EP1043018B1 - Pflaster mit magnetischer Wirkung - Google Patents

Pflaster mit magnetischer Wirkung Download PDF

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Publication number
EP1043018B1
EP1043018B1 EP00400490A EP00400490A EP1043018B1 EP 1043018 B1 EP1043018 B1 EP 1043018B1 EP 00400490 A EP00400490 A EP 00400490A EP 00400490 A EP00400490 A EP 00400490A EP 1043018 B1 EP1043018 B1 EP 1043018B1
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EP
European Patent Office
Prior art keywords
patch
matrix
acid
agents
polymer matrix
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP00400490A
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English (en)
French (fr)
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EP1043018A1 (de
Inventor
Jean-Louis H. Gueret
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LOreal SA
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LOreal SA
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Publication date
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Publication of EP1043018A1 publication Critical patent/EP1043018A1/de
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Publication of EP1043018B1 publication Critical patent/EP1043018B1/de
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0208—Tissues; Wipes; Patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A61K8/0245—Specific shapes or structures not provided for by any of the groups of A61K8/0241
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
    • A61F2013/0296—Apparatus or processes for manufacturing adhesive dressings or bandages for making transdermal patches (chemical processes excluded)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/47—Magnetic materials; Paramagnetic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

Definitions

  • the present invention relates to a patch intended to be temporarily applied to the skin to exert on it a cosmetic action and / or a pharmaceutical treatment.
  • Patches are known, in particular from document WO-96/14822, comprising a support sheet coated on one side with a reservoir layer called a matrix, containing one or more active substances intended to diffuse into the skin and / or to act on it.
  • German utility model DE 86 10 769.0 suggests incorporating into a cream intended to form a mask, beauty or care, small magnets, having a magnetic moment with at least one north pole and one south pole.
  • the cream is mineral, especially based on clay, petroleum jelly or plaster.
  • the size of the magnets may range from 0.5 mm to 30 mm, and preferably from 2 mm to 10 mm.
  • DE-A-36 19 987 discloses a major problem with the structure described in DE 86 10 769.0 mentioned above. This problem is due to the fact that magnets, because of their permanent magnetization, tend to attract, or repel, and thus form packets. In the resulting preparation, the magnets are not homogeneously dispersed. The results on application are not satisfactory. To solve this problem, the document DE-A-36 19 987 proposes to stick the magnets on a support, and then coat the support of said cosmetic preparation. The user thus applies the preparation as deposited on a support. Such a solution suffers mainly from the fact that the mineral matrix, especially when it is made from plaster or clay, will dry and harden or after a certain time of application, providing a feeling of discomfort relatively important. The rigidity of the whole is reinforced by the presence of magnets, of relatively large size, glued on the support. In addition, the distribution of magnets in the preparation is not homogeneous, which can be detrimental in terms of efficiency.
  • the Applicant has surprisingly discovered that such a magnetic field effect can be obtained, in a simple and effective manner, by incorporating the active agent (s) to be used in the polymeric matrix of a patch, preferably an adhesive patch, and dispersing in the matrix a quantity of magnetic particles, which is permanently oriented, after setting of the matrix, by passing the patch in a magnetic field.
  • the skin is thus placed in engagement, simultaneously with one or more active agents, and with magnetic particles, permanently oriented, in particular so as to promote the penetration of the active ingredients into the skin.
  • the present invention provides a patch according to claim 1.
  • the polymeric matrix is preferably anhydrous or hydrophobic.
  • the magnetic particles are dispersed homogeneously in the matrix.
  • the matrix once polymerized at least partially, in particular by crosslinking, polyaddition or polycondensation, forms a fixed structure in which the magnetic particles are immobilized.
  • the particles of all or part of the patch can be subjected to a magnetic field, so as to be permanently magnetized.
  • the particles remain dispersed homogeneously in the matrix and retain their magnetic orientation.
  • the effects are uniform over the entire magnetized surface of the patch.
  • the magnetic field lines generated by the permanently oriented magnetic particles, have a beneficial action, in particular on the oxygenation of the skin, and on the microcirculation, thus contributing to promoting the penetration of active in the skin and enhance its effectiveness.
  • the exposure times of the patches according to the invention can be reduced significantly.
  • the concentrations of certain active ingredients, considered to be aggressive for the skin, can be reduced significantly.
  • the magnetic particles can itself play the role of active substance, insofar as the magnetic field that they generate, may have, acting on the microcirculation, an effect, including slimming.
  • Said magnetic particles may in particular be ferrite particles, especially based on zinc and manganese.
  • particles sold under the trade name MagaBeads® are used by CORTEX BIOCHEM.
  • the volume percentage of said magnetic particles within the polymeric matrix may range from 0.1 to 80%, and preferably from 1% to 30%, and more preferably from 2% to 15%.
  • Said particles may be coated, in particular of polyurethane, epoxy, polyester, polyamide or cyanoacrylate. Such a coating contributes to the protection of magnetic particles when they are brought into the presence of water, especially under the effect of perspiration of the skin.
