EP1262177A3 - Medizinische Verwendung thyromimetischer Verbindungen gegen Haarausfall und Zusammensetzungen - Google Patents
Medizinische Verwendung thyromimetischer Verbindungen gegen Haarausfall und Zusammensetzungen Download PDFInfo
- Publication number
- EP1262177A3 EP1262177A3 EP02253607A EP02253607A EP1262177A3 EP 1262177 A3 EP1262177 A3 EP 1262177A3 EP 02253607 A EP02253607 A EP 02253607A EP 02253607 A EP02253607 A EP 02253607A EP 1262177 A3 EP1262177 A3 EP 1262177A3
- Authority
- EP
- European Patent Office
- Prior art keywords
- hair loss
- compositions
- medical use
- thyromimetic compounds
- treat hair
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 201000004384 Alopecia Diseases 0.000 title abstract 3
- 208000024963 hair loss Diseases 0.000 title abstract 3
- 230000003676 hair loss Effects 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 230000000929 thyromimetic effect Effects 0.000 title abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 230000003779 hair growth Effects 0.000 abstract 1
- 244000144972 livestock Species 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4966—Triazines or their condensed derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29496201P | 2001-05-31 | 2001-05-31 | |
| US294962P | 2001-05-31 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| EP1262177A2 EP1262177A2 (de) | 2002-12-04 |
| EP1262177A3 true EP1262177A3 (de) | 2003-09-03 |
| EP1262177B1 EP1262177B1 (de) | 2006-08-23 |
Family
ID=23135661
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP02253607A Expired - Lifetime EP1262177B1 (de) | 2001-05-31 | 2002-05-22 | Medizinische Verwendung thyromimetischer Verbindungen gegen Haarausfall und Zusammensetzungen |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US20030007941A1 (de) |
| EP (1) | EP1262177B1 (de) |
| JP (1) | JP4051230B2 (de) |
| KR (1) | KR100523503B1 (de) |
| CN (1) | CN1314393C (de) |
| AT (1) | ATE337009T1 (de) |
| AU (1) | AU784806B2 (de) |
| CA (1) | CA2387198C (de) |
| CY (1) | CY1105221T1 (de) |
| DE (1) | DE60214080T2 (de) |
| DK (1) | DK1262177T3 (de) |
| ES (1) | ES2267945T3 (de) |
| HK (1) | HK1049285B (de) |
| HU (1) | HUP0201834A3 (de) |
| IL (2) | IL149843A (de) |
| PL (1) | PL354216A1 (de) |
| PT (1) | PT1262177E (de) |
| TW (1) | TWI278313B (de) |
| ZA (1) | ZA200204189B (de) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7067148B2 (en) | 2001-02-15 | 2006-06-27 | King Pharmaceutical Research & Development, Inc. | Stabilized pharmaceutical and thyroid hormone compositions and method of preparation |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6555581B1 (en) | 2001-02-15 | 2003-04-29 | Jones Pharma, Inc. | Levothyroxine compositions and methods |
| US7101569B2 (en) | 2001-08-14 | 2006-09-05 | Franz G Andrew | Methods of administering levothyroxine pharmaceutical compositions |
| AU2003233681A1 (en) * | 2002-05-23 | 2003-12-12 | Michael J. Powell | Diagnosis and treatment of human dormancy syndrome |
| US7485298B2 (en) | 2002-05-23 | 2009-02-03 | Michael Powell | Diagnosis and treatment of human dormancy-related sequellae |
| US7622103B1 (en) * | 2003-03-27 | 2009-11-24 | Cielo Jill M | Hair and scalp toxin remover composition and method of its making |
| ES2931949T3 (es) * | 2005-03-29 | 2023-01-05 | Univ Pennsylvania | Minoxidilo para generar nuevos folículos pilosos y tratar la calvicie |
