EP1589996A4 - Preparation d'anticorps anti-integrine alpha beta 3 et utilisations associees - Google Patents

Preparation d'anticorps anti-integrine alpha beta 3 et utilisations associees

Info

Publication number
EP1589996A4
EP1589996A4 EP04707034A EP04707034A EP1589996A4 EP 1589996 A4 EP1589996 A4 EP 1589996A4 EP 04707034 A EP04707034 A EP 04707034A EP 04707034 A EP04707034 A EP 04707034A EP 1589996 A4 EP1589996 A4 EP 1589996A4
Authority
EP
European Patent Office
Prior art keywords
antibody
integrin alpha
alpha beta
formulat ions
formulat
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP04707034A
Other languages
German (de)
English (en)
Other versions
EP1589996A2 (fr
Inventor
Christian B Allan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MedImmune LLC
Original Assignee
MedImmune LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MedImmune LLC filed Critical MedImmune LLC
Publication of EP1589996A2 publication Critical patent/EP1589996A2/fr
Publication of EP1589996A4 publication Critical patent/EP1589996A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2848—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP04707034A 2003-01-30 2004-01-30 Preparation d'anticorps anti-integrine alpha beta 3 et utilisations associees Withdrawn EP1589996A4 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US44377703P 2003-01-30 2003-01-30
US44381003P 2003-01-30 2003-01-30
US443810P 2003-01-30
US443777P 2003-01-30
PCT/US2004/002701 WO2004066957A2 (fr) 2003-01-30 2004-01-30 Preparation d'anticorps anti-integrine $g(a)v$g(b)3 et utilisations associees

Publications (2)

Publication Number Publication Date
EP1589996A2 EP1589996A2 (fr) 2005-11-02
EP1589996A4 true EP1589996A4 (fr) 2009-01-21

Family

ID=32829839

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04707034A Withdrawn EP1589996A4 (fr) 2003-01-30 2004-01-30 Preparation d'anticorps anti-integrine alpha beta 3 et utilisations associees

Country Status (5)

Country Link
EP (1) EP1589996A4 (fr)
JP (1) JP2006516636A (fr)
AU (1) AU2004207003A1 (fr)
CA (1) CA2512174A1 (fr)
WO (1) WO2004066957A2 (fr)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7973134B2 (en) 2004-07-07 2011-07-05 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in anaplastic large cell lymphoma signaling pathways
US20060046961A1 (en) * 2004-09-02 2006-03-02 Mckay William F Controlled and directed local delivery of anti-inflammatory compositions
US7935790B2 (en) 2004-10-04 2011-05-03 Cell Singaling Technology, Inc. Reagents for the detection of protein phosphorylation in T-cell receptor signaling pathways
JO3000B1 (ar) 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
US7807789B2 (en) 2004-12-21 2010-10-05 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in EGFR-signaling pathways
MX336033B (es) 2005-08-03 2016-01-07 Immunogen Inc Formulaciones de inmunoconjugado.
EP1934867A2 (fr) 2005-08-31 2008-06-25 Cell Signaling Technology, Inc. Reactifs de detection de phosphorylation proteinique dans des voies de signalisation de leucemie
PL3167888T3 (pl) 2006-03-15 2024-08-26 Alexion Pharmaceuticals, Inc. Leczenie pacjentów z napadową nocną hemoglobinurią za pomocą inhibitora dopełniacza
US7939636B2 (en) 2006-08-11 2011-05-10 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in c-Src signaling pathways
KR101503540B1 (ko) 2006-09-05 2015-03-17 알렉시온 파마슈티칼스, 인코포레이티드 항체 매개된 신경병증의 치료를 위한 방법과 조성물
ES2925992T3 (es) 2006-10-20 2022-10-20 Amgen Inc Formulaciones estables de polipéptidos
US20090081659A1 (en) 2007-03-07 2009-03-26 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
EP1975184A3 (fr) 2007-03-26 2008-11-26 Cell Signaling Technology, Inc. Sites de phosphorylation à sérine ou thréonine
NZ580379A (en) 2007-03-29 2012-10-26 Abbott Lab Crystalline anti-human il-12 antibodies
US7977462B2 (en) 2007-04-19 2011-07-12 Cell Signaling Technology, Inc. Tyrosine phosphorylation sites
EP1983002A3 (fr) 2007-04-19 2009-03-11 Peter Hornbeck Sites de phosphorylation à tyrosine et anticorps spécifiques
EP1983003A3 (fr) 2007-04-19 2009-03-11 Peter Hornbeck Sites de phosphorylation à tyrosine et anticorps spécifiques
US20090053831A1 (en) 2007-05-01 2009-02-26 Cell Signaling Technology, Inc. Tyrosine phosphorylation sites
DK2197970T3 (da) * 2007-10-09 2011-09-05 Hercules Inc Klæbemiddelsammensætninger indeholdende krydsbindende middel
EP2062920A3 (fr) 2007-11-21 2009-06-17 Peter Hornbeck Phosphorylation de protéines par des kinases de sérine/thréonine basophiles dans des voies de signalisation de l'insuline
US8883146B2 (en) 2007-11-30 2014-11-11 Abbvie Inc. Protein formulations and methods of making same
EP2542696B1 (fr) 2010-03-01 2016-09-28 Caris Life Sciences Switzerland Holdings GmbH Biomarqueurs pour théranostique
JP2013528570A (ja) * 2010-03-31 2013-07-11 ユニベルシテ ドゥ ジュネーブ 安定化された抗体調製物およびその使用
BR112012025593A2 (pt) 2010-04-06 2019-06-25 Caris Life Sciences Luxembourg Holdings biomarcadores em circulação para doença
US10316095B2 (en) * 2012-02-16 2019-06-11 Santarus, Inc. Antibody formulations
IL287947B2 (en) 2014-10-23 2024-08-01 Amgen Inc Viscosity reduction of pharmaceutical preparations
KR20220119529A (ko) 2016-06-02 2022-08-29 애브비 인코포레이티드 글루코코르티코이드 수용체 작용제 및 이의 면역접합체
JP7377596B2 (ja) 2017-02-22 2023-11-10 アムジエン・インコーポレーテツド 低粘度、高濃度エボロクマブ製剤及びそれらの製造方法
WO2019106609A1 (fr) 2017-12-01 2019-06-06 Abbvie Inc. Agoniste du récepteur des glucocorticoïdes et immunoconjugués de celui-ci
WO2020060183A1 (fr) * 2018-09-18 2020-03-26 삼성바이오에피스 주식회사 Formation de liquide pour stabiliser un anticorps de trastuzumab
EP3907504A4 (fr) * 2019-01-04 2022-11-30 Kyoto University Méthode de test pour la rectocolite hémorragique et la cholangite sclérosante primitive