  • the magnetic particles can be oriented such that, on at least a portion of the patch surface, the generated magnetic field lines extend from a first face of the patch to a second face, opposite to the first face.
  • the magnetic particles are oriented such that on at least a portion of the patch surface the generated magnetic field lines extend from a first edge of the patch to a second edge opposite the first edge.
  • Other arrangements or combinations can be obtained, in particular by multiplying the passages in the same or different magnetic fields, or by acting on the characteristics of the magnetization bench used.
  • the active substance (s) may be chosen from slimming agents, cleansers, anti-oxidants, anti-free radicals, moisturizers, depigmenting agents, liporegulators, anti-acne agents, anti-seborrhoeic agents, anti-aging agents, anti-aging agents, -rides, keratolitics, anti-inflammatory, refreshing, healing, vascular protective, anti-bacterial, antifungal, antiperspirants, deodorants, skin conditioners, insensitizers, immunomodulators and nourishing, moisture absorbers (cotton, polyacrylate), sebum (Orgasol).
  • the polymeric matrix may comprise at least one water-soluble active substance chosen from the following compounds: ascorbic acid and its biologically compatible salts, enzymes, antibiotics, tensor-effect components, ⁇ -hydroxy acids and their salts, hydroxylated polyacids, sucroses and their derivatives, urea, amino acids, oligopeptides, water-soluble plant extracts, and yeasts, protein hydrolysates, hyaluronic acid, mucopolysaccharides, vitamins B 2 , B 6 , H, PP, panthenol, folic acid, acetyl salicylic acid, allantoin, glycyrrhetic acid, kojic acid, hydroquinone.
  • water-soluble active substance chosen from the following compounds: ascorbic acid and its biologically compatible salts, enzymes, antibiotics, tensor-effect components, ⁇ -hydroxy acids and their salts, hydroxylated polyacids, sucroses and their derivatives, urea, amino
  • the polymeric matrix may comprise at least one liposoluble active substance chosen from the following compounds: D- ⁇ -tocopherol, DL- ⁇ -tocopherol, D- ⁇ -tocopherol acetate, DL- ⁇ -tocopherol acetate, palmitate ascorbyl, vitamin F and vitamin F glycerides, vitamin D, vitamin D 2 , vitamin D 3 , retinol, retinol esters, retinol palmitate, retinol propionate, ⁇ -carotene, D-panthenol, farnesol, farnesyl acetate; jojoba and blackcurrant oils rich in essential fatty acids; keratolytics such as salicylic acid, its salts and its esters, 5-n-octanoyl salicylic acid and its esters, alkyl esters of ⁇ -hydroxy acids such as citric acid, lactic acid, glycolic acid; Asian acid, madecassic acid, asiaticoside, total
  • the oily phase that is to say the oil droplets dispersed in the polymeric matrix, may be present in a proportion ranging from 0.1% to 30% by weight relative to the total weight of the composition. Preferably, this percentage is between 5 and 25%.
  • the liposoluble active compound is incorporated in a hydrophobic polymer layer, in the form of powder or granules.
  • the polymeric matrix may contain at least one active substance having a cleaning effect on the skin, said patch comprising a colored layer so as to be able to visually quantify and / or qualify the impurities taken from the skin by said adhesive surface.
  • the presence of the colored layer makes it visually detectable and makes it possible to quantify (in number and size) and / or to qualify the impurities on the colored surface of the patch.
  • the amount of impurities collected is representative of the desirable frequency of application of said patch.
  • the presence of a significant amount of such residues indicates to the user that she must apply the patch on the basis of a relatively high frequency (e.g., every day).
  • a smaller amount of such impurities indicates that the frequency of use should be lower (for example, once a week).
  • the type of impurities collected allows the user to choose the best type of treatment needed for her skin.
  • the colored pigments may consist in particular of pigments of the type used in the field of food or cosmetics, in particular for lipsticks or nail polishes.
  • pigments of the type used in the field of food or cosmetics in particular for lipsticks or nail polishes.
  • synthetic pigments or mineral pigments, in particular pigments of zirconium oxide or of cerium, as well as iron or chromium oxides, and ferric blue.
  • organic pigments especially carbon black, barium lakes, strontium, calcium (DC Red No. 7) and aluminum.
  • a pigment bearing the reference DC violet 2 K7014 marketed by KOHNSTAMM®, is used.
  • the polymeric matrix may contain at least one active substance chosen from keratolytic agents such as alpha- and beta-hydroxy-carboxylic acids or beta-ketocarboxylic acids, their salts, amides or esters and more particularly alpha-hydroxy acids such as acid.
  • keratolytic agents such as alpha- and beta-hydroxy-carboxylic acids or beta-ketocarboxylic acids, their salts, amides or esters and more particularly alpha-hydroxy acids such as acid.