| US8147815B2 (en) * | 2005-12-16 | 2012-04-03 | Celmatrix Corporation | Topical administration carrier composition and therapeutic formulations comprising same |
| BRPI1015096A2 (pt) | 2009-04-20 | 2016-05-03 | Mitsubishi Tanabe Pharma Corp | agonista de receptor beta de hormônio tireoideano |
| WO2012078649A1 (en) | 2010-12-06 | 2012-06-14 | Follica, Inc. | Methods for treating baldness and promoting hair growth |
| JP6156371B2 (ja) * | 2012-06-08 | 2017-07-05 | 大正製薬株式会社 | 発毛組成物 |
| PL2695611T3 (pl) | 2012-08-06 | 2015-03-31 | Dr August Wolff Gmbh & Co Kg Arzneimittel | Eprotirom do stosowania w profilaktyce i/lub leczeniu zaburzeń włosów oraz jego kompozycje |
| US9827181B2 (en) | 2013-06-05 | 2017-11-28 | Industrial Technology Research Institute | Method and pharmaceutical composition for hair growth |
| US9402876B2 (en) | 2013-11-27 | 2016-08-02 | Industrial Technology Research Institute | Method and pharmaceutical composition for hair growth |
| CN104306168B (zh) * | 2014-10-15 | 2017-05-24 | 华东师范大学 | 氮‑(4‑氯‑2,5‑二甲氧基苯基)‑5‑异丙基‑2‑甲氧基苯磺酰胺在促进毛发生长的应用 |
| AU2017295038B2 (en) | 2016-07-15 | 2022-09-22 | Centre Hospitalier Sainte Anne Paris | 5-hydroxytryptamine 1B receptor-stimulating agent for skin and/or hair repair |
| US9962444B2 (en) | 2016-09-27 | 2018-05-08 | Shane Malek | Pharmacokinetically extended action topical hair growth formulation, and administration method |
| JP7360583B2 (ja) | 2017-09-14 | 2023-10-13 | 国立研究開発法人理化学研究所 | 網膜組織の製造方法 |
| CN108727344A (zh) * | 2018-05-14 | 2018-11-02 | 嘉兴特科罗生物科技有限公司 | 一种化合物及其合成方法和应用 |
| US11766392B2 (en) * | 2018-10-05 | 2023-09-26 | Jupiter Wellness, Inc. | Minoxidil adjuvant therapies |
| US11628132B2 (en) | 2018-10-05 | 2023-04-18 | Jupiter Wellness, Inc. | Minoxidil adjuvant therapies |
| US12533309B2 (en) | 2018-10-05 | 2026-01-27 | Caring Brands, Inc. | Minoxidil adjuvant therapies |
| WO2020184720A1 (ja) | 2019-03-13 | 2020-09-17 | 大日本住友製薬株式会社 | 移植用神経網膜の品質を評価する方法及び移植用神経網膜シート |
| MX2021013472A (es) | 2019-05-08 | 2022-01-06 | Aligos Therapeutics Inc | Moduladores de thr-? y metodos de uso de estos. |
| WO2021143706A1 (en) | 2020-01-13 | 2021-07-22 | Eccogene (Shanghai) Co., Ltd. | Substituted triazinones as thyroid hormone receptor agonists |
| CN114075173A (zh) * | 2020-08-19 | 2022-02-22 | 成都凡诺西生物医药科技有限公司 | 腈代三嗪类衍生物及其制备方法和应用 |
| US20230310614A1 (en) | 2020-09-11 | 2023-10-05 | Sumitomo Pharma Co., Ltd. | Medium for Tissue for Transplantation |
| US20230313133A1 (en) | 2020-09-11 | 2023-10-05 | Riken | Complex Containing Neural Retina-Containing Cell Aggregates and Matrix, and Method for Manufacturing Same |
| WO2023090427A1 (ja) | 2021-11-19 | 2023-05-25 | 国立研究開発法人理化学研究所 | シート状網膜組織の製造方法 |
| CN116327765A (zh) * | 2023-03-27 | 2023-06-27 | 广州许愿树毛发医学科技有限公司 | 莲心碱类化合物作为β2-肾上腺素受体阻断剂的应用 |
| WO2025214484A1 (en) * | 2024-04-12 | 2025-10-16 | Ascletis Pharma (China) Co., Limited | Thyromimetics for treatment of alopecia areata |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000051971A1 (en) * | 1999-03-01 | 2000-09-08 | Pfizer Products Inc. | Oxamic acids and derivatives as thyroid receptor ligands |
| WO2000058279A1 (en) * | 1999-03-29 | 2000-10-05 | Novartis Ag | Diaryl derivatives and their use as medicaments |
