EP1007073A4 - Procedes de modification du comportement alimentaire, composes utiles dans lesdits procedes, et adn codant un recepteur y5 atypique hypothalamique de neuropeptide y/peptide yy - Google Patents

Procedes de modification du comportement alimentaire, composes utiles dans lesdits procedes, et adn codant un recepteur y5 atypique hypothalamique de neuropeptide y/peptide yy

Info

Publication number: EP1007073A4
Authority: EP; European Patent Office
Prior art keywords: procedures; hypothalamic; neuropeptide; atypical; peptide
Prior art date: 1996-06-04
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP97928786A

Other languages

German (de)

English (en)

Other versions

EP1007073A1 (fr

Inventor

Christophe P G Gerald

Richard L Weinshank

Mary W Walker

Theresa Branchek

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Lundbeck Research USA Inc

Original Assignee

Synaptic Pharmaceutical Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-06-04

Filing date

1997-06-04

Publication date

2002-03-27

1996-06-04 Priority claimed from US08/668,650 external-priority patent/US5989920A/en

1997-06-04 Application filed by Synaptic Pharmaceutical Corp filed Critical Synaptic Pharmaceutical Corp

2000-06-14 Publication of EP1007073A1 publication Critical patent/EP1007073A1/fr

2002-03-27 Publication of EP1007073A4 publication Critical patent/EP1007073A4/fr

Status Withdrawn legal-status Critical Current

Links

238000000034 method Methods 0.000 title 2
108050002826 Neuropeptide Y Receptor Proteins 0.000 title 1
102100028427 Pro-neuropeptide Y Human genes 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
235000006694 eating habits Nutrition 0.000 title 1
230000002267 hypothalamic effect Effects 0.000 title 1
URPYMXQQVHTUDU-OFGSCBOVSA-N nucleopeptide y Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 URPYMXQQVHTUDU-OFGSCBOVSA-N 0.000 title 1
108010070727 peptide YY receptor Proteins 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Cell Biology (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Biomedical Technology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Neurology (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Engineering & Computer Science (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

EP97928786A 1996-06-04 1997-06-04 Procedes de modification du comportement alimentaire, composes utiles dans lesdits procedes, et adn codant un recepteur y5 atypique hypothalamique de neuropeptide y/peptide yy Withdrawn EP1007073A4 (fr)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US08/668,650 US5989920A (en)	1994-12-02	1996-06-04	Methods of modifying feeding behavior compounds useful in such methods and DNA encoding a hypothalmic atypical neuropeptide Y/peptide YY receptor Y5
US668650		1996-06-04
US80360097A	1997-02-21	1997-02-21
US803600		1997-02-21
PCT/US1997/009504 WO1997046250A1 (fr)	1996-06-04	1997-06-04	Procedes de modification du comportement alimentaire, composes utiles dans lesdits procedes, et adn codant un recepteur y5 atypique hypothalamique de neuropeptide y/peptide yy

Publications (2)

Publication Number	Publication Date
EP1007073A1 EP1007073A1 (fr)	2000-06-14
EP1007073A4 true EP1007073A4 (fr)	2002-03-27

Family

ID=27099966

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP97928786A Withdrawn EP1007073A4 (fr)	1996-06-04	1997-06-04	Procedes de modification du comportement alimentaire, composes utiles dans lesdits procedes, et adn codant un recepteur y5 atypique hypothalamique de neuropeptide y/peptide yy

Country Status (3)

