EP1353671A4 - Analogues de tacrolimus neurotrophiques - Google Patents

Analogues de tacrolimus neurotrophiques

Info

Publication number: EP1353671A4
Authority: EP; European Patent Office
Prior art keywords: neurotrophic; tacrolimus analogs; tacrolimus; analogs; neurotrophic tacrolimus
Prior art date: 2000-12-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP01991558A

Other languages

German (de)

English (en)

Other versions

EP1353671A1 (fr

Inventor

Nobuya Matsuoka

Takayuki Yamaji

Bruce Gold

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Astellas Pharma Inc

Original Assignee

Fujisawa Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-29

Filing date

2001-12-31

Publication date

2004-07-14

2001-12-31 Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd

2003-10-22 Publication of EP1353671A1 publication Critical patent/EP1353671A1/fr

2004-07-14 Publication of EP1353671A4 publication Critical patent/EP1353671A4/fr

Status Withdrawn legal-status Critical Current

Links

QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical class C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 title 1
230000000508 neurotrophic effect Effects 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Immunology (AREA)
Diabetes (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Psychiatry (AREA)
Psychology (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Hospice & Palliative Care (AREA)
Hematology (AREA)
Endocrinology (AREA)
Transplantation (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Packages (AREA)
Medical Preparation Storing Or Oral Administration Devices (AREA)
Saccharide Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

EP01991558A 2000-12-29 2001-12-31 Analogues de tacrolimus neurotrophiques Withdrawn EP1353671A4 (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US25850000P	2000-12-29	2000-12-29
US258500P		2000-12-29
PCT/US2001/050419 WO2002053159A1 (fr)	2000-12-29	2001-12-31	Analogues de tacrolimus neurotrophiques

Publications (2)

Publication Number	Publication Date
EP1353671A1 EP1353671A1 (fr)	2003-10-22
EP1353671A4 true EP1353671A4 (fr)	2004-07-14

Family

ID=22980816

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP01991558A Withdrawn EP1353671A4 (fr)	2000-12-29	2001-12-31	Analogues de tacrolimus neurotrophiques

Country Status (18)

Country	Link
EP (1)	EP1353671A4 (fr)
JP (1)	JP2004527472A (fr)
KR (2)	KR20070030331A (fr)
CN (1)	CN1293877C (fr)
AR (1)	AR035411A1 (fr)
AU (1)	AU2002231277B2 (fr)
BR (1)	BR0116762A (fr)
CA (1)	CA2433384A1 (fr)
CZ (1)	CZ20032060A3 (fr)
HU (1)	HUP0302521A3 (fr)
IL (1)	IL156664A0 (fr)
MX (1)	MXPA03005941A (fr)
NO (1)	NO20032913D0 (fr)
NZ (1)	NZ527209A (fr)
PL (1)	PL366301A1 (fr)
RU (1)	RU2288716C2 (fr)
WO (1)	WO2002053159A1 (fr)
ZA (1)	ZA200305806B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2003901023A0 (en) *	2003-03-04	2003-03-20	Fujisawa Pharmaceutical Co., Ltd.	New use
EP1706117A1 (fr) *	2004-01-20	2006-10-04	Astellas Pharma Inc.	Methode de traitement des troubles de l'erection
EP1810675A1 (fr) *	2006-01-18	2007-07-25	Institut Curie	Methode de traitement de la maladie de Huntington par l'inhibition de la dephosphorylation de la S421
JP2009102226A (ja) *	2006-02-14	2009-05-14	Meiji Milk Prod Co Ltd	脊髄損傷治療剤
US9149459B2 (en)	2008-07-23	2015-10-06	Novartis Ag	Sphingosine 1 phosphate receptor modulators and their use to treat muscle inflammation
JP2015511242A (ja) *	2012-02-23	2015-04-16	インセルム（インスティチュートナショナルデラサンテエデラリシェルシェメディカル）	病変性前庭障害の治療に使用するカルシニューリン阻害剤
GB201309375D0 (en) *	2013-05-24	2013-07-10	Chronos Therapeutics Ltd	Medical methods and compounds for medical use

Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0323042A1 (fr) *	1987-12-09	1989-07-05	FISONS plc	Procédé pour macrolides
WO1993014771A1 (fr) *	1992-02-01	1993-08-05	Fisons Plc	Composes macrocycliques servant au traitement prophylactique du sida
WO1994004148A1 (fr) *	1992-08-25	1994-03-03	Fisons Plc	Utilisation de composes de la classe des macrolides dans le traitement de maladies entrainant une obstruction reversible des voies aeriennes
WO2001005385A2 (fr) *	1999-07-21	2001-01-25	Fujisawa Pharmaceutical Co Ltd	Nouvelle utilisation d'un compose de macrolide

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US537663A (en) *		1895-04-16		wubstee
GR1001225B (el) *	1989-09-14	1993-06-30	Fisons Plc	Νέαι μακροκυκλικαί ενώσεις και νέα μέ?οδος χρήσεως τους.
US5534520A (en) *	1990-04-10	1996-07-09	Fisher; Abraham	Spiro compounds containing five-membered rings
US5541193A (en) *	1991-09-05	1996-07-30	Abbott Laboratories	Heterocycle-containing macrocyclic immunomodulators
US5696135A (en) *	1995-06-07	1997-12-09	Gpi Nil Holdings, Inc.	Inhibitors of rotamase enzyme activity effective at stimulating neuronal growth
US5968921A (en) *	1997-10-24	1999-10-19	Orgegon Health Sciences University	Compositions and methods for promoting nerve regeneration

