EP0863704A4 - Stimulation de reponses immunes cellulaires par une imunisation genique ciblee utilisant un agent particulaire - Google Patents

Stimulation de reponses immunes cellulaires par une imunisation genique ciblee utilisant un agent particulaire

Info

Publication number: EP0863704A4
Authority: EP; European Patent Office
Prior art keywords: immuned; stimulation; cell; immune response; genetic immunization
Prior art date: 1995-09-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP96933987A

Other languages

German (de)

English (en)

Other versions

EP0863704A1 (fr

Inventor

Louis D Falo Jr

Kenneth L Rock

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Dana Farber Cancer Institute Inc

University of Pittsburgh

Original Assignee

Dana Farber Cancer Institute Inc

University of Pittsburgh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-09-28

Filing date

1996-09-27

Publication date

2003-09-10

1996-09-27 Application filed by Dana Farber Cancer Institute Inc, University of Pittsburgh filed Critical Dana Farber Cancer Institute Inc

1998-09-16 Publication of EP0863704A1 publication Critical patent/EP0863704A1/fr

2003-09-10 Publication of EP0863704A4 publication Critical patent/EP0863704A4/fr

Status Withdrawn legal-status Critical Current

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/00119—Melanoma antigens
- A61K39/001192—Glycoprotein 100 [Gp100]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001103—Receptors for growth factors
- A61K39/001106—Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ErbB4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001148—Regulators of development
- A61K39/00115—Apoptosis related proteins, e.g. survivin or livin
- A61K39/001151—Apoptosis related proteins, e.g. survivin or livin p53
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/00118—Cancer antigens from embryonic or fetal origin
- A61K39/001182—Carcinoembryonic antigen [CEA]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001184—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
- A61K39/001186—MAGE
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/00119—Melanoma antigens
- A61K39/001191—Melan-A/MART
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/19—Dendritic cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
- A61K40/24—Antigen-presenting cells [APC]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Immunology (AREA)
Mycology (AREA)
Microbiology (AREA)
Organic Chemistry (AREA)
Virology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Molecular Biology (AREA)
Cell Biology (AREA)
Communicable Diseases (AREA)
Engineering & Computer Science (AREA)
Gynecology & Obstetrics (AREA)
Reproductive Health (AREA)
Pregnancy & Childbirth (AREA)
Developmental Biology & Embryology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
AIDS & HIV (AREA)
Pulmonology (AREA)
Tropical Medicine & Parasitology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicinal Preparation (AREA)

EP96933987A 1995-09-28 1996-09-27 Stimulation de reponses immunes cellulaires par une imunisation genique ciblee utilisant un agent particulaire Withdrawn EP0863704A4 (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US53555695A	1995-09-28	1995-09-28
PCT/US1996/015728 WO1997011605A1 (fr)	1995-09-28	1996-09-27	Stimulation de reponses immunes cellulaires par une imunisation genique ciblee utilisant un agent particulaire
US535556		2000-03-27

Publications (2)

Publication Number	Publication Date
EP0863704A1 EP0863704A1 (fr)	1998-09-16
EP0863704A4 true EP0863704A4 (fr)	2003-09-10

Family

ID=24134735

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP96933987A Withdrawn EP0863704A4 (fr)	1995-09-28	1996-09-27	Stimulation de reponses immunes cellulaires par une imunisation genique ciblee utilisant un agent particulaire

Country Status (15)

Country	Link
EP (1)	EP0863704A4 (fr)
JP (1)	JPH11512724A (fr)
KR (1)	KR19990063672A (fr)
CN (1)	CN1201369A (fr)
AU (1)	AU716497B2 (fr)
BG (1)	BG102355A (fr)
CA (1)	CA2233278A1 (fr)
CZ (1)	CZ92998A3 (fr)
HU (1)	HUP9802651A3 (fr)
NO (1)	NO981386L (fr)
NZ (1)	NZ319891A (fr)
PL (1)	PL325953A1 (fr)
SK (1)	SK40198A3 (fr)
TR (1)	TR199800573T2 (fr)
WO (1)	WO1997011605A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1997044446A1 (fr) *	1996-05-24	1997-11-27	University Of Maryland At Baltimore	Vaccins d'adn induisant une immunoreaction des muqueuses
TW570803B (en) *	1997-04-09	2004-01-11	Duphar Int Res	Influenza vaccine
US6287569B1 (en) *	1997-04-10	2001-09-11	The Regents Of The University Of California	Vaccines with enhanced intracellular processing
AU3291099A (en) *	1998-02-11	1999-08-30	Maxygen, Inc.	Genetic vaccine vector engineering
US7390619B1 (en)	1998-02-11	2008-06-24	Maxygen, Inc.	Optimization of immunomodulatory properties of genetic vaccines
AU2487300A (en)	1998-12-31	2000-07-31	Chiron Corporation	Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof
AU2221600A (en)	1998-12-31	2000-07-31	Chiron Corporation	Improved expression of hiv polypeptides and production of virus-like particles
JP2002542264A (ja) *	1999-04-21	2002-12-10	パウダージェクトヴァクシンズ，インコーポレイテッド	核酸による免疫化
JP4430868B2 (ja)	2001-03-30	2010-03-10	ジーエイチシーリサーチディベロップメントコーポレイション	単球に特異的な粒子性送達媒体
EP1411770A4 (fr)	2001-07-05	2006-05-10	Chiron Corp	Polynucleotides codant des polypeptides de type c du vih antigeniques, polypeptides et leurs utilisations
US20030170614A1 (en)	2001-08-31	2003-09-11	Megede Jan Zur	Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof
US11529414B2 (en)	2020-06-23	2022-12-20	Orbis Health Solutions, Llc	Viral vaccines for in vivo expression of a nucleic acid encoding an immunogenic peptide and methods of using the same