Country	Link
EP (1)	EP1007073A4 (fr)
AU (1)	AU3295297A (fr)
WO (1)	WO1997046250A1 (fr)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5602024A (en)	1994-12-02	1997-02-11	Synaptic Pharmaceutical Corporation	DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) and uses thereof
US5989920A (en)	1994-12-02	1999-11-23	Synaptic Pharmaceutical Corporation	Methods of modifying feeding behavior compounds useful in such methods and DNA encoding a hypothalmic atypical neuropeptide Y/peptide YY receptor Y5
AUPN646795A0 (en)	1995-11-09	1995-11-30	Garvan Institute Of Medical Research	Neuropeptide Y-Y5 receptor
US6713265B1 (en)	1997-06-04	2004-03-30	Synaptic Pharmaceutical Corporation	Methods of modifying feeding behavior, compounds useful in such methods, and DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5)
SE9703414D0 (sv) *	1997-09-23	1997-09-23	Astra Ab	New compounds
ATE314371T1 (de)	1998-11-10	2006-01-15	Merck & Co Inc	Spiro-indole als y5-rezeptor antagonisten
WO2000063171A1 (fr)	1999-04-20	2000-10-26	Meiji Seika Kaisha, Ltd.	Composes tricycliques
CA2403307A1 (fr)	2001-10-23	2003-04-23	Neurogen Corporation	Derives de l'imidazole 2-cyclohexyl-4-phenyl-1h substitue
NZ534757A (en)	2002-03-12	2006-07-28	Merck & Co Inc	Substituted amides
WO2004066966A2 (fr)	2003-01-17	2004-08-12	Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S.	Analogues du peptide yy
JP2004315511A (ja) *	2003-03-31	2004-11-11	Taisho Pharmaceut Co Ltd	Ｍｃｈ受容体アンタゴニスト
JP4806628B2 (ja)	2003-05-05	2011-11-02	プロビオドルグエージー	グルタミニルシクラーゼ阻害剤
EP2338490A3 (fr)	2003-11-03	2012-06-06	Probiodrug AG	Combinaisons utiles pour le traitement de désordres neuronales
US7304086B2 (en)	2004-02-05	2007-12-04	Probiodrug Ag	Inhibitors of glutaminyl cyclase
US8193206B2 (en)	2005-06-14	2012-06-05	Taigen Biotechnology Co., Ltd.	Pyrimidine compounds
JP5118029B2 (ja)	2005-06-14	2013-01-16	タイゲンバイオテクノロジーカンパニー，リミテッド	ピリミジン化合物
EP2089383B1 (fr)	2006-11-09	2015-09-16	Probiodrug AG	Dérivés 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one utiles en tant qu' inhibiteurs de la glutaminyl-cyclase dans le traitement des ulcères, du cancer et d'autres maladies
US9126987B2 (en)	2006-11-30	2015-09-08	Probiodrug Ag	Inhibitors of glutaminyl cyclase
AU2008220785B2 (en)	2007-03-01	2013-02-21	Vivoryon Therapeutics N.V.	New use of glutaminyl cyclase inhibitors
JP5667440B2 (ja)	2007-04-18	2015-02-12	プロビオドルグエージー	グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体
AU2008355098B2 (en)	2008-04-21	2012-11-15	Gpcr Therapeutics, Inc	Heterocyclic compounds
US20090298834A1 (en) *	2008-06-02	2009-12-03	Hassan Pajouhesh	4-(aminomethyl)cyclohexanamine derivatives as calcium channel blockers
WO2010056847A2 (fr)	2008-11-13	2010-05-20	Taigen Biotechnology Co., Ltd.	Formule lyophilisée
JP5934645B2 (ja)	2009-09-11	2016-06-15	プロビオドルグエージー	グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体
WO2011107530A2 (fr)	2010-03-03	2011-09-09	Probiodrug Ag	Nouveaux inhibiteurs
JP5688745B2 (ja)	2010-03-10	2015-03-25	プロビオドルグエージー	グルタミニルシクラーゼ（ｑｃ、ｅｃ２．３．２．５）の複素環阻害剤
WO2011131748A2 (fr)	2010-04-21	2011-10-27	Probiodrug Ag	Nouveaux inhibiteurs
EP2686313B1 (fr)	2011-03-16	2016-02-03	Probiodrug AG	Dérivés de benzimidazole en tant qu'inhibiteurs de la glutaminyl cyclase
ES2812698T3 (es)	2017-09-29	2021-03-18	Probiodrug Ag	Inhibidores de glutaminil ciclasa
CN114340670B (zh)	2019-07-11	2026-02-17	普拉克西斯精密药物股份有限公司	T-型钙通道调节剂的制剂及其使用方法
PL448201A1 (pl) *	2024-04-05	2025-10-06	Politechnika Krakowska im. Tadeusza Kościuszki	Nowe pochodne N-{6-[(3,4-dihydrochinazolin-2-ylo)amino]heksylo}naftaleno-sulfonamidów, sposób ich otrzymywania oraz ich zastosowanie

Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1996016542A1 (fr) *	1994-12-02	1996-06-06	Synaptic Pharmaceutical Corporation	Procedes de modification du comportement alimentaire, composes utiles dans ces procedes, et adn codant un recepteur (y5) d'un neuropeptide y/peptide yy atypique hypothalamique
WO1997017440A1 (fr) *	1995-11-09	1997-05-15	Garvan Institute Of Medical Research	Recepteur de neuropeptide y-y5
WO1997020822A1 (fr) *	1995-12-01	1997-06-12	Novartis Ag	Quinazolin-2,4-diazirines en tant qu'antagoniste du recepteur du neuropeptide y
WO1997020820A1 (fr) *	1995-12-01	1997-06-12	Novartis Ag	Composes heteroaryles
WO1997037998A2 (fr) *	1996-04-08	1997-10-16	Bayer Corporation	Recepteur y5 du neuropeptide y et sequence d'acide nucleique

