EP1174138A2 - Utilisation du furoate de mometasone pour le traitement des affections pulmonaires et des voies respiratoires - Google Patents

Utilisation du furoate de mometasone pour le traitement des affections pulmonaires et des voies respiratoires Download PDF

Info

Publication number
EP1174138A2
EP1174138A2 EP01119613A EP01119613A EP1174138A2 EP 1174138 A2 EP1174138 A2 EP 1174138A2 EP 01119613 A EP01119613 A EP 01119613A EP 01119613 A EP01119613 A EP 01119613A EP 1174138 A2 EP1174138 A2 EP 1174138A2
Authority
EP
European Patent Office
Prior art keywords
mometasone furoate
day
mcg
asthma
nasal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP01119613A
Other languages
German (de)
English (en)
Other versions
EP1174138A3 (fr
EP1174138B1 (fr
Inventor
Joel A. Sequeira
Keith B. Nolop
Nagamani Nagabhushan
Francis M. Cuss
Imtiaz A. Chaudry
James E. Patrick
Mitchell Cayen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp & Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22692858&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP1174138(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Priority to DK09007995.5T priority Critical patent/DK2156840T3/da
Priority to EP02001144A priority patent/EP1201242B1/fr
Priority to EP09007995A priority patent/EP2156840B1/fr
Publication of EP1174138A2 publication Critical patent/EP1174138A2/fr
Publication of EP1174138A3 publication Critical patent/EP1174138A3/fr
Application granted granted Critical
Publication of EP1174138B1 publication Critical patent/EP1174138B1/fr
Priority to CY1100007A priority patent/CY2617B2/xx
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Definitions

  • Efficacy was evaluated by spirometry and by physician and patient evaluation of asthma signs and symptoms.
  • the forced expiratory volume in one second (FEV 1 ), forced vital capacity (FVC), and forced expiratory flow between 25% to 75% (FEF 25%-75% ) were measured at each visit by the investigator.
  • the peak expiratory flow rate (PEFR) was measured twice daily (AM and PM) by the patient.
  • FEV 1 at endpoint of treatment (last evaluable visit) was the primary measure of efficacy.
  • the investigator at all visits) and the patient (twice daily) rated wheezing, tightness in chest, shortness of breath, and cough on a scale from 0 (None) to 6 (Incapacitating).

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP01119613A 1994-01-27 1995-01-26 Utilisation du furoate de mometasone pour le traitement des affections pulmonaires et des voies respiratoires Expired - Lifetime EP1174138B1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DK09007995.5T DK2156840T3 (da) 1994-01-27 1995-01-26 Anvendelse af mometasonfuroat til behandling af luftvejs- og lungesygdomme
EP02001144A EP1201242B1 (fr) 1994-01-27 1995-01-26 Utilisation du furoate de mométasone dans une thérapie adjuvante
EP09007995A EP2156840B1 (fr) 1994-01-27 1995-01-26 Utilisation du furoate de mometasone pour le traitement des affections pulmonaires et des voies respiratoires
CY1100007A CY2617B2 (en) 1994-01-27 2011-10-27 Use of mometasone furoate for treating airway passage and lung diseases

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18837294A 1994-01-27 1994-01-27
US188372 1994-01-27
EP95909242A EP0740550B1 (fr) 1994-01-27 1995-01-26 Utilisation du furoate de mometasone pour le traitement des affections pulmonaires et des voies respiratoires

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
EP95909242A Division EP0740550B1 (fr) 1994-01-27 1995-01-26 Utilisation du furoate de mometasone pour le traitement des affections pulmonaires et des voies respiratoires
EP95909242.0 Division 1995-08-03

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP02001144.1 Division-Into 2002-01-25
EP09007995.5 Division-Into 2009-06-18

Publications (3)

Publication Number Publication Date
EP1174138A2 true EP1174138A2 (fr) 2002-01-23
EP1174138A3 EP1174138A3 (fr) 2002-01-30
EP1174138B1 EP1174138B1 (fr) 2011-08-03