| WO2000073292A1 (en) * | 1999-06-01 | 2000-12-07 | The University Of Texas Southwestern Medical Center | Biaryl compounds |
| WO2000072920A1 (en) * | 1999-06-01 | 2000-12-07 | The University Of Texas Southwestern Medical Center | Substituted biaryl ether compounds |
| WO2000072812A1 (en) * | 1999-06-01 | 2000-12-07 | The University Of Texas Southwestern Medical Center | Method of treating hair loss using diphenylether derivatives |
| WO2000073265A1 (en) * | 1999-06-01 | 2000-12-07 | The University Of Texas Southwestern Medical Centre | Sulfur-containing thyroxane derivatives and their use as hair growth promotors |
| EP1088819A2 (de) * | 1999-09-30 | 2001-04-04 | Pfizer Products Inc. | 6-Azauracilderivate als Liganden der Thyroidrezeptoren |
| WO2001070687A1 (de) * | 2000-03-23 | 2001-09-27 | Bayer Aktiengesellschaft | Indole zur behandlung von krankheiten die mit schilddrüsenhormonen behandeln werden können |
| WO2002032408A2 (en) * | 2000-10-20 | 2002-04-25 | Novartis Ag | Combinations of a thyromimetic compound and a statin |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH26708A (en) * | 1983-08-17 | 1992-09-15 | Wellcome Found | Physiologically active compositions containing anti-hormone anti-bodies and their use |
| JPS61165311A (ja) * | 1985-01-14 | 1986-07-26 | Takeo Kinji | 養毛化粧料 |
| US5061798A (en) * | 1985-01-18 | 1991-10-29 | Smith Kline & French Laboratories, Ltd. | Benzyl pyridyl and pyridazinyl compounds |
| US5284971A (en) * | 1992-07-16 | 1994-02-08 | Syntex (U.S.A.) Inc. | 4-(3-cyclohexyl-4-hydroxy or-methoxy phenylsulfonyl) 3,5 dibromo phenyl acetic thyromimetic cholesterol-lowering agents |
| EP0695181A1 (de) * | 1993-04-20 | 1996-02-07 | The Procter & Gamble Company | Verfahren zur verwendung von hesperetin zur sebumreduktion und behandlung von akne |
| TW382595B (en) * | 1993-10-15 | 2000-02-21 | Merck & Co Inc | Pharmaceutical composition for use in arresting and reversing androgenic alopecia |
| AU729411B2 (en) * | 1997-01-23 | 2001-02-01 | Taisho Pharmaceutical Co., Ltd. | Sustained release hair growth preparation |
| US6646005B1 (en) * | 1999-06-01 | 2003-11-11 | The University Of Texas Southwestern Medical Center | Method of treating hair loss using sulfonyl thyromimetic compounds |
-
2002
- 2002-05-22 CA CA002387198A patent/CA2387198C/en not_active Expired - Fee Related
- 2002-05-22 PT PT02253607T patent/PT1262177E/pt unknown
- 2002-05-22 ES ES02253607T patent/ES2267945T3/es not_active Expired - Lifetime
- 2002-05-22 AT AT02253607T patent/ATE337009T1/de not_active IP Right Cessation
- 2002-05-22 EP EP02253607A patent/EP1262177B1/de not_active Expired - Lifetime
- 2002-05-22 DK DK02253607T patent/DK1262177T3/da active
- 2002-05-22 DE DE60214080T patent/DE60214080T2/de not_active Expired - Lifetime
- 2002-05-23 IL IL149843A patent/IL149843A/en not_active IP Right Cessation
- 2002-05-23 IL IL188110A patent/IL188110A0/en unknown
- 2002-05-27 ZA ZA200204189A patent/ZA200204189B/xx unknown
- 2002-05-30 CN CNB021216533A patent/CN1314393C/zh not_active Expired - Fee Related
- 2002-05-30 TW TW091111565A patent/TWI278313B/zh not_active IP Right Cessation
- 2002-05-30 US US10/160,516 patent/US20030007941A1/en not_active Abandoned
- 2002-05-30 HU HU0201834A patent/HUP0201834A3/hu unknown
- 2002-05-30 AU AU44462/02A patent/AU784806B2/en not_active Ceased