2001
- 2001-12-27 AR ARP010106058A patent/AR035411A1/es unknown
- 2001-12-31 MX MXPA03005941A patent/MXPA03005941A/es active IP Right Grant
- 2001-12-31 WO PCT/US2001/050419 patent/WO2002053159A1/fr not_active Ceased
- 2001-12-31 NZ NZ527209A patent/NZ527209A/en unknown
- 2001-12-31 AU AU2002231277A patent/AU2002231277B2/en not_active Ceased
- 2001-12-31 PL PL01366301A patent/PL366301A1/xx not_active Application Discontinuation
- 2001-12-31 KR KR1020077003889A patent/KR20070030331A/ko not_active Ceased
- 2001-12-31 RU RU2003123493/15A patent/RU2288716C2/ru not_active IP Right Cessation
- 2001-12-31 CA CA002433384A patent/CA2433384A1/fr not_active Abandoned
- 2001-12-31 BR BR0116762-6A patent/BR0116762A/pt not_active Application Discontinuation
- 2001-12-31 CN CNB018228860A patent/CN1293877C/zh not_active Expired - Fee Related
- 2001-12-31 EP EP01991558A patent/EP1353671A4/fr not_active Withdrawn
- 2001-12-31 JP JP2002554109A patent/JP2004527472A/ja not_active Ceased
- 2001-12-31 IL IL15666401A patent/IL156664A0/xx unknown
- 2001-12-31 HU HU0302521A patent/HUP0302521A3/hu unknown
- 2001-12-31 KR KR1020037008787A patent/KR100794204B1/ko not_active Expired - Fee Related
- 2001-12-31 CZ CZ20032060A patent/CZ20032060A3/cs unknown
2003
- 2003-06-24 NO NO20032913A patent/NO20032913D0/no not_active Application Discontinuation
- 2003-07-28 ZA ZA2003/05806A patent/ZA200305806B/en unknown

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0323042A1 (fr) *	1987-12-09	1989-07-05	FISONS plc	Procédé pour macrolides
WO1993014771A1 (fr) *	1992-02-01	1993-08-05	Fisons Plc	Composes macrocycliques servant au traitement prophylactique du sida
WO1994004148A1 (fr) *	1992-08-25	1994-03-03	Fisons Plc	Utilisation de composes de la classe des macrolides dans le traitement de maladies entrainant une obstruction reversible des voies aeriennes
WO2001005385A2 (fr) *	1999-07-21	2001-01-25	Fujisawa Pharmaceutical Co Ltd	Nouvelle utilisation d'un compose de macrolide

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GOLD B G: "NEUROIMMUNOPHILIN LIGANDS: EVALUATION OF THEIR THERAPEUTIC POTENTIAL FOR THE TREATMENT OF NEUROLOGICAL DISORDERS", EXPERT OPINION ON INVESTIGATIONAL DRUGS, ASHLEY PUBLICATIONS LTD., LONDON, GB, vol. 9, no. 10, 2000, pages 2331 - 2342, XP001011856, ISSN: 1354-3784 *
See also references of WO02053159A1 *
STEINER ET AL: "Neurotrophic actions of non-immunosuppressive analogs of immunosuppressive drugs FK506, rapamycin and cyclosporin A", NATURE MEDICINE, NATURE PUBLISHING, CO, US, vol. 3, no. 4, April 1997 (1997-04-01), pages 421 - 428, XP002125244, ISSN: 1078-8956 *

Also Published As

Publication number	Publication date
BR0116762A (pt)	2004-08-10
CZ20032060A3 (cs)	2004-01-14
RU2003123493A (ru)	2005-01-20
NO20032913D0 (no)	2003-06-24
KR20040007431A (ko)	2004-01-24
CN1538843A (zh)	2004-10-20
PL366301A1 (en)	2005-01-24
HUP0302521A3 (en)	2007-03-28
KR100794204B1 (ko)	2008-01-14
AR035411A1 (es)	2004-05-26
KR20070030331A (ko)	2007-03-15
JP2004527472A (ja)	2004-09-09
CA2433384A1 (fr)	2002-07-11
ZA200305806B (en)	2005-01-26
AU2002231277B2 (en)	2006-11-30
RU2288716C2 (ru)	2006-12-10
HUP0302521A2 (hu)	2003-11-28
NZ527209A (en)	2005-09-30
CN1293877C (zh)	2007-01-10
IL156664A0 (en)	2004-01-04
MXPA03005941A (es)	2005-02-14
WO2002053159A1 (fr)	2002-07-11
EP1353671A1 (fr)	2003-10-22

Legal Events

Date	Code	Title	Description
2003-09-05	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2003-10-22	17P	Request for examination filed	Effective date: 20030723
2003-10-22	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
2003-10-22	AX	Request for extension of the european patent	Extension state: AL LT LV MK RO SI
2004-07-14	A4	Supplementary search report drawn up and despatched	Effective date: 20040528
2004-07-14	RIC1	Information provided on ipc code assigned before grant	Ipc: 7A 61P 25/28 B Ipc: 7A 61P 25/00 B Ipc: 7A 61K 31/436 A
2004-07-23	REG	Reference to a national code	Ref country code: HK Ref legal event code: DE Ref document number: 1059891 Country of ref document: HK
2006-01-04	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: ASTELLAS PHARMA INC.
2009-07-01	GRAP	Despatch of communication of intention to grant a patent	Free format text: ORIGINAL CODE: EPIDOSNIGR1
2010-04-16	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2010-05-19	18D	Application deemed to be withdrawn	Effective date: 20091121
2010-08-13	REG	Reference to a national code	Ref country code: HK Ref legal event code: WD Ref document number: 1059891 Country of ref document: HK

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