Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q19/00—Preparations for care of the skin
  • A61Q19/08—Anti-ageing preparations
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
  • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
  • A61K8/9783—Angiosperms [Magnoliophyta]
  • A61K8/9789—Magnoliopsida [dicotyledons]
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P17/00—Drugs for dermatological disorders
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P17/00—Drugs for dermatological disorders
  • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P17/00—Drugs for dermatological disorders
  • A61P17/16—Emollients or protectives, e.g. against radiation
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
  • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q19/00—Preparations for care of the skin
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q19/00—Preparations for care of the skin
  • A61Q19/004—Aftersun preparations
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q19/00—Preparations for care of the skin
  • A61Q19/005—Preparations for sensitive skin
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
  • A61K2800/74—Biological properties of particular ingredients
  • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
  • A61K2800/782—Enzyme inhibitors; Enzyme antagonists
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q15/00—Anti-perspirants or body deodorants
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q5/00—Preparations for care of the hair
  • A61Q5/02—Preparations for cleaning the hair

Definitions

• Vitis vinifera plant extract as a NO synthase inhibitor and uses
• the subject of the present invention is the use of an effective amount of at least one extract of at least one plant of the species Vitis vinifera, in a physiologically acceptable medium, in a composition or for the preparation of a composition , the extract or composition being intended to inhibit NO-synthase.
• NO-synthase covers a family of enzymes which ensure the enzymatic catalysis of L-arginine into citrulline, during which catalysis is produced a gaseous mediator with multiple functions, nitrogen monoxide or NO.
• NO-synthases exist in three forms, two constitutive forms, nomenclature grouping together neuronal NO-synthase (or NOS 1) and endothelial NO-synthase (or NOS 3), and the inducible form (or NOS 2) (Medicine / Sciences , 1992, 8, pp. 843-845).
• NO-synthase covers all of the isoforms of the enzyme.
• NO-synthase inhibitors is understood to mean any product which, in the end, results, notwithstanding the isoform of NO-synthase, in the reduction of the concentration of NO.
• Nitric oxide has, by its structure, an additional electron making it extremely chemically reactive. It is well known that such compounds are harmful and we seek to limit their production as much as possible. Thus, in the case of nitric oxide, the NO-synthase inhibitors have been widely studied.
• NO is a multifunctional signal molecule active in a wide variety of body systems and tissues.
• cardiovascular system regulatory of blood pressure with vasodilator effect, inhibitor of platelet aggregation with anticoagulant effect
• nerve system mesoid aggregation with anticoagulant effect
• immunological system modulation of immune defenses, inflammation, involvement in autoimmune pathologies.
• NO plays a predominant role in the skin. NO can be synthesized by all varieties of cells constituting the skin and as such it intervenes in multiple and complex regulatory processes such as the regulation of cell differentiation and / or proliferation, vasodilation, melanogenesis , response to environmental variations (homeostasis).
• NO is involved in apoptotic processes and in intrinsic and / or extrinsic aging of the skin. It is involved in the skin's immunological and inflammatory processes. It is indeed commonly accepted that NO plays a role in contact hypersensitivity reactions, in allergic skin manifestations, in the skin's immune response. Similarly, in addition to its direct proinflammatory role, it is the mediator between neuropeptides such as substance P and or the peptide associated with the calcitonin gene (calcitonin gene related peptide or CGRP) in cutaneous neurogenic inflammatory processes, hence its involvement. in so-called sensitive skin phenomena. The implication of.
• NO in vasodilation causes it to be associated with skin erythema, particularly erythema induced by ultraviolet radiation, localized or diffuse erythematous rashes on the skin such as those caused by drugs, toxins and / or viral or bacterial infections , with rosacea.
• NO is recognized as an intermediary in melanogenesis induced by type B ultraviolet radiation (UVB). It is also one of the factors involved in hypermelanosis-like disorders. NO also seems to be involved in the control of sweating as well as in that of lipolysis (inhibitory effect) or even in hair loss. Finally, NO is known to have an influence on the barrier function of the skin and therefore on its hydration (inhibitory effect). We therefore understand the interest that exists in having inhibitors of NO-synthases. In this regard, numerous inhibitors have already been proposed in the prior art.
