EP0997472A3 - Spirocyclische C-Glykoside - Google Patents

Spirocyclische C-Glykoside Download PDF

Info

Publication number
EP0997472A3
EP0997472A3 EP99307672A EP99307672A EP0997472A3 EP 0997472 A3 EP0997472 A3 EP 0997472A3 EP 99307672 A EP99307672 A EP 99307672A EP 99307672 A EP99307672 A EP 99307672A EP 0997472 A3 EP0997472 A3 EP 0997472A3
Authority
EP
European Patent Office
Prior art keywords
spirocyclic
glycosides
glycoside compounds
intermediates
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99307672A
Other languages
English (en)
French (fr)
Other versions
EP0997472A2 (de
Inventor
Chafiq Hamdouchi
Stephen Andrew Hitchcock
Almudena Rubio Esteban
Concepcion Sanchez-Martinez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of EP0997472A2 publication Critical patent/EP0997472A2/de
Publication of EP0997472A3 publication Critical patent/EP0997472A3/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP99307672A 1998-09-30 1999-09-29 Spirocyclische C-Glykoside Withdrawn EP0997472A3 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10240098P 1998-09-30 1998-09-30
US102400P 1998-09-30

Publications (2)

Publication Number Publication Date
EP0997472A2 EP0997472A2 (de) 2000-05-03
EP0997472A3 true EP0997472A3 (de) 2001-03-28

Family

ID=22289644

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99307672A Withdrawn EP0997472A3 (de) 1998-09-30 1999-09-29 Spirocyclische C-Glykoside

Country Status (4)

