EP1192009A4 - Verfahren zur erzeugung eines aerosols - Google Patents

Verfahren zur erzeugung eines aerosols

Info

Publication number
EP1192009A4
EP1192009A4 EP00938249A EP00938249A EP1192009A4 EP 1192009 A4 EP1192009 A4 EP 1192009A4 EP 00938249 A EP00938249 A EP 00938249A EP 00938249 A EP00938249 A EP 00938249A EP 1192009 A4 EP1192009 A4 EP 1192009A4
Authority
EP
European Patent Office
Prior art keywords
producing aerosol
aerosol
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP00938249A
Other languages
English (en)
French (fr)
Other versions
EP1192009B1 (de
EP1192009A1 (de
Inventor
Joan Rosell
Alfonso Ganan-Calvo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidad de Sevilla
Aradigm Corp
Original Assignee
Universidad de Sevilla
Aradigm Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidad de Sevilla, Aradigm Corp filed Critical Universidad de Sevilla
Publication of EP1192009A1 publication Critical patent/EP1192009A1/de
Publication of EP1192009A4 publication Critical patent/EP1192009A4/de
Application granted granted Critical
Publication of EP1192009B1 publication Critical patent/EP1192009B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/02—Spray pistols; Apparatus for discharge
    • B05B7/04—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge
    • B05B7/0416—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge with arrangements for mixing one gas and one liquid
    • B05B7/0441—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge with arrangements for mixing one gas and one liquid with one inner conduit of liquid surrounded by an external conduit of gas upstream the mixing chamber
    • B05B7/0475—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge with arrangements for mixing one gas and one liquid with one inner conduit of liquid surrounded by an external conduit of gas upstream the mixing chamber with means for deflecting the peripheral gas flow towards the central liquid flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/02—Spray pistols; Apparatus for discharge
    • B05B7/04—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge
    • B05B7/0416—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge with arrangements for mixing one gas and one liquid
    • B05B7/0483—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge with arrangements for mixing one gas and one liquid with gas and liquid jets intersecting in the mixing chamber
EP00938249.0A 1999-06-11 2000-06-09 Verfahren zur erzeugung eines aerosols Expired - Lifetime EP1192009B1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13869899P 1999-06-11 1999-06-11
US138698P 1999-06-11
PCT/US2000/015931 WO2000076673A1 (en) 1999-06-11 2000-06-09 Method for producing an aerosol

Publications (3)

Publication Number Publication Date
EP1192009A1 EP1192009A1 (de) 2002-04-03
EP1192009A4 true EP1192009A4 (de) 2006-10-18
EP1192009B1 EP1192009B1 (de) 2013-05-01

Family

ID=22483216

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00938249.0A Expired - Lifetime EP1192009B1 (de) 1999-06-11 2000-06-09 Verfahren zur erzeugung eines aerosols

Country Status (6)