Family

ID=22692858

Family Applications (6)

Application Number Title Priority Date Filing Date
EP02001144A Expired - Lifetime EP1201242B1 (fr) 1994-01-27 1995-01-26 Utilisation du furoate de mométasone dans une thérapie adjuvante
EP95909242A Expired - Lifetime EP0740550B1 (fr) 1994-01-27 1995-01-26 Utilisation du furoate de mometasone pour le traitement des affections pulmonaires et des voies respiratoires
EP09007995A Expired - Lifetime EP2156840B1 (fr) 1994-01-27 1995-01-26 Utilisation du furoate de mometasone pour le traitement des affections pulmonaires et des voies respiratoires
EP01119614A Expired - Lifetime EP1174139B1 (fr) 1994-01-27 1995-01-26 Utilisation du furoate de mometasone pour le traitement des affections pulmonaires et des voies respiratoires
EP01119613A Expired - Lifetime EP1174138B1 (fr) 1994-01-27 1995-01-26 Utilisation du furoate de mometasone pour le traitement des affections pulmonaires et des voies respiratoires
EP01119615A Ceased EP1192946A1 (fr) 1994-01-27 1995-01-26 Utilisation du furoate de mometasone pour le traitement des affections pulmonaires et des voies respiratoires

Family Applications Before (4)

Application Number Title Priority Date Filing Date
EP02001144A Expired - Lifetime EP1201242B1 (fr) 1994-01-27 1995-01-26 Utilisation du furoate de mométasone dans une thérapie adjuvante
EP95909242A Expired - Lifetime EP0740550B1 (fr) 1994-01-27 1995-01-26 Utilisation du furoate de mometasone pour le traitement des affections pulmonaires et des voies respiratoires
EP09007995A Expired - Lifetime EP2156840B1 (fr) 1994-01-27 1995-01-26 Utilisation du furoate de mometasone pour le traitement des affections pulmonaires et des voies respiratoires
EP01119614A Expired - Lifetime EP1174139B1 (fr) 1994-01-27 1995-01-26 Utilisation du furoate de mometasone pour le traitement des affections pulmonaires et des voies respiratoires

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP01119615A Ceased EP1192946A1 (fr) 1994-01-27 1995-01-26 Utilisation du furoate de mometasone pour le traitement des affections pulmonaires et des voies respiratoires

Country Status (29)

Country Link
EP (6) EP1201242B1 (fr)
JP (6) JP3480736B2 (fr)
KR (1) KR100234864B1 (fr)
CN (4) CN101156860A (fr)
AT (5) ATE518520T1 (fr)
AU (1) AU691880B2 (fr)
CA (1) CA2182086C (fr)
CO (1) CO4340692A1 (fr)
CY (2) CY2617B2 (fr)
CZ (1) CZ219196A3 (fr)
DE (1) DE69526425T2 (fr)
DK (3) DK2156840T3 (fr)
ES (3) ES2369516T3 (fr)
FI (2) FI122395B (fr)
HK (4) HK1040911B (fr)
HU (1) HU227837B1 (fr)
IL (1) IL112459A (fr)
MX (1) MX9602246A (fr)
MY (1) MY114665A (fr)
NO (2) NO314535B1 (fr)
NZ (1) NZ279979A (fr)
PE (1) PE44995A1 (fr)
PL (1) PL315575A1 (fr)
PT (3) PT1174138E (fr)
SG (1) SG47387A1 (fr)
SK (1) SK283338B6 (fr)
TW (1) TW329387B (fr)
WO (1) WO1995020393A1 (fr)
ZA (1) ZA95637B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005072704A3 (fr) * 2004-01-21 2006-07-20 Schering Corp Procedes de traitement