Country Link
US (1) US6069238A (de)
EP (1) EP0997472A3 (de)
JP (1) JP2000109497A (de)
CA (1) CA2278960A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH12000002657B1 (en) 1999-10-12 2006-02-21 Bristol Myers Squibb Co C-aryl glucoside SGLT2 inhibitors
US6683056B2 (en) 2000-03-30 2004-01-27 Bristol-Myers Squibb Company O-aryl glucoside SGLT2 inhibitors and method
US6555519B2 (en) 2000-03-30 2003-04-29 Bristol-Myers Squibb Company O-glucosylated benzamide SGLT2 inhibitors and method
US6936590B2 (en) 2001-03-13 2005-08-30 Bristol Myers Squibb Company C-aryl glucoside SGLT2 inhibitors and method
JP2006516257A (ja) 2003-01-03 2006-06-29 ブリストル−マイヤーズ　スクイブ　カンパニー Ｃ−アリールグルコシドｓｇｌｔ２阻害剤の製造法
WO2004076470A2 (en) * 2003-02-27 2004-09-10 Bristol-Myers Squibb Company A non-cryogenic process for forming glycosides
CA2634468C (en) 2005-12-23 2014-10-07 Ecobiotics Limited Spiroketals
US7803778B2 (en) * 2006-05-23 2010-09-28 Theracos, Inc. Glucose transport inhibitors and methods of use
US7919598B2 (en) 2006-06-28 2011-04-05 Bristol-Myers Squibb Company Crystal structures of SGLT2 inhibitors and processes for preparing same
US7795228B2 (en) * 2006-12-28 2010-09-14 Theracos, Inc. Spiroheterocyclic glycosides and methods of use
RS56990B1 (sr) * 2007-09-10 2018-05-31 Janssen Pharmaceutica Nv Postupak za dobijanje jedinjenja koja su korisna kao inhibitori sglt
UA101004C2 (en) 2007-12-13 2013-02-25 Теракос, Инк. Derivatives of benzylphenylcyclohexane and use thereof
FR2926021B1 (fr) * 2008-01-03 2012-12-14 Oreal Utilisation de derives c-glycoside a titre d'actif vasculaire
CN103910702A (zh) * 2008-08-22 2014-07-09 泰拉科斯有限公司 制备sglt2抑制剂的方法
AU2009286380B2 (en) * 2008-08-28 2011-09-15 Pfizer Inc. Dioxa-bicyclo[3.2.1.]octane-2,3,4-triol derivatives
US9056850B2 (en) * 2008-10-17 2015-06-16 Janssen Pharmaceutica N.V. Process for the preparation of compounds useful as inhibitors of SGLT
US20110009347A1 (en) 2009-07-08 2011-01-13 Yin Liang Combination therapy for the treatment of diabetes
EP2451797B1 (de) 2009-07-10 2013-04-03 Janssen Pharmaceutica, N.V. Kristallisationsverfahren für 1-(beta-d-glucopyranosyl)-4-methyl-3-[5-(4-fluorphenyl)-2-thienylmethyl]benzol
HUE031375T2 (en) * 2009-10-14 2017-07-28 Janssen Pharmaceutica Nv Process for the preparation of compounds useful as inhibitors of sglt2
RS53827B1 (sr) 2009-11-02 2015-06-30 Pfizer Inc. Derivati dioksa-biciklo[3.2.1]oktan-2,3,4-triola
SG10201506114UA (en) 2010-05-11 2015-09-29 Janssen Pharmaceutica Nv Pharmaceutical formulations comprising 1 - (beta-d-glucopyranosyl) - 2 -thienylmethylbenzene derivatives as inhibitors of sglt
WO2011153712A1 (en) 2010-06-12 2011-12-15 Theracos, Inc. Crystalline form of benzylbenzene sglt2 inhibitor
EP2697218B1 (de) 2011-04-13 2016-05-25 Janssen Pharmaceutica NV Verfahren zur herstellung von verbindungen die als sglt2 inhibitoren verwendbar sind
TWI542596B (zh) 2011-05-09 2016-07-21 健生藥品公司 （２ｓ,３ｒ,４ｒ,５ｓ,６ｒ）－２－（３－（（５－（４－氟苯基）噻吩－２－基）甲基）－４－甲基苯基）－６－（羥甲基）四氫－２ｈ－哌喃－３,４,５－三醇之ｌ－脯胺酸及檸檬酸共晶體
WO2013152476A1 (en) 2012-04-10 2013-10-17 Theracos, Inc. Process for the preparation of benzylbenzene sglt2 inhibitors
CN105611920B (zh) 2013-10-12 2021-07-16 泰拉科斯萨普有限责任公司 羟基-二苯甲烷衍生物的制备
US20170071970A1 (en) 2015-09-15 2017-03-16 Janssen Pharmaceutica Nv Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders
CN111233915B (zh) * 2018-11-28 2023-09-22 上海科胜药物研发有限公司 一种2,3,4,6-四-o-三甲基硅基-d-葡萄糖酸内酯的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4278665A (en) * 1975-03-13 1981-07-14 Ciba-Geigy Corporation Papulacandin derivatives and pharmaceutical compositions containing same
EP0443654A2 (de) * 1990-02-13 1991-08-28 Merck & Co. Inc. Antibiotisch wirksames Mittel

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4278665A (en) * 1975-03-13 1981-07-14 Ciba-Geigy Corporation Papulacandin derivatives and pharmaceutical compositions containing same
EP0443654A2 (de) * 1990-02-13 1991-08-28 Merck & Co. Inc. Antibiotisch wirksames Mittel
US5091413A (en) * 1990-02-13 1992-02-25 Merck & Co., Inc. Antibiotic agent

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
A.G.M.BARRETT ET AL.: "Total Synthesis and Structural Elucidation of the Antifungal Agent Papulacandin D.", JOURNAL OF ORGANIC CHEMISTRY., vol. 61, no. 3, 9 February 1996 (1996-02-09), AMERICAN CHEMICAL SOCIETY. EASTON., US, pages 1082 - 1100, XP002158240, ISSN: 0022-3263 *

Also Published As

Publication number Publication date
EP0997472A2 (de) 2000-05-03
US6069238A (en) 2000-05-30
JP2000109497A (ja) 2000-04-18
CA2278960A1 (en) 2000-03-30

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