EP1017383A4 - Thrombininhibitoren - Google Patents

Thrombininhibitoren

Info

Publication number
EP1017383A4
EP1017383A4 EP98947119A EP98947119A EP1017383A4 EP 1017383 A4 EP1017383 A4 EP 1017383A4 EP 98947119 A EP98947119 A EP 98947119A EP 98947119 A EP98947119 A EP 98947119A EP 1017383 A4 EP1017383 A4 EP 1017383A4
Authority
EP
European Patent Office
Prior art keywords
thrombin inhibitors
thrombin
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98947119A
Other languages
English (en)
French (fr)
Other versions
EP1017383A1 (de
Inventor
Craig Coburn
Joseph P Vacca
Peter D Williams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9807941.1A external-priority patent/GB9807941D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP1017383A1 publication Critical patent/EP1017383A1/de
Publication of EP1017383A4 publication Critical patent/EP1017383A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EP98947119A 1997-09-23 1998-09-18 Thrombininhibitoren Withdrawn EP1017383A4 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5980197P 1997-09-23 1997-09-23
US59801P 1997-09-23
GB9807941 1998-04-15
GBGB9807941.1A GB9807941D0 (en) 1998-04-15 1998-04-15 Thrombin inhibitors
PCT/US1998/019471 WO1999015169A1 (en) 1997-09-23 1998-09-18 Thrombin inhibitors

Publications (2)

Publication Number Publication Date
EP1017383A1 EP1017383A1 (de) 2000-07-12
EP1017383A4 true EP1017383A4 (de) 2001-11-28

Family

ID=26313472

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98947119A Withdrawn EP1017383A4 (de) 1997-09-23 1998-09-18 Thrombininhibitoren

Country Status (5)

Country Link
EP (1) EP1017383A4 (de)
JP (1) JP2001517623A (de)
AU (1) AU740447B2 (de)
CA (1) CA2301614A1 (de)
WO (1) WO1999015169A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6239132B1 (en) 1999-04-23 2001-05-29 Merck & Co., Inc. Thrombin inhibitors
CA2374654A1 (en) * 1999-06-04 2000-12-14 Merck & Co., Inc. Thrombin inhibitors
FR2795072B1 (fr) * 1999-06-15 2001-07-27 Adir Nouveaux derives bicycliques d'amino-pyrazinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds
BR112020018094A2 (pt) 2018-03-08 2020-12-22 Incyte Corporation Compostos de aminopirazina diol como inibidores de pi3k-¿
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996019483A1 (en) * 1994-12-22 1996-06-27 Biochem Pharma Inc. Low molecular weight bicyclic thrombin inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW263498B (de) * 1993-11-10 1995-11-21 Takeda Pharm Industry Co Ltd

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996019483A1 (en) * 1994-12-22 1996-06-27 Biochem Pharma Inc. Low molecular weight bicyclic thrombin inhibitors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
OKAYAMA T ET AL: "LACTAM-CONFORMATIONALLY RESTRICTED ANALOGS OF NALPHA-ARYLSULFONYL ARGININE AMIDE: DESIGN, SYNTHESIS AND INHIBITORY ACTIVITY TOWARD THROMBIN AND RELATED ENZYMES", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN. TOKYO, JP, vol. 43, no. 10, October 1995 (1995-10-01), pages 1683 - 1691, XP000942057, ISSN: 0009-2363 *
See also references of WO9915169A1 *

Also Published As

Publication number Publication date
WO1999015169A1 (en) 1999-04-01
AU740447B2 (en) 2001-11-01
EP1017383A1 (de) 2000-07-12
AU9397398A (en) 1999-04-12
JP2001517623A (ja) 2001-10-09
CA2301614A1 (en) 1999-04-01

Similar Documents

Publication Publication Date Title
EP0969840A4 (de) Thrombin inhibitoren
EP0971891A4 (de) Thrombin-inhibitoren
EP1124822A4 (de) Thrombin inhibitoren
EP0927035A4 (de) Thrombin inhibitoren
EP0820453A4 (de) Thrombin-inhibitoren
EP0923372A4 (de) Inhibitoren von pyridinone thrombin
NO973657D0 (no) Trombin-inhibitorer
PT936912E (pt) Inibidores de cisteina protease
EP1017393A4 (de) Pyrazinon thrombininhibitoren
DK0956294T3 (da) Thrombininhibitorer
ATE239755T1 (de) Thrombin inhibitoren
PT958287E (pt) Inibidores de sulfamida-metaloprotease
NO20002659D0 (no) Trombinreseptorantagonister
EP1117660A4 (de) Thrombin-inhibitoren
NO20003814D0 (no) Trombininhibitorer
EP1017383A4 (de) Thrombininhibitoren
GB9613718D0 (en) Thrombin inhibitors
ATE282629T1 (de) Thrombininhibitoren
EP1039907A4 (de) Thrombin hemmer
EP1189618A4 (de) Thrombinhemmer
EP1027333A4 (de) Thrombin-inhibitoren
GB9704209D0 (en) Thrombin inhibitors
GB9716872D0 (en) Thrombin Inhibitors
MA26429A1 (fr) Inhibiteurs de protease
GB9806034D0 (en) Thrombin inhibitors

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20000425

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

AX Request for extension of the european patent

Free format text: AL PAYMENT 20000425;LT PAYMENT 20000425;LV PAYMENT 20000425;MK PAYMENT 20000425;RO PAYMENT 20000425;SI PAYMENT 20000425

A4 Supplementary search report drawn up and despatched

Effective date: 20011016

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

RIC1 Information provided on ipc code assigned before grant

Free format text: 7C 07K 5/06 A, 7A 61K 31/435 B, 7C 07D 471/04 B

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20040331