EP0877652B1 - Flacon a echantillon pour prelevement de sang - Google Patents

Flacon a echantillon pour prelevement de sang Download PDF

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Publication number
EP0877652B1
EP0877652B1 EP97949956A EP97949956A EP0877652B1 EP 0877652 B1 EP0877652 B1 EP 0877652B1 EP 97949956 A EP97949956 A EP 97949956A EP 97949956 A EP97949956 A EP 97949956A EP 0877652 B1 EP0877652 B1 EP 0877652B1
Authority
EP
European Patent Office
Prior art keywords
vessel
blood
sample
capillary
pct
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP97949956A
Other languages
German (de)
English (en)
Other versions
EP0877652A1 (fr
Inventor
Walter Sarstedt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sarstedt AG and Co KG
Original Assignee
Sarstedt AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sarstedt AG and Co KG filed Critical Sarstedt AG and Co KG
Publication of EP0877652A1 publication Critical patent/EP0877652A1/fr
Application granted granted Critical
Publication of EP0877652B1 publication Critical patent/EP0877652B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Rigid containers without fluid transport within
    • B01L3/5082—Test tubes per se
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5021—Test tubes specially adapted for centrifugation purposes

Definitions

  • the invention relates to a sample vessel for taking small amounts of blood, consisting of an outer vessel having a collar and an inner vessel arranged therein, which is closed at the bottom and at the top on the discharge side with an open, by a stopper closable, formed from the outer vessel blood collection ring.
  • EP 0 517 119 B1 and US Pat. No. 5,458,854 A have disclosed such blood collection devices with a collecting tube for the blood.
  • the tube or the blood collection vessel has an integrated, vessel-like blood collection chamber with an open-topped and a closed bottom, rounded end.
  • the open end of the container is integrally provided with a scoop-shaped lip portion, via the receiving edge of which the discharged blood can drain into the blood collection space, which in contrast is larger in diameter.
  • the upper end of the vessel together with the blade-shaped lip part formed thereon can be closed by a cap. This is attached to the lower end of the vessel during blood collection.
  • a supplementary vessel is coupled to the bottom of the vessel according to the US patent.
  • a scoop-shaped lip portion or a capillary tube serving as a blood-sampling device is an integral part of a cap which can be attached to the blood-collecting vessel.
  • This Blutabitate- or blood sampling devices have in common that they must be specifically targeted for collecting and passing the blood into the blood collection vessel, namely exactly with the blade-shaped Lippelteil on the for the blood collection dotted place of the patient. If positioned incorrectly, the blood can not be properly directed into the vessel, with the result that some of the blood may run along the outside of the vessel. The small amount of capillary blood anyway is therefore sometimes reduced sensitively. In addition, the risk of contamination or injection increases for the taking blood Persons and the laboratory staff considerably.
  • Another problem in the preparation and analysis of very small amounts of blood in the laboratory is to find such vessels that fit on the one hand due to their external dimensions in the common laboratory equipment, are labeled (eg with barcode labels) and yet at the same time ensure a level of the sample , which is still good to pipette or manageable.
  • a capillary blood volume with the volume of one or more droplets has such a low level that the bulk of the blood is distributed over the inner vessel surface and therefore almost no more sample for the analysis is available.
  • vessels are used with a smaller diameter ensuring a sufficient fill level, these do not fit into the commercially available devices.
  • vessels that have sufficient dimensions in their relevant, relevant for the upper relevant area and taper downwards, the problem arises that this Do not stick the containers with the standard barcode labels.
  • vessels are commercially available whose outer contours correspond to the required dimensions of the commercial laboratory equipment and whose inner vessel diameter is as small and narrow.
  • these large dimensional differences between the outer and inner diameter are compensated by a relatively large wall thickness.
  • the preparation of such vessels then leads to the injection molding specialist well-known technical problems.
  • the required, quite expensive injection molding tool for the preparation of these large wall thickness possessing vessels is always suitable only for the production of vessels made of plastics of a genus.
  • vessels of different types of plastic are consequently required depending on the requirements of the sample material. This means that each time the preparation or use of another injection molding tool is necessary, resulting in high investment.
  • the invention has for its object to provide a sample container for taking smallest amounts of blood, which can be used to remedy the aforementioned disadvantages and facilitates the removal of but easier to manufacture and provides more variable uses.
  • a sample vessel in which the inner vessel is arranged in a separate outer vessel with a fixed seat and provided with a round constantly very thin-walled blood collection ring, the collar of the outer vessel both the inner vessel below the Blutab shakingringes and in a centrifuge introduced outer vessel itself supports. Due to the bipartite of the sample vessel according to the invention with the same round constantly very thin-walled Blood collection ring of the inner vessel and the support collar of the separate outer vessel can achieve several advantages simultaneously.
  • So can be different than in one-piece blood vessels with much less effort and far less complicated injection molds for the inner vessel any form and in particular to provide such a design, which has an optimized for the good miscibility of the sample vessel geometry and - eg in a conical inner vessel - a high level of serum or plasma after centrifugation, allowing for a good and easy pipetting off of the supernatant.
  • different inner vessels of eg 200, 300 or 500 microliters can be inserted into the outer vessel with regard to their filling volume.
  • the wall of the inner vessel extension projecting from the outer vessel in the installed position i.
  • the blood collection ring makes handling much easier, as it no longer needs to be taken to specifically target the sample vial, because the extremely thin rim of the blood collection ring makes it easy to catch blood at any point without requiring centering of the vial.
  • the blood collection ring is also suitable as a seat for a stopper closing the sample vessel.
  • the outer vessel can be - because it is not directly involved in the blood collection - provide such a size that it provides a sufficiently large area for attaching a measure or identification carrier (bar code).
  • the covenant of the outer vessel fulfills a dual function; it serves both to support the inner vessel which can be introduced into the outer vessel due to an interference fit with a fixed seat or to be pasted or latched therein, and to support it when introduced into any of the centrifuges commonly used on the market.
  • a sample vessel 1 shown in Fig. 1 consists of a tube-shaped outer vessel 2, an inner vessel 3 and a plug 4.
  • the outer vessel 2 is provided with a collar 5, to which in the installation position shown in Fig. 2 with a press fit in the outer vessel 2 inserted inner vessel 3 is supported.
  • the bottom closed inner vessel 3 has in the embodiment shown a conical vessel section 6, which still ensures a high level of the serum or plasma after centrifugation, especially in case of a small filling volume, which allows a good and easy pipetting off the desired amount of liquid.
  • the inner vessel 3 is formed with an extension in the form of a very thin-walled blood collecting ring 7, which allows an all-round decrease of the collected blood in the inner vessel 3, so that the sample vessel 1 can be attached to any point of the blood collection ring 7; it is thus possible a simple peripheral blood collection by shoveling the exiting blood.
  • the plugged in the delivery state on the blood collection ring 7 of the inner vessel 3 plug 4 can be inserted during the blood intake to the lower end of the outer vessel 2, as illustrated in Fig. 2 by the arrow 8.
  • the two-part sample container 1 according to the modification shown in Fig. 3 in a simple way also the possibility of blood sampling through a capillary 9. This is there arranged in a holding stopper 10, which is attached to the blood collection ring 7, so that the lower end of the capillary in the inner vessel 3 opens and the discharged blood consequently leads into the inner vessel 3.
  • a suitable venting of the inner vessel ensures that the blood enters the capillary 9- In the delivery state of the capillary 9 carrying holding plug 10 closes the inner vessel 3, while a as shown in Fig. 2, not shown here sealing plug 4 on the lower end the outer vessel 2 is inserted.
  • the empty capillary 9 is removed together with the holding stopper 10 from the sample vessel 1 or the blood withdrawal ring 7 of the inner vessel 3 and disposed of; the stopper 4 is then attached to the blood collection ring 7 and the sample vessel 1 thus closed.
  • the inner vessel 3 can be formed with a flow aid 11, the embodiment of the flow aid 11 shown in FIG. 4 a largely simplified production, eg by milling, enabled.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Centrifugal Separators (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Claims (1)

