EP1146883A4 - Modulierung der immunreaktion durch ribavirin - Google Patents

Modulierung der immunreaktion durch ribavirin

Info

Publication number: EP1146883A4
Authority: EP; European Patent Office
Prior art keywords: ribavirin; modulation; immune response; immune; response
Prior art date: 1999-01-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP99968159A

Other languages

English (en)

French (fr)

Other versions

EP1146883A1 (de

Inventor

Robert Tam

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bausch Health Americas Inc

Original Assignee

ICN Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-01-29

Filing date

1999-12-20

Publication date

2004-11-24

1999-12-20 Application filed by ICN Pharmaceuticals Inc filed Critical ICN Pharmaceuticals Inc

1999-12-20 Priority to DE29924200U priority Critical patent/DE29924200U1/de

2001-10-24 Publication of EP1146883A1 publication Critical patent/EP1146883A1/de

2004-11-24 Publication of EP1146883A4 publication Critical patent/EP1146883A4/de

Status Withdrawn legal-status Critical Current

Links

IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 title 1
230000028993 immune response Effects 0.000 title 1
229960000329 ribavirin Drugs 0.000 title 1
HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Rheumatology (AREA)
Endocrinology (AREA)
Epidemiology (AREA)
Physical Education & Sports Medicine (AREA)
Molecular Biology (AREA)
Orthopedic Medicine & Surgery (AREA)
Obesity (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Emergency Medicine (AREA)
Gastroenterology & Hepatology (AREA)
Transplantation (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Dermatology (AREA)
Reproductive Health (AREA)
Neurology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

EP99968159A 1999-01-29 1999-12-20 Modulierung der immunreaktion durch ribavirin Withdrawn EP1146883A4 (de)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
DE29924200U DE29924200U1 (de)	1999-01-29	1999-12-20	Modulation einer Immunantwort durch Ribavirin

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US24136799A	1999-01-29	1999-01-29
US241367		1999-01-29
PCT/US1999/030490 WO2000044388A1 (en)	1999-01-29	1999-12-20	Modulation of immune response by ribavirin

Publications (2)

Publication Number	Publication Date
EP1146883A1 EP1146883A1 (de)	2001-10-24
EP1146883A4 true EP1146883A4 (de)	2004-11-24

Family

ID=22910442

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP99968159A Withdrawn EP1146883A4 (de)	1999-01-29	1999-12-20	Modulierung der immunreaktion durch ribavirin

Country Status (20)

Country	Link
EP (1)	EP1146883A4 (de)
JP (1)	JP2002535371A (de)
KR (1)	KR20020023939A (de)
CN (1)	CN1334736A (de)
AU (1)	AU2483300A (de)
BR (1)	BR9917090A (de)
CA (1)	CA2357735A1 (de)
CZ (1)	CZ20012519A3 (de)
HK (1)	HK1040937A1 (de)
HR (1)	HRP20010496A2 (de)
HU (1)	HUP0200027A2 (de)
IL (1)	IL144130A0 (de)
MX (1)	MXPA01007211A (de)
NO (1)	NO20013529L (de)
PL (1)	PL364699A1 (de)
RU (1)	RU2211698C2 (de)
SI (1)	SI20802A (de)
SK (1)	SK10092001A3 (de)
WO (1)	WO2000044388A1 (de)
ZA (1)	ZA200105595B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6680059B2 (en)	2000-08-29	2004-01-20	Tripep Ab	Vaccines containing ribavirin and methods of use thereof
JP5175417B2 (ja)	2000-08-17	2013-04-03	トリペップアクチボラゲット	リバビリンを含むワクチンおよびその使用方法
US7022830B2 (en)	2000-08-17	2006-04-04	Tripep Ab	Hepatitis C virus codon optimized non-structural NS3/4A fusion gene
US6858590B2 (en)	2000-08-17	2005-02-22	Tripep Ab	Vaccines containing ribavirin and methods of use thereof
US20050182252A1 (en)	2004-02-13	2005-08-18	Reddy K. R.	Novel 2'-C-methyl nucleoside derivatives
CN101410122A (zh) *	2006-03-14	2009-04-15	厚生药业股份有限公司	治疗过敏性疾病的方法及组合物
US8071561B2 (en)	2007-08-16	2011-12-06	Chrontech Pharma Ab	Immunogen platform

Citations (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4211771A (en) *	1971-06-01	1980-07-08	Robins Ronald K	Treatment of human viral diseases with 1-B-D-ribofuranosyl-1,2,4-triazole-3-carboxamide
EP0038629A1 (de) *	1980-04-17	1981-10-28	Beecham Group Plc	Virazol-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als antivirale Mittel
WO1987005807A1 (en) *	1986-03-27	1987-10-08	Harry Edward Gruber	A method of increasing adenosine excretion
EP0383361A2 (de) *	1984-10-29	1990-08-22	Viratek, Inc.	1-Beta-D-ribofuranosyl-1,2,4-triazol-3-carboxamid für die Verwendung bei der medizinischen Behandlung von Menschen
US5030623A (en) *	1986-03-27	1991-07-09	The Regents Of The University Of California	Methods for increasing extracellular adenosine and for stabilizing mast cells
WO1997026883A1 (en) *	1996-01-23	1997-07-31	Icn Pharmaceuticals, Inc.	Modulation of th1/th2 cytokine expression by ribavirin® and ribavirin® analogs in activated t-lymphocytes

