EP1150942A4 - Verbesserte verbindungen zur proteinbindung - Google Patents

Verbesserte verbindungen zur proteinbindung

Info

Publication number
EP1150942A4
EP1150942A4 EP00904701A EP00904701A EP1150942A4 EP 1150942 A4 EP1150942 A4 EP 1150942A4 EP 00904701 A EP00904701 A EP 00904701A EP 00904701 A EP00904701 A EP 00904701A EP 1150942 A4 EP1150942 A4 EP 1150942A4
Authority
EP
European Patent Office
Prior art keywords
protein binding
improved compounds
compounds
improved
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00904701A
Other languages
English (en)
French (fr)
Other versions
EP1150942A1 (de
Inventor
Ping Yin
Christopher John Burns
Matthew Peter Wilkinson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ambri Ltd
Original Assignee
Ambri Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ambri Ltd filed Critical Ambri Ltd
Publication of EP1150942A1 publication Critical patent/EP1150942A1/de
Publication of EP1150942A4 publication Critical patent/EP1150942A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
EP00904701A 1999-02-08 2000-02-08 Verbesserte verbindungen zur proteinbindung Withdrawn EP1150942A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AUPP856399 1999-02-08
AUPP8563A AUPP856399A0 (en) 1999-02-08 1999-02-08 Improved compounds for protein binding
PCT/AU2000/000075 WO2000047548A1 (en) 1999-02-08 2000-02-08 Improved compounds for protein binding

Publications (2)

Publication Number Publication Date
EP1150942A1 EP1150942A1 (de) 2001-11-07
EP1150942A4 true EP1150942A4 (de) 2003-02-12

Family

ID=3812765

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00904701A Withdrawn EP1150942A4 (de) 1999-02-08 2000-02-08 Verbesserte verbindungen zur proteinbindung

Country Status (6)

Country Link
EP (1) EP1150942A4 (de)
JP (1) JP2002536428A (de)
CN (1) CN1345301A (de)
AU (1) AUPP856399A0 (de)
CA (1) CA2341348A1 (de)
WO (1) WO2000047548A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6919333B2 (en) * 2002-11-12 2005-07-19 Rutgers, The State University Of New Jersey Bis-transition-metal-chelate probes
EP1506402A2 (de) * 2002-03-28 2005-02-16 Rutgers, The State University of New Jersey Bis-übergangsmetall-chelat probe
DE10227599B4 (de) * 2002-06-20 2005-04-28 Proteome Factory Ag Verfahren und Reagenz zur spezifischen Identifizierung und Quantifizierung von einem oder mehreren Proteinen in einer Probe
AU2004254295B2 (en) * 2003-07-08 2010-05-27 Tacnia Pty Ltd Improvements in sensor chips
AU2003903504A0 (en) * 2003-07-08 2003-07-24 Johnson, Daniel Improvements in sensor chips
WO2005018610A1 (en) * 2003-08-21 2005-03-03 Lipotek Pty Ltd In vivo targeting of dendritic cells
US7371585B2 (en) 2003-12-31 2008-05-13 Genencor International, Inc. Membranes incorporating recognition moieties
DE102004038134B4 (de) * 2004-08-05 2013-07-25 Johann Wolfgang Goethe-Universität Frankfurt am Main Multivalente Chelatoren zum Modifizieren und Organisieren von Zielmolekülen, Verfahren zu ihrer Herstellung sowie ihre Verwendung
JP2008508333A (ja) * 2004-08-05 2008-03-21 ヨハン ウォルフガング ゲーテ−ウニベルジテート フランクフルト アム マイン 標的分子の改変および組織化のための多価キレーター
EP2015071A1 (de) 2007-07-13 2009-01-14 FUJIFILM Corporation Träger, Herstellungsverfahren dafür, Bioreaktor und Chip für die Oberflächenplasmon-Resonanzanalyse
EP2062921B1 (de) 2007-11-22 2014-02-26 FUJIFILM Corporation Verfahren zur Herstellung eines Trägers
JP2010190891A (ja) * 2009-01-22 2010-09-02 Fujifilm Corp 担体およびその製造方法並びに抽出操作器具
DE102010008417A1 (de) * 2010-02-18 2011-08-18 Johann Wolfgang Goethe-Universität Frankfurt am Main, 60323 Hochaffine multivalente Chelatorverbindungen (MCHs) und deren Verwendung zur Struktur- und Funktionsanalyse von Zielmolekülen
WO2013160453A2 (en) * 2012-04-26 2013-10-31 Iba Gmbh Adapter molecule capable of reversibly equipping a fusion protein carrying an oligohistidine affinity tag with a further affinity tag and methods of using the same
US11639929B2 (en) * 2014-04-29 2023-05-02 Yeda Research And Development Co. Ltd. Universal histidine-tag binding compounds and methods of use thereof as fluorescent probes and sensors
US12332246B2 (en) * 2014-04-29 2025-06-17 Yeda Research And Development Co. Ltd. Quinoline based cyanine dye turn-on fluorescent probes and methods of use thereof
WO2015166491A2 (en) * 2014-04-29 2015-11-05 Yeda Research And Development Co. Ltd. Fluorescent molecular sensor for targeting changes in protein surfaces, and methods of use thereof
CN110183672B (zh) * 2019-05-31 2021-07-09 天津大学 PETx聚合物、制备方法以及三维荆棘状传感器界面
CN116970027A (zh) * 2020-11-04 2023-10-31 中国药科大学 哑铃型两亲性肽类树形分子、合成及其作为药物递送系统的应用