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE44995A1 (es) * 1994-01-27 1995-12-18 Schering Corp Furoato de mometasona para el tratamiento de las enfermedades pulmonares y de las vias respiratorias
CN1245982C (zh) 1996-05-09 2006-03-22 阿姆瑞德手术有限公司 哮喘和气道疾病的治疗
US6068832A (en) * 1996-08-29 2000-05-30 Schering Corporation Chlorofluorocarbon-free mometasone furoate aerosol formulations
CO4900027A1 (es) * 1996-08-29 2000-03-27 Schering Corp Formulaciones en aerosol de furoato de mometasona sin cloro- fluorocarburos .
US5968547A (en) 1997-02-24 1999-10-19 Euro-Celtique, S.A. Method of providing sustained analgesia with buprenorphine
US6503537B2 (en) 1997-03-20 2003-01-07 Schering Corporation Preparation of powder agglomerates
EP1393721B1 (fr) * 1997-03-20 2008-11-26 Schering Corporation Forme galénique d'un agglomérat de particules
US6495167B2 (en) 1997-03-20 2002-12-17 Schering Corporation Preparation of powder agglomerates
EP1033991B1 (fr) * 1997-10-09 2002-04-17 Schering Corporation Suspensions de mometasone furoate pour la nebulisation
MY133181A (en) * 1998-09-10 2007-10-31 Schering Corp Methods and compositions for treating sinusitis, otitis media and other related disorders using antihistamines
GB9904919D0 (en) 1999-03-03 1999-04-28 Novartis Ag Organic compounds
SE9900833D0 (sv) * 1999-03-09 1999-03-09 Astra Ab Novel combination
EP1227812B1 (fr) * 1999-10-08 2007-04-18 Schering Corporation Traitement nasal topique avec la desloratadine et furoate du mometasone
AR029189A1 (es) * 1999-11-02 2003-06-18 Smithkline Beecham Corp Uso de un inhibidor de fosfodiesterasa 4 y un corticoesteroide antiinflamatorio en forma combinada, separadamente o separadamente secuencial para la preparacion de un medicamento
GB0015876D0 (en) 2000-06-28 2000-08-23 Novartis Ag Organic compounds
AU2001278115A1 (en) * 2000-08-04 2002-02-18 Longwood Pharmaceutical Research, Inc. Formulations of mometasone and a bronchodilator for pulmonary administration
EP1344526B1 (fr) 2000-12-22 2008-05-28 Nippon Shinyaku Co., Ltd. Agents preventifs/remedes destines a des maladies inflammatoires des voies aeriennes
GB0207906D0 (en) 2002-04-05 2002-05-15 3M Innovative Properties Co Formoterol and mometasone aerosol formulations
CA2540005A1 (fr) * 2003-09-26 2005-04-07 Schering Corporation Traitement de maladie pulmonaire
EP1680084A2 (fr) * 2003-10-21 2006-07-19 Direct-Haler A/S Medication a administration par voies multiples, servant a traiter une rhinite et un asthme
WO2005044187A2 (fr) * 2003-10-28 2005-05-19 Glaxo Group Limited Preparations pharmaceutiques inhalables employant de l'anhydrate de lactose, et methodes d'administration desdites preparations
EP1806148A4 (fr) * 2004-10-22 2009-12-02 Ono Pharmaceutical Co Préparation thérapeutique pour inhalation
US8497258B2 (en) 2005-11-12 2013-07-30 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