  • glycolic acid, lactic acid, tartaric acid, malic acid, citric acid, mandelic acid and in general fruit acids and beta-hydroxy acids such as salicylic acid and its derivatives especially alkylated as n-octanoyl-5-salicylic acid; Kaolin powder, polyamide particles (ORGASOL®), waxes, honey, Sienna, tannins or mineral salts.
  • the polymeric matrix may consist of a self-adhesive matrix (on dry skin and / or on wet skin) based in particular on polyacrylic adhesive, polyvinyl, or a hydrophobic matrix based on a silicone polymer or polyurethane, the crosslinking of which is preferably partial so as to give it adhesion without requiring additional adhesive layer.
  • An adhesive matrix of latex, butyl, or other elastomeric adhesive may also be used.
  • a polyacrylic compound is used for producing the polymer matrix, in solution in a solvent, in particular ethyl acetate or alcohol.
  • the adhesion of the patch may be between 50 g / cm 2 and 800 g / cm 2 (force exerted perpendicular to the plane of the adhesive surface, necessary for its peeling of the skin), and preferably between 100 and 700 g / cm 2 , and more preferably between 300 and 600 g / cm 2 .
  • the surface of the matrix intended to come into contact with the skin may be smooth or have asperities or reliefs.
  • the self-adhesive matrix may contain particles of at least one water-absorbing agent dispersed homogeneously in said matrix. Indeed, in particular contact with the moisture of the skin, the particles of the water-absorbing agent capture water, thereby promoting the solubilization of the solid, water-soluble active compound. In a way, by this solubilization "in situ" of the water-soluble active, its bioavailability is almost instantaneous, and any possible interaction with the other compounds present in the polymeric layer is minimized.
  • the moisture of the skin can act as a solubilizer of the water-soluble active, especially since the support layer of the patch and / or the matrix can create occlusive conditions.
  • water-absorbing agents that may be present in the hydrophobic polymeric matrix in the dispersed state
  • superabsorbable cross-linked polyacrylates with a high degree of swelling in water such as those marketed by the company NORSOLOR under the name Aquakeep ®; polyvinyl alcohol; carboxyvinyl polymers such as those marketed by the company GOODRICH under the names "Carbopol”®; semi-synthetic derivatives of cellulose such as carboxymethylcellulose; natural substances such as starches, natural gums (guar gum, gum arabic, gum tragacanth), casein, phytocolloids (carrageenans, alginates, agar-agar), cotton fibers and gelatin.
  • superabsorbent crosslinked polyacrylates whose presence in the dispersed state in a hydrophobic polymeric matrix makes it possible to pump perspiration, for example, and promotes, after hydration, a better contact with the particles of the other active agents present, if appropriate in the matrix.
  • the water-absorbing agent as defined above is present, preferably, in a proportion ranging from about 0.2% to about 20% by weight, and more particularly ranging from 0.5% to 10% by weight. total of the polymer layer.
  • the matrix is formed of at least one water-soluble polymer, capable, after hydration, to form a gel which, on drying, adheres to the skin, by way of example, mention may be made of PVP or PVA.
  • the patch can be applied dry on wet skin, or wet on dry skin.
  • the first solution is preferred.
  • the polymeric matrix is formed of a high water content gel, hydrogel type, especially based on at least one hydrocolloid, and having a contact adhesion, similar to that resulting from a suction effect.
  • Such gels may be reversible or irreversible gels.
  • the support on which the polymeric matrix is deposited may be any suitable material impervious to the active compounds contained in the adjacent matrix.
  • the support layer not only serves to support the matrix but also to serve as protective coating thereof. It may be of the same size as the matrix or larger in size so that it extends beyond the periphery of the matrix.
  • the support can be an occlusive support.
  • the support consists of a thermoplastic material chosen from high and low density polyethylenes, polypropylenes, polyvinyl chlorides, copolymers of ethylene and vinyl acetate, polyesters and polyurethanes. , or a complex of such materials. These materials may also be present in laminated form with at least one sheet of metal such as aluminum foil.
  • the support layer may be of any suitable thickness which will provide the desired support and protection functions.
  • the thickness of the support layer is between about 20 ⁇ m and about 1.5 mm.
  • the support layer is sufficiently flexible so as to perfectly fit the profile of the skin, and not to cause the user, a feeling of discomfort.
  • the support is non-occlusive.
  • a support consisting of a paper, a porous or perforated thermoplastic material, a woven fabric, a nonwoven fabric or a perforated nonwoven fabric.
  • the patch according to the invention comprises at least one protective sheet, peelable before application of the patch.
  • the polymeric matrix When the polymeric matrix is protected by a protective release layer, it is removed at the time of use. It may be made of any material impermeable to the active compound as well as to any other component present in the polymeric matrix. Among the materials that can be used, there may be mentioned preferably a silicone paper sheet or a sheet of thermoplastic material treated to make it non-adherent, for example by means of a varnish.
  • this detachable protective layer consists of polyethylene.