1996
- 1996-09-27 TR TR1998/00573T patent/TR199800573T2/xx unknown
- 1996-09-27 CA CA002233278A patent/CA2233278A1/fr not_active Abandoned
- 1996-09-27 WO PCT/US1996/015728 patent/WO1997011605A1/fr not_active Ceased
- 1996-09-27 HU HU9802651A patent/HUP9802651A3/hu unknown
- 1996-09-27 JP JP9513762A patent/JPH11512724A/ja active Pending
- 1996-09-27 SK SK401-98A patent/SK40198A3/sk unknown
- 1996-09-27 CN CN96198106A patent/CN1201369A/zh active Pending
- 1996-09-27 NZ NZ319891A patent/NZ319891A/xx unknown
- 1996-09-27 CZ CZ98929A patent/CZ92998A3/cs unknown
- 1996-09-27 EP EP96933987A patent/EP0863704A4/fr not_active Withdrawn
- 1996-09-27 KR KR1019980702134A patent/KR19990063672A/ko not_active Ceased
- 1996-09-27 AU AU72515/96A patent/AU716497B2/en not_active Ceased
- 1996-09-27 PL PL96325953A patent/PL325953A1/xx unknown
1998
- 1998-03-26 NO NO981386A patent/NO981386L/no unknown
- 1998-03-26 BG BG102355A patent/BG102355A/xx unknown

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; 15 April 1995 (1995-04-15), ZAROZINSKI C C ET AL: "Protective CTL-dependent immunity and enhanced immunopathology in mice immunized by particle bombardment with DNA encoding an internal virion protein.", XP002238694, Database accession no. NLM7706740 *
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; 4 September 1995 (1995-09-04), FOMSGAARD A: "[Genetic immunization--"the biological equivalent of cold fusion"?]", XP002238693, Database accession no. NLM7676526 *
FYNAN E F ET AL: "DNA VACCINES: PROTECTIVE IMMUNIZATIONS BY PARENTERAL, MUCOSAL, AND GENE-GUN INOCULATIONS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 90, 1 December 1993 (1993-12-01), pages 11478 - 11482, XP000770731, ISSN: 0027-8424 *
HEYDENBURG FULLER D ET AL: "A QUALITATIVE PROGRESSION IN HIV TYPE 1 GLYCOPROTEIN 120-SPECIFIC CYTOTOXIC CELLULAR AND HUMORAL IMMUNE RESPONSES IN MICE RECEIVING ADNA-BASED GLYCOPROTEIN 120 VACCINE", AIDS RESEARCH AND HUMAN RETROVIRUSES, NEW YORK, NY, US, vol. 10, no. 11, 1 November 1994 (1994-11-01), pages 1433 - 1441, XP000572444, ISSN: 0889-2229 *
JOURNAL OF IMMUNOLOGY (BALTIMORE, MD.: 1950) UNITED STATES 15 APR 1995, vol. 154, no. 8, 15 April 1995 (1995-04-15), pages 4010 - 4017, ISSN: 0022-1767 *
LAI W C: "PROTECTION AGAINST MYCOPLASMA PULMONIS INFECTION BY GENETIC VACCINATION", DNA AND CELL BIOLOGY, NEW YORK, NY, US, vol. 14, no. 7, 1 July 1995 (1995-07-01), pages 643 - 651, XP000575588, ISSN: 1044-5498 *
See also references of WO9711605A1 *
UGESKRIFT FOR LAEGER. DENMARK 4 SEP 1995, vol. 157, no. 36, 4 September 1995 (1995-09-04), pages 4932 - 4936, ISSN: 0041-5782 *

