EP1039907A4 - Thrombin hemmer - Google Patents

Thrombin hemmer

Info

Publication number
EP1039907A4
EP1039907A4 EP98959636A EP98959636A EP1039907A4 EP 1039907 A4 EP1039907 A4 EP 1039907A4 EP 98959636 A EP98959636 A EP 98959636A EP 98959636 A EP98959636 A EP 98959636A EP 1039907 A4 EP1039907 A4 EP 1039907A4
Authority
EP
European Patent Office
Prior art keywords
thrombin inhibitors
thrombin
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98959636A
Other languages
English (en)
French (fr)
Other versions
EP1039907A1 (de
Inventor
Craig Coburn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9809784.3A external-priority patent/GB9809784D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP1039907A1 publication Critical patent/EP1039907A1/de
Publication of EP1039907A4 publication Critical patent/EP1039907A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EP98959636A 1997-12-01 1998-11-25 Thrombin hemmer Withdrawn EP1039907A4 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6709697P 1997-12-01 1997-12-01
US67096P 1997-12-01
GB9809784 1998-05-07
GBGB9809784.3A GB9809784D0 (en) 1998-05-07 1998-05-07 Thrombin Inhibitors
PCT/US1998/025362 WO1999027930A1 (en) 1997-12-01 1998-11-25 Thrombin inhibitors

Publications (2)

Publication Number Publication Date
EP1039907A1 EP1039907A1 (de) 2000-10-04
EP1039907A4 true EP1039907A4 (de) 2001-09-19

Family

ID=26313616

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98959636A Withdrawn EP1039907A4 (de) 1997-12-01 1998-11-25 Thrombin hemmer

Country Status (5)

Country Link
EP (1) EP1039907A4 (de)
JP (1) JP2001524522A (de)
AU (1) AU741766B2 (de)
CA (1) CA2309347A1 (de)
WO (1) WO1999027930A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002528543A (ja) * 1998-10-30 2002-09-03 メルク エンド カムパニー インコーポレーテッド トロンビン阻害剤
DE19900471A1 (de) * 1999-01-08 2000-07-13 Merck Patent Gmbh Imidazo[4,5c]-pyridin-4-on-derivate
MD3762368T2 (ro) 2018-03-08 2022-07-31 Incyte Corp Compuși diol aminopirazină ca inhibitori ai PI3K-Y
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997001338A1 (en) * 1995-06-27 1997-01-16 Merck & Co., Inc. Pyridinone-thrombin inhibitors
WO1997030708A1 (en) * 1996-02-22 1997-08-28 Merck & Co., Inc. Pyridinone thrombin inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5658930A (en) * 1994-12-13 1997-08-19 Corvas International, Inc. Aromatic heterocyclic derivatives as enzyme inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997001338A1 (en) * 1995-06-27 1997-01-16 Merck & Co., Inc. Pyridinone-thrombin inhibitors
WO1997030708A1 (en) * 1996-02-22 1997-08-28 Merck & Co., Inc. Pyridinone thrombin inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9927930A1 *

Also Published As

Publication number Publication date
WO1999027930A1 (en) 1999-06-10
EP1039907A1 (de) 2000-10-04
JP2001524522A (ja) 2001-12-04
AU1539599A (en) 1999-06-16
AU741766B2 (en) 2001-12-06
CA2309347A1 (en) 1999-06-10

Similar Documents

Publication Publication Date Title
EP0969840A4 (de) Thrombin inhibitoren
EP0971891A4 (de) Thrombin-inhibitoren
EP1124822A4 (de) Thrombin inhibitoren
EP0927035A4 (de) Thrombin inhibitoren
EP0820453A4 (de) Thrombin-inhibitoren
EP0923372A4 (de) Inhibitoren von pyridinone thrombin
FI973282A7 (fi) Trombiinin inhibiittoreita
PT936912E (pt) Inibidores de cisteina protease
EP1017393A4 (de) Pyrazinon thrombininhibitoren
DK0956294T3 (da) Thrombininhibitorer
ATE239755T1 (de) Thrombin inhibitoren
PT958287E (pt) Inibidores de sulfamida-metaloprotease
NO20002659D0 (no) Trombinreseptorantagonister
EP1117660A4 (de) Thrombin-inhibitoren
NO20003814L (no) Trombininhibitorer
EP1017383A4 (de) Thrombininhibitoren
GB9613718D0 (en) Thrombin inhibitors
ATE282629T1 (de) Thrombininhibitoren
EP1189618A4 (de) Thrombinhemmer
EP1027333A4 (de) Thrombin-inhibitoren
GB9716872D0 (en) Thrombin Inhibitors
GB9704209D0 (en) Thrombin inhibitors
MA26429A1 (fr) Inhibiteurs de protease
GB9809784D0 (en) Thrombin Inhibitors
GB9807941D0 (en) Thrombin inhibitors

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20000703

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

AX Request for extension of the european patent

Free format text: AL PAYMENT 20000703;LT PAYMENT 20000703;LV PAYMENT 20000703;MK PAYMENT 20000703;RO PAYMENT 20000703;SI PAYMENT 20000703

A4 Supplementary search report drawn up and despatched

Effective date: 20010806

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

17Q First examination report despatched

Effective date: 20021023

GRAH Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOS IGRA

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20031210