  • the protective sheet consists of two parts superimposed on a medial portion of the patch, so as to facilitate installation without the fingers come into contact with the matrix containing the asset or assets. Alternatively, the protective sheet extends over a surface greater than the surface of the patch, and protrudes beyond the limits of the latter, so as to promote the detachment.
  • the patches according to the present invention can be cut into an appropriate contour corresponding to the skin surface area to be treated, for example in the form of a mask for application to the face, in particular for application on the nose , the lips, the cheeks, the area between the nose and the upper lip, on the forehead, or in any other form necessary for application to a specific area of the body, in particular the thighs for a slimming action patch or bust for a firming action patch.
  • the size of a patch according to the invention is between 0.25 cm 2 and 500 cm 2 , and preferably between 1 cm 2 and 30 cm 2 .
  • the patch can be packaged in a tray or in a protective bag formed from two sheets of a paper / plastic film complex sealed, the paper being coated with a cold sealable adhesive, the sheets being sealed around the patch by contact of the coated faces of adhesive.
  • such a patch is used for a relatively short duration of application compared to conventional patches. Its duration of application is preferably between 30 s and 15 min, and more preferably between 30 s and 5 min.
  • the patch according to the invention comprises at least one zone of small dimension, in the form of a tab, able to promote the detachment of the patch.
  • a weft consisting of a woven or a nonwoven, especially polyamide, may be embedded at least partially in the matrix.
  • the frame can act as support and vice versa. It makes it possible to confer greater cohesion on the patch, in particular when the matrix is of the gel-forming type.
  • the frame allows to play on the adhesion of the patch to the skin.
  • a part of said magnetic particles is contained directly in the frame, which is thus magnetizable. Such a characteristic may be advantageous, especially in the event of incompatibility of one of the active substances with certain magnetic particles in the event that they are directly incorporated into the matrix.
  • a method of manufacturing a patch according to claim 21 is also realized.
  • the magnetization of the polymeric matrix can be obtained in different ways.
  • magnetization devices of the type consisting of coils with or without soft iron are used. Such windings, crossed by a pulse current created by a magnetization bench, generate the magnetic field necessary for the magnetization of the matrix.
  • magnetization benches as listed in the TE2M® catalog (TECHNIQUES AND MAGNETIC MATERIALS) under the references CE 500, PM 1000 or PM 2500, which are medium to large power devices, allowing to magnetize to a high cadence of magnets of different shades and shapes.
  • the opening of the tray can then be closed by means of a removable protective film.
  • the tray can be inserted open in a protective bag.
  • the patch may be applied as part of a skin treatment method.
  • the patch 1 shown schematically in FIG. 1A comprises a support 2 made of polyethylene and on which is deposited a matrix 3 comprising at least one active substance, having an effect on the skin, in particular a cosmetic skin, and incorporating magnetic particles 4, which , as will be seen in more detail later, are oriented magnetically, permanently.
  • the face 5 of the die 3, opposite the support 2 is intended to be engaged with the skin, and to adhere to it.
  • the adhesion of the face 5 of the matrix 3 to the skin may result from the use of a self-adhesive matrix, in particular based on an acrylic or vinyl polymer.
  • a self-adhesive matrix in particular based on an acrylic or vinyl polymer.
  • Such a matrix can be self-adhesive dry or on wet skin. In the latter case, it will preferably be incorporated into the matrix of water-absorbing agents able to locally dry the skin, and to form anchoring points of the adhesive matrix on the skin.
  • the adhesion to the skin of the face 5 of the matrix 3 may result from the production of the matrix in a hydratable gel, in particular based on PVP or PVA, which on drying adheres to the skin.
  • the adhesion to the skin of the face 5 of the matrix 3 may result from a suction effect resulting from the production of the matrix in the form of a gel with a high water content, comprising at least one hydrocolloid, such as gellan gum.
  • the patch 1 is disposed inside a protective bag 6, the face 5 of the matrix having been previously covered with a peelable film 7, consisting of two portions 8 and 9 overlapping one another. middle zone of the patch 1.
  • the protective bag 6 is formed of two sheets 10, 11 of a paper complex / waterproof plastic film, the paper being coated with a cold sealable adhesive, the sheets being sealed around the patch 1 by contact of the coated faces of adhesive.
  • FIGS. 2A and 2B two magnetization patterns of patch 1 have been illustrated by way of example.
  • the patch is magnetized so that the magnetic "north" N is disposed at a first end 13 of the patch 1 while the “south” magnetic S is disposed at a second end 14 of the patch 1, opposite to the first.
  • the flow lines 12 extend in the manner shown schematically in FIG. 2A.
  • the patch is magnetized so that the magnetic "north" S is disposed on a first face 15 of patch 1 while the magnetic "south” is disposed on a second face 16 of patch 1, opposite to the first one.
  • the flow lines 12 extend in the manner shown schematically in FIG. 2B.
