EP1450784A4 - Hsp90-hemmende zearalanol-verbindungen und verfahren zu ihrer herstellung und verwendung - Google Patents

Hsp90-hemmende zearalanol-verbindungen und verfahren zu ihrer herstellung und verwendung

Info

Publication number
EP1450784A4
EP1450784A4 EP02803196A EP02803196A EP1450784A4 EP 1450784 A4 EP1450784 A4 EP 1450784A4 EP 02803196 A EP02803196 A EP 02803196A EP 02803196 A EP02803196 A EP 02803196A EP 1450784 A4 EP1450784 A4 EP 1450784A4
Authority
EP
European Patent Office
Prior art keywords
hsp90
compounds
producing
methods
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02803196A
Other languages
English (en)
French (fr)
Other versions
EP1450784A2 (de
Inventor
Srinivas Rao Kasibhatla
Brazidec Jean-Yves Le
Sean Konrad Mchugh
Marcus F Boehm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Conforma Therapeutics Corp
Original Assignee
Conforma Therapeutics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Conforma Therapeutics Corp filed Critical Conforma Therapeutics Corp
Publication of EP1450784A2 publication Critical patent/EP1450784A2/de
Publication of EP1450784A4 publication Critical patent/EP1450784A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP02803196A 2001-11-09 2002-11-08 Hsp90-hemmende zearalanol-verbindungen und verfahren zu ihrer herstellung und verwendung Withdrawn EP1450784A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33791901P 2001-11-09 2001-11-09
US337919P 2001-11-09
PCT/US2002/035938 WO2003041643A2 (en) 2001-11-09 2002-11-08 Hsp90-inhibiting zearalanol compounds and methods of producing and using same

Publications (2)

Publication Number Publication Date
EP1450784A2 EP1450784A2 (de) 2004-09-01
EP1450784A4 true EP1450784A4 (de) 2005-02-09

Family

ID=23322576

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02803196A Withdrawn EP1450784A4 (de) 2001-11-09 2002-11-08 Hsp90-hemmende zearalanol-verbindungen und verfahren zu ihrer herstellung und verwendung

Country Status (4)

Country Link
US (1) US7553979B2 (de)
EP (1) EP1450784A4 (de)
AU (1) AU2002356922A1 (de)
WO (1) WO2003041643A2 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6872715B2 (en) 2001-08-06 2005-03-29 Kosan Biosciences, Inc. Benzoquinone ansamycins
EP1472230B1 (de) 2002-02-08 2009-06-17 Conforma Therapeutic Corporation Ansamycine mit verbesserten pharmakologischen und biologischen eigenschaften
US7691838B2 (en) * 2003-05-30 2010-04-06 Kosan Biosciences Incorporated Method for treating diseases using HSP90-inhibiting agents in combination with antimitotics
NZ546611A (en) * 2003-09-18 2010-02-26 Conforma Therapeutics Corp Novel heterocyclic compounds as HSP90-inhibitors
DE102004039280A1 (de) 2004-08-13 2006-02-23 Merck Patent Gmbh 1,5-Diphenyl-pyrazole
US20060067953A1 (en) * 2004-09-29 2006-03-30 Conforma Therapeutics Corporation Oral pharmaceutical formulations and methods for producing and using same
DE102004049078A1 (de) 2004-10-08 2006-04-13 Merck Patent Gmbh Phenylpyrazole
DE102005009440A1 (de) 2005-03-02 2006-09-07 Merck Patent Gmbh Thienopyridinderivate
BRPI0609509A2 (pt) 2005-03-30 2010-04-13 Conforma Therapeutics Corp composto ou um polimorfo, solvato, tautÈmero, enanciÈmero, pró-droga ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso do composto, polimorfo, solvato, tautÈmero, enanciÈmero, pró-droga ou sal farmaceuticamente aceitável
US20070105874A1 (en) * 2005-09-23 2007-05-10 Conforma Therapeutics Corporation Anti-Tumor Methods Using Multi Drug Resistance Independent Synthetic HSP90 Inhibitors
AU2006320435A1 (en) * 2005-12-01 2007-06-07 Conforma Therapeutics Corporation Compositions containing ansamycin
US7601852B2 (en) * 2006-05-11 2009-10-13 Kosan Biosciences Incorporated Macrocyclic kinase inhibitors
JP5599610B2 (ja) 2006-06-30 2014-10-01 スローン − ケッタリング インスティチュート フォー キャンサー リサーチ Ｈｓｐ９０の阻害による神経変性疾患の処置
EP2136799B1 (de) * 2006-08-11 2017-10-04 Universite De Strasbourg Makrocyclische verbindungen als hemmer von kinase und hsp90
FR2907453B1 (fr) 2006-10-24 2008-12-26 Sanofi Aventis Sa Nouveaux derives du fluorene,compositions les contenant et utilisation
DE102007002715A1 (de) 2007-01-18 2008-07-24 Merck Patent Gmbh Triazolderivat
DE102007028521A1 (de) 2007-06-21 2008-12-24 Merck Patent Gmbh Indazolamidderivate
DE102007032739A1 (de) 2007-07-13 2009-01-15 Merck Patent Gmbh Chinazolinamidderivate
DE102007041116A1 (de) 2007-08-30 2009-03-05 Merck Patent Gmbh 1,3-Dihydro-isoindolderivate
GB0718023D0 (en) * 2007-09-14 2007-10-24 Univ London Pharmacy Anti-bacterial agents
US20110190237A1 (en) * 2008-01-15 2011-08-04 Nexgenix Pharmaceuticals Macrocyclic Prodrug Compounds Useful as Therapeutics
DE102008061214A1 (de) 2008-12-09 2010-06-10 Merck Patent Gmbh Chinazolinamidderivate
AR077405A1 (es) 2009-07-10 2011-08-24 Sanofi Aventis Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer
FR2949467B1 (fr) 2009-09-03 2011-11-25 Sanofi Aventis Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
WO2011044394A1 (en) 2009-10-07 2011-04-14 Sloan-Kettering Institute For Cancer Research Purine derivatives useful as hsp90 inhibitors
DE102009054302A1 (de) 2009-11-23 2011-05-26 Merck Patent Gmbh Chinazolinderivate
DE102010046837A1 (de) 2010-09-29 2012-03-29 Merck Patent Gmbh Phenylchinazolinderivate
EP2694505B1 (de) 2011-04-05 2022-04-27 Sloan-kettering Institute For Cancer Research Hsp90-inhibitoren
EP2694506B1 (de) 2011-04-05 2017-09-20 Sloan-kettering Institute For Cancer Research Hsp90-inhibitoren
EA201690406A1 (ru) 2013-08-16 2016-08-31 Мемориал Слоун-Кеттеринг Кэнсэ Сентр Селективные ингибиторы grp94 и способы их применения
GB2623090A (en) 2022-10-04 2024-04-10 Sublino Ltd Method of colouring