Country Link
EP (1) EP1192009B1 (de)
JP (1) JP2003501257A (de)
AU (1) AU767486B2 (de)
CA (1) CA2374232C (de)
ES (1) ES2424713T4 (de)
WO (1) WO2000076673A1 (de)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060169800A1 (en) * 1999-06-11 2006-08-03 Aradigm Corporation Aerosol created by directed flow of fluids and devices and methods for producing same
US7575761B2 (en) 2000-06-30 2009-08-18 Novartis Pharma Ag Spray drying process control of drying kinetics
JP2005503425A (ja) 2001-05-24 2005-02-03 アレックザ モレキュラー デリヴァリー コーポレイション 所定の吸入ルートによる薬剤エステルの送出
US7090830B2 (en) 2001-05-24 2006-08-15 Alexza Pharmaceuticals, Inc. Drug condensation aerosols and kits
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US7078016B2 (en) 2001-11-21 2006-07-18 Alexza Pharmaceuticals, Inc. Delivery of caffeine through an inhalation route
US7498019B2 (en) 2001-05-24 2009-03-03 Alexza Pharmaceuticals, Inc. Delivery of compounds for the treatment of headache through an inhalation route
US7585493B2 (en) 2001-05-24 2009-09-08 Alexza Pharmaceuticals, Inc. Thin-film drug delivery article and method of use
US20030051728A1 (en) 2001-06-05 2003-03-20 Lloyd Peter M. Method and device for delivering a physiologically active compound
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
ATE415155T1 (de) 2001-05-24 2008-12-15 Alexza Pharmaceuticals Inc Verabreichung von alprazolam, estazolam, midazolam oder triazolam durch inhalation
WO2002094242A1 (en) 2001-05-24 2002-11-28 Alexza Molecular Delivery Corporation Delivery of rizatriptan or zolmitriptan through an inhalation route
JP4834861B2 (ja) * 2001-09-25 2011-12-14 株式会社イノアックコーポレーション 流体混合機構
KR100951750B1 (ko) 2001-11-01 2010-04-09 노바르티스 아게 분무 건조 방법 및 그 조성물
WO2003041693A1 (en) 2001-11-09 2003-05-22 Alexza Molecular Delivery Corporation Delivery of diazepam through an inhalation route
US9339459B2 (en) 2003-04-24 2016-05-17 Nektar Therapeutics Particulate materials
JP2006507921A (ja) * 2002-06-28 2006-03-09 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 流体分散のための方法および装置
US7550133B2 (en) 2002-11-26 2009-06-23 Alexza Pharmaceuticals, Inc. Respiratory drug condensation aerosols and methods of making and using them
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
AU2004229440B2 (en) 2003-04-10 2010-08-12 President And Fellows Of Harvard College Formation and control of fluidic species
US20040234916A1 (en) 2003-05-21 2004-11-25 Alexza Molecular Delivery Corporation Optically ignited or electrically ignited self-contained heating unit and drug-supply unit employing same
US20040235308A1 (en) 2003-05-22 2004-11-25 Dainippon Screen Mfg. Co., Ltd. Substrate treatment method and sustrate treatment apparatus
WO2005021151A1 (en) 2003-08-27 2005-03-10 President And Fellows Of Harvard College Electronic control of fluidic species
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
US7540286B2 (en) 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
US7655470B2 (en) 2004-10-29 2010-02-02 University Of Chicago Method for manipulating a plurality of plugs and performing reactions therein in microfluidic systems
US9477233B2 (en) 2004-07-02 2016-10-25 The University Of Chicago Microfluidic system with a plurality of sequential T-junctions for performing reactions in microdroplets
EP1781360A1 (de) 2004-08-12 2007-05-09 Alexza Pharmaceuticals, Inc. Aerosol-arzneiabgabevorrichtung mit perkussiv aktivierten wärmepackungen
ES2264608B2 (es) * 2004-09-30 2007-08-16 Universidad De Sevilla Dispositivo y procedimiento para la atomizacion neumatica de liquidos mediante flujo implosivo de gas.
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
EP1839760A1 (de) * 2005-01-17 2007-10-03 Universidad de Sevilla Verfahren und vorrichtung zum mikromischen von flüssigkeiten mithilfe einer rücklaufzelle
ES2265270B1 (es) * 2005-04-18 2008-01-01 Universidad De Sevilla Procedimiento y dispositivo para micro-mezclado de fluidos mediante celula de reflujo.
WO2006096571A2 (en) 2005-03-04 2006-09-14 President And Fellows Of Harvard College Method and apparatus for forming multiple emulsions
WO2007081385A2 (en) 2006-01-11 2007-07-19 Raindance Technologies, Inc. Microfluidic devices and methods of use in the formation and control of nanoreactors
EP2530167A1 (de) 2006-05-11 2012-12-05 Raindance Technologies, Inc. Mikrofluidische Vorrichtungen
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
EP2077912B1 (de) 2006-08-07 2019-03-27 The President and Fellows of Harvard College Fluorkohlenstoffemulsionsstabilisierende tenside
WO2008097559A2 (en) 2007-02-06 2008-08-14 Brandeis University Manipulation of fluids and reactions in microfluidic systems
WO2008112661A2 (en) 2007-03-09 2008-09-18 Alexza Pharmaceuticals, Inc. Heating unit for use in a drug delivery device
EP2136786B8 (de) 2007-03-28 2012-11-14 President and Fellows of Harvard College Vorrichtung zur Formung von Tröpfchen
US8592221B2 (en) 2007-04-19 2013-11-26 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
US9091434B2 (en) 2008-04-18 2015-07-28 The Board Of Trustees Of The University Of Alabama Meso-scaled combustion system
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
EP4047367A1 (de) 2008-07-18 2022-08-24 Bio-Rad Laboratories, Inc. Verfahren zum nachweis von zielanalyten unter verwendung von tropfenbibliotheken
US20100176063A1 (en) * 2009-01-12 2010-07-15 Yuri Kokotov Method for coalescence induced liquid-liquid separations and apparatus thereof
WO2010111231A1 (en) 2009-03-23 2010-09-30 Raindance Technologies, Inc. Manipulation of microfluidic droplets
WO2011028764A2 (en) 2009-09-02 2011-03-10 President And Fellows Of Harvard College Multiple emulsions created using jetting and other techniques
US10520500B2 (en) 2009-10-09 2019-12-31 Abdeslam El Harrak Labelled silica-based nanomaterial with enhanced properties and uses thereof
US10837883B2 (en) 2009-12-23 2020-11-17 Bio-Rad Laboratories, Inc. Microfluidic systems and methods for reducing the exchange of molecules between droplets
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
EP4484577A3 (de) 2010-02-12 2025-03-26 Bio-Rad Laboratories, Inc. Digitale analytanalyse
EP2576078B1 (de) 2010-05-28 2018-04-25 Arizona Board of Regents acting for and on behalf of Arizona State University Vorrichtung und verfahren für gasdynamische virtuelle düse
US20120048963A1 (en) 2010-08-26 2012-03-01 Alexza Pharmaceuticals, Inc. Heat Units Using a Solid Fuel Capable of Undergoing an Exothermic Metal Oxidation-Reduction Reaction Propagated without an Igniter
US9562897B2 (en) 2010-09-30 2017-02-07 Raindance Technologies, Inc. Sandwich assays in droplets
EP3412778A1 (de) 2011-02-11 2018-12-12 Raindance Technologies, Inc. Verfahren zur bildung gemischter tröpfchen
WO2012112804A1 (en) 2011-02-18 2012-08-23 Raindance Technoligies, Inc. Compositions and methods for molecular labeling
BR112013029729A2 (pt) 2011-05-23 2017-01-24 Basf Se controle de emulsões, incluindo emulsões múltiplas
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
EP3216872B1 (de) 2011-06-02 2020-04-01 Bio-Rad Laboratories, Inc. Enzymquantifizierung
CN103764265A (zh) 2011-07-06 2014-04-30 哈佛学院院长等 多重乳剂和用于配制多重乳剂的技术
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
EP2777818A1 (de) 2013-03-15 2014-09-17 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Verfahren und Vorrichtung zur Herstellung eines intermittierenden Flüssigkeitsstrahls
WO2014179193A1 (en) 2013-04-30 2014-11-06 Uwe Weierstall Apparatus and methods for lipidic cubic phase (lcp) injection for membrane protein investigations
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
WO2015103367A1 (en) 2013-12-31 2015-07-09 Raindance Technologies, Inc. System and method for detection of rna species
WO2016145075A1 (en) 2015-03-11 2016-09-15 Alexza Pharmaceuticals, Inc. Use of antistatic materials in the airway for thermal aerosol condensation process
CN108348933B (zh) 2015-08-28 2022-01-28 明尼苏达州大学董事会 喷嘴和混合流体流的方法
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
ES2663217B1 (es) * 2016-10-10 2019-02-07 Ingeniatrics Tecnologias S L Aparato y método para mezclar al menos dos líquidos
US12214118B2 (en) 2018-02-02 2025-02-04 Alexza Pharmaceuticals, Inc. Electrical condensation aerosol device
US11872583B2 (en) 2018-06-14 2024-01-16 Regents Of The University Of Minnesota Counterflow mixer and atomizer
US10369579B1 (en) 2018-09-04 2019-08-06 Zyxogen, Llc Multi-orifice nozzle for droplet atomization
CN115228642A (zh) * 2022-08-02 2022-10-25 北京航空航天大学 小流量分散流雾化喷嘴及低流速雾化器

