implement an equation such as equation (I) given above, for the purposes of the longitudinal bending of the stent 1.
  • equation (I) the difference in comparison with the embodiment shown in Figures 1 to 4 lies in the fact that, in this first solution, the axes x and y in fact correspond to the axes about which the bending of the pairs of bridges 3, 4 can take place.
  • each section of the spine 30 extending to connect two adjacent segments 2 can express two possibilities for relative orientation between the two segments 2 connected, that is:
  • the generally sinusoidal shape of the two spines 30 enables the longitudinal extensibility of the spines to be utilized for bending purposes without giving rise to stresses which are oriented tangentially relative to the wall of the stent and hence risk giving rise to undesired twisting. It will, in any case, be appreciated that the length of the stent of Figures 7 to 9 (that is, its extent along the axis z) can change entirely independently of the radial expansion of the segments 2.
  • the overall shape of the spines 30 is sinusoidal and, even where they are connected to concave portions of respective loops (see in particular the portion of the spine 30 which is shown in the lower portion of Figure 9 connecting the two elements 2 of which the median planes X2 are indicated) the connection with these concave portions 5 does not change the general sinusoidal shape of the spine in question.
  • the spine 30 is connected to the outer edge of the outside of the concave portion 5 on one side or wall thereof and continues from the inside of the concave portion, from the opposite side or wall.
  • the solution described provides for the entire body 1 of the stent, or at least part of it, to be constituted by a substantially reticular structure, the branches of which (in the embodiment shown, the annular walls of the segments 2 and the two spines 30) define geometrical figures which can be identified as fractals.
  • fractal coined by the mathematician B. Mandelbrot in 1975, indicates in general a geometrical figure which has internal symmetries to whatever scale it is enlarged, and which is produced as a limit configuration of a succession of fragmentary curves from each of which the next is obtained on the basis of an assigned rule, for example, by replacing each side with a predetermined fragmentary, so-called generative or generator line.
  • Figure 10 shows, by way of example, the use of higher-order fractals to produce segments 2
  • Figure 11 shows, by way of example, the use of higher-order fractals to produce the spine or spines 30.
  • the solutions shown by way of example may be combined, in the sense that the higher-order fractals may be used both for the segments 2 and for the spines 30.
  • fractal geometry has been found advantageous since it enables the performance and/or the mechanical characteristics of the various portions of the wall of the stent 1 to be optimized with regard to the specific stresses to which it has to respond in use.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Prostheses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Materials For Medical Uses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Claims (5)

  1. Endoprothèse vasculaire pour angioplastie comprenant un corps (1) qui a généralement une enveloppe tubulaire et qui peut se déployer en fonctionnement depuis un état de contraction radiale vers un état d'extension radiale dans laquelle l'endoprothèse vasculaire soutient la paroi d'une lumière, dans laquelle le corps de l'endoprothèse vasculaire est constitué par un ensemble de segments successifs, extensibles suivant une direction radiale et généralement annulaires (2), et la paroi du corps comprend des bras (6) pour soutenir la lumière, ainsi que des régions (5) qui sont sélectivement déformables pendant le déploiement de l'endoprothèse vasculaire, dans laquelle la paroi des segments (2) dudit corps (1) comprend un ensemble de boucles ayant chacune une partie concave (5) formant l'une desdites régions sélectivement déformables à partir de laquelle s'étendent des bras latéraux (6), caractérisée en ce que les bras (6) ont une forme qui est généralement aplatie dans le plan général de la paroi du corps de telle sorte que les faces externes des bras (6) définissent de larges surfaces de soutien respectives pour la paroi de la lumière, et en ce que la partie concave (5) a une coupe transversale essentiellement circulaire, de telle sorte que pendant le déploiement radial de l'endoprothèse vasculaire, la partie concave (5) et les bras (6) adoptent différents comportements.
  2. Endoprothèse vasculaire selon la revendication 1, caractérisée en ce que la paroi du corps (1) est constituée essentiellement par au moins un élément en fil métallique recourbé.
  3. Endoprothèse vasculaire selon la revendication 2, caractérisée en ce que la paroi comprend des parties adjacentes de fil métallique fermement reliées les unes aux autres.
  4. Endoprothèse vasculaire selon la revendication 3, caractérisée en ce que les parties adjacentes de fil métallique sont reliées les unes aux autres par soudage, brasage, collage, sertissage ou une combinaison de ceux-ci.
  5. Endoprothèse vasculaire selon la revendication 1, caractérisée en ce que lesdits segments (2) sont reliés entre eux par des éléments de ponts (30) s'étirant essentiellement dans la direction de l'axe longitudinal (z) de l'endoprothèse vasculaire de telle sorte que les éléments de ponts (30) ne sont sensiblement pas affectés par le déploiement radial des segments (2) et les éléments de ponts (30) sont généralement déformables dans la direction de l'axe longitudinal (z) de telle sorte que la longueur de l'endoprothèse vasculaire (1) le long de l'axe (z) peut changer sensiblement indépendamment du déploiement radial.
EP97107423A 1996-05-08 1997-05-06 Un stent pour angioplastie Expired - Lifetime EP0806190B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP03016995A EP1354569B1 (fr) 1996-05-08 1997-05-06 Un stent pour angioplastie

