EP1496076A4 - Hydrophiles polymerderivat mit y-verzweigung und herstellungsverfahren dafür; obige verbindung enthaltender medizinischer verbundwerkstoff - Google Patents

Hydrophiles polymerderivat mit y-verzweigung und herstellungsverfahren dafür; obige verbindung enthaltender medizinischer verbundwerkstoff

Info

Publication number
EP1496076A4
EP1496076A4 EP03709581A EP03709581A EP1496076A4 EP 1496076 A4 EP1496076 A4 EP 1496076A4 EP 03709581 A EP03709581 A EP 03709581A EP 03709581 A EP03709581 A EP 03709581A EP 1496076 A4 EP1496076 A4 EP 1496076A4
Authority
EP
European Patent Office
Prior art keywords
derivate
preparation
hydrophilic polymer
above compound
type branch
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP03709581A
Other languages
English (en)
French (fr)
Other versions
EP1496076A1 (de
EP1496076B1 (de
Inventor
Shishan Ji
Dequan Zhu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beijing Jiankai Technology Co Ltd
Original Assignee
Beijing Jiankai Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beijing Jiankai Technology Co Ltd filed Critical Beijing Jiankai Technology Co Ltd
Publication of EP1496076A1 publication Critical patent/EP1496076A1/de
Publication of EP1496076A4 publication Critical patent/EP1496076A4/de
Application granted granted Critical
Publication of EP1496076B1 publication Critical patent/EP1496076B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Polyethers (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
EP03709581A 2002-03-13 2003-03-12 Hydrophiles polymerderivat mit y-verzweigung und herstellungsverfahren dafür; obige verbindung enthaltender medizinischer verbundwerkstoff Expired - Lifetime EP1496076B1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN0200147 2002-03-13
WOPCT/CN02/00147 2002-03-13
PCT/CN2003/000179 WO2003076490A1 (en) 2002-03-13 2003-03-12 Hydrophilic polymer derivate with y type branch and preparation method of it medical composite comprising above compound

Publications (3)

Publication Number Publication Date
EP1496076A1 EP1496076A1 (de) 2005-01-12
EP1496076A4 true EP1496076A4 (de) 2006-06-21
EP1496076B1 EP1496076B1 (de) 2007-07-25

Family

ID=27792878

Family Applications (1)

Application Number Title Priority Date Filing Date
EP03709581A Expired - Lifetime EP1496076B1 (de) 2002-03-13 2003-03-12 Hydrophiles polymerderivat mit y-verzweigung und herstellungsverfahren dafür; obige verbindung enthaltender medizinischer verbundwerkstoff

Country Status (9)

Country Link
US (3) US8003089B2 (de)
EP (1) EP1496076B1 (de)
JP (1) JP4272537B2 (de)
CN (1) CN1243779C (de)
AT (1) ATE368066T1 (de)
AU (1) AU2003221291A1 (de)
DE (1) DE60315145T2 (de)
ES (1) ES2291620T3 (de)
WO (1) WO2003076490A1 (de)

