EP0876818A4 - Wirkstoff zur behandlung neurodegenerativer störungen - Google Patents
Wirkstoff zur behandlung neurodegenerativer störungenInfo
- Publication number
- EP0876818A4 EP0876818A4 EP96935637A EP96935637A EP0876818A4 EP 0876818 A4 EP0876818 A4 EP 0876818A4 EP 96935637 A EP96935637 A EP 96935637A EP 96935637 A EP96935637 A EP 96935637A EP 0876818 A4 EP0876818 A4 EP 0876818A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- agent
- degenerative disorders
- treating neuro
- treating
- neuro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000015122 neurodegenerative disease Diseases 0.000 title abstract 2
- RDMFHRSPDKWERA-UHFFFAOYSA-N 5H-Pyrido[4,3-b]indole Chemical class C1=NC=C2C3=CC=CC=C3NC2=C1 RDMFHRSPDKWERA-UHFFFAOYSA-N 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Physics & Mathematics (AREA)
- Neurosurgery (AREA)
- Optics & Photonics (AREA)
- Oncology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Steroid Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SI9630572T SI0876818T1 (en) | 1995-10-23 | 1996-10-23 | Agent for treating neuro-degenerative disorders |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU95118252A RU2106864C1 (ru) | 1995-10-23 | 1995-10-23 | Средство для лечения болезни альцгеймера |
| RU95118252 | 1995-10-23 | ||
| PCT/RU1996/000306 WO1997015225A1 (en) | 1995-10-23 | 1996-10-23 | Agent for treating neuro-degenerative disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| EP0876818A2 EP0876818A2 (de) | 1998-11-11 |
| EP0876818A4 true EP0876818A4 (de) | 1999-01-07 |
| EP0876818B1 EP0876818B1 (de) | 2002-12-18 |
Family
ID=20173218
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP96935637A Expired - Lifetime EP0876818B1 (de) | 1995-10-23 | 1996-10-23 | Wirkstoff zur behandlung neurodegenerativer störungen |
Country Status (10)
| Country | Link |
|---|---|
| US (6) | US6187785B1 (de) |
| EP (1) | EP0876818B1 (de) |
| AT (1) | ATE229806T1 (de) |
| AU (1) | AU7347496A (de) |
| CA (1) | CA2269698C (de) |
| DE (1) | DE69625518T2 (de) |
| DK (1) | DK0876818T3 (de) |
| ES (1) | ES2188793T3 (de) |
| RU (1) | RU2106864C1 (de) |
| WO (1) | WO1997015225A1 (de) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2106864C1 (ru) | 1995-10-23 | 1998-03-20 | Николай Серафимович Зефиров | Средство для лечения болезни альцгеймера |
| IT1312107B1 (it) * | 1999-05-14 | 2002-04-04 | Umberto Cornelli | Glicosaminoglicani aventi peso molecolare medio di 2400 d atti altrattamento della demenza senile |
| CA2363244C (en) * | 2000-11-07 | 2006-06-13 | Research In Motion Limited | Multifunctional keyboard for a mobile communication device and method of operating the same |
| US20040024043A1 (en) * | 2002-03-22 | 2004-02-05 | Nigel Greig | Method for treating cognitive disorders |
| AU2003272175A1 (en) * | 2002-10-21 | 2004-05-04 | Aprea Ab | Reactivation of wild type p53 in human tumour cells by a low molecular weight compound |
| RU2283108C2 (ru) * | 2003-12-08 | 2006-09-10 | Сергей Олегович Бачурин | ГЕРОПРОТЕКТОР НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО(4,3-b) ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ |
| US20070179174A1 (en) * | 2003-12-08 | 2007-08-02 | Bachurin Sergei O | Methods and compositions for slowing aging |
| FR2885905A1 (fr) * | 2005-05-23 | 2006-11-24 | Trophos Sa | Nouveaux composes chimiques et leurs utilisations comme medicament |
| WO2007032699A1 (en) * | 2005-09-12 | 2007-03-22 | Avdulov, Nikolai Andreevich | (+)-and-(-)-trans-2,3,4,4a,5,9b-hexahydro-2,8-dimethyl-1h-pyrido[4,3-b] indole optical isomers |
| US20070117834A1 (en) * | 2005-10-04 | 2007-05-24 | David Hung | Methods and compositions for treating Huntington's disease |
| RU2338537C2 (ru) * | 2006-01-25 | 2008-11-20 | Сергей Олегович Бачурин | СРЕДСТВО ДЛЯ ЛЕЧЕНИЯ ШИЗОФРЕНИИ НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО(4,3-b)ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ |
| RU2317989C1 (ru) | 2006-08-24 | 2008-02-27 | Андрей Александрович Иващенко | ЗАМЕЩЕННЫЕ АЗЕПИНО[4,3-b]ИНДОЛЫ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ |
| EP2066322A2 (de) * | 2006-09-20 | 2009-06-10 | Medivation Neurology, Inc. | Hydrierte pyrido-[4,3-b]-indole wie z. b. dimebon zur behandlung kognitiver dysfunktionen bei hunden |
| JP2010504338A (ja) * | 2006-09-20 | 2010-02-12 | メディベイション ニューロロジー， インコーポレイテッド | 筋萎縮性側索硬化症（ＡＬＳ）の治療のための水素化ピリド［４，３−ｂ］インドール |
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| RU2329044C1 (ru) * | 2006-11-16 | 2008-07-20 | Андрей Александрович Иващенко | Лиганды 5-ht6 рецепторов, фармацевтическая композиция, способ ее получения и лекарственное средство |
| RU2334514C1 (ru) * | 2006-12-01 | 2008-09-27 | Институт физиологически активных веществ Российской Академии наук | СРЕДСТВО ДЛЯ УЛУЧШЕНИЯ КОГНИТИВНЫХ ФУНКЦИЙ И ПАМЯТИ НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО (4,3-b) ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ |
| RU2340342C2 (ru) * | 2006-12-07 | 2008-12-10 | Сергей Олегович Бачурин | СРЕДСТВО ДЛЯ ЛЕЧЕНИЯ ОСТРЫХ И ХРОНИЧЕСКИХ НАРУШЕНИЙ МОЗГОВОГО КРОВООБРАЩЕНИЯ, В ТОМ ЧИСЛЕ ИНСУЛЬТА, НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО[4,3-b]ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ |
| WO2008112238A1 (en) * | 2007-03-12 | 2008-09-18 | Grey Fox Llc | 2, 8-dimethyl-5- [2- (6-methylpyridin-3-yl) -ethyl] -2,3,4, 5-tetrahydro- ih- pyrido [4, 3 -b] indole dihydrochloride (dimebon) for the treatment of chronic pain |
| UA98324C2 (ru) * | 2007-04-05 | 2012-05-10 | Андрей Александрович Иващенко | ЗАМЕЩЕННЫЕ 2,3,4,5-ТЕТРАГИДРО-1H-ПИРИДО[4,3-b]ИНДОЛЫ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ |
| RU2327480C1 (ru) | 2007-05-23 | 2008-06-27 | Виктор Иванович Рощин | Активный ингредиент лекарственного средства, лекарственное средство, фармацевтическая композиция и способ лечения больных с дементным синдромом |
| RU2338533C1 (ru) * | 2007-06-28 | 2008-11-20 | Сергей Олегович Бачурин | СРЕДСТВО, ОБЛАДАЮЩЕЕ АНКСИОЛИТИЧЕСКИМ ДЕЙСТВИЕМ, НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО(4,3-b)ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ |
| AU2008302751A1 (en) * | 2007-09-20 | 2009-03-26 | D2E, Llc | Fluoro-containing derivatives of hydrogenated pyrido[4,3-b]indoles with neuroprotective and cognition enhancing properties, process for preparing, and use |