US8679545B2 (en) 2005-11-12 2014-03-25 The Regents Of The University Of California Topical corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract
US8324192B2 (en) 2005-11-12 2012-12-04 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
DK3354276T3 (da) 2007-11-13 2020-03-30 Meritage Pharma Inc Sammensætninger til behandlingen af gastrointestinal inflammation
US20090143343A1 (en) 2007-11-13 2009-06-04 Meritage Pharma, Inc. Compositions for the treatment of inflammation of the gastrointestinal tract
EP2309858A4 (fr) 2008-07-31 2011-09-14 Dekel Pharmaceuticals Ltd Compositions et procédés de traitement de troubles inflammatoires
EP2328553B1 (fr) * 2008-08-20 2020-06-10 The Regents of The University of California Corticostéroïdes destinés au traitement de maladies inflammatoires du tube digestif
CA2739353A1 (fr) * 2008-10-10 2010-04-15 Schering Corporation Compositions a base de corticoides et procedes de traitement associes
US9937189B2 (en) 2013-09-13 2018-04-10 Glenmark Specialty S.A. Stable fixed dose pharmaceutical composition comprising mometasone and olopatadine
US9370483B2 (en) 2013-09-13 2016-06-21 Glenmark Specialty S.A. Stable fixed dose pharmaceutical composition comprising mometasone and olopatadine
US10653661B2 (en) 2013-10-04 2020-05-19 Glenmark Specialty S.A. Treatment of allergic rhinitis using a combination of mometasone and olopatadine
MX2015009429A (es) 2013-10-04 2015-10-09 Glenmark Pharmaceuticals Ltd Tratamiento de rinitis alergica utilizando una combinacion de mometasona y olopatadina.
US10548907B2 (en) 2013-10-04 2020-02-04 Glenmark Specialty S.A. Treatment of allergic rhinitis using a combination of mometasone and olopatadine
US10758550B2 (en) 2013-10-04 2020-09-01 Glenmark Specialty S.A. Treatment of allergic rhinitis using a combination of mometasone and olopatadine
US10016443B2 (en) 2013-10-04 2018-07-10 Glenmark Specialty S.A. Treatment of allergic rhinitis using a combination of mometasone and olopatadine
US11679210B2 (en) 2014-10-03 2023-06-20 Glenmark Specialty S.A. Dispensing device and pharmaceutical composition for the treatment of rhinitis
CN107260665B (zh) * 2016-04-08 2021-03-30 天津金耀集团有限公司 一种吸入用糠酸莫米松混悬液组合物
CN111787954B (zh) 2018-02-23 2023-09-05 格兰马克专业公司 使用莫美他松和奥洛他定的组合治疗儿科受试者的过敏性鼻炎
US12303635B2 (en) 2018-04-16 2025-05-20 Glenmark Specialty S.A. Dispensing device and pharmaceutical composition for the treatment of rhinitis
CN113933415B (zh) * 2021-09-30 2023-03-24 北京阳光德美医药科技有限公司 一种hplc-ms/ms测定人血浆中糠酸酯浓度的方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4472393A (en) 1981-02-02 1984-09-18 Schering Corporation 3,20-Dioxo-1,4-pregnadiene-17α-ol 17-aromatic heterocycle carboxylates
US4873335A (en) 1986-03-12 1989-10-10 Schering Corporation 3-phenethyl-2-benzene-amides or aza-derivatives thereof
EP0518600A1 (fr) 1991-06-10 1992-12-16 Schering Corporation Formulations d'aérosols non-chlorofluorocarbonés