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5405837A (en) *	1993-05-18	1995-04-11	Indiana University Foundation	Method for the treatment of neoplastic disease utilizing tiazofurin and ribavirin
RU2088232C1 (ru) *	1995-02-14	1997-08-27	Государственный научный центр вирусологии и биотехнологии "Вектор"	Ингибитор репродукции вируса марбург
US5767097A (en) *	1996-01-23	1998-06-16	Icn Pharmaceuticals, Inc.	Specific modulation of Th1/Th2 cytokine expression by ribavirin in activated T-lymphocytes
ATE238328T1 (de) *	1996-10-16	2003-05-15	Ribapharm Inc	Monozyklische l-nukleoside, analoga und ihre anwendungen

1999
- 1999-12-20 IL IL14413099A patent/IL144130A0/xx unknown
- 1999-12-20 CZ CZ20012519A patent/CZ20012519A3/cs unknown
- 1999-12-20 AU AU24833/00A patent/AU2483300A/en not_active Abandoned
- 1999-12-20 CA CA002357735A patent/CA2357735A1/en not_active Abandoned
- 1999-12-20 BR BR9917090-6A patent/BR9917090A/pt not_active IP Right Cessation
- 1999-12-20 JP JP2000595690A patent/JP2002535371A/ja not_active Withdrawn
- 1999-12-20 RU RU2001119056/14A patent/RU2211698C2/ru not_active IP Right Cessation
- 1999-12-20 EP EP99968159A patent/EP1146883A4/de not_active Withdrawn
- 1999-12-20 WO PCT/US1999/030490 patent/WO2000044388A1/en not_active Ceased
- 1999-12-20 SI SI9920099A patent/SI20802A/sl not_active IP Right Cessation
- 1999-12-20 HK HK02102923.6A patent/HK1040937A1/zh unknown
- 1999-12-20 SK SK1009-2001A patent/SK10092001A3/sk unknown
- 1999-12-20 PL PL99364699A patent/PL364699A1/xx not_active Application Discontinuation
- 1999-12-20 MX MXPA01007211A patent/MXPA01007211A/es unknown
- 1999-12-20 HR HR20010496A patent/HRP20010496A2/hr not_active Application Discontinuation
- 1999-12-20 KR KR1020017009609A patent/KR20020023939A/ko not_active Withdrawn
- 1999-12-20 HU HU0200027A patent/HUP0200027A2/hu unknown
- 1999-12-20 CN CN99815897A patent/CN1334736A/zh active Pending
2001
- 2001-07-06 ZA ZA200105595A patent/ZA200105595B/xx unknown
- 2001-07-17 NO NO20013529A patent/NO20013529L/no not_active Application Discontinuation

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4211771A (en) *	1971-06-01	1980-07-08	Robins Ronald K	Treatment of human viral diseases with 1-B-D-ribofuranosyl-1,2,4-triazole-3-carboxamide
EP0038629A1 (de) *	1980-04-17	1981-10-28	Beecham Group Plc	Virazol-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als antivirale Mittel
EP0383361A2 (de) *	1984-10-29	1990-08-22	Viratek, Inc.	1-Beta-D-ribofuranosyl-1,2,4-triazol-3-carboxamid für die Verwendung bei der medizinischen Behandlung von Menschen
EP0643970A2 (de) *	1984-10-29	1995-03-22	Viratek, Inc.	1-Beta-D-ribofuranosyl-1,2,4-triazol-3-carboxamid für die Verwendung in medizinischer Behandlung von Menschen
WO1987005807A1 (en) *	1986-03-27	1987-10-08	Harry Edward Gruber	A method of increasing adenosine excretion
US5030623A (en) *	1986-03-27	1991-07-09	The Regents Of The University Of California	Methods for increasing extracellular adenosine and for stabilizing mast cells
WO1997026883A1 (en) *	1996-01-23	1997-07-31	Icn Pharmaceuticals, Inc.	Modulation of th1/th2 cytokine expression by ribavirin® and ribavirin® analogs in activated t-lymphocytes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO0044388A1 *

Also Published As

Publication number	Publication date
SI20802A (sl)	2002-08-31
WO2000044388A1 (en)	2000-08-03
HRP20010496A2 (en)	2003-08-31
CN1334736A (zh)	2002-02-06
MXPA01007211A (es)	2002-05-06
NO20013529D0 (no)	2001-07-17
CA2357735A1 (en)	2000-08-03
JP2002535371A (ja)	2002-10-22
CZ20012519A3 (cs)	2002-05-15
HUP0200027A2 (en)	2002-04-29
BR9917090A (pt)	2001-10-16
IL144130A0 (en)	2002-05-23
EP1146883A1 (de)	2001-10-24
KR20020023939A (ko)	2002-03-29
NO20013529L (no)	2001-09-12
HK1040937A1 (zh)	2002-06-28
RU2211698C2 (ru)	2003-09-10
SK10092001A3 (sk)	2002-02-05
AU2483300A (en)	2000-08-18
ZA200105595B (en)	2002-10-07
PL364699A1 (en)	2004-12-13

Legal Events

Date	Code	Title	Description
2001-09-07	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2001-10-24	17P	Request for examination filed	Effective date: 20010822
2001-10-24	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2001-10-24	AX	Request for extension of the european patent	Free format text: AL;LT;LV;MK;RO;SI
2002-01-30	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: ICN PHARMACEUTICALS, INC.
2004-11-24	A4	Supplementary search report drawn up and despatched	Effective date: 20041013
2004-12-10	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2005-01-26	18D	Application deemed to be withdrawn	Effective date: 20040701
2008-08-01	REG	Reference to a national code	Ref country code: HK Ref legal event code: WD Ref document number: 1040937 Country of ref document: HK

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