EP0900086A4 - Stimulation du sommeil avec un secretagogue d'hormone de croissance - Google Patents

Stimulation du sommeil avec un secretagogue d'hormone de croissance

Info

Publication number
EP0900086A4
EP0900086A4 EP97924576A EP97924576A EP0900086A4 EP 0900086 A4 EP0900086 A4 EP 0900086A4 EP 97924576 A EP97924576 A EP 97924576A EP 97924576 A EP97924576 A EP 97924576A EP 0900086 A4 EP0900086 A4 EP 0900086A4
Authority
EP
European Patent Office
Prior art keywords
growth hormone
hormone secretagogue
sleep stimulation
sleep
stimulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97924576A
Other languages
German (de)
English (en)
Other versions
EP0900086A1 (fr
Inventor
Joanne Waldstreicher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9611002.8A external-priority patent/GB9611002D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0900086A1 publication Critical patent/EP0900086A1/fr
Publication of EP0900086A4 publication Critical patent/EP0900086A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/25—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Anesthesiology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EP97924576A 1996-05-07 1997-05-05 Stimulation du sommeil avec un secretagogue d'hormone de croissance Withdrawn EP0900086A4 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US1678796P 1996-05-07 1996-05-07
US16787P 1996-05-07
GB9611002 1996-05-24
GBGB9611002.8A GB9611002D0 (en) 1996-05-24 1996-05-24 Enhancement of sleep with a growth hormone secreragogue
PCT/US1997/007516 WO1997041879A1 (fr) 1996-05-07 1997-05-05 Stimulation du sommeil avec un secretagogue d'hormone de croissance

Publications (2)

Publication Number Publication Date
EP0900086A1 EP0900086A1 (fr) 1999-03-10
EP0900086A4 true EP0900086A4 (fr) 2000-01-12

Family

ID=26309399

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97924576A Withdrawn EP0900086A4 (fr) 1996-05-07 1997-05-05 Stimulation du sommeil avec un secretagogue d'hormone de croissance

Country Status (5)

Country Link
EP (1) EP0900086A4 (fr)
JP (1) JP2000511885A (fr)
AU (1) AU711884B2 (fr)
CA (1) CA2253390A1 (fr)
WO (1) WO1997041879A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3220097A (en) 1996-05-22 1997-12-09 Arch Development Corporation Sleep quality improvement using a growth hormone secretagogue
WO2000048623A1 (fr) 1999-02-18 2000-08-24 Kaken Pharmaceutical Co., Ltd. Nouveaux derives amide secretagogues de l'hormone de croissance
IL143690A0 (en) * 2000-06-19 2002-04-21 Pfizer Prod Inc The use of growth hormone secretagogues to treat systemic lupus erythematosus and inflammatory bowel disease
IL144468A0 (en) * 2000-07-27 2002-05-23 Pfizer Prod Inc Use of growth hormone secretagogues for improvement of functional health status
JP4731031B2 (ja) * 2001-03-30 2011-07-20 株式会社デンソー 睡眠解析装置及びプログラム並びに記録媒体
EP1605940A1 (fr) * 2003-03-14 2005-12-21 Merck Sharp & Dohme Ltd. Methode permettant de traiter une deficience cognitive legere et de prevenir ou de retarder l'apparition la maladie d'alzheimer
WO2004108120A1 (fr) * 2003-06-11 2004-12-16 Pfizer Products Inc. Utilisation de sécrétagogues de l'hormone de croissance pour le traitement de la fibromyalgie
US7476653B2 (en) 2003-06-18 2009-01-13 Tranzyme Pharma, Inc. Macrocyclic modulators of the ghrelin receptor
KR20070046929A (ko) 2004-08-19 2007-05-03 버텍스 파마슈티칼스 인코포레이티드 무스카린 수용체 조절제
US7786141B2 (en) 2004-08-19 2010-08-31 Vertex Pharmaceuticals Incorporated Dihydrospiroindene modulators of muscarinic receptors
RU2007124373A (ru) 2004-11-29 2009-01-10 Вертекс Фармасьютикалз Инкорпорейтед (Us) Модуляторы мускариновых рецептеров
JP2009521483A (ja) 2005-12-22 2009-06-04 バーテックス ファーマシューティカルズ インコーポレイテッド ムスカリン受容体のモジュレーター
AU2007221214A1 (en) 2006-02-22 2007-09-07 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
EP1987034B1 (fr) 2006-02-22 2011-07-20 Vertex Pharmceuticals Incorporated Modulateurs des recepteurs muscariniques
CU23558A1 (es) 2006-02-28 2010-07-20 Ct Ingenieria Genetica Biotech Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento
CN101500565A (zh) 2006-06-29 2009-08-05 弗特克斯药品有限公司 毒蕈碱性受体的调节剂
AU2007284548A1 (en) 2006-08-15 2008-02-21 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
EP2051715A2 (fr) 2006-08-18 2009-04-29 Vertex Pharmceuticals Incorporated Modulateurs des récepteurs muscariniques
CA2677399C (fr) 2007-02-09 2016-09-13 Tranzyme Pharma, Inc. Modulateurs macrocycliques du recepteur de la ghreline et leurs procedes d'utilisation
US7973162B2 (en) 2007-10-03 2011-07-05 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0662481A1 (fr) * 1992-12-11 1995-07-12 Merck & Co. Inc. Spiro piperidines et ses homologues favorisants la libération de l'hormone de croissance.
WO1996040105A1 (fr) * 1995-06-07 1996-12-19 Arch Development Corporation UTILISATION DE η-HYDROXYBUTYRATE POUR STIMULER LA SECRETION DE L'HORMONE DE CROISSANCE ASSOCIEE AU SOMMEIL
WO1997034604A1 (fr) * 1996-03-21 1997-09-25 Merck & Co., Inc. 4-spiroindoline piperidines favorisant la liberation de l'hormone de croissance