Also Published As

Publication number	Publication date
HUP9802651A2 (hu)	1999-02-01
AU7251596A (en)	1997-04-17
CN1201369A (zh)	1998-12-09
SK40198A3 (en)	1998-11-04
WO1997011605A1 (fr)	1997-04-03
NZ319891A (en)	1999-01-28
CA2233278A1 (fr)	1997-04-03
NO981386L (no)	1998-05-28
HUP9802651A3 (en)	2001-08-28
EP0863704A1 (fr)	1998-09-16
AU716497B2 (en)	2000-02-24
CZ92998A3 (cs)	1998-09-16
NO981386D0 (no)	1998-03-26
TR199800573T2 (xx)	1998-07-21
JPH11512724A (ja)	1999-11-02
PL325953A1 (en)	1998-08-17
BG102355A (bg)	1999-04-30
KR19990063672A (ko)	1999-07-26

Legal Events

Date	Code	Title	Description
1998-07-31	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1998-09-16	17P	Request for examination filed	Effective date: 19980324
1998-09-16	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
1998-09-16	AX	Request for extension of the european patent	Free format text: LT PAYMENT 980324;LV PAYMENT 980324;SI PAYMENT 980324
1999-01-27	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: DANA FARBER CANCER INSTITUTE Owner name: UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTE
1999-06-23	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: DANA FARBER CANCER INSTITUTE Owner name: DANA FARBER CANCER INSTITUTE, INC.
2000-01-12	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: DANA FARBER CANCER INSTITUTE, INC. Owner name: UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTE
2003-06-11	RIC1	Information provided on ipc code assigned before grant	Ipc: 7A 61K 47/02 B Ipc: 7A 61K 48/00 B Ipc: 7A 61K 39/00 A
2003-09-10	A4	Supplementary search report drawn up and despatched	Effective date: 20030723
2003-11-14	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN
2004-01-02	18W	Application withdrawn	Effective date: 20031103
2006-05-12	REG	Reference to a national code	Ref country code: HK Ref legal event code: WD Ref document number: 1015223 Country of ref document: HK

Publication	Publication Date	Title
DE69633333D1 (de)	2004-10-14	Diphosphonatderivate von therapeutischen substanzen
DE69638248D1 (de)	2010-10-07	Nachweis von DNS-Sequenz Variationen
DE69627895D1 (de)	2003-06-05	Herstellungsverfahren von mikroprismenmatrixen
DE69608448D1 (de)	2000-06-21	Reduktion des biobewuchses
EP0863704A4 (fr)	2003-09-10	Stimulation de reponses immunes cellulaires par une imunisation genique ciblee utilisant un agent particulaire
ATE198190T1 (de)	2001-01-15	Modulatoren von durch aminosäuren anregbare rezeptoren
DE69602011D1 (de)	1999-05-12	Implantierbare stimulationselektroden
NO974089L (no)	1997-09-05	Stimulering av meiose
EP0817798A4 (fr)	2004-08-25	Sequences nucleotidiques et proteiques de genes lats et procedes les utilisant
FI973484L (fi)	1997-10-24	Menetelmä immuunivasteen stimuloimiseksi
DE69628195D1 (de)	2003-06-18	Verwendung von xyloglucanendotransglycosylase
IT1285405B1 (it)	1998-06-03	Modificazione di farmaci polipeptidici per accrescere il flusso per elettrotrasporto.
DE69622472D1 (de)	2002-08-29	Behandlung von Krankheiten durch Induktion von BEF-1 Transkriptionsfaktor
FI952176A7 (fi)	1996-11-06	Suovan neutralointi
DE69608454D1 (de)	2000-06-21	Simulation von atmosphärischen effekten
ATA136995A (de)	1997-03-15	Abreicherung von 7-adca in 3-vinyl-aca
ITRM960887A0 (it)	1996-12-20	Composizioni di esteri vinilici di novolacca
DE69603578D1 (de)	1999-09-09	Synthese von tetrafluorethylen
DE69634725D1 (de)	2005-06-16	Verbesserte haftung von fluorpolymeren
DE69605708D1 (de)	2000-01-27	Reinigung von Pentafluorethan
NO980862L (no)	1998-02-27	Zwitterionformer av trovafloxacin
DE69610739D1 (de)	2000-11-30	Umwandlung von substituierten 8-Chlorochinolinen in substituierte 8-Hydroxychinoline
DE59506059D1 (de)	1999-07-01	Halterung fur die biegemomentfreie lagerung von glastafeln
HK1015223A (en)	1999-10-15	Stimulation of cell-mediated immune responses by targeted particulate genetic immunization
KR970011240U (ko)	1997-03-29	바란스 블럭의 다기능 도그