- 2002-05-31 KR KR10-2002-0030677A patent/KR100523503B1/ko not_active Expired - Fee Related
- 2002-05-31 JP JP2002159170A patent/JP4051230B2/ja not_active Expired - Fee Related
- 2002-05-31 PL PL02354216A patent/PL354216A1/xx unknown
-
2003
- 2003-02-25 HK HK03101401.8A patent/HK1049285B/zh not_active IP Right Cessation
-
2005
- 2005-03-24 US US11/089,146 patent/US20080125433A1/en not_active Abandoned
-
2006
- 2006-09-14 CY CY20061101319T patent/CY1105221T1/el unknown
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000051971A1 (en) * | 1999-03-01 | 2000-09-08 | Pfizer Products Inc. | Oxamic acids and derivatives as thyroid receptor ligands |
| WO2000058279A1 (en) * | 1999-03-29 | 2000-10-05 | Novartis Ag | Diaryl derivatives and their use as medicaments |
| WO2000073292A1 (en) * | 1999-06-01 | 2000-12-07 | The University Of Texas Southwestern Medical Center | Biaryl compounds |
| WO2000072920A1 (en) * | 1999-06-01 | 2000-12-07 | The University Of Texas Southwestern Medical Center | Substituted biaryl ether compounds |
| WO2000072812A1 (en) * | 1999-06-01 | 2000-12-07 | The University Of Texas Southwestern Medical Center | Method of treating hair loss using diphenylether derivatives |
| WO2000073265A1 (en) * | 1999-06-01 | 2000-12-07 | The University Of Texas Southwestern Medical Centre | Sulfur-containing thyroxane derivatives and their use as hair growth promotors |
| EP1088819A2 (de) * | 1999-09-30 | 2001-04-04 | Pfizer Products Inc. | 6-Azauracilderivate als Liganden der Thyroidrezeptoren |
| WO2001070687A1 (de) * | 2000-03-23 | 2001-09-27 | Bayer Aktiengesellschaft | Indole zur behandlung von krankheiten die mit schilddrüsenhormonen behandeln werden können |
| WO2002032408A2 (en) * | 2000-10-20 | 2002-04-25 | Novartis Ag | Combinations of a thyromimetic compound and a statin |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7067148B2 (en) | 2001-02-15 | 2006-06-27 | King Pharmaceutical Research & Development, Inc. | Stabilized pharmaceutical and thyroid hormone compositions and method of preparation |
Also Published As
| Publication number | Publication date |
|---|---|
| PL354216A1 (en) | 2002-12-02 |
| AU784806B2 (en) | 2006-06-29 |
| CN1314393C (zh) | 2007-05-09 |
| IL149843A0 (en) | 2002-11-10 |
| JP2002370978A (ja) | 2002-12-24 |
| KR100523503B1 (ko) | 2005-10-26 |
| HUP0201834A3 (en) | 2004-03-29 |
| PT1262177E (pt) | 2006-12-29 |
| JP4051230B2 (ja) | 2008-02-20 |
| DE60214080T2 (de) | 2007-01-04 |
| US20080125433A1 (en) | 2008-05-29 |
| DE60214080D1 (de) | 2006-10-05 |
| ATE337009T1 (de) | 2006-09-15 |
| CY1105221T1 (el) | 2010-03-03 |
| KR20020092247A (ko) | 2002-12-11 |
| CN1389203A (zh) | 2003-01-08 |
| HK1049285A1 (en) | 2003-05-09 |
| TWI278313B (en) | 2007-04-11 |
| US20030007941A1 (en) | 2003-01-09 |
| IL188110A0 (en) | 2008-03-20 |
| IL149843A (en) | 2008-11-26 |
| HUP0201834A2 (hu) | 2003-01-28 |
| HU0201834D0 (de) | 2002-08-28 |
| CA2387198C (en) | 2007-02-13 |
| HK1049285B (zh) | 2007-08-24 |
| AU4446202A (en) | 2002-12-05 |
| EP1262177B1 (de) | 2006-08-23 |
| CA2387198A1 (en) | 2002-11-30 |
| EP1262177A2 (de) | 2002-12-04 |
| ES2267945T3 (es) | 2007-03-16 |
| DK1262177T3 (da) | 2006-11-20 |
| ZA200204189B (en) | 2003-11-27 |
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