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010016645A1 (en) * 1997-01-30 2001-08-23 Ixsys, Incorporated Anti-alphavbeta3 recombinant human antibodies, nucleic acids encoding same and methods of use
WO2002013860A1 (fr) * 2000-08-11 2002-02-21 Chugai Seiyaku Kabushiki Kaisha Preparations stabilisees contenant un anticorps

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6267958B1 (en) * 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010016645A1 (en) * 1997-01-30 2001-08-23 Ixsys, Incorporated Anti-alphavbeta3 recombinant human antibodies, nucleic acids encoding same and methods of use
WO2002013860A1 (fr) * 2000-08-11 2002-02-21 Chugai Seiyaku Kabushiki Kaisha Preparations stabilisees contenant un anticorps
EP1314437A1 (fr) * 2000-08-11 2003-05-28 Chugai Seiyaku Kabushiki Kaisha Preparations stabilisees contenant un anticorps

Also Published As

Publication number Publication date
WO2004066957A3 (fr) 2005-04-07
JP2006516636A (ja) 2006-07-06
AU2004207003A1 (en) 2004-08-12
EP1589996A2 (fr) 2005-11-02
WO2004066957A2 (fr) 2004-08-12
CA2512174A1 (fr) 2004-08-12

Similar Documents

Publication Publication Date Title
EP1589996A4 (fr) Preparation d'anticorps anti-integrine alpha beta 3 et utilisations associees
IL225633A0 (en) Anti-alpha-v-beta - 6 antibodies and uses thereof
IL174637A0 (en) Fibrosis-inducing agents, compositions containing the same and medical implants containing the same
AU2003272187A8 (en) Novel nanoparticles and use thereof
AU2003299778A8 (en) Antibodies against gpr64 and uses thereof
PT1736541E (pt) Nova proteína galectina 9 modificada e sua utilização
AU2003295402A8 (en) Acyl guanidine compounds and use thereof
GB0220214D0 (en) Compounds and their use
AU2003296369A8 (en) Imminoamines and preparation thereof
AU2003215257A8 (en) Modified defensins and their use
EP1767634A4 (fr) Nouvelle proteine de modification galectine 8 et utilisation de celle-ci
IL165112A0 (en) Variant integrinpolypeptides and thereof
AU2003231827A8 (en) Pseudo-tissues and uses thereof
GB0318546D0 (en) Quinoxalinones and their use
AU2003275123A8 (en) Composition containing ribavirin and use thereof
GB0230134D0 (en) Compounds and their use
GB0317864D0 (en) Compounds and their use
GB0230281D0 (en) Compounds and their use
FR2859108B1 (fr) Composition anti-stress et son inhalateur
GB2420345B (en) 3-alpha-glycosyl alpha, alpha-trehaloses their preparation and use
GB0321300D0 (en) Protein structure and uses thereof
GB0220215D0 (en) Compounds and their use
GB0228538D0 (en) Protein structure and uses thereof
GB0325241D0 (en) Composition and use
GB0301401D0 (en) Composition and use

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20050816

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL LT LV MK

DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20081219

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20090318