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
ITTO960377 1996-05-08
ITTO960373 1996-05-08
ITTO960374 IT1285089B1 (it) 1996-05-08 1996-05-08 Stent per angioplastica.
IT96TO000376 IT1285091B1 (it) 1996-05-08 1996-05-08 Stent per angioplastica.
ITTO960373 IT1285088B1 (it) 1996-05-08 1996-05-08 Stent per angioplastica.
ITTO960374 1996-05-08
ITTO960376 1996-05-08
ITTO960375 1996-05-08
IT96TO000377 IT1285092B1 (it) 1996-05-08 1996-05-08 Stent per angioplastica.
ITTO960375 IT1285090B1 (it) 1996-05-08 1996-05-08 Stent per angioplastica.

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP03016995A Division EP1354569B1 (fr) 1996-05-08 1997-05-06 Un stent pour angioplastie

Publications (2)

Publication Number Publication Date
EP0806190A1 EP0806190A1 (fr) 1997-11-12
EP0806190B1 true EP0806190B1 (fr) 2004-01-02

Family

ID=27517904

Family Applications (2)

Application Number Title Priority Date Filing Date
EP97107423A Expired - Lifetime EP0806190B1 (fr) 1996-05-08 1997-05-06 Un stent pour angioplastie
EP03016995A Expired - Lifetime EP1354569B1 (fr) 1996-05-08 1997-05-06 Un stent pour angioplastie

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP03016995A Expired - Lifetime EP1354569B1 (fr) 1996-05-08 1997-05-06 Un stent pour angioplastie

Country Status (5)

Country Link
EP (2) EP0806190B1 (fr)
AT (2) ATE398425T1 (fr)
DE (2) DE69727004T2 (fr)
DK (1) DK0806190T3 (fr)
ES (1) ES2212013T3 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6846323B2 (en) 2003-05-15 2005-01-25 Advanced Cardiovascular Systems, Inc. Intravascular stent
US8449597B2 (en) 1995-03-01 2013-05-28 Boston Scientific Scimed, Inc. Longitudinally flexible expandable stent