  1. Récipient d'échantillonnage (1), pour prélever des quantités infimes de sang, composé d'un récipient (2) extérieur comportant un épaulement (5) et d'un récipient intérieur (3) disposé dans celui-ci qui est fermé sur le bas et conçu sur le haut côté prélèvement avec une bague de prélèvement sanguin (7) ouverte, saillant hors du récipient extérieur (2) et pouvant être fermée par un bouchon (4),
    caractérisé en ce que
    le récipient intérieur (3) est disposé dans un récipient extérieur séparé (2) avec une assise fixe et est muni d'une bague de prélèvement sanguin (7) à paroi extrêmement mince, restant constante sur sa circonférence, l'épaulement (5) du récipient extérieur (2) soutenant lui-même le récipient intérieur (3) situé sous la bague de prélèvement sanguin (7), ainsi que le récipient extérieur (2) introduit dans une centrifugeuse.
EP97949956A 1996-11-19 1997-11-18 Flacon a echantillon pour prelevement de sang Expired - Lifetime EP0877652B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19647673 1996-11-19
DE19647673A DE19647673C2 (de) 1996-11-19 1996-11-19 Probengefäß zur Blutabnahme
PCT/DE1997/002712 WO1998022218A1 (fr) 1996-11-19 1997-11-18 Flacon a echantillon pour prelevement de sang

Publications (2)

Publication Number Publication Date
EP0877652A1 EP0877652A1 (fr) 1998-11-18
EP0877652B1 true EP0877652B1 (fr) 2007-01-03

Family

ID=7812024

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97949956A Expired - Lifetime EP0877652B1 (fr) 1996-11-19 1997-11-18 Flacon a echantillon pour prelevement de sang

Country Status (10)

