EP1049472A4 - Antagonisten des gonadotropin freisetzenden hormons - Google Patents

Antagonisten des gonadotropin freisetzenden hormons

Info

Publication number
EP1049472A4
EP1049472A4 EP98955082A EP98955082A EP1049472A4 EP 1049472 A4 EP1049472 A4 EP 1049472A4 EP 98955082 A EP98955082 A EP 98955082A EP 98955082 A EP98955082 A EP 98955082A EP 1049472 A4 EP1049472 A4 EP 1049472A4
Authority
EP
European Patent Office
Prior art keywords
gonadoliberin
antagonists
gonadoliberin antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98955082A
Other languages
English (en)
French (fr)
Other versions
EP1049472A1 (de
Inventor
Lin Chu
Mark T Goulet
Thomas F Walsh
Stephanie L Witkin
Matthew J Wyvratt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9806694.7A external-priority patent/GB9806694D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP1049472A1 publication Critical patent/EP1049472A1/de
Publication of EP1049472A4 publication Critical patent/EP1049472A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
EP98955082A 1997-10-28 1998-10-23 Antagonisten des gonadotropin freisetzenden hormons Withdrawn EP1049472A4 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6331297P 1997-10-28 1997-10-28
US63312P 1997-10-28
GB9806694 1998-03-27
GBGB9806694.7A GB9806694D0 (en) 1998-03-27 1998-03-27 Antagonists of gonadotropin releasing hormone
PCT/US1998/022487 WO1999021557A1 (en) 1997-10-28 1998-10-23 Antagonists of gonadotropin releasing hormone

Publications (2)

Publication Number Publication Date
EP1049472A1 EP1049472A1 (de) 2000-11-08
EP1049472A4 true EP1049472A4 (de) 2002-04-03

Family

ID=26313385

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98955082A Withdrawn EP1049472A4 (de) 1997-10-28 1998-10-23 Antagonisten des gonadotropin freisetzenden hormons

Country Status (5)

Country Link
EP (1) EP1049472A4 (de)
JP (1) JP2001520997A (de)
AU (1) AU1197299A (de)
CA (1) CA2308069A1 (de)
WO (1) WO1999021557A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6479535B1 (en) 1998-05-15 2002-11-12 Wyeth 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations
HRP20000778B1 (en) * 1998-05-15 2004-10-31 Wyeth Corp 2-phenyl-1-/4-(2-aminoethoxy)-benzyl/-indole in combination with estrogens
GB0017256D0 (en) 2000-07-13 2000-08-30 Merck Sharp & Dohme Therapeutic agents
GB0022670D0 (en) 2000-09-15 2000-11-01 Astrazeneca Ab Molecules
SE0100566D0 (sv) 2001-02-20 2001-02-20 Astrazeneca Ab Compounds
SE0101692D0 (sv) 2001-05-14 2001-05-14 Astrazeneca Ab Compounds
TW200413351A (en) 2002-08-21 2004-08-01 Astrazeneca Ab Chemical compounds
GB0219472D0 (en) 2002-08-21 2002-10-02 Astrazeneca Ab Chemical compounds
ES2286493T3 (es) 2002-08-21 2007-12-01 Astrazeneca Ab Derivados de pirazol como inhibidores de gnrh.
DE60318716T2 (de) 2002-08-21 2009-01-08 Astrazeneca Ab Thieno-pyrrole verbindungen als antagonisten der gonadotropin-freisetzenden hormonrezeptoren
TW200407127A (en) 2002-08-21 2004-05-16 Astrazeneca Ab Chemical compounds
GB0307777D0 (en) 2003-04-04 2003-05-07 Medical Res Council Conjugate compounds
BRPI0511722A (pt) 2004-06-01 2008-01-08 Hoffmann La Roche 3-amino-1-arilpropilindóis como inibidores da recaptação de monoamina
AU2006319231A1 (en) 2005-11-30 2007-06-07 F. Hoffmann-La Roche Ag 3-amino-1-arylpropyl indoles and aza-substituted indoles
JP2009517432A (ja) 2005-11-30 2009-04-30 エフ．ホフマン−ラ ロシュ アーゲー ３−アミノ−２−アリールプロピルアザインドールおよびその使用
AU2006319229B2 (en) 2005-11-30 2011-09-15 F. Hoffmann-La Roche Ag Methods for synthesis of 3-amino-1-arylpropyl indoles
WO2010039977A2 (en) 2008-10-01 2010-04-08 Amira Pharmaceuticals, Inc. Heteroaryl antagonists of prostaglandin d2 receptors