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1289815B1 (it) 1996-12-30 1998-10-16 Sorin Biomedica Cardio Spa Stent per angioplastica e relativo procedimento di produzione
US20020133222A1 (en) * 1997-03-05 2002-09-19 Das Gladwin S. Expandable stent having a plurality of interconnected expansion modules
US6451049B2 (en) * 1998-04-29 2002-09-17 Sorin Biomedica Cardio, S.P.A. Stents for angioplasty
FR2764794B1 (fr) * 1997-06-20 1999-11-12 Nycomed Lab Sa Dispositif tubulaire expanse a epaisseur variable
US6309414B1 (en) 1997-11-04 2001-10-30 Sorin Biomedica Cardio S.P.A. Angioplasty stents
US6342067B1 (en) * 1998-01-09 2002-01-29 Nitinol Development Corporation Intravascular stent having curved bridges for connecting adjacent hoops
US6019789A (en) * 1998-04-01 2000-02-01 Quanam Medical Corporation Expandable unit cell and intraluminal stent
US6264687B1 (en) 1998-04-20 2001-07-24 Cordis Corporation Multi-laminate stent having superelastic articulated sections
EP1014891B1 (fr) * 1998-07-17 2004-06-02 B. Braun Melsungen Ag Tuteur extensible
FR2781143B1 (fr) * 1998-07-17 2000-11-10 Braun Celsa Sa Support expansible a meandres pour un conduit anatomique,en particulier, un vaisseau sanguin
US6254564B1 (en) 1998-09-10 2001-07-03 Percardia, Inc. Left ventricular conduit with blood vessel graft
EP1152710A1 (fr) * 1999-01-22 2001-11-14 Khalid Al-Saadon Extenseurs intravasculaires tubulaires expansibles
WO2000042945A1 (fr) * 1999-01-22 2000-07-27 Al Saadon Khalid Extenseur medical tubulaire expansible pour application endovasculaire
US6425855B2 (en) 1999-04-06 2002-07-30 Cordis Corporation Method for making a multi-laminate stent having superelastic articulated sections
WO2001000112A1 (fr) * 1999-06-30 2001-01-04 Advanced Cardiovascular Systems, Inc. Stent a epaisseur variable, et son procede de fabrication
EP1194079B1 (fr) * 1999-07-02 2005-06-01 Endotex Interventional Systems, Inc. Stent souple et etirable en bande
IT1307263B1 (it) 1999-08-05 2001-10-30 Sorin Biomedica Cardio Spa Stent per angioplastica con azione antagonista della restenosi,relativo corredo e componenti.
US6540774B1 (en) 1999-08-31 2003-04-01 Advanced Cardiovascular Systems, Inc. Stent design with end rings having enhanced strength and radiopacity
ES2279610T3 (es) 1999-11-23 2007-08-16 Sorin Biomedica Cardio S.R.L. Dispositivo para transferir agentes radioactivos sobre stents de angioplastia y kit respectivo.
DE10010074B4 (de) 2000-02-28 2005-04-14 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung zur Befestigung und Verankerung von Herzklappenprothesen
DE10010073B4 (de) 2000-02-28 2005-12-22 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verankerung für implantierbare Herzklappenprothesen
US6616689B1 (en) * 2000-05-03 2003-09-09 Advanced Cardiovascular Systems, Inc. Intravascular stent
US6652579B1 (en) 2000-06-22 2003-11-25 Advanced Cardiovascular Systems, Inc. Radiopaque stent
US6547818B1 (en) * 2000-10-20 2003-04-15 Endotex Interventional Systems, Inc. Selectively thinned coiled-sheet stents and methods for making them
EP1212986A1 (fr) 2000-12-08 2002-06-12 SORIN BIOMEDICA CARDIO S.p.A. Stent pour angioplastie et son méthode de manufacture
DE60143308D1 (de) † 2000-12-11 2010-12-02 Orbusneich Medical Inc Stent mit spiralen elementen
US6929660B1 (en) * 2000-12-22 2005-08-16 Advanced Cardiovascular Systems, Inc. Intravascular stent
WO2002060521A1 (fr) * 2001-02-01 2002-08-08 Kaneka Corporation Endoprothese
JP4815057B2 (ja) * 2001-02-13 2011-11-16 株式会社カネカ ステント
JP5011604B2 (ja) * 2001-02-01 2012-08-29 株式会社カネカ ステント
JP4857470B2 (ja) * 2001-02-01 2012-01-18 株式会社カネカ ステント
US7201940B1 (en) 2001-06-12 2007-04-10 Advanced Cardiovascular Systems, Inc. Method and apparatus for thermal spray processing of medical devices
US6749629B1 (en) 2001-06-27 2004-06-15 Advanced Cardiovascular Systems, Inc. Stent pattern with figure-eights
US6605110B2 (en) 2001-06-29 2003-08-12 Advanced Cardiovascular Systems, Inc. Stent with enhanced bendability and flexibility
EP1277449B2 (fr) 2001-07-20 2012-07-11 Sorin Biomedica Cardio S.R.L. Stent
FR2828263B1 (fr) 2001-08-03 2007-05-11 Philipp Bonhoeffer Dispositif d'implantation d'un implant et procede d'implantation du dispositif
DE10144430A1 (de) * 2001-09-06 2003-03-27 Biotronik Mess & Therapieg Stent mit variablem Stegquerschnitt
US6796999B2 (en) 2001-09-06 2004-09-28 Medinol Ltd. Self articulating stent
EP1310242A1 (fr) 2001-11-13 2003-05-14 SORIN BIOMEDICA CARDIO S.p.A. Support et kit pour l'administration endoluminale des agents actifs
US7537607B2 (en) 2001-12-21 2009-05-26 Boston Scientific Scimed, Inc. Stent geometry for improved flexibility
US6656220B1 (en) 2002-06-17 2003-12-02 Advanced Cardiovascular Systems, Inc. Intravascular stent
US20040054398A1 (en) * 2002-09-13 2004-03-18 Cully Edward H. Stent device with multiple helix construction
US20040102831A1 (en) * 2002-11-22 2004-05-27 Murray Robert J. Stent having tapered edges
EP1449546B1 (fr) 2003-02-21 2010-10-27 Sorin Biomedica Cardio S.R.L. Procédé de fabrication d'un stent et stent correspondant
EP1677706A4 (fr) * 2003-09-30 2010-12-29 Merit Medical Systems Inc Stent amovible