| RU2007139634A (ru) | 2007-10-25 | 2009-04-27 | Сергей Олегович Бачурин (RU) | Новые тиазол-, триазол- или оксадиазол-содержащие тетрациклические соединения |
| TWI447117B (zh) * | 2007-10-25 | 2014-08-01 | Medivation Technologies Inc | 新穎四環化合物 |
| JP2011507835A (ja) * | 2007-12-21 | 2011-03-10 | アンドレイ・アレクサンドロビッチ・イワシェンコ | α−アドレナリン受容体、ドーパミン、ヒスタミン、イミダゾリン及びセロトニン受容体のリガンド並びにその使用 |
| RU2544856C2 (ru) | 2008-01-25 | 2015-03-20 | Сергей Олегович Бачурин | НОВЫЕ ПРОИЗВОДНЫЕ 2,3,4,5-ТЕТРАГИДРО-1-ПИРИДО[4,3-b]ИНДОЛА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ |
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| DE1952800C3 (de) | 1969-10-20 | 1974-04-18 | Nautschno-Issledowatelskij Institut Farmakologii I Chimioterapii, Moskau | 3,6-Dimethyl-l,2,3,4,4a,9a-hexahydro-gamma-carbolin-dihydrochlorid |
| US3718657A (en) * | 1970-12-03 | 1973-02-27 | Abbott Lab | Certain-2-substituted-1,2,3,4-tetrahydro-beta or gamma carbolines |
| SE7414572L (de) * | 1973-12-06 | 1975-06-09 | Endo Lab | |
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-
1995
- 1995-10-23 RU RU95118252A patent/RU2106864C1/ru active
-
1996
- 1996-10-23 WO PCT/RU1996/000306 patent/WO1997015225A1/ru not_active Ceased
- 1996-10-23 DK DK96935637T patent/DK0876818T3/da active
- 1996-10-23 AU AU73474/96A patent/AU7347496A/en not_active Abandoned
- 1996-10-23 ES ES96935637T patent/ES2188793T3/es not_active Expired - Lifetime
- 1996-10-23 DE DE69625518T patent/DE69625518T2/de not_active Expired - Lifetime
- 1996-10-23 EP EP96935637A patent/EP0876818B1/de not_active Expired - Lifetime
- 1996-10-23 AT AT96935637T patent/ATE229806T1/de active
- 1996-10-23 CA CA002269698A patent/CA2269698C/en not_active Expired - Fee Related
- 1996-10-23 US US09/269,602 patent/US6187785B1/en not_active Expired - Lifetime
-
2001
- 2001-02-06 US US09/778,662 patent/US20010020028A1/en not_active Abandoned
-
2002
- 2002-01-23 US US10/057,688 patent/US20020115682A1/en not_active Abandoned
-
2003
- 2003-08-28 US US10/652,435 patent/US20040044022A1/en not_active Abandoned
-
2004
- 2004-12-02 US US11/004,001 patent/US7071206B2/en not_active Expired - Fee Related
-
2006
- 2006-02-24 US US11/361,628 patent/US20060140866A1/en not_active Abandoned
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Also Published As
| Publication number | Publication date |
|---|---|
| CA2269698C (en) | 2007-09-18 |
| US20040044022A1 (en) | 2004-03-04 |
| AU7347496A (en) | 1997-05-15 |
| US20060140866A1 (en) | 2006-06-29 |
| DE69625518D1 (de) | 2003-01-30 |
| WO1997015225A1 (en) | 1997-05-01 |
| US7071206B2 (en) | 2006-07-04 |
| EP0876818A2 (de) | 1998-11-11 |
| US20010020028A1 (en) | 2001-09-06 |
| RU2106864C1 (ru) | 1998-03-20 |
| HK1016893A1 (en) | 1999-11-12 |
| ES2188793T3 (es) | 2003-07-01 |
| US20020115682A1 (en) | 2002-08-22 |
| DE69625518T2 (de) | 2003-09-04 |
| EP0876818B1 (de) | 2002-12-18 |
| US6187785B1 (en) | 2001-02-13 |
| US20050096342A1 (en) | 2005-05-05 |
| CA2269698A1 (en) | 1997-05-01 |
| ATE229806T1 (de) | 2003-01-15 |
| DK0876818T3 (da) | 2003-03-31 |
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