• NMMA N G -monomethyl-L-arginine
• NAME N G -nitro-L-arginine
• NNA N G -nitro-L-arginine
• NAA N G - amino-L-arginine
• ADMA diphenyleneiodonium chloride
• 2- (4-carboxyphenyl) -4,4,5 5-tetramethylimidazoline-1 -oxy-3-oxide
• the object of the present invention is to provide a new inhibitor of NO-synthase which is moreover a natural inhibitor of NO-synthase.
• an extract of at least one plant of the species Vitis vinifera has the property of being an inhibitor of NO-synthase, in particular of inducible NO-synthase (NOS 2) which makes it a good candidate for uses in applications where it turns out to be advantageous to use a NO-synthase inhibitor, particularly in cosmetics.
• NOS 2 inducible NO-synthase
• Plant extracts of the Vitis vinifera species are known in the prior art as promoting vasodilation or also as being able to be used in compositions intended for skin and / or hair care.
• an extract of at least one plant of the species Vitis vinifera has the property of being an inhibitor of NO synthase, particularly of inducible NO synthase (OUR 2).
• a primary object of the invention is therefore the use of an effective amount of at least one extract of at least one plant of the species Vitis vinifera, in a physiologically acceptable medium, in a composition or for the preparation of a composition, the extract or the composition being intended to inhibit NO-synthase, particularly inducible NO-synthase (NOS 2).
• physiologically acceptable medium is understood a medium compatible with the skin, mucous membranes, nails, hair.
• a second object of the invention is the use of an effective amount of at least one extract of at least one plant of the species Vitis vinifera, in a physiologically acceptable medium, in a composition or for the preparation of a composition, the extract or the composition being intended for application in all fields in which inhibition of NO synthases, particularly of inducible NO synthase (NOS 2), proves to be necessary, particularly in the skin area and / or capillary.
• NOS 2 inducible NO synthase
• the plant extract of the Vitis vinifera species or the composition containing it can be used to slow down or even inhibit cell differentiation and / or proliferation, and / or vasodilation, and / or melanogenesis, and / or response to environmental variations (homeostasis).
• the third object of the invention is the use of an effective amount of at least one extract of at least one plant of the species Vitis vinifera, in a physiologically acceptable medium, in a composition or for the preparation of a composition, the extract or the composition being intended to slow down or even inhibit cell differentiation and / or proliferation, in particular to regulate the growth of the epidermis and / or to treat hyperproliferative disorders such as for example psoriasis.
• a fourth object of the invention is the use of an effective amount of at least one extract of at least one plant of the species Vitis vinifera, in a physiologically acceptable medium, in a composition or for the preparation of a composition, the extract or the composition being intended to inhibit the degradation and / or destruction of cells and to inhibit apoptotic processes, particularly skin cells, very particularly keratinocytes and / or to treat intrinsic aging and / or extrinsic cells, especially skin cells.
• a fifth object of the invention is the use of an effective amount of at least one extract of at least one plant of the Vitis vinifera species, in a physiologically acceptable medium, in a composition or for the preparation of a composition, the extract or the composition being intended to inhibit or even suppress the immunological and / or inflammatory processes linked to the synthesis of NO, such as for example contact hypersensitivity reactions and / or allergic manifestations and / or the immune response, particularly in the skin.
• the extract or the composition are intended to reduce or even inhibit skin inflammation, very particularly the neurogenic inflammatory skin processes, and therefore to treat so-called sensitive skin.
• the sixth object of the invention is the use of an effective amount of at least one extract of at least one plant of the Vitis vinifera species, in a physiologically acceptable medium, in a composition or for the preparation of a composition, the extract or the composition being intended to treat rosacea and / or skin erythemas, particularly erythemas induced by ultraviolet radiation and or localized or diffuse erythematous rashes of the skin such as those caused by drugs toxins and / or viral or bacterial infections.
• the seventh subject of the invention is the use of an effective amount of at least one extract of at least one plant of the species Vitis vinifera, in a physiologically acceptable medium, in a composition or for the preparation of a composition, the extract or the composition being intended to inhibit melanogenesis induced by ultraviolet radiation of type A and or B and / or to treat disorders of hypermelanosis type.
• the eighth object of the invention is the use of an effective amount of at least one extract of at least one plant of the Vitis vinifera species, in a physiologically acceptable medium, in a composition or for the preparation of a composition, the extract or the composition being intended to control sweating and / or to stimulate lipolysis and / or to inhibit hair loss and / or to reinforce the barrier function of the skin and / or to stimulate the hydration of the skin.