  • a multitude of different patterns can be obtained depending in particular on the configuration of the magnetic field (s) in which the patch is passed, and / or the number of passage of the patch 1 in such a magnetic field.
  • the ferro-magnetic particles can be oriented in such a way that a first polarity is central while the other is arranged annularly all around the first.
  • a mixture is prepared from a polymer, in particular an acrylic polymer, solubilized in a solvent such as an alcohol, for example an ethyl alcohol or ethyl acetate.
  • a solvent such as an alcohol, for example an ethyl alcohol or ethyl acetate.
  • the active compound (s) and the ferromagnetic particles are added to the mixture.
  • the mixture is then introduced into a hopper 20 and poured onto a sheet of silicone paper, or treated polyethylene 21, constituting the detachable or peelable protective film of the patch. Downstream of the hopper 20 is disposed a doctor blade 22 for equalizing the thickness of the polymer layer 28 of the polymeric matrix, this thickness generally being between 10 microns and 300 microns.
  • Evaporation of the solvents is carried out at a temperature of between 30 ° C. and 100 ° C., by passing the layer 28 thus formed on the sheet 21 in an oven 23.
  • the assembly is then calendered by means of a calendering roll 25, and is driven continuously through a magnetization bench 26, so as to permanently orient the ferromagnetic particles contained in the polymer layer 28.
  • the assembly thus formed is then wound on a core 27.
  • the individual patches are made by passing the support through a cutting station, where it is cut to the shape and dimensions desired.
  • the sheet 21 of silicone paper or treated polyethylene, and which served to drive the polymeric layer 28 through the various positions mentioned above of the device, can be replaced by a two-leaf structure overlapping in a middle zone. After cutting, the patches are then put in individual bags.
  • the magnetization of the patches is done sequentially, after the packetization of the latter.
  • FIG. 4 to which reference is now made represents a tray 100 defining a compartment 101 inside which is molded a patch according to another embodiment of the invention.
  • the matrix is formed from a hydrocolloid, such as a gellan gum.
  • the matrix comprises ferromagnetic particles.
  • the tray 100 is obtained by thermoforming or thin-wall injection of a material such as polypropylene.
  • the compartment 101 is shaped corresponding to that of a mask for the eyes. Said compartment has an edge delimiting an opening, closed off by a heat-sealed lid 103.
  • FIGS. 5A-5C show a sectional view along the line 5-5 of the assembly of FIG. 4.
  • the tray 100 is placed on its bottom, the opening 102 of the compartment 101 not being closed.
  • the liquid composition P capable of forming the gelled matrix 3 of the patch 1 is poured into the compartment 101 via the opening 102.
  • the temperature of the liquid composition P is equal to order of 90 °.
  • the liquid composition freezes to form a gelled patch 1.
  • freezing occurs at a temperature which can be in the range of 60 ° C to 70 ° C.
  • a cap 103 is heat-sealed so as to seal the opening 102.
  • it is driven through a magnetization bench of the type of that used in the previous embodiment, so as to permanently orient the magnetic particles contained in the matrix 3.
  • the product is introduced into a hopper and is spread with a doctor blade in a layer of 0.8 mm thick on a polyethylene sheet with a thickness of 200 microns.
  • This sheet can be previously treated on the surface to reduce its adhesion.
  • the whole is heated to 60 ° C so as to allow the evaporation of the solvent.
  • a nonwoven made of 30% polyethylene terephthalate and 70% viscose is applied to the free surface of the polymeric layer. support layer of the patch, and it is calendering the assembly.
  • An assembly is thus obtained comprising a support layer and a self-adhesive polymer layer formed of a polyacrylic matrix, this assembly further comprising a detachable protective layer.
  • the assembly thus formed is then driven into a magnetization bench marketed under the reference PM 1000 by the company TE2M®, and then cut to the desired shape and dimensions.
  • the patches after cutting are then packaged in polyethylene bags.
  • Such a patch is particularly effective for the treatment of wrinkles and pockets to the contours of the eyes, the penetration of the assets of the patch being favored by the presence of ferrite particles permanently magnetized, and which have an action on the micro circulation at the level of the area of application of the patch.
  • Such a patch has a relaxing, lightening and defatigating effect, the action of the active ingredients being reinforced by the presence of ferrite particles, magnetized permanently, and which contribute to making the skin more receptive to such assets.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Compositions Of Macromolecular Compounds (AREA)

Claims (28)

  1. Pflaster (1), das mindestens eine Polymermatrix (3) und einen Träger (2) umfasst, auf den die Polymermatrix aufgebracht wurde, wobei eine Oberfläche (5) der Polymermatrix, die adhäsiv ist oder insbesondere nach Hydratisierung adhäsiv werden kann, dazu vorgesehen ist, mit der Haut in Kontakt zu kommen, wobei die Matrix (3) mindestens einen Wirkstoff, der auf die Haut eine Wirkung und insbesondere eine kosmetische Wirkung haben kann, und dispergiert in der Matrix (3) magnetische Partikel (4) enthält, wobei die Partikel zumindest an einem Teil der Oberfläche des Pflasters (1) in permanenter Weise orientiert sind.