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3239345A (en) * 1965-02-15 1966-03-08 Estrogenic compounds and animal growth promoters
US3239342A (en) * 1965-02-15 1966-03-08 Commercial Solvents Corp Estrogenic compounds and animal growth promoters
US3239341A (en) * 1965-02-15 1966-03-08 Commercial Solvents Corp Estrogenic compounds and animal growth promoters
WO2000006143A1 (en) * 1998-07-27 2000-02-10 Texas Pharmaceuticals, Inc. Chemically induced intracellular hyperthermia
WO2002048136A1 (en) * 2000-12-14 2002-06-20 Chugai Seiyaku Kabushiki Kaisha Keratinocyte proliferation inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3196019A (en) * 1964-04-06 1965-07-20 Purdue Research Foundation Anabolic and estrogenic compound and process of making
US5795910A (en) * 1994-10-28 1998-08-18 Cor Therapeutics, Inc. Method and compositions for inhibiting protein kinases
JP2002533389A (ja) * 1998-12-24 2002-10-08 ノーベーション ファーマシューティカルズ インコーポレーテッド ｍＲＮＡ安定性に影響する化合物およびそのための使用

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3239345A (en) * 1965-02-15 1966-03-08 Estrogenic compounds and animal growth promoters
US3239342A (en) * 1965-02-15 1966-03-08 Commercial Solvents Corp Estrogenic compounds and animal growth promoters
US3239341A (en) * 1965-02-15 1966-03-08 Commercial Solvents Corp Estrogenic compounds and animal growth promoters
WO2000006143A1 (en) * 1998-07-27 2000-02-10 Texas Pharmaceuticals, Inc. Chemically induced intracellular hyperthermia
WO2002048136A1 (en) * 2000-12-14 2002-06-20 Chugai Seiyaku Kabushiki Kaisha Keratinocyte proliferation inhibitors

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
A. FÜRSTNER ET AL.: "MACROCYCLES BY RING-CLOSING-METHATESIS,XI.", TETRAHEDRON., vol. 55, no. 27, 1999, NLELSEVIER SCIENCE PUBLISHERS, AMSTERDAM., pages 8215 - 8230, XP004169314 *
L HILAKIVI-CLARKE ET AL.: "prepubertal exposure to zearalenone or genistein reduces mammary tumorigenesis", BRITISH JOURNAL OF CANCER, vol. 80, no. 11, 1999, GB, pages 1682 - 1688, XP002310176 *
See also references of WO03041643A2 *

Also Published As

Publication number Publication date
US20050256183A1 (en) 2005-11-17
WO2003041643A2 (en) 2003-05-22
US7553979B2 (en) 2009-06-30
AU2002356922A1 (en) 2003-05-26
EP1450784A2 (de) 2004-09-01
WO2003041643A3 (en) 2003-10-16

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Legal Events

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Ipc: 7A 61P 35/00 B

Ipc: 7A 61K 31/365 B

Ipc: 7C 07D 313/00 B

Ipc: 7C 07D 321/00 B

Ipc: 7C 07D 313/06 B

Ipc: 7C 07D 323/00 B

Ipc: 7A 61K 31/335 A

A4 Supplementary search report drawn up and despatched

Effective date: 20041230

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