• the composition comprising the extract can be a cosmetic or dermatological composition.
• the composition is a cosmetic composition.
• the extract or the composition comprising it is applied to the skin topically.
• the plant of the species Vitis vinifera is one of the 28 plant species belonging to the genus Vitis which itself belongs to the family of Ampelidae.
• the extract can be prepared from at least any one of the numerous varieties associated with each of the plant species belonging to the genus Vitis. It is therefore understood that in the text the term Vitis vinifera must be understood as designating any one of the numerous plant varieties associated with each of the plant species belonging to the genus Vitis and particularly as designating the species Vitis vinifera.
• the plant extract of the species Vitis vinifera can be any extract prepared from any plant material obtained from at least one plant of the genus Vitis.
• Vitis vinifera used according to the invention can be obtained from plant material obtained from whole plants or from parts of plants such as leaves, stems, flowers, petals, seeds, roots. or even dedifferentiated cells.
• dedifferentiated plant cells any plant cell having none of the characteristics of a particular specialization and capable of living by itself and not in dependence on other cells.
• an extract prepared from green leaves is used.
• the extract of at least one plant of the genus Vitis can be any extract prepared from any plant material derived from at least one plant of the genus Vitis cultivated in vivo or derived from culture in vitro.
• in vivo culture means any culture of the conventional type, that is to say in soil in the open air or in a greenhouse, or even above ground.
• in vitro culture means all of the techniques known to those skilled in the art which artificially make it possible to obtain a plant or part of a plant.
• the selection pressure imposed by the physicochemical conditions during the growth of plant cells in vitro makes it possible to obtain standardized plant material available throughout the year. unlike plants grown in vivo.
• a plant originating from culture in vivo is used.
• Mention may in particular be made of aqueous extracts, alcoholic extracts or those using an organic solvent.
• aqueous solvent means any solvent consisting wholly or partly of water. Mention may thus be made of water itself, hydroalcoholic solvents in any proportion or even solvents consisting of water and a compound such as propylene glycol in any proportion.
• the plant material is ground in a cold aqueous solution
• the particles in suspension are removed from the aqueous solution obtained from the first step
• the aqueous solution obtained from the second step is obtained from the second step.
• This aqueous solution corresponds to the extract.
• the first step can advantageously be replaced by a simple freezing operation of the plant tissues (for example at -20 ° C.), followed by an aqueous extraction repeating the second and third steps described above.
• the extract obtained can be lyophilized by any conventional lyophilization method.
• a powder is thus obtained which can be used directly or else mix in an appropriate solvent before use.
• an extract sold by the company Euromed under the name Leucocyanidins from extra grapes is used.
• the amount of plant extract of the species Vitis vinifera used in the composition is of course a function of the desired effect and can therefore vary to a large extent.
• the extract can be used in an amount representing from 10 "4 % to 20% of the total weight of the composition and preferably in an amount representing from 5.10 " 3 % to 10% of the total weight of the composition.
• the extract of at least one plant of the Vitis vinifera species can be combined with other NO-synthase inhibitors such as, for example, lipochroman-6, or other plant extracts such as example an extract of Ginkgo biloba, an extract of Olea europaea or an extract of green tea or cocoa.
• NO-synthase inhibitors such as, for example, lipochroman-6, or other plant extracts such as example an extract of Ginkgo biloba, an extract of Olea europaea or an extract of green tea or cocoa.
• the ninth subject of the invention is a cosmetic treatment process with a view to treating disorders linked to the synthesis of NO, characterized in that it is used by application on the skin, on the hair, and / or on the mucous membranes , a cosmetic composition comprising at least one extract of at least one plant of the Vitis vinifera species in a physiologically acceptable medium.
• the cosmetic treatment method of the invention aims to improve the appearance of the individual affected by the disorders due to the synthesis of NO.
• the cosmetic treatment process of the invention can be implemented in particular by applying the cosmetic compositions as defined above, according to the usual technique for using these compositions.
• the cosmetic compositions as defined above, according to the usual technique for using these compositions.
• it is possible to carry out applications of creams, gels, serums, lotions, cleansing milks or anti-sun compositions on the skin or on dry hair, applications of a hair lotion on wet hair, shampoos, or even toothpaste applications on the gums.
• the extract it can be ingested, injected or applied to the skin (on any cutaneous zone of the body), the hair, the nails or the mucous membranes ( buccal, jugale, gingival, genital, conjunctiva).