  2. Pflaster nach Anspruch 1, dadurch gekennzeichnet, dass die magnetischen Partikel (4) insbesondere Ferrite sind.
  3. Pflaster nach Anspruch 1 oder 2, dadurch gekennzeichnet, dass der prozentuale Volumenanteil der magnetischen Partikel (4) im Inneren der Polymermatrix im Bereich von 0,2 bis 80 %, vorzugsweise 1 bis 30 % und noch bevorzugter 2 bis 15 % liegt.
  4. Pflaster nach einem der Ansprüche 1 bis 3, dadurch gekennzeichnet, dass die Partikel (4) insbesondere mit Polyurethan, Epoxy, Polyester, Polyamid oder Cyanoacrylat umhüllt sind.
  5. Pflaster nach einem der Ansprüche 1 bis 4, dadurch gekennzeichnet, dass die magnetischen Partikel (4) so orientiert sind, dass sich an zumindest einem Teil der Oberfläche des Pflasters (1) die erzeugten Magnetfeldlinien (12) von einer ersten Fläche (15) des Pflasters bis zu einer zweiten Fläche (16) erstrecken, die der ersten Fläche gegenüberliegt.
  6. Pflaster nach einem der Ansprüche 1 bis 5, dadurch gekennzeichnet, dass die magnetischen Partikel (4) so orientiert sind, dass sich an zumindest einem Teil der Oberfläche des Pflasters (1) die erzeugten Magnetfeldlinien (12) von einem ersten Rand (13) des Pflasters bis zu einem zweiten Rand (14) erstrecken, der dem ersten gegenüberliegt.
  7. Pflaster nach einem der Ansprüche 1 bis 6, dadurch gekennzeichnet, dass der oder die Wirkstoff(e) unter den schlanker machenden Wirkstoffen, reinigenden Wirkstoffen, Antioxidantien, Radikalfängern für freie Radikale, Hydratisierungsmitteln, Depigmentierungsmitteln, Liporegulatoren, Wirkstoffen gegen Akne, Wirkstoffen gegen Seborrhoe, Wirkstoffen gegen Alterung, reizlindernden Wirkstoffen, Wirkstoffen gegen Falten, Keratolytika, entzündungshemmenden Wirkstoffen, erfrischenden Mitteln, Vernarbungsmitteln, vaskulären Schutzmitteln, antibakteriellen Wirkstoffen, Fungiziden, Antiperspirantien, Deodorants, Hautkonditionierern, unempfindlich machenden Wirkstoffen, Immunomodulatoren und Nährstoffen, Feuchtigkeitsabsorbern (Baumwolle, Polyacrylat) und Sebumabsorbern (Orgasol) ausgewählt sind.
  8. Pflaster nach einem der Ansprüche 1 bis 7, dadurch gekennzeichnet, dass die Polymermatrix (3) mindestens einen wasserlöslichen Wirkstoff enthält, der unter den folgenden Verbindungen ausgewählt ist: Ascorbinsäure und ihren biologisch kompatiblen Salzen, Enzymen, Antibiotika, Komponenten mit straffender Wirkung, α-Hydroxysäuren und ihren Salzen, hydroxylierten Polysäuren, Zuckern und deren Derivaten, Harnstoff, Aminosäuren, Oligopeptiden, wasserlöslichen pflanzlichen Extrakten und Hefeextrakten, Proteinhydrolysaten, Hyluronsäure, Mucopolysacchariden, Vitamin B2, B6, H, PP, Panthenol, Folsäure, Acetylsalicylsäure, Allantoin, Glycyrrhetinsäure, Kojisäure und Hydrochinon.
  9. Pflaster nach einem der Ansprüche 1 bis 8, dadurch gekennzeichnet, dass die Polymermatrix (3) mindestens einen fettlöslichen Wirkstoff enthält, der unter den folgenden Verbindungen ausgewählt ist: D-α-Tocopherol, DL-α-Tocopherol, D-α-Tocopherolacetat, DL-α-Tocopherolacetat, Ascorbylpalmitat, Vitamin F und Glyceride von Vitamin F, D-Vitamine, Vitamin D2, Vitamin D3, Retinol, Retinolester, Retinolpalmitat, Retinolpropionat, β-Carotin, D-Panthenol, Farnesol, Farnesylacetat; Jojobaöl und Johannisbeeröl mit einem hohen Anteil an essentiellen Fettsäuren; Keratolytika, wie Salicylsäure und ihre Salze und ihre Ester, 5-n-Octanoylsalicylsäure und ihren Estern, Alkylestern von α-Hydroxysäuren, wie Citronensäure, Milchsäure, Glykolsäure; Asiatsäure, Madecassäure, Asiaticosid, dem Gesamtextrakt von Centella asiatica, β-Glycyrrhetinsäure, α-Bisabolol, Ceramide, wie 1,3-Oleylamino-octadecan; Phytantriol, Milchsphingomyclin, Phospholipiden mariner Herkunft mit einem hohen Anteil an mehrfach ungesättigten essentiellen Fettsäuren, Ethoxyquin; Rosmarinextrakt, Melissenextrakt, Quercetin, Extrakten aus getrockneten Mikroalgen, steroidalen entzündungshemmenden Wirkstoffen.