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DE10209822A1 (de) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung niedermolekularer Substanzen an ein modifiziertes Polysaccharid
DE10209821A1 (de) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung von Proteinen an ein modifiziertes Polysaccharid
WO2003076490A1 (en) 2002-03-13 2003-09-18 Beijing Jiankai Technology Co., Ltd. Hydrophilic polymer derivate with y type branch and preparation method of it medical composite comprising above compound
MXPA05002594A (es) 2002-09-11 2005-05-27 Fresenius Kabi Gmbh Derivados de polipeptidos con hidroxialquilalmidon, especialmente derivados de eritropoyetina con hidroxialquilalmidon.
DE10326303A1 (de) * 2003-06-11 2004-12-30 Celares Gmbh Reagenzien zur Modifikation von Biopharmazeutika, deren Herstellung und Anwendung
WO2005014655A2 (en) 2003-08-08 2005-02-17 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein
GB0329825D0 (en) 2003-12-23 2004-01-28 Celltech R&D Ltd Biological products
AR048035A1 (es) 2004-03-11 2006-03-22 Fresenius Kabi De Gmbh Conjugados de almidon de hidroxialquilo y una proteina, preparados por aminacion reductora
US7858080B2 (en) 2005-05-20 2010-12-28 Agency For Science, Technology And Research Aldehyde conjugated flavonoid preparations
AU2006248166B2 (en) * 2005-05-20 2012-11-01 Agency For Science, Technology And Research Aldehyde conjugated flavonoid preparations
AU2006304856A1 (en) * 2005-10-21 2007-04-26 Synageva Biopharma Corp. Glycolated and glycosylated poultry derived therapeutic proteins
US20080171696A1 (en) * 2005-10-21 2008-07-17 Avigenics, Inc. Pharmacodynamically enhanced therapeutic proteins
US20090285780A1 (en) * 2006-05-24 2009-11-19 Chyi Lee Peg linker compounds and biologically active conjugates thereof
CN101168594B (zh) * 2006-10-24 2011-07-27 北京键凯科技有限公司 寡肽为骨架的聚乙二醇活性衍生物、其制备方法及与药物分子的结合物
CN102827284B (zh) * 2006-11-14 2015-07-29 上海仁会生物制药股份有限公司 带有聚乙二醇基团的Exendin或其类似物及其制剂和用途
CN101835482A (zh) * 2007-08-20 2010-09-15 安佐制药股份有限公司 含吡啶基二硫化物部分的聚合连接基
CA2698173C (en) * 2007-09-04 2015-02-03 Biosteed Gene Expression Tech. Co., Ltd. Interferon alpha 2b modified by polyethylene glycol, the preparation and use thereof
CN101636411B (zh) * 2007-09-04 2013-01-09 厦门伯赛基因转录技术有限公司 聚乙二醇修饰的干扰素α2a及其制备方法和应用
EP2070950A1 (de) 2007-12-14 2009-06-17 Fresenius Kabi Deutschland GmbH Hydroxyalkylstärkederivate und deren Herstellungsverfahren
US8530417B2 (en) 2007-12-29 2013-09-10 Biosteed Gene Expression Tech Co. Ltd. Y-shaped polyethylene glycol modified G-CSF, the preparation and use thereof
JP5458416B2 (ja) * 2008-04-03 2014-04-02 バイオスティード ジーン エクスプレッション テック． カンパニー リミテッド 二本鎖ポリエチレングリコール化成長ホルモン、その製造方法およびその使用
CN101701068B (zh) * 2009-10-30 2011-09-21 北京化工大学 一种pH响应性的Y型药物输送材料及其制备方法
JP2011105792A (ja) * 2009-11-12 2011-06-02 Japan Science & Technology Agency ブロックコポリマー、ブロックコポリマー−金属錯体複合体、及びそれを用いた中空構造体キャリア
FR2953720B1 (fr) 2009-12-11 2012-05-11 Oreal Utilisation de derives de benzyloxy-ethylamines comme conservateur,