Country Link
US (1) US6056925A (fr)
EP (1) EP0877652B1 (fr)
JP (1) JP3853374B2 (fr)
AT (1) ATE350165T1 (fr)
AU (1) AU719213B2 (fr)
CA (1) CA2241792C (fr)
DE (2) DE19647673C2 (fr)
ES (1) ES2283030T3 (fr)
PL (1) PL185194B1 (fr)
WO (1) WO1998022218A1 (fr)

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KR100548188B1 (ko) 2001-05-07 2006-02-02 가부시기가이샤 교오리스리가꾸겐규우쇼 간이분석기 및 이를 제조하기 위한 방법
US6878346B2 (en) * 2002-05-17 2005-04-12 Bayer Corporation Serum transfer cup
US20060018799A1 (en) * 2004-07-21 2006-01-26 Wong Cai Ne W Universal tissue homogenizer device and methods
JP2007167123A (ja) * 2005-12-19 2007-07-05 Fujifilm Corp 真空採血管
EP2172778B1 (fr) 2007-07-12 2017-12-27 Sysmex Corporation Récipient à échantillon
MX2010009668A (es) * 2008-03-05 2010-10-15 Becton Dickinson Co Tapon perforable comoldeado y metodo para hacerlo.
USD621522S1 (en) 2009-09-03 2010-08-10 Becton, Dickinson And Company Pierceable collection container device
USD640796S1 (en) 2009-03-05 2011-06-28 Becton, Dickinson And Company Collection container
USD634024S1 (en) 2010-01-22 2011-03-08 Becton, Dickinson And Company Closure for a specimen container having an indicator surface
USD662216S1 (en) 2010-01-22 2012-06-19 Becton, Dickinson And Company Closure or a specimen container having an indicator surface
USD645972S1 (en) 2010-01-25 2011-09-27 Becton, Dickinson And Company Specimen collection container having a label
USD640797S1 (en) 2010-01-25 2011-06-28 Becton, Dickinson And Company Specimen collection container having a label
US8973293B2 (en) 2010-11-19 2015-03-10 Becton, Dickinson And Company Specimen container label for automated clinical laboratory processing systems
US8460620B2 (en) * 2010-12-03 2013-06-11 Becton, Dickinson And Company Specimen collection container assembly
KR101308107B1 (ko) 2011-01-03 2013-09-12 이철문 체액 보관용 보조용기
US9636062B2 (en) 2012-09-06 2017-05-02 Theranos, Inc. Systems, devices, and methods for bodily fluid sample collection
US9427184B2 (en) 2012-09-06 2016-08-30 Theranos, Inc. Systems, devices, and methods for bodily fluid sample collection
BR112015005028B1 (pt) 2012-09-06 2020-12-15 Theranos Ip Company, Llc Sistema, dispositivos e métodos para a coleta de amostras de fluídos corporais
US10248765B1 (en) 2012-12-05 2019-04-02 Theranos Ip Company, Llc Systems, devices, and methods for bodily fluid sample collection, transport, and handling
US9386948B2 (en) 2012-12-05 2016-07-12 Theranos, Inc. Systems, devices, and methods for bodily fluid sample transport
BR112015022738B1 (pt) 2013-03-15 2022-11-29 Labrador Diagnostics Llc Dispositivo para utilização com um componente de amostra líquida formado
USD754361S1 (en) 2013-09-06 2016-04-19 Theranos, Inc. Sample container
US10391497B1 (en) * 2013-09-09 2019-08-27 Theranos Ip Company, Llc Devices, methods and systems for reducing sample volume
CN106456439B (zh) 2014-03-12 2021-06-25 赛拉诺斯知识产权有限责任公司 用于体液样品收集的系统、装置和方法
US10371606B2 (en) 2015-07-21 2019-08-06 Theraos IP Company, LLC Bodily fluid sample collection and transport
WO2017044888A1 (fr) 2015-09-09 2017-03-16 Theranos, Inc. Procédés et dispositifs de collecte et de séparation d'échantillons
US10022079B2 (en) * 2016-06-15 2018-07-17 True Concepts Medical Technologies, Llc Syringe systems and methods for bodily fluid collection and sampling
US11857966B1 (en) 2017-03-15 2024-01-02 Labrador Diagnostics Llc Methods and devices for sample collection and sample separation
US11209405B2 (en) * 2017-12-01 2021-12-28 Shimadzu Corporation Liquid chromatograph analysis system

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Also Published As

Publication number Publication date
ES2283030T3 (es) 2007-10-16
EP0877652A1 (fr) 1998-11-18
JP2000506419A (ja) 2000-05-30
CA2241792A1 (fr) 1998-05-28
WO1998022218A1 (fr) 1998-05-28
AU5308798A (en) 1998-06-10
PL185194B1 (pl) 2003-03-31
PL327663A1 (en) 1998-12-21
JP3853374B2 (ja) 2006-12-06
CA2241792C (fr) 2006-11-07
DE19647673C2 (de) 2000-08-24
DE59712791D1 (de) 2007-02-15
AU719213B2 (en) 2000-05-04
DE19647673A1 (de) 1998-05-28
US6056925A (en) 2000-05-02
ATE350165T1 (de) 2007-01-15

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