ITTO20040056A1 (it) 2004-02-05 2004-05-05 Sorin Biomedica Cardio Spa Stent per l'erogazione endoliminale di principi o agenti attivi
US8961583B2 (en) * 2004-09-08 2015-02-24 Cordis Corporation Optimized flex link for expandable stent
DE102005003632A1 (de) 2005-01-20 2006-08-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Katheter für die transvaskuläre Implantation von Herzklappenprothesen
US8628565B2 (en) 2005-04-13 2014-01-14 Abbott Cardiovascular Systems Inc. Intravascular stent
DE102005051849B4 (de) 2005-10-28 2010-01-21 JenaValve Technology Inc., Wilmington Vorrichtung zur Implantation und Befestigung von Herzklappenprothesen
DE102005052628B4 (de) 2005-11-04 2014-06-05 Jenavalve Technology Inc. Selbstexpandierendes, flexibles Drahtgeflecht mit integrierter Klappenprothese für den transvaskulären Herzklappenersatz und ein System mit einer solchen Vorrichtung und einem Einführkatheter
US20070213813A1 (en) 2005-12-22 2007-09-13 Symetis Sa Stent-valves for valve replacement and associated methods and systems for surgery
US7896915B2 (en) 2007-04-13 2011-03-01 Jenavalve Technology, Inc. Medical device for treating a heart valve insufficiency
US9138315B2 (en) 2007-04-13 2015-09-22 Jenavalve Technology Gmbh Medical device for treating a heart valve insufficiency or stenosis
CN101720211B (zh) 2007-05-15 2013-06-05 耶拿阀门科技公司 用于操纵导管尖端的手柄、导管系统和用于插入自扩式心脏瓣膜支架的医疗插入系统
US8465540B2 (en) 2008-02-26 2013-06-18 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis
US9044318B2 (en) 2008-02-26 2015-06-02 Jenavalve Technology Gmbh Stent for the positioning and anchoring of a valvular prosthesis
ES2903231T3 (es) 2008-02-26 2022-03-31 Jenavalve Tech Inc Stent para el posicionamiento y anclaje de una prótesis valvular en un sitio de implantación en el corazón de un paciente
US8398704B2 (en) 2008-02-26 2013-03-19 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US8317858B2 (en) 2008-02-26 2012-11-27 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US9168130B2 (en) 2008-02-26 2015-10-27 Jenavalve Technology Gmbh Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US8468667B2 (en) 2009-05-15 2013-06-25 Jenavalve Technology, Inc. Device for compressing a stent
US10856978B2 (en) 2010-05-20 2020-12-08 Jenavalve Technology, Inc. Catheter system
US11278406B2 (en) 2010-05-20 2022-03-22 Jenavalve Technology, Inc. Catheter system for introducing an expandable heart valve stent into the body of a patient, insertion system with a catheter system and medical device for treatment of a heart valve defect
CA2799459A1 (fr) 2010-05-25 2011-12-01 Jenavalve Technology Inc. Valvule prothetique et endoprothese mise en place par catheterisme comprenant une valvule prothetique et un stent
EP2572681A1 (fr) * 2011-09-23 2013-03-27 Biotronik AG Implant et son procédé de fabrication
EP2768432A1 (fr) 2011-10-21 2014-08-27 JenaValve Technology Inc. Système de cathéter pour l'introduction d'un stent expansible pour valvule cardiaque dans le corps d'un patient, système d'insertion avec un système de cathéter et dispositif médical pour le traitement d'un défaut d'une valvule cardiaque
DE202013011734U1 (de) 2012-05-16 2014-04-29 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Katheter-Zuführsystem zum Einführen einer expandierbaren Herzklappenprothese sowie medizinische Vorrichtung zum Behandeln eines Herzklappendefekts
US9913740B2 (en) * 2012-10-25 2018-03-13 W. L. Gore & Associates, Inc. Stent with varying cross-section
EP4098226A1 (fr) 2013-08-30 2022-12-07 JenaValve Technology, Inc. Endoprothèse comprenant une armature radialement repliable et une valve prothétique
US10307273B2 (en) 2015-03-03 2019-06-04 Boston Scientific Scimed, Inc. Stent with anti-migration features
US12121461B2 (en) 2015-03-20 2024-10-22 Jenavalve Technology, Inc. Heart valve prosthesis delivery system and method for delivery of heart valve prosthesis with introducer sheath
JP6767388B2 (ja) 2015-05-01 2020-10-14 イェーナヴァルヴ テクノロジー インコーポレイテッド 心臓弁置換におけるペースメーカー割合を低減させるデバイス及び方法
EP4183371A1 (fr) 2016-05-13 2023-05-24 JenaValve Technology, Inc. Système de pose de prothèse de valvule cardiaque et procédé de pose de prothèse de valvule cardiaque avec gaine d'introduction et système de chargement
EP3573579B1 (fr) 2017-01-27 2023-12-20 JenaValve Technology, Inc. Mimétisme de valve cardiaque
JP7502264B2 (ja) 2018-08-10 2024-06-18 ルイ ヴィトン マルティエ 旅行鞄用の剛性シェルを製作するための方法、旅行鞄用のシェル、および旅行鞄
FR3084822B1 (fr) 2018-08-10 2022-01-07 Vuitton Louis Sa Procede pour realiser un bagage, en particulier un sac de voyage souple ou semi-rigide
WO2020150557A1 (fr) 2019-01-18 2020-07-23 W. L. Gore & Associates, Inc. Dispositifs médicaux bioabsorbables
IT201900003579A1 (it) 2019-03-12 2020-09-12 Alvimedica Tibbi Ueruenler Sanayi Ve Dis Ticaret A S Stent per ostio coronarico
US12582538B2 (en) * 2020-03-24 2026-03-24 The Foundry, Llc Expandable devices and associated systems and methods
EP4337443B1 (fr) * 2021-02-20 2025-04-30 Christian-Albrechts-Universität zu Kiel Structure de bande auxétique ou structure de champ, et utilisation
WO2024102411A1 (fr) 2022-11-09 2024-05-16 Jenavalve Technology, Inc. Système de cathéter pour le déploiement séquentiel d'un implant expansible

