EP1606264A4 - Antagonistes des recepteurs du cgrp d'anilide spirohydantoine monocyclique - Google Patents
Antagonistes des recepteurs du cgrp d'anilide spirohydantoine monocycliqueInfo
- Publication number
- EP1606264A4 EP1606264A4 EP04719323A EP04719323A EP1606264A4 EP 1606264 A4 EP1606264 A4 EP 1606264A4 EP 04719323 A EP04719323 A EP 04719323A EP 04719323 A EP04719323 A EP 04719323A EP 1606264 A4 EP1606264 A4 EP 1606264A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- antagonists
- spirohydantoin
- anilide
- monocyclic
- cgrp receptors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45494403P | 2003-03-14 | 2003-03-14 | |
| US454944P | 2003-03-14 | ||
| PCT/US2004/007678 WO2004083187A1 (fr) | 2003-03-14 | 2004-03-10 | Antagonistes des recepteurs du cgrp d'anilide spirohydantoine monocyclique |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| EP1606264A1 EP1606264A1 (fr) | 2005-12-21 |
| EP1606264A4 true EP1606264A4 (fr) | 2009-02-18 |
| EP1606264B1 EP1606264B1 (fr) | 2012-05-02 |
Family
ID=33029931
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP04719323A Expired - Lifetime EP1606264B1 (fr) | 2003-03-14 | 2004-03-10 | Antagonistes des recepteurs du cgrp d'anilide spirohydantoine monocyclique |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7192954B2 (fr) |
| EP (1) | EP1606264B1 (fr) |
| JP (1) | JP4673295B2 (fr) |
| AT (1) | ATE556060T1 (fr) |
| AU (1) | AU2004221891B2 (fr) |
| CA (1) | CA2518852A1 (fr) |
| WO (1) | WO2004083187A1 (fr) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7220862B2 (en) | 2002-06-05 | 2007-05-22 | Bristol-Myers Squibb Company | Calcitonin gene related peptide receptor antagonists |
| US7842808B2 (en) | 2002-06-05 | 2010-11-30 | Bristol-Myers Squibb Company | Anti-migraine spirocycles |
| JP4673296B2 (ja) * | 2003-03-14 | 2011-04-20 | メルク・シャープ・エンド・ドーム・コーポレイション | アリールスピロヒダントインｃｇｒｐ受容体拮抗物質 |
| CA2519475A1 (fr) * | 2003-03-14 | 2004-09-30 | Merck & Co., Inc. | Antagonistes des recepteurs du cgrp spirohydantoine anilides bicycliques |
| US7205293B2 (en) * | 2003-03-14 | 2007-04-17 | Merck & Co., Inc. | Benodiazepine spirohydantoin CGRP receptor antagonists |
| US7569578B2 (en) | 2003-12-05 | 2009-08-04 | Bristol-Meyers Squibb Company | Heterocyclic anti-migraine agents |
| TW200533398A (en) | 2004-03-29 | 2005-10-16 | Bristol Myers Squibb Co | Novel therapeutic agents for the treatment of migraine |
| US7659300B2 (en) * | 2004-09-08 | 2010-02-09 | Merck Sharp & Dohme Corp. | Monocyclic anilide spirolactam CGRP receptor antagonists |
| WO2006031491A2 (fr) | 2004-09-09 | 2006-03-23 | Merck & Co., Inc. | Antagonistes des recepteurs cgrp sous forme de spirolactame d'anilide tricyclique |
| CA2580020A1 (fr) | 2004-09-09 | 2006-03-23 | Ian M. Bell | Antagonistes des recepteurs cgrp d'aryle-spirolactame |
| CA2579847A1 (fr) | 2004-09-13 | 2006-03-23 | Merck & Co., Inc. | Antagonistes des recepteurs du cgrp de spirolactame anilide bicyclique |
| ATE518852T1 (de) * | 2004-09-13 | 2011-08-15 | Merck Sharp & Dohme | Tricyclische anilid-spirohydantoin-cgrp- rezeptorantagonisten |
| US7384931B2 (en) | 2004-11-03 | 2008-06-10 | Bristol-Myers Squibb Company | Constrained compounds as CGRP-receptor antagonists |
| US7384930B2 (en) | 2004-11-03 | 2008-06-10 | Bristol-Myers Squibb Company | Constrained compounds as CGRP-receptor antagonists |
| US7449586B2 (en) | 2004-12-03 | 2008-11-11 | Bristol-Myers Squibb Company | Processes for the preparation of CGRP-receptor antagonists and intermediates thereof |