• the composition according to the invention can be in all the dosage forms normally used.
• the composition may take the form in particular of an aqueous or oily solution or of a dispersion of the lotion or serum type, of emulsions of liquid or semi-liquid consistency of the milk type, obtained by dispersion of a phase fatty in an aqueous phase (O / W) or vice versa (W / O), or of suspensions or emulsions of soft consistency of the aqueous or anhydrous cream or gel type, or of microcapsules or microparticles, or of vesicular dispersions of the ionic type and / or non-ionic.
• These compositions are prepared according to the usual methods.
• They can also be used for the hair in the form of aqueous, alcoholic or hydroalcoholic solutions, or in the form of creams, gels, emulsions, foams or also in the form of aerosol compositions also comprising a propellant under pressure.
• the composition may be in the form of an aqueous, oily lotion or in the form of a serum.
• the eyes it can be in the form of drops and for ingestion, it can be in the form of capsules, granules of syrups or tablets.
• compositions according to the invention are those conventionally used in the fields considered.
• compositions constitute in particular cleansing, protective, treatment or care creams for the face, for the hands, for the feet, for large anatomical folds or for the body (for example day creams, night creams, make-up remover creams, foundation creams, sunscreen creams), fluid foundations, make-up removal milks, body protection or care milks, anti-sun milks, lotions, gels or foams for care skin, such as cleansing lotions, sunscreen lotions, artificial tanning lotions, bath compositions, deodorant compositions comprising a bactericidal agent, aftershave gels or lotions, depilatory creams, compositions against insect bites, pain relieving compositions, compositions for treating certain skin diseases such as eczema, rosacea, psoriasis, lichens, severe pruritus.
• compositions according to the invention may also consist of solid preparations constituting soaps or cleaning bars.
• compositions can also be packaged in the form of an aerosol composition also comprising a propellant under pressure.
• the composition according to the invention may also be a composition for hair care, and in particular a shampoo, a styling lotion, a treating lotion, a styling cream or gel, a composition of dyes (in particular oxidation dyes) in the form of coloring shampoos, restructuring hair lotions, a perm composition (in particular a composition for the first time of a perm), a fall prevention lotion or gel, an antiparasitic shampoo, etc.
• a composition for hair care and in particular a shampoo, a styling lotion, a treating lotion, a styling cream or gel, a composition of dyes (in particular oxidation dyes) in the form of coloring shampoos, restructuring hair lotions, a perm composition (in particular a composition for the first time of a perm), a fall prevention lotion or gel, an antiparasitic shampoo, etc.
• the composition can also be for oral use, for example a toothpaste.
• the composition may contain adjuvants and additives customary for compositions for oral use and in particular surfactants, thickening agents, humectants, polishing agents such as silica, various active ingredients such as fluorides, in particular particularly sodium fluoride, and optionally sweetening agents such as sodium saccharinate.
• the proportion of the fatty phase can range from 5% to 80% by weight, and preferably from 5% to 50% by weight relative to the total weight of the composition.
• the oils, waxes, emulsifiers and coemulsifiers used in the composition in the form of an emulsion are chosen from those conventionally used in the cosmetic field.
• the emulsifier and the coemulsifier are present in the composition in a proportion ranging from 0.3% to 30% by weight, and preferably from 0.5 to 20% by weight relative to the total weight of the composition.
• the emulsion may, in addition, contain lipid vesicles.
• the fatty phase may represent more than 90% of the total weight of the composition.
• the cosmetic composition may also contain adjuvants customary in the cosmetic field, such as hydrophilic or lipophilic gelling agents, hydrophilic or lipophilic additives, preservatives, antioxidants, solvents, perfumes, fillers, filters, odor absorbers and coloring matters.
• adjuvants customary in the cosmetic field such as hydrophilic or lipophilic gelling agents, hydrophilic or lipophilic additives, preservatives, antioxidants, solvents, perfumes, fillers, filters, odor absorbers and coloring matters.
• the amounts of these various adjuvants are those conventionally used in the cosmetic field, and for example from 0.01% to 10% of the total weight of the composition.
• These adjuvants depending on their nature, can be introduced into the fatty phase, into the aqueous phase and / or into the lipid spherules.
• emulsifiers which can be used in the invention, there may be mentioned for example glycerol stearate, polysorbate 60 and the mixture of PEG-6 / PEG-32 / Glycol Stearate sold under the name Tefose R 63 by the company Gattefosse.