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4503569A (en) 1983-03-03 1985-03-12 Dotter Charles T Transluminally placed expandable graft prosthesis
EP0210466A3 (fr) 1985-08-01 1991-07-10 International Business Machines Corporation Procédé de transfert de groupes VSAM en gardant des indices remplaçants dans le groupe
US4733665C2 (en) 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
EP0257091B1 (fr) 1986-02-24 1993-07-28 Robert E. Fischell Distendeur intravasculaire et systeme d'introduction percutanee
US4907336A (en) 1987-03-13 1990-03-13 Cook Incorporated Method of making an endovascular stent and delivery system
US4800882A (en) 1987-03-13 1989-01-31 Cook Incorporated Endovascular stent and delivery system
US4886062A (en) 1987-10-19 1989-12-12 Medtronic, Inc. Intravascular radially expandable stent and method of implant
US4830003A (en) 1988-06-17 1989-05-16 Wolff Rodney G Compressive stent and delivery system
US4856516A (en) 1989-01-09 1989-08-15 Cordis Corporation Endovascular stent apparatus and method
CA2380683C (fr) * 1991-10-28 2006-08-08 Advanced Cardiovascular Systems, Inc. Empreintes extensibles et leur methode de fabrication
US5449373A (en) * 1994-03-17 1995-09-12 Medinol Ltd. Articulated stent
US5733303A (en) * 1994-03-17 1998-03-31 Medinol Ltd. Flexible expandable stent