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2181559A1 (en) * 1972-04-28 1973-12-07 Aec Chimie Organique Bio N-Phenylalkyl-N-3-indolylalkyl-alkylamines - with sedative, neuroleptic, analgesic, hypotensive, antiserotonin, adrenolytic activity
GB1562825A (en) * 1975-10-29 1980-03-19 Lilly Co Eli N-(2-(5-methoxa-6-halo-indol-3-yl)-ethyl)-amides methods for their preparation and their use
US4544663A (en) * 1984-05-07 1985-10-01 Sandoz, Inc. Indolamine derivatives as anti-fertility agents
US5030640A (en) * 1989-01-05 1991-07-09 Merck & Co., Inc. Novel β-adrenergic agonists and pharmaceutical compositions thereof
WO1997021703A1 (en) * 1995-12-14 1997-06-19 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
WO1997021704A1 (en) * 1995-12-14 1997-06-19 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
WO1998055119A1 (en) * 1997-06-05 1998-12-10 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2933636A1 (de) * 1978-08-30 1980-03-20 Sandoz Ag Neue n-phenylindolinderivate, ihre herstellung und pharmazeutische praeparate, welche diese verbindungen enthalten
US4255432A (en) * 1979-09-06 1981-03-10 Syntex (U.S.A.) Inc. 8-[2-3-Indolyl)ethyl]-1-oxa-3-,8-diazaspiro[4.5]decan-2-ones, pharmaceutical compositions thereof and methods of use thereof
US5604253A (en) * 1995-05-22 1997-02-18 Merck Frosst Canada, Inc. N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors
US5756507A (en) * 1995-12-14 1998-05-26 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2181559A1 (en) * 1972-04-28 1973-12-07 Aec Chimie Organique Bio N-Phenylalkyl-N-3-indolylalkyl-alkylamines - with sedative, neuroleptic, analgesic, hypotensive, antiserotonin, adrenolytic activity
GB1562825A (en) * 1975-10-29 1980-03-19 Lilly Co Eli N-(2-(5-methoxa-6-halo-indol-3-yl)-ethyl)-amides methods for their preparation and their use
US4544663A (en) * 1984-05-07 1985-10-01 Sandoz, Inc. Indolamine derivatives as anti-fertility agents
US5030640A (en) * 1989-01-05 1991-07-09 Merck & Co., Inc. Novel β-adrenergic agonists and pharmaceutical compositions thereof
WO1997021703A1 (en) * 1995-12-14 1997-06-19 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
WO1997021704A1 (en) * 1995-12-14 1997-06-19 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
WO1998055119A1 (en) * 1997-06-05 1998-12-10 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9921557A1 *

Also Published As

Publication number Publication date
CA2308069A1 (en) 1999-05-06
AU1197299A (en) 1999-05-17
WO1999021557A1 (en) 1999-05-06
EP1049472A1 (de) 2000-11-08
JP2001520997A (ja) 2001-11-06

Similar Documents

Publication Publication Date Title
EP0986557A4 (de) Antagonisten des gonadotropin freisetzenden hormons
EP0986385A4 (de) Antagonisten des gonadorelins
EP0868178A4 (de) Antagonisten des gonadotropin releasing hormons
MX208461B (es) Polisacaridos de termofraguado
DK0973746T3 (da) Substituerede 3-cyanoquinoliner
DE69819125D1 (de) Unwechselbare Verbindungsanordnung
DE69831181D1 (de) Positionsbestimmung
EP0984779A4 (de) Somatostatin agonisten
DE69734833D1 (de) Vitronektin rezeptor antagonisten
DE69822740D1 (de) Verbinder
ID23168A (id) Reseptor anatagonis vitronektin
DE69819057D1 (de) Verbinder
DE69834906D1 (de) Verbinder
NO994850D0 (no) Farmakologiske midler
DE69829560D1 (de) Verbinder
DE59813487D1 (de) Substituierte 4-benzoyl-pyrazole
PT981652E (pt) Biolixiviacao de concentrado mineral de sulfureto
PT1045691E (pt) Combinacoes de estatina-eter carboxialquilico
EP0994900A4 (de) Semaphorinrezeptoren
DE69838828D1 (de) Verbinder
DE69823611D1 (de) Verbinder
DE59809844D1 (de) Stoffauflauf
DE69808562D1 (de) Verbinder
DE59710430D1 (de) Substituierte 4-benzoyl-pyrazole
ID20403A (id) PEMBUATAN α-TOKOFEROL

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20000529

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

AX Request for extension of the european patent

Free format text: AL PAYMENT 20000529;LT PAYMENT 20000529;LV PAYMENT 20000529;MK PAYMENT 20000529;RO PAYMENT 20000529;SI PAYMENT 20000529

A4 Supplementary search report drawn up and despatched

Effective date: 20020219

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

RIC1 Information provided on ipc code assigned before grant

Free format text: 7A 61K 31/47 A, 7A 61K 31/445 B, 7A 61K 31/405 B, 7A 61K 31/38 B, 7A 61K 31/35 B, 7C 07D 209/04 B, 7C 07D 209/14 B, 7C 07D 333/52 B, 7C 07D 409/14 B, 7C 07D 401/10 B, 7C 07D 209/18 B, 7C 07D 209/42 B, 7A 61P 5/24 B

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20020510

R18D Application deemed to be withdrawn (corrected)

Effective date: 20020501