US20140073778A9 (en) 2010-07-09 2014-03-13 Fresenius Kabi Deutschland Gmbh Conjugates comprising hydroxyalkyl starch and a cytotoxic agent and process for their preparation
EP2590677A1 (de) 2010-07-09 2013-05-15 Fresenius Kabi Deutschland GmbH Konjugate mit hydroxyalkylstärke und einem zytotoxischen mittel sowie verfahren zu ihrer herstellung
EP2590678A1 (de) 2010-07-09 2013-05-15 Fresenius Kabi Deutschland GmbH Konjugate mit hydroxyalkylstärke und einem zytotoxischen mittel sowie verfahren zu ihrer herstellung
EP2590680A1 (de) 2010-07-09 2013-05-15 Fresenius Kabi Deutschland GmbH Konjugate mit hydroxyalkylstärke und einem zytotoxischen mittel sowie verfahren zu ihrer herstellung
JP2014503187A (ja) 2010-10-29 2014-02-13 ノクソン ファーマ エージー 身体からヘプシジンを除去するためのヘプシジン結合核酸の使用
CN103083680B (zh) * 2011-11-07 2014-12-24 北京键凯科技有限公司 聚乙二醇-氨基酸寡肽-依诺替康药物结合物及其药物组合物
JP5999659B2 (ja) * 2011-12-14 2016-09-28 国立大学法人 筑波大学 新規分岐ポリエチレングリコール及びその用途
WO2014114262A1 (zh) * 2013-01-28 2014-07-31 天津键凯科技有限公司 水溶性聚合物-氨基酸寡肽-药物结合物及其制备方法和用途
US9700633B2 (en) 2013-01-28 2017-07-11 Jenkem Technology Co., Ltd., Tianjin Branch Conjugates of water soluble polymer-amino acid oligopeptide-drug, preparation method and use thereof
CN103965458B (zh) * 2013-01-28 2017-02-15 天津键凯科技有限公司 聚乙二醇‑氨基酸寡肽‑达沙替尼结合物及其药物组合物
CN104109235B (zh) * 2014-05-30 2017-07-18 厦门赛诺邦格生物科技股份有限公司 一种具有氮原子支化中心的单一官能化聚乙二醇、制备方法及其生物相关物质
CN106146325B (zh) * 2015-04-24 2019-01-29 北京键凯科技股份有限公司 一种y型多缩乙二醇衍生物及其制备方法
CN107446908A (zh) * 2016-06-01 2017-12-08 湖南华腾制药有限公司 分支型聚乙二醇修饰的l‑门冬酰胺酶及其制备方法
CN106750250B (zh) * 2016-12-21 2019-04-23 沈阳化工大学 以氨基酸作为连接臂的聚乙二醇齐墩果酸衍生物及其制备方法和应用
CN108530637B (zh) * 2017-03-05 2021-03-30 厦门赛诺邦格生物科技股份有限公司 一种单一功能化支化聚乙二醇的制备方法
WO2018177055A1 (zh) * 2017-03-30 2018-10-04 北京键凯科技股份有限公司 一种y型分支的亲水性聚合物羧酸衍生物的制备方法
CN108659227B (zh) * 2017-03-30 2020-11-06 北京键凯科技股份有限公司 一种y型分支的亲水性聚合物羧酸衍生物的制备方法
CN108530642B (zh) * 2017-11-24 2021-01-15 四川大学 可生物降解的三嵌段杂臂星形双亲性高分子材料及其制备方法
CN109400868B (zh) * 2018-11-30 2021-01-15 吉林化工学院 一种聚乙二醇单苯甲醚化合物的合成方法
JP2023541816A (ja) 2020-08-27 2023-10-04 イノージ・セラピューティクス・コーポレイション 自己免疫性疾患および癌を治療するための方法および組成物
CN112898561A (zh) * 2021-01-27 2021-06-04 大连理工大学 马来酰亚胺封端聚苯醚及其制备方法
EP4509544A4 (de) 2022-04-12 2025-07-02 Xiamen Sinopeg Biotech Co Ltd Nichtlineares pegyliertes lipid mit tertiärem amin und anwendung davon
CN117510828A (zh) 2022-07-28 2024-02-06 厦门赛诺邦格生物科技股份有限公司 一种含氨基酸残基的三臂聚乙二醇衍生物
JP2026505416A (ja) 2023-02-09 2026-02-13 シェ、ヤンホイ ポリエチレングリコール修飾インターロイキン２、グルココルチコイドおよびヒアルロン酸によるアトピー性皮膚炎の治療

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Also Published As

Publication number Publication date
JP2005520006A (ja) 2005-07-07
WO2003076490A1 (en) 2003-09-18
US20050180946A1 (en) 2005-08-18
US20100221213A1 (en) 2010-09-02
DE60315145D1 (de) 2007-09-06
WO2003076490A8 (en) 2004-10-28
CN1556828A (zh) 2004-12-22
ATE368066T1 (de) 2007-08-15
DE60315145T2 (de) 2008-04-30
CN1243779C (zh) 2006-03-01
EP1496076A1 (de) 2005-01-12
EP1496076B1 (de) 2007-07-25
JP4272537B2 (ja) 2009-06-03
US8003089B2 (en) 2011-08-23
ES2291620T3 (es) 2008-03-01
US20110243892A1 (en) 2011-10-06
AU2003221291A1 (en) 2003-09-22

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