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR890000664B1 (ko) * 1981-10-19 1989-03-22 바리 안소니 뉴우샘 미분된 베클로메타손 디프로피오네이트 일수화물의 제조방법
US4731447A (en) 1985-05-13 1988-03-15 Schering Corporation Process for preparing piperidylidene dihydro-dibenzo(a,d)-cycloheptenes or aza-derivatives thereof
US4972830A (en) 1985-07-31 1990-11-27 Vortran Medical Technology, Inc. Inhalation device and method
US4910192A (en) * 1987-12-04 1990-03-20 Sri International Topically active steroidal anti-inflammatory agents
JPH05501505A (ja) * 1989-04-28 1993-03-25 ライカー ラボラトリーズ,インコーポレイティド 乾燥粉末吸入装置
JPH05505824A (ja) * 1990-03-23 1993-08-26 ミネソタ マイニング アンド マニュファクチャリング カンパニー 所定投与量エアロゾル製剤の製造のための可溶性弗素界面活性剤の使用
DK0548114T5 (da) * 1990-09-10 1995-01-30 Schering Corp Mometason-furoat-monohydrat, fremgangsmåde til fremtilling deraf og farmaceutiske præparater indeholdende dette
ATE146970T1 (de) * 1990-10-16 1997-01-15 John Lezdey Behandlung von entzündungen
ATE114112T1 (de) * 1990-10-18 1994-12-15 Minnesota Mining & Mfg Aerosolzubereitung, die beclometason 17,21- dipropionat enthält.
GB9105705D0 (en) * 1991-03-18 1991-05-01 Sandoz Ltd Improvements in or relating to organic compounds
US6503482B1 (en) * 1991-06-10 2003-01-07 Schering Corporation Non-chlorofluorocarbon aerosol formulations
NZ243314A (en) * 1991-06-26 1994-07-26 Schering Corp Powder dispenser; single metered dose rotated to dispensing conduit
DE4140689B4 (de) * 1991-12-10 2007-11-22 Boehringer Ingelheim Kg Inhalationspulver und Verfahren zu ihrer Herstellung
IL104068A (en) * 1991-12-12 1998-10-30 Glaxo Group Ltd Surfactant-free pharmaceutical aerosol formulation comprising 1,1,1,2-tetrafluoroethane or 1,1,1,2,3,3,3-heptafluoro-n- propane as propellant
NZ246046A (en) * 1991-12-12 1995-12-21 Glaxo Group Ltd Aerosol comprising a particulate medicament in a fluorocarbon or chlorofluorohydrocarbon and a polar cosolvent
JP3026841B2 (ja) * 1991-12-12 2000-03-27 グラクソ、グループ、リミテッド 医 薬
DE69306379T2 (de) * 1992-03-10 1997-06-12 Fisons Plc Inhalierbare arzneimittel
GB9207400D0 (en) * 1992-04-02 1992-05-13 Smithkline Beecham Plc Novel use
PE44995A1 (es) * 1994-01-27 1995-12-18 Schering Corp Furoato de mometasona para el tratamiento de las enfermedades pulmonares y de las vias respiratorias