1997
- 1997-06-04 WO PCT/US1997/009504 patent/WO1997046250A1/fr not_active Ceased
- 1997-06-04 AU AU32952/97A patent/AU3295297A/en not_active Abandoned
- 1997-06-04 EP EP97928786A patent/EP1007073A4/fr not_active Withdrawn

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1996016542A1 (fr) *	1994-12-02	1996-06-06	Synaptic Pharmaceutical Corporation	Procedes de modification du comportement alimentaire, composes utiles dans ces procedes, et adn codant un recepteur (y5) d'un neuropeptide y/peptide yy atypique hypothalamique
WO1997017440A1 (fr) *	1995-11-09	1997-05-15	Garvan Institute Of Medical Research	Recepteur de neuropeptide y-y5
WO1997020822A1 (fr) *	1995-12-01	1997-06-12	Novartis Ag	Quinazolin-2,4-diazirines en tant qu'antagoniste du recepteur du neuropeptide y
WO1997020820A1 (fr) *	1995-12-01	1997-06-12	Novartis Ag	Composes heteroaryles
WO1997037998A2 (fr) *	1996-04-08	1997-10-16	Bayer Corporation	Recepteur y5 du neuropeptide y et sequence d'acide nucleique

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
BARD JONATHAN A ET AL: "Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 45, 1995, pages 26762 - 26765, XP002187958, ISSN: 0021-9258 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1993, HERZOG HERBERT ET AL: "Molecular cloning, characterization, and localization of the human homolog to the reported bovine NPY Y3 receptor: Lack of NPY binding and activation.", XP002187960, Database accession no. PREV199396087299 *
DNA AND CELL BIOLOGY, vol. 12, no. 6, 1993, pages 465 - 471, ISSN: 1044-5498 *
GERALD C ET AL: "A RECEPTOR SUBTYPE INVOLVED IN NEUROPEPTIDE-Y-INDUCED FOOD INTAKE", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 382, 11 July 1996 (1996-07-11), pages 168 - 171, XP000612078, ISSN: 0028-0836 *
GERALD CHRISTOPHE ET AL: "Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 45, 1995, pages 26758 - 26761, XP002187957, ISSN: 0021-9258 *
HU Y ET AL: "IDENTIFICATION OF A NOVEL HYPOTHALAMIC NEUROPEPTIDE Y RECEPTOR ASSOCIATED WITH FEEDING BEHAVIOR", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 271, no. 42, 18 October 1996 (1996-10-18), pages 26315 - 26319, XP002040612, ISSN: 0021-9258 *
LARHAMMAR D ET AL: "CLONING AND FUNCTIONAL EXPRESSION OF A HUMAN NEUROPEPTIDE Y-PEPTIDE YY RECEPTOR OF THE Y1 TYPE", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 267, no. 16, 1992, pages 10935 - 10938, XP000612077, ISSN: 0021-9258 *
LUNDELL INGRID ET AL: "Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 49, 1995, pages 29123 - 29128, XP002187959, ISSN: 0021-9258 *
ROSE PATRICIA M ET AL: "Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 39, 1995, pages 22661 - 22664, XP002187956, ISSN: 0021-9258 *
See also references of WO9746250A1 *

Also Published As

Publication number	Publication date
AU3295297A (en)	1998-01-05
WO1997046250A1 (fr)	1997-12-11
EP1007073A1 (fr)	2000-06-14

Legal Events

Date	Code	Title	Description
2000-04-28	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2000-06-14	17P	Request for examination filed	Effective date: 19990104
2000-06-14	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2002-03-27	A4	Supplementary search report drawn up and despatched	Effective date: 20020213
2002-03-27	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2003-11-05	17Q	First examination report despatched	Effective date: 20030917
2006-01-20	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2006-03-08	18D	Application deemed to be withdrawn	Effective date: 20050830

Publication	Publication Date	Title
EP1007073A4 (fr)	2002-03-27	Procedes de modification du comportement alimentaire, composes utiles dans lesdits procedes, et adn codant un recepteur y5 atypique hypothalamique de neuropeptide y/peptide yy
ATE244304T1 (de)	2003-07-15	Verfahren zur veränderung des essverhaltens, dafür verwendbare verbindungen und dna, die einen hypothalamischen atypischen neuropeptid y/peptid yy rezeptor (y5) kodiert
DE59705513D1 (de)	2002-01-10	Verfahren zur Hydrierung
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DE60117726D1 (de)	2006-05-04	System und Verfahren zur Schlüsselumwandlung
IS5410A (is)	2000-03-20	Ný mótlyf taugapeptíðs Y (NPY)
EP0654947A4 (fr)	1996-04-03	Codeur et procede de codage.
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