| US7834007B2 (en) | 2005-08-25 | 2010-11-16 | Bristol-Myers Squibb Company | CGRP antagonists |
| US8168592B2 (en) * | 2005-10-21 | 2012-05-01 | Amgen Inc. | CGRP peptide antagonists and conjugates |
| MY153249A (en) | 2005-11-14 | 2015-01-29 | Rinat Neuroscience Corp | Antagonist antibodies directed against calcitonin gene-related peptide and methods using same |
| WO2007061695A2 (fr) * | 2005-11-18 | 2007-05-31 | Merck & Co., Inc. | Antagonistes du recepteur cgrp biclyclique de spirohydantoine |
| ATE493412T1 (de) | 2005-11-18 | 2011-01-15 | Merck Sharp & Dohme | Spirohydantoin-aryl-cgrp-rezeptorantagonisten |
| WO2007061692A2 (fr) * | 2005-11-18 | 2007-05-31 | Merck & Co., Inc. | Antagonistes du recepteur cgrp du spirolactam |
| WO2007061677A2 (fr) * | 2005-11-18 | 2007-05-31 | Merck & Co., Inc. | Antagoniste du recepteur cgpr de spirolactam aryle |
| WO2007061694A2 (fr) | 2005-11-18 | 2007-05-31 | Merck & Co., Inc. | Antagonistes du recepteur cgrp tricyclique de la spirohydantoine |
| CA2650932C (fr) | 2006-05-09 | 2013-01-22 | Merck & Co., Inc. | Antagonistes spirocycliques substitues des recepteurs cgrp |
| DE102006024024A1 (de) * | 2006-05-23 | 2007-11-29 | Bayer Healthcare Aktiengesellschaft | Substituierte Arylimidazolone und -triazolone sowie ihre Verwendung |
| JP5511379B2 (ja) * | 2006-07-21 | 2014-06-04 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ｃｇｒｐレセプターアンタゴニスト |
| US7951795B2 (en) * | 2006-12-08 | 2011-05-31 | Merck Sharp & Dohme Corp. | Constrained spirocyclic compounds as CGRP receptor antagonists |
| JP2010521457A (ja) | 2007-03-12 | 2010-06-24 | メルク・シャープ・エンド・ドーム・コーポレイション | 単環式アニリドスピロラクタムｃｇｒｐ受容体アンタゴニスト |
| JP2010523663A (ja) * | 2007-04-11 | 2010-07-15 | メルク・シャープ・エンド・ドーム・コーポレイション | 第３級アミド、スルホンアミド、カルバミン酸及び尿素末端基をもつｃｇｒｐ受容体アンタゴニスト |
| AU2008241488A1 (en) * | 2007-04-16 | 2008-10-30 | Merck Sharp & Dohme Corp. | Bicyclic anilide heterocyclic CGRP receptor antagonists |
| EP2146712A4 (fr) * | 2007-04-16 | 2010-10-13 | Merck Sharp & Dohme | Antagonistes des récepteurs du cgrp aryl hétérocycliques |
| JP5511657B2 (ja) * | 2007-06-05 | 2014-06-04 | メルク・シャープ・アンド・ドーム・コーポレーション | カルボキサミドヘテロ環式ｃｇｒｐ受容体アンタゴニスト |
| WO2008153852A1 (fr) * | 2007-06-07 | 2008-12-18 | Merck & Co., Inc. | Antagonistes de récepteurs cgrp hétérocycliques de l'anilide tricyclique |
| CA2716424C (fr) | 2008-03-04 | 2015-04-28 | Pfizer Limited | Procedes de traitement d'une douleur chronique |
| CA2735821A1 (fr) * | 2008-09-08 | 2010-03-11 | Merck Sharp & Dohme Corp. | Antagonistes du recepteur cgrp d'amide monocyclique |
| WO2010039673A1 (fr) * | 2008-10-03 | 2010-04-08 | Merck Sharp & Dohme Corp. | Antagonistes des récepteurs cgrp |
| DE102008060967A1 (de) | 2008-12-06 | 2010-06-10 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Phenylsulfonyltriazolone und ihre Verwendung |
| DE102010001064A1 (de) * | 2009-03-18 | 2010-09-23 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 2-Acetamido-5-Aryl-1,2,4-triazolone und deren Verwendung |
| KR101519192B1 (ko) | 2009-08-28 | 2015-05-11 | 리나트 뉴로사이언스 코프. | 칼시토닌 유전자-관련된 펩티드에 대해 지시된 길항제 항체의 투여에 의한 내장 통증의 치료 방법 |
| EA023221B1 (ru) | 2010-02-27 | 2016-05-31 | Байер Интеллектуэль Проперти Гмбх | СВЯЗАННЫЕ БИС-АРИЛЬНЫЕ АРИЛ-ТРИАЗОЛОНЫ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ, ИХ ПРИМЕНЕНИЕ, ЛЕКАРСТВЕННОЕ СРЕДСТВО НА ИХ ОСНОВЕ И ДВОЙНОЙ АНТАГОНИСТ V1a/V2-РЕЦЕПТОРОВ |
| DE102010040187A1 (de) | 2010-09-02 | 2012-03-08 | Bayer Schering Pharma Aktiengesellschaft | Substituierte N-Phenethyl-triazolonacetamide und ihre Verwendung |