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4472393A (en) 1981-02-02 1984-09-18 Schering Corporation 3,20-Dioxo-1,4-pregnadiene-17α-ol 17-aromatic heterocycle carboxylates
US4873335A (en) 1986-03-12 1989-10-10 Schering Corporation 3-phenethyl-2-benzene-amides or aza-derivatives thereof
EP0518600A1 (fr) 1991-06-10 1992-12-16 Schering Corporation Formulations d'aérosols non-chlorofluorocarbonés

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LEE ET AL.: "Anti-Inflammatory Steroids: Research Trends and New Compounds", DRUGS TODAY, vol. 25, no. 9, September 1989 (1989-09-01), pages 577 - 588

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005072704A3 (fr) * 2004-01-21 2006-07-20 Schering Corp Procedes de traitement
EP2201936A1 (fr) * 2004-01-21 2010-06-30 Schering Corporation Procédé de traitement de la rhinosinusite aiguë

Also Published As

Publication number Publication date
IL112459A0 (en) 1995-03-30
CN1531967A (zh) 2004-09-29
EP1192946A1 (fr) 2002-04-03
MX9602246A (es) 1997-07-31
JP3480736B2 (ja) 2003-12-22
AU1727195A (en) 1995-08-15
NO20025002L (no) 1996-09-26
FI20115742L (fi) 2011-07-08
NO963132L (no) 1996-09-26
CN100441192C (zh) 2008-12-10
PE44995A1 (es) 1995-12-18
CN1139384A (zh) 1997-01-01
HK1040911A1 (en) 2002-06-28
CN100358528C (zh) 2008-01-02
HK1040911B (en) 2011-11-18
NZ279979A (en) 2001-03-30
ES2368827T3 (es) 2011-11-22
SK82296A3 (en) 1997-03-05
PT1174138E (pt) 2011-10-03
DE69526425D1 (de) 2002-05-23
EP1174139B1 (fr) 2011-09-21
CY2616B2 (en) 2012-05-23
JP2012036222A (ja) 2012-02-23
JP5247265B2 (ja) 2013-07-24
HK1041829A1 (en) 2002-07-26
FI122395B (fi) 2011-12-30
HK1135331A1 (en) 2010-06-04
KR100234864B1 (ko) 1999-12-15
IL112459A (en) 1999-04-11
EP1201242B1 (fr) 2011-11-02
JP2003313128A (ja) 2003-11-06
SG47387A1 (en) 1998-04-17
DE69526425T2 (de) 2002-12-05
EP1174139A2 (fr) 2002-01-23
JP2008285497A (ja) 2008-11-27
HK1040918A1 (en) 2002-06-28
ATE531364T1 (de) 2011-11-15
FI962828L (fi) 1996-07-12
DK1174138T3 (da) 2011-11-21
FI962828A0 (fi) 1996-07-12
MY114665A (en) 2002-12-31
PT2156840E (pt) 2011-10-18
CN101156860A (zh) 2008-04-09
HU227837B1 (en) 2012-05-02
HU9602043D0 (en) 1996-09-30
EP0740550B1 (fr) 2002-04-17
NO314535B1 (no) 2003-04-07
HK1040912A1 (en) 2002-06-28
ATE518520T1 (de) 2011-08-15
EP2156840A2 (fr) 2010-02-24
CZ219196A3 (en) 1996-12-11
CO4340692A1 (es) 1996-07-30
EP1201242A3 (fr) 2003-12-03
WO1995020393A1 (fr) 1995-08-03
EP1174139A3 (fr) 2002-01-30
FI123580B (fi) 2013-07-31
NO328698B1 (no) 2010-04-26
DK0740550T3 (da) 2002-06-24
ES2173947T3 (es) 2002-11-01
NO963132D0 (no) 1996-07-26
JP2008031184A (ja) 2008-02-14
EP2156840A3 (fr) 2010-05-19
CY2617B2 (en) 2012-05-23
ES2369516T3 (es) 2011-12-01
JPH11286447A (ja) 1999-10-19
ATE519489T1 (de) 2011-08-15
CA2182086A1 (fr) 1995-08-03
ATE216243T1 (de) 2002-05-15
CN101164542A (zh) 2008-04-23
EP0740550A1 (fr) 1996-11-06
NO20025002D0 (no) 2002-10-17
HUT74884A (en) 1997-02-28
ZA95637B (en) 1995-07-26
EP2156840B1 (fr) 2011-08-10
PT740550E (pt) 2002-08-30
EP1201242A2 (fr) 2002-05-02
SK283338B6 (sk) 2003-06-03
JPH09501700A (ja) 1997-02-18
DK2156840T3 (da) 2011-11-21
PL315575A1 (en) 1996-11-12
CA2182086C (fr) 2000-04-11
EP1174138A3 (fr) 2002-01-30
ATE525075T1 (de) 2011-10-15
EP1174138B1 (fr) 2011-08-03
AU691880B2 (en) 1998-05-28
TW329387B (en) 1998-04-11

Similar Documents

Publication Publication Date Title
US6723713B2 (en) Use of mometasone furoate for treating upper airway diseases
CA2182086C (fr) Utilisation du furoate de mometasone pour le traitement des affections pulmonaires et des voies respiratoires
HK1135331B (en) Use of mometasone furoate for treating airway passage and lung diseases

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AC Divisional application: reference to earlier application

Ref document number: 740550

Country of ref document: EP

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE

17P Request for examination filed

Effective date: 20020311

AKX Designation fees paid

Free format text: AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE

17Q First examination report despatched

Effective date: 20050729

17Q First examination report despatched

Effective date: 20050729

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

RIC1 Information provided on ipc code assigned before grant

Ipc: A61P 11/02 20060101AFI20110110BHEP

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 9/00 20060101AFI20110124BHEP

