EP1093368A4 - Indol- und tetrahydroisoquinolinenthaltende alpha-ketooxadiazole als serin proteaseinhibitoren - Google Patents

Indol- und tetrahydroisoquinolinenthaltende alpha-ketooxadiazole als serin proteaseinhibitoren

Info

Publication number: EP1093368A4
Authority: EP; European Patent Office
Prior art keywords: oxadiazoles; tetrahydroisoquinoline; keto; indole; protease inhibitors
Prior art date: 1998-06-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP99927189A

Other languages

English (en)

French (fr)

Other versions

EP1093368A1 (de

Inventor

Lyle Spruce

Albert Gyorkos

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Ono Pharmaceutical Co Ltd

Cortech Inc

Original Assignee

Ono Pharmaceutical Co Ltd

Cortech Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-06-03

Filing date

1999-06-03

Publication date

2002-11-13

1998-06-03 Priority claimed from US09/089,587 external-priority patent/US6100238A/en

1999-06-03 Application filed by Ono Pharmaceutical Co Ltd, Cortech Inc filed Critical Ono Pharmaceutical Co Ltd

1999-06-03 Priority to EP01200500A priority Critical patent/EP1114822A3/de

2001-04-25 Publication of EP1093368A1 publication Critical patent/EP1093368A1/de

2002-11-13 Publication of EP1093368A4 publication Critical patent/EP1093368A4/de

Status Withdrawn legal-status Critical Current

Links

UWYZHKAOTLEWKK-UHFFFAOYSA-N 1,2,3,4-tetrahydroisoquinoline Chemical compound C1=CC=C2CNCCC2=C1 UWYZHKAOTLEWKK-UHFFFAOYSA-N 0.000 title 2
SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 2
FRYPWUYDPUBMRU-UHFFFAOYSA-N 2-[(4-chlorophenoxy)methyl]-5-(2,4-dichloro-5-fluorophenyl)-1,3,4-oxadiazole Chemical compound C1=C(Cl)C(F)=CC(C=2OC(COC=3C=CC(Cl)=CC=3)=NN=2)=C1Cl FRYPWUYDPUBMRU-UHFFFAOYSA-N 0.000 title 1
PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 title 1
RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 title 1
239000003001 serine protease inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Dermatology (AREA)
Pulmonology (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

EP99927189A 1998-06-03 1999-06-03 Indol- und tetrahydroisoquinolinenthaltende alpha-ketooxadiazole als serin proteaseinhibitoren Withdrawn EP1093368A4 (de)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
EP01200500A EP1114822A3 (de)	1998-06-03	1999-06-03	Alpha-Keto-oxadiazole enthaltende Indole und Tetrahydroisochinoline zur Verwendung als Serin-Protease-Hemmer

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
		1997-12-23
US09/089,587 US6100238A (en)	1994-11-21	1998-06-03	Indole and tetrahydroisoquinoline containing Alpha-keto oxadiazoles as serine protease inhibitors
PCT/US1999/012352 WO1999062514A1 (en)	1998-06-03	1999-06-03	INDOLE AND TETRAHYDROISOQUINOLINE CONTAINING α-KETO OXADIAZOLES AS SERINE PROTEASE INHIBITORS

Related Child Applications (1)

Application Number	Title	Priority Date	Filing Date
EP01200500A Division EP1114822A3 (de)	1998-06-03	1999-06-03	Alpha-Keto-oxadiazole enthaltende Indole und Tetrahydroisochinoline zur Verwendung als Serin-Protease-Hemmer

Publications (2)

Publication Number	Publication Date
EP1093368A1 EP1093368A1 (de)	2001-04-25
EP1093368A4 true EP1093368A4 (de)	2002-11-13

Family

ID=26780737

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP99927189A Withdrawn EP1093368A4 (de)	1998-06-03	1999-06-03	Indol- und tetrahydroisoquinolinenthaltende alpha-ketooxadiazole als serin proteaseinhibitoren

Country Status (4)

Country	Link
EP (1)	EP1093368A4 (de)
JP (1)	JP2004517028A (de)
KR (1)	KR20010078724A (de)
WO (1)	WO1999062514A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN101646437A (zh) *	2007-02-09	2010-02-10	Irm责任有限公司	作为通道活化蛋白酶抑制剂的化合物和组合物
CN114650819A (zh)	2019-09-17	2022-06-21	美莱奥生物制药第四有限公司	用于治疗移植物排斥、闭塞性细支气管炎综合征和移植物抗宿主病的阿维来司他
WO2021209740A1 (en)	2020-04-16	2021-10-21	Mereo Biopharma 4 Limited	Methods involving neutrophil elastase inhibitor alvelestat for treating coronavirus infection
EP4419102A1 (de)	2021-10-20	2024-08-28	Mereo Biopharma 4 Limited	Inhibitoren der neutrophilen elastase zur behandlung von fibrose