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0899017A1 (de) * 1996-05-13 1999-03-03 Universidad De Sevilla, Vicerrectorado De Investigacion Verfahren zur zerstäubung von flüssigkeiten

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05138080A (ja) * 1991-11-25 1993-06-01 Matsushita Electric Ind Co Ltd 霧化装置
US5868322A (en) * 1996-01-31 1999-02-09 Hewlett-Packard Company Apparatus for forming liquid droplets having a mechanically fixed inner microtube
US5884846A (en) * 1996-09-19 1999-03-23 Tan; Hsiaoming Sherman Pneumatic concentric nebulizer with adjustable and capillaries
EP1037858A1 (de) 1997-12-17 2000-09-27 Universidad de Sevilla Vorrichtung und verfahren zur herstellung von kugelförmigen teilchen einheitlicher grösse

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0899017A1 (de) * 1996-05-13 1999-03-03 Universidad De Sevilla, Vicerrectorado De Investigacion Verfahren zur zerstäubung von flüssigkeiten

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO0076673A1 *

Also Published As

Publication number Publication date
JP2003501257A (ja) 2003-01-14
AU767486B2 (en) 2003-11-13
ES2424713T3 (es) 2013-10-07
ES2424713T4 (es) 2014-01-23
AU5331800A (en) 2001-01-02
CA2374232C (en) 2013-08-20
CA2374232A1 (en) 2000-12-21
EP1192009B1 (de) 2013-05-01
EP1192009A1 (de) 2002-04-03
WO2000076673A1 (en) 2000-12-21

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