Ipc: A61P 11/02 20060101ALI20110124BHEP

Ipc: A61K 31/58 20060101ALI20110124BHEP

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AC Divisional application: reference to earlier application

Ref document number: 0740550

Country of ref document: EP

Kind code of ref document: P

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: NL

Ref legal event code: T3

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 69536184

Country of ref document: DE

Effective date: 20110929

REG Reference to a national code

Ref country code: CH

Ref legal event code: NV

Representative=s name: SERVOPATENT GMBH

REG Reference to a national code

Ref country code: PT

Ref legal event code: SC4A

Free format text: AVAILABILITY OF NATIONAL TRANSLATION

Effective date: 20110926

REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1040911

Country of ref document: HK

REG Reference to a national code

Ref country code: DK

Ref legal event code: T3

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2368827

Country of ref document: ES

Kind code of ref document: T3

Effective date: 20111122

Ref country code: SE

Ref legal event code: TRGR

REG Reference to a national code

Ref country code: GR

Ref legal event code: EP

Ref document number: 20110402573

Country of ref document: GR

Effective date: 20120117

PLBI Opposition filed

Free format text: ORIGINAL CODE: 0009260

PLAX Notice of opposition and request to file observation + time limit sent

Free format text: ORIGINAL CODE: EPIDOSNOBS2

26 Opposition filed

Opponent name: LEK PHARMACEUTICALS D.D.

Effective date: 20120503

REG Reference to a national code

Ref country code: CH

Ref legal event code: PFA

Owner name: MERCK SHARP & DOHME CORP.

Free format text: SCHERING CORPORATION#2000 GALLOPING HILL ROAD#KENILWORTH, NJ 07033 (US) -TRANSFER TO- MERCK SHARP & DOHME CORP.#126 EAST LINCOLN AVENUE#RAHWAY, NEW JERSEY 07065 (US)

REG Reference to a national code

Ref country code: DE

Ref legal event code: R026

Ref document number: 69536184

Country of ref document: DE

Effective date: 20120503

REG Reference to a national code

Ref country code: FR

Ref legal event code: CD

Owner name: MERCK SHARP & DOHME CORP., US

Effective date: 20120709

Ref country code: FR

Ref legal event code: CA

Effective date: 20120709

RAP2 Party data changed (patent owner data changed or rights of a patent transferred)

Owner name: MERCK SHARP & DOHME CORP.

PLAF Information modified related to communication of a notice of opposition and request to file observations + time limit

Free format text: ORIGINAL CODE: EPIDOSCOBS2

REG Reference to a national code

Ref country code: NL

Ref legal event code: TD

Effective date: 20120924

REG Reference to a national code

Ref country code: ES

Ref legal event code: PC2A

Owner name: MERCK SHARP & DOHME CORP.

Effective date: 20121023

PLBB Reply of patent proprietor to notice(s) of opposition received

Free format text: ORIGINAL CODE: EPIDOSNOBS3

PLBP Opposition withdrawn

Free format text: ORIGINAL CODE: 0009264

PLBD Termination of opposition procedure: decision despatched

Free format text: ORIGINAL CODE: EPIDOSNOPC1

REG Reference to a national code

Ref country code: FR

Ref legal event code: CL

Name of requester: MDS FRANCE, FR

Effective date: 20130222

PLBM Termination of opposition procedure: date of legal effect published

Free format text: ORIGINAL CODE: 0009276

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: OPPOSITION PROCEDURE CLOSED

REG Reference to a national code

Ref country code: DE

Ref legal event code: R081

Ref document number: 69536184

Country of ref document: DE

Owner name: MERCK SHARP & DOHME CORP., RAHWAY, US

Free format text: FORMER OWNER: SCHERING CORP., 07033-0530 KENILWORTH, NEW JERSEY, US