| DE102010040924A1 (de) | 2010-09-16 | 2012-03-22 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Phenylacet- und Phenylpropanamide und ihre Verwendung |
| NZ717704A (en) | 2011-05-20 | 2022-08-26 | H Lundbeck As | Use of anti-cgrp or anti-cgrp-r antibodies or antibody fragments to treat or prevent chronic and acute forms of diarrhea |
| AU2012258980B8 (en) | 2011-05-20 | 2017-06-15 | H. Lundbeck A/S | Use of anti-CGRP antibodies and antibody fragments to prevent or inhibit photophobia or light aversion in subjects in need thereof, especially migraine sufferers |
| TWI685505B (zh) | 2011-05-20 | 2020-02-21 | 美商艾爾德生物控股有限責任公司 | 抗降血鈣素基因相關胜肽（ａｎｔｉ-ｃｇｒｐ）組成物及其用途 |
| US20170114122A1 (en) | 2015-10-23 | 2017-04-27 | Alderbio Holdings Llc | Regulation of glucose metabolism using anti-cgrp antibodies |
| US10556945B2 (en) | 2014-03-21 | 2020-02-11 | Teva Pharmaceuticals International Gmbh | Antagonist antibodies directed against calcitonin gene-related peptide and methods using same |
| PE20161439A1 (es) | 2014-03-21 | 2017-01-26 | Teva Pharmaceuticals Int Gmbh | Anticuerpos antagonistas dirigidos contra el peptido relacionado con el gen de calcitonina y metodos que usan los mismos |
| UA121558C2 (uk) | 2014-11-03 | 2020-06-25 | Баєр Фарма Актіенгезеллшафт | Гідроксіалкілзаміщені фенілтриазольні похідні та їх застосування |
| FR3030521B1 (fr) * | 2014-12-23 | 2019-07-26 | Galderma Research & Development | Nouveaux composes heterocycliques et leur utilisation en medecine ainsi qu'en cosmetique |
| US9988367B2 (en) | 2016-05-03 | 2018-06-05 | Bayer Pharma Aktiengesellschaft | Amide-substituted pyridinyltriazole derivatives and uses thereof |
| WO2018055574A1 (fr) | 2016-09-23 | 2018-03-29 | Teva Pharmaceuticals International Gmbh | Traitement de la migraine réfractaire |
| EP3366286A1 (fr) | 2017-02-22 | 2018-08-29 | Johannes Keller | Composés destinés au traitement de septicémie |
| CN113227140A (zh) | 2019-01-08 | 2021-08-06 | H.隆德贝克有限公司 | 使用抗cgrp抗体急性治疗和快速治疗头痛 |
| KR20210124867A (ko) | 2020-04-06 | 2021-10-15 | 하. 룬드벡 아크티에셀스카브 | 항-cgrp 항체를 사용하는 편두통 관련 성가심 증상 (mbs) 의 치료 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4772632A (en) * | 1987-02-24 | 1988-09-20 | The United States Of America As Represented By The Department Of Health And Human Services | Antineoplastic, system - L specific amino acid nitrogen mustards |
| JP3449084B2 (ja) * | 1995-12-25 | 2003-09-22 | 富士レビオ株式会社 | ヒダントイン誘導体 |
-
2004
- 2004-03-10 AU AU2004221891A patent/AU2004221891B2/en not_active Ceased
- 2004-03-10 US US10/547,082 patent/US7192954B2/en not_active Expired - Lifetime
- 2004-03-10 CA CA002518852A patent/CA2518852A1/fr not_active Abandoned
- 2004-03-10 EP EP04719323A patent/EP1606264B1/fr not_active Expired - Lifetime
- 2004-03-10 AT AT04719323T patent/ATE556060T1/de active
- 2004-03-10 JP JP2006507138A patent/JP4673295B2/ja not_active Expired - Fee Related
- 2004-03-10 WO PCT/US2004/007678 patent/WO2004083187A1/fr not_active Ceased
Non-Patent Citations (1)
| Title |
|---|
| No further relevant documents disclosed * |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004221891B2 (en) | 2009-11-19 |
| US7192954B2 (en) | 2007-03-20 |
| ATE556060T1 (de) | 2012-05-15 |
| WO2004083187A1 (fr) | 2004-09-30 |
| US20060148779A1 (en) | 2006-07-06 |
| JP4673295B2 (ja) | 2011-04-20 |
| JP2006520387A (ja) | 2006-09-07 |
| EP1606264A1 (fr) | 2005-12-21 |
| EP1606264B1 (fr) | 2012-05-02 |
| CA2518852A1 (fr) | 2004-09-30 |
| AU2004221891A1 (en) | 2004-09-30 |
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