EP1206477A4 - Clonage des genes streptomyces avermitilis pour la glycosylation d'aglycones d'avermectine - Google Patents

Clonage des genes streptomyces avermitilis pour la glycosylation d'aglycones d'avermectine

Info

Publication number
EP1206477A4
EP1206477A4 EP00950713A EP00950713A EP1206477A4 EP 1206477 A4 EP1206477 A4 EP 1206477A4 EP 00950713 A EP00950713 A EP 00950713A EP 00950713 A EP00950713 A EP 00950713A EP 1206477 A4 EP1206477 A4 EP 1206477A4
Authority
EP
European Patent Office
Prior art keywords
avmectin
avermitil
streptomyce
aglycones
glycosylation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00950713A
Other languages
German (de)
English (en)
Other versions
EP1206477A1 (fr
Inventor
Douglas J Macneil
James Occi
Keith M Gewain
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP1206477A1 publication Critical patent/EP1206477A1/fr
Publication of EP1206477A4 publication Critical patent/EP1206477A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP00950713A 1999-07-30 2000-07-26 Clonage des genes streptomyces avermitilis pour la glycosylation d'aglycones d'avermectine Withdrawn EP1206477A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14669999P 1999-07-30 1999-07-30
US146699P 1999-07-30
PCT/US2000/020331 WO2001009155A1 (fr) 1999-07-30 2000-07-26 Clonage des genes streptomyces avermitilis pour la glycosylation d'aglycones d'avermectine

Publications (2)

Publication Number Publication Date
EP1206477A1 EP1206477A1 (fr) 2002-05-22
EP1206477A4 true EP1206477A4 (fr) 2004-11-24

Family

ID=22518585

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00950713A Withdrawn EP1206477A4 (fr) 1999-07-30 2000-07-26 Clonage des genes streptomyces avermitilis pour la glycosylation d'aglycones d'avermectine

Country Status (4)

Country Link
EP (1) EP1206477A4 (fr)
JP (1) JP2003506022A (fr)
CA (1) CA2380639A1 (fr)
WO (1) WO2001009155A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000245457A (ja) 1999-02-24 2000-09-12 Kitasato Inst:The エバーメクチンアグリコン合成酵素遺伝子
JP2004535175A (ja) * 2001-04-26 2004-11-25 エコピア バイオサイエンシーズ インク ポリケチド生合成用遺伝子及びタンパク質
EP1524318A1 (fr) * 2001-04-26 2005-04-20 Ecopia Biosciences Inc. Gènes et protéines pour la biosynthèse de polyketides
US7630836B2 (en) 2001-05-30 2009-12-08 The Kitasato Institute Polynucleotides
EP1477563A3 (fr) * 2003-05-16 2004-11-24 Wyeth Clonage de gènes de Streptomyces cyaneogriseus subsp.noncyanogenus pour la biosynthèse des antibiotiques et procédés pour leur utilisation

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0391594A2 (fr) * 1989-03-31 1990-10-10 Merck & Co. Inc. Clonage de gènes de Streptomyces avermitilis pour la biosynthèse de l'avermectine et procédés pour leur utilisation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6822696A (en) * 1995-08-30 1997-03-19 Novartis Ag Staurosporin biosynthesis gene clusters

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0391594A2 (fr) * 1989-03-31 1990-10-10 Merck & Co. Inc. Clonage de gènes de Streptomyces avermitilis pour la biosynthèse de l'avermectine et procédés pour leur utilisation

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL 10 February 1999 (1999-02-10), "Streptomyces cyanogenus landomycin biosynthetic gene cluster, complete sequence", XP002298610, Database accession no. AF080235 *
MACNEIL D J ET AL: "ANALYSIS OF STREPTOMYCES AVERMITILIS GENES REQUIRED FOR AVERMECTIN BIOSYNTHESIS UTILIZING A NOVEL INTEGRATION VECTOR", GENE, ELSEVIER BIOMEDICAL PRESS. AMSTERDAM, NL, vol. 111, no. 1, 1992, pages 61 - 68, XP001180832, ISSN: 0378-1119 *
OCCI J L ET AL: "CLONING AND SEQUENCING A 5.2 KB REGION FROM STREPTOMYCES-AVERMITILIS INVOLVED IN GLYCOSYLATION OF AVERMECTIN", ABSTRACTS OF THE ANNUAL MEETING OF THE AMERICAN SOCIETY FOR MICROBIOLOGY, vol. 90, 1990, 90TH ANNUAL MEETING OF THE AMERICAN SOCIETY FOR MICROBIOLOGY 1990, ANAHEIM, CALIFORNIA, USA, MAY 13-, pages 268, XP008036043, ISSN: 0094-8519 *
SCHULMAN M D ET AL: "PURIFICATION AND IDENTIFICATION OF D-TDP-OLEANDROSE THE PRECURSOR OF THE OLEANDROSE UNITS OF THE AVERMECTINS", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 265, no. 28, 1990, pages 16965 - 16970, XP002298197, ISSN: 0021-9258 *
See also references of WO0109155A1 *

Also Published As

Publication number Publication date
WO2001009155A1 (fr) 2001-02-08
CA2380639A1 (fr) 2001-02-08
JP2003506022A (ja) 2003-02-18
EP1206477A1 (fr) 2002-05-22

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 20020228

A4 Supplementary search report drawn up and despatched

Effective date: 20041013

RIC1 Information provided on ipc code assigned before grant

Ipc: 7C 12R 1:465 J

Ipc: 7C 12N 9/00 J

Ipc: 7C 12N 9/00 A

Ipc: 7C 12N 15/52 B

17Q First examination report despatched

Effective date: 20050307

STAA Information on the status of an ep patent application or granted ep patent

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18D Application deemed to be withdrawn

Effective date: 20050920