Effective date: 20110809

Ref country code: DE

Ref legal event code: R081

Ref document number: 69536184

Country of ref document: DE

Owner name: MERCK SHARP & DOHME CORP., RAHWAY, US

Free format text: FORMER OWNER: SCHERING CORPORATION, KENILWORTH, N.J., US

Effective date: 20130516

Ref country code: DE

Ref legal event code: R082

Ref document number: 69536184

Country of ref document: DE

Representative=s name: ABITZ & PARTNER PATENTANWAELTE MBB, DE

Effective date: 20130516

Ref country code: DE

Ref legal event code: R082

Ref document number: 69536184

Country of ref document: DE

Representative=s name: ABITZ & PARTNER, DE

Effective date: 20130516

Ref country code: DE

Ref legal event code: R081

Ref document number: 69536184

Country of ref document: DE

Owner name: MERCK SHARP & DOHME CORP., US

Free format text: FORMER OWNER: SCHERING CORPORATION, KENILWORTH, US

Effective date: 20130516

Ref country code: DE

Ref legal event code: R081

Ref document number: 69536184

Country of ref document: DE

Owner name: MERCK SHARP & DOHME CORP., US

Free format text: FORMER OWNER: SCHERING CORP., 07033-0530 KENILWORTH, US

Effective date: 20110809

27C Opposition proceedings terminated

Effective date: 20130316

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20131227

Year of fee payment: 20

Ref country code: DK

Payment date: 20131227

Year of fee payment: 20

Ref country code: PT

Payment date: 20131230

Year of fee payment: 20

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GR

Payment date: 20131230

Year of fee payment: 20

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: LU

Payment date: 20140211

Year of fee payment: 20

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: BE

Payment date: 20140127

Year of fee payment: 20

Ref country code: IE

Payment date: 20140102

Year of fee payment: 20

Ref country code: NL

Payment date: 20140108

Year of fee payment: 20

Ref country code: CH

Payment date: 20140127

Year of fee payment: 20

Ref country code: SE

Payment date: 20140109

Year of fee payment: 20

Ref country code: DE

Payment date: 20140131

Year of fee payment: 20

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20131223

Year of fee payment: 20

Ref country code: AT

Payment date: 20131227

Year of fee payment: 20

Ref country code: IT

Payment date: 20140117

Year of fee payment: 20

Ref country code: ES

Payment date: 20140120

Year of fee payment: 20

REG Reference to a national code

Ref country code: DE

Ref legal event code: R071

Ref document number: 69536184

Country of ref document: DE

REG Reference to a national code

Ref country code: DE

Ref legal event code: R071

Ref document number: 69536184

Country of ref document: DE

REG Reference to a national code

Ref country code: DK

Ref legal event code: EUP

Effective date: 20150126

REG Reference to a national code

Ref country code: PT

Ref legal event code: MM4A

Free format text: MAXIMUM VALIDITY LIMIT REACHED

Effective date: 20150126

REG Reference to a national code

Ref country code: NL

Ref legal event code: V4

Effective date: 20150126

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

REG Reference to a national code

Ref country code: GB

Ref legal event code: PE20

Expiry date: 20150125

REG Reference to a national code

Ref country code: IE

Ref legal event code: MK9A

REG Reference to a national code

Ref country code: SE

Ref legal event code: EUG

REG Reference to a national code

Ref country code: AT

Ref legal event code: MK07

Ref document number: 518520

Country of ref document: AT

Kind code of ref document: T

Effective date: 20150126

REG Reference to a national code

Ref country code: GR

Ref legal event code: MA

Ref document number: 20110402573

Country of ref document: GR

Effective date: 20150127

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IE

Free format text: LAPSE BECAUSE OF EXPIRATION OF PROTECTION

Effective date: 20150126

Ref country code: PT

Free format text: LAPSE BECAUSE OF EXPIRATION OF PROTECTION

Effective date: 20150203

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF EXPIRATION OF PROTECTION

Effective date: 20150125

REG Reference to a national code

Ref country code: ES

Ref legal event code: FD2A

Effective date: 20150826

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF EXPIRATION OF PROTECTION

Effective date: 20150127