  10. Pflaster nach einem der Ansprüche 1 bis 9, dadurch gekennzeichnet, dass die Polymermatrix (3) mindestens einen Wirkstoff enthält, der auf die Haut reinigend wirkt, wobei das Pflaster eine farbige Schicht aufweist, damit visuell die durch die adhäsive Oberfläche (3) abgenommenen Unreinheiten der Haut quantifiziert und/oder qualifiziert werden können.
  11. Pflaster nach Anspruch 10, dadurch gekennzeichnet, dass die Polymermatrix (3) mindestens einen Wirkstoff enthält, der unter den Keratolytika, wie α- und β-Hydroxycarbonsäuren oder β-Ketocarbonsäuren, ihren Salzen, Amiden oder Estern und insbesondere α-Hydroxysäuren, wie Glykolsäure, Milchsäure, Weinsäure, Äpfelsäure, Citronensäure, Mandelsäure und allgemein Fruchtsäuren und β-Hydroxysäuren, wie Salicylsäure und ihren Derivaten und insbesondere den alkylierten Derivaten, wie 5-n-Octanoylsalicylsäure; Kaolinpulver, Polyamidpartikeln (ORGASOL® ), Wachsen, Honig, Terra de Siena, Tanninen oder anorganischen Salzen ausgewählt ist.
  12. Pflaster nach einem der Ansprüche 1 bis 11, dadurch gekennzeichnet, dass die Polymermatrix (3) selbsthaftend ist und insbesondere auf der Basis eines Acrylpolymers, Vinylpolymers, Silicons, Polyurethans, Latex oder einer Butylverbindung gebildet ist.
  13. Pflaster nach Anspruch 12, dadurch gekennzeichnet, dass die Polymermatrix (3) mindestens einen wasserabsorbierenden Stoff enthält, der insbesondere unter den superabsorbierenden vernetzten Polyacrylaten, Polyvinylalkohol, Carboxyvinylpolymeren, halbsynthetischen Cellulosederivaten, Stärkeverbindungen, Guargummi, Gummi arabicum, Tragant, Casein, Phytocolloiden, Baumwollfasern und Gelatine ausgewählt ist.
  14. Pflaster nach einem der Ansprüche 1 bis 11, dadurch gekennzeichnet, dass die Polymermatrix (3) aus mindestens einem wasserlöslichen Polymer, insbesondere PVP oder PVA, gebildet ist, das nach Hydratisierung ein Gel bilden kann, das beim Trocknen an der Haut haftet.
  15. Pflaster nach einem der Ansprüche 1 bis 11, dadurch gekennzeichnet, dass die Polymermatrix (3) aus einem wässrigen Gel auf der Basis mindestens eines Hydrokolloids gebildet ist, wie Gellangummi oder Xanthangummi.
  16. Pflaster nach einem der Ansprüche 1 bis 15, dadurch gekennzeichnet, dass der Träger (2) ein okklusiver Träger, der insbesondere aus einem thermoplastischen Material, das unter den Polyethylenen mit hoher oder niedriger Dichte, Polypropylenen, Polyvinylchloriden, Copolymeren von Ethylen und Vinylacetat, Polyestern und Polyurethanen ausgewählt ist, oder einem Komplex dieser Materialien besteht, oder ein nicht okklusiver Träger ist, der insbesondere aus einem Papier, einem porösen oder perforierten thermoplastischen Material, einem Gewebe, einem Nonwoven oder einem perforierten Nonwoven.
  17. Pflaster nach einem der Ansprüche 1 bis 16, dadurch gekennzeichnet, dass es mindestens eine Schutzfolie (7) umfasst, insbesondere in Form von zwei Teilen (8, 9), die sich in einem mittleren Bereich des Pflasters überlappen und vor dem Aufbringen des Pflasters abgezogen werden können.
  18. Pflaster nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, dass ein Geflecht, das aus einem Gewebe oder einem Nonwoven besteht, insbesondere aus Polyamid, zumindest teilweise in die Polymermatrix (3) eingebettet ist.
  19. Pflaster nach Anspruch 18, dadurch gekennzeichnet, dass zumindest ein Teil der Magnetpartikel (4) in dem Geflecht enthalten ist.
  20. Pflaster nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, dass es in einem Schutzbeutel (6) konfektioniert ist, der aus zwei Folien (10, 11) eines dichten Papier/Kunststofffolie-Komplexes besteht, wobei das Papier mit einem in der Kälte adhäsiven Klebstoff beschichtet ist, wobei die Folien durch Kontakt der mit dem Klebstoff beschichteten Seiten um das Pflaster geklebt sind.