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8449597B2 (en) 1995-03-01 2013-05-28 Boston Scientific Scimed, Inc. Longitudinally flexible expandable stent
US8728147B2 (en) 1995-03-01 2014-05-20 Boston Scientific Limited Longitudinally flexible expandable stent
US6846323B2 (en) 2003-05-15 2005-01-25 Advanced Cardiovascular Systems, Inc. Intravascular stent

Also Published As

Publication number Publication date
DE69727004D1 (de) 2004-02-05
EP0806190A1 (fr) 1997-11-12
ATE257002T1 (de) 2004-01-15
DE69727004T2 (de) 2004-11-25
DK0806190T3 (da) 2004-05-03
ATE398425T1 (de) 2008-07-15
DE69738786D1 (de) 2008-07-31
ES2212013T3 (es) 2004-07-16
EP1354569A1 (fr) 2003-10-22
EP1354569B1 (fr) 2008-06-18

Similar Documents

Publication Publication Date Title
EP0806190B1 (fr) Un stent pour angioplastie
US8439965B2 (en) Angioplasty stents
US8728147B2 (en) Longitudinally flexible expandable stent
EP0875215B1 (fr) Stent pour Angioplastie
CA2316286C (fr) Prothese endovasculaire extensible et longitudinalement flexible
EP1970033B1 (fr) Extenseur dilatable à flexibilité longitudinale améliorée
EP1163889A2 (fr) Extenseur dilatable a flexibilite longitudinale amelioree
ITTO960376A1 (it) Stent per angioplastica.
ITTO960374A1 (it) Stent per angioplastica.
ITTO960375A1 (it) Stent per angioplastica.

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB IE IT LI NL SE

17P Request for examination filed

Effective date: 19980418

17Q First examination report despatched

Effective date: 20020912

GRAH Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOS IGRA

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

RIN1 Information on inventor provided before grant (corrected)

Inventor name: CERISE, OSVALDO

Inventor name: VALLANA, FRANCO

Inventor name: GASCHINO, PAOLO

Inventor name: ROLANDO, GIOVANNI

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE CH DE DK ES FR GB IE IT LI NL SE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20040102

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20040102

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: NV

Representative=s name: ISLER & PEDRAZZINI AG

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: SE

Ref legal event code: TRGR

REF Corresponds to:

Ref document number: 69727004

Country of ref document: DE

Date of ref document: 20040205

Kind code of ref document: P

REG Reference to a national code

Ref country code: DK

Ref legal event code: T3

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2212013

Country of ref document: ES

Kind code of ref document: T3

ET Fr: translation filed
PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

RAP2 Party data changed (patent owner data changed or rights of a patent transferred)

Owner name: SORIN BIOMEDICA CARDIO S.R.L.