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3158635A (en) * 1959-03-18 1964-11-24 Stauffer Chemical Co Bis-adduction products and methods of preparing same
US3700671A (en) * 1967-05-15 1972-10-24 Monacelli Walter J Chelating compositions
EP0243929A2 (de) * 1986-04-30 1987-11-04 Robin Ewart Offord Polypeptid- und Proteinderivate und Verfahren zu deren Herstellung
US5096946A (en) * 1989-08-18 1992-03-17 Rainer Norman B Polymer product for the selective absorption of dissolved ions
US5342604A (en) * 1988-10-31 1994-08-30 The Dow Chemical Company Complexes possessing ortho ligating functionality
WO1996003646A1 (en) * 1994-07-22 1996-02-08 Akzo Nobel N.V. Chelator idac-2 and method for purifying chelator conjugated compounds
DE19505960A1 (de) * 1995-02-21 1996-08-22 Deutsches Krebsforsch Konjugat zur individuellen Dosierung von Arzneimitteln
DE19518421A1 (de) * 1995-05-19 1996-11-21 Basf Ag Oligomere der Asparaginsäure
WO1999066780A2 (en) * 1998-06-25 1999-12-29 Smithkline Beecham Plc Cinoxacin lanthanide chelates and their use as biomolecular probes

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SE462454B (sv) * 1988-11-10 1990-06-25 Pharmacia Ab Maetyta foer anvaendning i biosensorer
US5580527A (en) * 1992-05-18 1996-12-03 Moltech Corporation Polymeric luminophores for sensing of oxygen
DE4430023A1 (de) * 1994-08-24 1996-02-29 Boehringer Mannheim Gmbh Elektrochemischer Sensor
DE4433980C2 (de) * 1994-09-23 1996-08-22 Boehringer Ingelheim Int Verfahren und Biosensorhit zur Untersuchung der Wechselwirkung von Biomolekülen mittels Oberflächen-Plasma-Resonanz
US5620850A (en) * 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
ES2153097T3 (es) * 1995-04-07 2001-02-16 Mogens Havsteen Jakobsen Procedimiento de inmovilizacion fotoquimica de ligandos usando quinonas.
DE19607279A1 (de) * 1996-02-27 1997-08-28 Bayer Ag Durch Festkörper unterstützte Membran-Biosensoren
JP2000514799A (ja) * 1996-07-03 2000-11-07 プレジデント・アンド・フェローズ・オブ・ハーバード・カレッジ オリゴヌクレオチドリンカーおよび固定化および結合オリゴヌクレオチドを用いる技術

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3158635A (en) * 1959-03-18 1964-11-24 Stauffer Chemical Co Bis-adduction products and methods of preparing same
US3700671A (en) * 1967-05-15 1972-10-24 Monacelli Walter J Chelating compositions
EP0243929A2 (de) * 1986-04-30 1987-11-04 Robin Ewart Offord Polypeptid- und Proteinderivate und Verfahren zu deren Herstellung
US5342604A (en) * 1988-10-31 1994-08-30 The Dow Chemical Company Complexes possessing ortho ligating functionality
US5096946A (en) * 1989-08-18 1992-03-17 Rainer Norman B Polymer product for the selective absorption of dissolved ions
WO1996003646A1 (en) * 1994-07-22 1996-02-08 Akzo Nobel N.V. Chelator idac-2 and method for purifying chelator conjugated compounds
DE19505960A1 (de) * 1995-02-21 1996-08-22 Deutsches Krebsforsch Konjugat zur individuellen Dosierung von Arzneimitteln
DE19518421A1 (de) * 1995-05-19 1996-11-21 Basf Ag Oligomere der Asparaginsäure
WO1999066780A2 (en) * 1998-06-25 1999-12-29 Smithkline Beecham Plc Cinoxacin lanthanide chelates and their use as biomolecular probes

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
HOCHULI E ET AL: "NEW METAL CHELATE ADSORBENT SELECTIVE FOR PROTEINS AND PEPTIDES CONTAINING NEIGHBOURING HISTIDINE RESIDUES", JOURNAL OF CHROMATOGRAPHY, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 411, 1987, pages 177 - 184, XP002059738, ISSN: 0021-9673 *
MICHAELIS, L. ET AL., J. BIOL. CHEM., vol. 106, 1934, pages 331 - 341, XP001040686 *
See also references of WO0047548A1 *
TERCERO-MORENO, J.M. ET AL., J. COORD. CHEM., vol. 35, 1995, pages 73 - 83, XP001040664 *
YASHUNSKII V G ET AL: "SYNTHESIS, ACID-BASE CHARACTERISTICS, AND COMPLEX-FORMING PROPERTIES OF ÄÄ(2-HYDROXYTRIMETHYLENE)DINITRILOÜTETRAKIS(ETHYLENEDINITRILLO)Ü-O CTAACETIC ACID", JOURNAL OF GENERAL CHEMISTRY USSR, CONSULTANTS BUREAU. NEW YORK, US, vol. 60, no. 2, 1990, pages 309 - 313, XP001109160 *

Also Published As

Publication number Publication date
CN1345301A (zh) 2002-04-17
EP1150942A1 (de) 2001-11-07
WO2000047548A1 (en) 2000-08-17
CA2341348A1 (en) 2000-08-17
JP2002536428A (ja) 2002-10-29
AUPP856399A0 (en) 1999-03-04

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Owner name: AUSTRALIAN MEMBRANE AND BIOTECHNOLOGY RESEARCH INS

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