• solvents which can be used in the invention mention may be made of lower alcohols, in particular ethanol and isopropanol, propylene glycol.
• hydrophilic gelling agents which can be used in the invention, mention may be made of carboxyvinyl polymers (carbomer), acrylic copolymers such as acrylate / alkylacrylate copolymers, polyacrylamides, polysaccharides such as hydroxypropylcellulose, natural gums and clays, and, as lipophilic gelling agents, mention may be made of modified clays such as bentones, metal salts of fatty acids such as aluminum stearates and hydrophobic silica, ethylcellulose, polyethylene.
• carboxyvinyl polymers carboxyvinyl polymers
• acrylic copolymers such as acrylate / alkylacrylate copolymers
• polyacrylamides polysaccharides
• polysaccharides such as hydroxypropylcellulose
• natural gums and clays and, as lipophilic gelling agents
• modified clays such as bentones, metal salts of fatty acids such as aluminum stearates and hydrophobic silica,
• composition may contain other hydrophilic active agents such as proteins or protein hydrolysates, amino acids, polyols, urea, allantoin, sugars and sugar derivatives, water-soluble vitamins, plant extracts and hydroxy acids.
• hydrophilic active agents such as proteins or protein hydrolysates, amino acids, polyols, urea, allantoin, sugars and sugar derivatives, water-soluble vitamins, plant extracts and hydroxy acids.
• retinol and its derivatives
• tocopherol vitamin E
• essential fatty acids ceramides
• essential oils ceramides
• the composition can combine at least one extract of at least one plant of the Vitis vinifera species with other active agents intended in particular for the prevention and / or treatment of skin conditions.
• active agents there may be mentioned by way of example:
• agents modulating differentiation and / or proliferation and / or skin pigmentation such as retinoic acid and its isomers, retinol and its esters, vitamin D and its derivatives, kojic acid or hydroquinone;
• - antibacterials such as clindamycin phosphate, erythromycin or antibiotics of the tetracycline class
• - antifungals in particular compounds belonging to the class of imidazoles such as Peconazole, ketoconazole or miconazole or their salts, polyene compounds, such as amphotericin B, compounds of the allylamine family, such as terbinafine , or octopirox;
• non-steroidal anti-inflammatory agents such as ibuprofen and its salts, diclofenac and its salts, acetylsalicylic acid, acetaminophen or glycyrrhetinic acid;
• - anesthetic agents such as lidocaine hydrochloride and its derivatives
• - antipruritic agents such as thenaldine, trimeprazine or cyproheptadine;
• - keratolytic agents such as alpha- and beta-hydroxycarboxylic or beta-ketocarboxylic acids, their salts, amides or esters and more particularly hydroxy acids such as glycolic acid, lactic acid, salicylic acid, acid citric and generally fruit acids, and n-octanoyl-5-salicylic acid;
• - anti-free radical agents such as alpha-tocopherol or its esters, superoxide dismutases, certain metal chelating agents or ascorbic acid and its esters;
• anti-dandruff agents such as octopirox or zinc pyrithione
• anti-acne drugs such as retinoic acid or benzoyl peroxide
• - plant or microbial extracts
• compositions illustrate the invention without limiting it in any way.
• proportions indicated are percentages by weight.
• A positive control (induction of the enzyme): mixtures of interferon- ⁇ (1 OOOU / ml) and Interleukin 1- ⁇ (100 U / ml);
• B negative control (maximum inhibition): N G -monomethyl-L-arginine (form L) at 200 ⁇ M;
• C inhibition specificity control: N G -monomethyl-L-arginine (form D) at
• the quantity of stable NO reaction products is measured using the “nitric colorimetric assay” kit sold by the company Boehringer under the reference 1756.28.
• the extracts have an inhibitory effect on inducible NO synthase.
• Composition 1 Lotion
• Composition 2 Gel for care
• Composition 3 Care cream (oil in water emulsion)
• Composition 4 Shampoo
• Composition 5 Care cream (oil / water emulsion)
• Composition 6 Pain relieving gel
• Composition 7 Sun erythema care cream (oil-in-water emulsion)
• Composition 8 Gel for the treatment of acne
• Composition 9 Lotion for eliminating scars due to acne

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• Bioinformatics & Cheminformatics (AREA)
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• Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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• 2000
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