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1993020099A2 (en) *	1992-03-27	1993-10-14	Ferring B.V.	Cck and/or gastrin receptor ligands
WO1996016080A1 (en) *	1994-11-21	1996-05-30	Cortech, Inc.	Human neutrophil elastase inhibitors

1999
- 1999-06-03 EP EP99927189A patent/EP1093368A4/de not_active Withdrawn
- 1999-06-03 WO PCT/US1999/012352 patent/WO1999062514A1/en not_active Ceased
- 1999-06-03 KR KR1020007013664A patent/KR20010078724A/ko not_active Withdrawn
- 1999-06-03 JP JP2000551770A patent/JP2004517028A/ja not_active Withdrawn

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1993020099A2 (en) *	1992-03-27	1993-10-14	Ferring B.V.	Cck and/or gastrin receptor ligands
WO1996016080A1 (en) *	1994-11-21	1996-05-30	Cortech, Inc.	Human neutrophil elastase inhibitors
US5618792A (en) *	1994-11-21	1997-04-08	Cortech, Inc.	Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9962514A1 *

Also Published As

Publication number	Publication date
EP1093368A1 (de)	2001-04-25
WO1999062514A1 (en)	1999-12-09
JP2004517028A (ja)	2004-06-10
KR20010078724A (ko)	2001-08-21

Legal Events

Date	Code	Title	Description
2001-03-09	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2001-04-25	17P	Request for examination filed	Effective date: 20001228
2001-04-25	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2001-04-25	AX	Request for extension of the european patent	Free format text: AL PAYMENT 20001228;LT PAYMENT 20001228;LV PAYMENT 20001228;MK PAYMENT 20001228;RO PAYMENT 20001228;SI PAYMENT 20001228
2002-11-13	A4	Supplementary search report drawn up and despatched	Effective date: 20020930
2002-11-13	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2002-11-13	RIC1	Information provided on ipc code assigned before grant	Free format text: 7C 07D 413/12 A, 7A 61K 31/405 B, 7A 61K 31/41 B, 7A 61K 31/47 B, 7C 07D 217/12 B, 7C 07D 217/16 B, 7C 07D 249/08 B, 7C 07D 271/06 B, 7C 07D 271/10 B
2006-05-26	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2006-06-21	18D	Application deemed to be withdrawn	Effective date: 20051201
2006-06-28	R18D	Application deemed to be withdrawn (corrected)	Effective date: 20060103

Publication	Publication Date	Title
AU4330899A (en)	2000-06-19	Peptoid and nonpeptoid containing alpha-keto oxadiazoles as serine protease inhibitors
ZA983629B (en)	1998-11-04	Serine protease inhibitors
ZA983843B (en)	1998-11-09	Protease inhibitors
PL349192A1 (en)	2002-07-01	Protease inhibitors
EP1021199A4 (de)	2003-08-20	Peptidhaltige alpha-ketoamide als cystein-und serinproteaseinhibitoren
HUP9902409A3 (en)	2000-06-28	Inhibitors of cysteine protease
HUP9901187A3 (en)	1999-11-29	Serine protease inhibitors
AU7127298A (en)	1998-11-11	Serine protease inhibitors
PL347948A1 (en)	2002-04-22	Serine protease inhibitor
IL132630A0 (en)	2001-03-19	Protease inhibitors
HUP0002247A3 (en)	2003-01-28	Protease inhibitors
IL132629A0 (en)	2001-03-19	Protease inhibitors
EP0923535A4 (de)	2001-01-10	Inhibitoren der cystein-protease
EP1093367A4 (de)	2003-03-05	Proteaseinhibitoren
ZA988479B (en)	1998-10-26	Protease inhibitors
IL139187A0 (en)	2001-11-25	Cysteine protease inhibitors
EP1115390A4 (de)	2004-08-11	Hydroxamat-enthaltende inhibitoren der cystein- und serinproteasen
EP1079821A4 (de)	2001-08-29	Protease inhibitoren
GB9800817D0 (en)	1998-03-11	Serine protease inhibitors
EP1093368A4 (de)	2002-11-13	Indol- und tetrahydroisoquinolinenthaltende alpha-ketooxadiazole als serin proteaseinhibitoren
ZA988064B (en)	1999-05-28	Protease inhibitors
EP1086083A4 (de)	2001-09-26	Proteaseinhibitoren
EP1140897A4 (de)	2002-04-03	Protease inhibitoren
ZA961225B (en)	1996-08-23	Serine protease inhibitors
GB9613719D0 (en)	1996-08-28	Serine protease inhibitors