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206235A (en) * 1991-03-20 1993-04-27 Merck & Co., Inc. Benzo-fused lactams that promote the release of growth hormone
US5578593A (en) * 1992-12-11 1996-11-26 Merck & Co., Inc. Spiro piperidines and homologs promote release of growth hormone
US5284841A (en) * 1993-02-04 1994-02-08 Merck & Co., Inc. Benzo-fused lactams promote release of growth hormone

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0662481A1 (fr) * 1992-12-11 1995-07-12 Merck & Co. Inc. Spiro piperidines et ses homologues favorisants la libération de l'hormone de croissance.
WO1996040105A1 (fr) * 1995-06-07 1996-12-19 Arch Development Corporation UTILISATION DE η-HYDROXYBUTYRATE POUR STIMULER LA SECRETION DE L'HORMONE DE CROISSANCE ASSOCIEE AU SOMMEIL
WO1997034604A1 (fr) * 1996-03-21 1997-09-25 Merck & Co., Inc. 4-spiroindoline piperidines favorisant la liberation de l'hormone de croissance

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BIOLOGICAL ABSTRACTS, vol. 1994, 1994, Philadelphia, PA, US; abstract no. 75188, M L HARTMAN ET AL.: "Normal control of growth hormone secretion" XP002122541 *
DATABASE MEDLINE 1 January 1900 (1900-01-01), XP002122540, Database accession no. 96320058 *
G COPINSCHI ET AL.: "Effects of a 7-day treatment with a novel, orally active, growth hormone secretagogue, MK-677,on 24-hour GH profiles, insulin-like growth factor I, amd adrenocortical function in normal young men", J. CLIN. ENDOCRINOL. METABOLISM, vol. 81, no. 8, August 1996 (1996-08-01), pages 2776 - 2782 *
HORMONE RESEARCH, vol. 40, no. 1-3, 1993, Basel, pages 37 - 47 *
J TAKAHARA ET AL.: "Inhibitory effects of substance P on the gamma-aminobutyric acid and gamma-hydroxybutyric acid-induced growth hormone and prolactin release in male rats", LIFE SCIENCES, vol. 29, no. 12, 1981, UK, pages 1229 - 1233, XP000600046 *
J TAKAHARA ET AL.: "Stimulatory effects of gamma-hydroxybutyric acid on growth hormone and prolactin release in humans", J CLIN. ENDOCRIN. METAB., vol. 44, no. 5, 1977, USA, pages 1014 - 1017, XP000600031 *
M MAMELAK ET AL.: "The effects of gamma-hydroxybutyrate on sleep", BIOLOGICAL PSYCHIATRY, vol. 12, no. 2, 1977, USA, pages 273 - 288, XP000600034 *
See also references of WO9741879A1 *

Also Published As

Publication number Publication date
AU711884B2 (en) 1999-10-21
EP0900086A1 (fr) 1999-03-10
AU2996397A (en) 1997-11-26
CA2253390A1 (fr) 1997-11-13
WO1997041879A1 (fr) 1997-11-13
JP2000511885A (ja) 2000-09-12

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