26N No opposition filed

Effective date: 20041005

NLT2 Nl: modifications (of names), taken from the european patent patent bulletin

Owner name: SORIN BIOMEDICA CARDIO S.R.L.

REG Reference to a national code

Ref country code: CH

Ref legal event code: PCAR

Free format text: ISLER & PEDRAZZINI AG;POSTFACH 1772;8027 ZUERICH (CH)

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: NL

Payment date: 20120515

Year of fee payment: 16

Ref country code: DK

Payment date: 20120510

Year of fee payment: 16

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: SE

Payment date: 20120511

Year of fee payment: 16

REG Reference to a national code

Ref country code: DE

Ref legal event code: R082

Ref document number: 69727004

Country of ref document: DE

Representative=s name: PAUL & ALBRECHT PATENTANWALTSSOZIETAET, DE

REG Reference to a national code

Ref country code: CH

Ref legal event code: PUE

Owner name: CID S.P.A., IT

Free format text: FORMER OWNER: SORIN BIOMEDICA CARDIO S.P.A., IT

REG Reference to a national code

Ref country code: DE

Ref legal event code: R082

Ref document number: 69727004

Country of ref document: DE

Representative=s name: PAUL & ALBRECHT PATENTANWALTSSOZIETAET, DE

Effective date: 20130107

Ref country code: DE

Ref legal event code: R081

Ref document number: 69727004

Country of ref document: DE

Owner name: CID S.P.A., IT

Free format text: FORMER OWNER: SORIN BIOMEDICA CARDIO S.P.A., SALUGGIA, VERCELLI, IT

Effective date: 20130107

Ref country code: DE

Ref legal event code: R081

Ref document number: 69727004

Country of ref document: DE

Owner name: CID S.P.A., IT

Free format text: FORMER OWNER: SORIN BIOMEDICA CARDIO S.P.A., SALUGGIA, IT

Effective date: 20130107

REG Reference to a national code

Ref country code: FR

Ref legal event code: TP

Owner name: CID S.P.A., IT

Effective date: 20130506

Ref country code: FR

Ref legal event code: CD

Owner name: CID S.P.A., IT

Effective date: 20130506

REG Reference to a national code

Ref country code: GB

Ref legal event code: 732E

Free format text: REGISTERED BETWEEN 20130627 AND 20130703

REG Reference to a national code

Ref country code: NL

Ref legal event code: V1

Effective date: 20131201

REG Reference to a national code

Ref country code: SE

Ref legal event code: EUG

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20130507

REG Reference to a national code

Ref country code: DK

Ref legal event code: EBP

Effective date: 20130531

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20131201

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DK

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20130531

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 20

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: ES

Payment date: 20160412

Year of fee payment: 20

Ref country code: GB

Payment date: 20160504

Year of fee payment: 20

Ref country code: DE

Payment date: 20160504

Year of fee payment: 20

Ref country code: IE

Payment date: 20160509

Year of fee payment: 20

Ref country code: CH

Payment date: 20160511

Year of fee payment: 20

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IT

Payment date: 20160524

Year of fee payment: 20

Ref country code: FR

Payment date: 20160412

Year of fee payment: 20

REG Reference to a national code

Ref country code: DE

Ref legal event code: R071

Ref document number: 69727004

Country of ref document: DE

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

REG Reference to a national code

Ref country code: GB

Ref legal event code: PE20

Expiry date: 20170505

REG Reference to a national code

Ref country code: IE

Ref legal event code: MK9A

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF EXPIRATION OF PROTECTION

Effective date: 20170505

Ref country code: IE

Free format text: LAPSE BECAUSE OF EXPIRATION OF PROTECTION

Effective date: 20170506

REG Reference to a national code

Ref country code: ES

Ref legal event code: FD2A

Effective date: 20180508

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF EXPIRATION OF PROTECTION

Effective date: 20170507