  21. Verfahren zur Herstellung eines Pflasters (1), das darin besteht:
    a) eine Polymermatrix (3) zu formen und auf einem Träger (2) aufzubringen, wobei eine Oberfläche (5) der Polymermatrix, die adhäsiv ist oder insbesondere nach Hydratisierung adhäsiv werden kann, mit der Haut in Kontakt kommen soll, wobei die Matrix (3) mindestens einen Wirkstoff, der befähigt ist, eine Wirkung und insbesondere eine kosmetische Wirkung auf die Haut auszuüben, und dispergiert in der Matrix magnetische Partikel (4) enthält; und
    b) nach der zumindest teilweisen Polymerisation der Matrix die Polymermatrix (3) so durch ein Magnetfeld (26) zu führen, dass zumindest an einem Teil der Oberfläche des Pflasters die Partikel (4) permanent ausgerichtet werden.
  22. Verfahren nach Anspruch 21, dadurch gekennzeichnet, dass es darin besteht:
    i) die Matrix (3) kontinuierlich auf einen bandförmigen Träger (24) aufzubringen;
    ii) nach der zumindest teilweisen Polymerisation der Matrix (3) den so mit der Polymermatrix (3) bedeckten Träger durch das Magnetfeld (26) zu führen;
    iii) den magnetisierten Träger in Form von Pflastern (1) in der gewünschten Form und der gewünschten Abmessung zu schneiden; und
    iv) die derart geschnitten Pflaster in Schutzhüllen (6) zu geben.
  23. Verfahren nach Anspruch 21, dadurch gekennzeichnet, dass es darin besteht:
    i) die Matrix (3) kontinuierlich auf einen bandförmigen Träger (24) aufzubringen;
    ii) den mit der Polymermatrix bedeckten Träger in Form von Pflastern (1) in der gewünschten Form und den gewünschten Abmessungen zu schneiden;
    iii) die so geformten Pflaster durch ein Magnetfeld (26) zu führen; und
    iv) die derart magnetisierten Pflaster in Schutzhüllen (6) anzubringen.
  24. Verfahren nach Anspruch 21, dadurch gekennzeichnet, dass es darin besteht:
    i) die Matrix (3) kontinuierlich auf einen bandförmigen Träger (24) aufzubringen;
    ii) den mit der Matrix bedeckten Träger in Form von Pflastern (1) in der gewünschten Form und den gewünschten Abmessungen zu schneiden;
    iii) die derart geschnittenen Pflaster in Schutzhüllen (6) zu geben; und
    iv) die Schutzhüllen durch das Magnetfeld (26) zu führen.
  25. Verfahren nach Anspruch 21, dadurch gekennzeichnet, dass die Polymermatrix (3) aus einem Gel und insbesondere aus einem wässrigen Gel besteht, das aus mindestens einem Hydrokolloid gebildet ist, wobei das Verfahren darin besteht:
    i) die Matrix in flüssiger Form ins Innere einer Form (100) in der Form und in den Abmessungen des herzustellenden Pflasters zu gießen, in der gegebenenfalls ein Geflecht angeordnet ist, wobei die Matrix (3) über eine Öffnung (102) in die Form gegossen wird, die an einem Rand der Form ausgebildet ist;
    ii) die Verfestigung der Matrix (3) durch zumindest teilweise Polymerisation hervorzurufen; und
    iii) die Form (100) einem Magnetfeld auszusetzen, das geeignet ist, die magnetischen Partikel der Matrix (3) permanent auszurichten.
  26. Verfahren nach Anspruch 25, dadurch gekennzeichnet, dass es ferner einen Schritt umfasst, der darin besteht:
    iv) die Öffnung der Form mit mindestens einer ablösbaren Schutzschicht (103) zu verschließen.
  27. Verfahren nach Anspruch 25, dadurch gekennzeichnet, dass vor oder nach Schritt iii) die Form (100) in eine Schutzhülle gegeben wird.
  28. Verfahren zur nicht-therapeutischen Behandlung der Haut, dadurch gekennzeichnet, dass ein Pflaster nach einem der Ansprüche 1 bis 20 auf die Haut aufgebracht wird.
EP00400490A 1999-03-31 2000-02-23 Pflaster mit magnetischer Wirkung Expired - Lifetime EP1043018B1 (de)

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CA2301989C (fr) 2005-01-25
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AR018704A1 (es) 2001-11-28
FR2791570A1 (fr) 2000-10-06
BR0001154A (pt) 2000-10-10
DE60028642D1 (de) 2006-07-27
CA2301989A1 (fr) 2000-09-30
CN1156272C (zh) 2004-07-07
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ATE329566T1 (de) 2006-07-15
DE60028642T2 (de) 2007-05-16

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