EP1606264A4 - Antagonistes des recepteurs du cgrp d'anilide spirohydantoine monocyclique - Google Patents
Antagonistes des recepteurs du cgrp d'anilide spirohydantoine monocycliqueInfo
- Publication number
- EP1606264A4 EP1606264A4 EP04719323A EP04719323A EP1606264A4 EP 1606264 A4 EP1606264 A4 EP 1606264A4 EP 04719323 A EP04719323 A EP 04719323A EP 04719323 A EP04719323 A EP 04719323A EP 1606264 A4 EP1606264 A4 EP 1606264A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- antagonists
- spirohydantoin
- anilide
- monocyclic
- cgrp receptors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45494403P | 2003-03-14 | 2003-03-14 | |
| US454944P | 2003-03-14 | ||
| PCT/US2004/007678 WO2004083187A1 (fr) | 2003-03-14 | 2004-03-10 | Antagonistes des recepteurs du cgrp d'anilide spirohydantoine monocyclique |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| EP1606264A1 EP1606264A1 (fr) | 2005-12-21 |
| EP1606264A4 true EP1606264A4 (fr) | 2009-02-18 |
| EP1606264B1 EP1606264B1 (fr) | 2012-05-02 |
Family
ID=33029931
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP04719323A Expired - Lifetime EP1606264B1 (fr) | 2003-03-14 | 2004-03-10 | Antagonistes des recepteurs du cgrp d'anilide spirohydantoine monocyclique |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7192954B2 (fr) |
| EP (1) | EP1606264B1 (fr) |
| JP (1) | JP4673295B2 (fr) |
| AT (1) | ATE556060T1 (fr) |
| AU (1) | AU2004221891B2 (fr) |
| CA (1) | CA2518852A1 (fr) |
| WO (1) | WO2004083187A1 (fr) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7220862B2 (en) | 2002-06-05 | 2007-05-22 | Bristol-Myers Squibb Company | Calcitonin gene related peptide receptor antagonists |
| US7842808B2 (en) | 2002-06-05 | 2010-11-30 | Bristol-Myers Squibb Company | Anti-migraine spirocycles |
| AU2004222328B2 (en) * | 2003-03-14 | 2009-10-08 | Merck Sharp & Dohme Corp. | Aryl spirohydantoin CGRP receptor antagonists |
| CA2519515A1 (fr) * | 2003-03-14 | 2004-10-14 | Merck & Co., Inc. | Antagonistes benodiazepine spirohydantoin des recepteurs de cgrp |
| ATE394400T1 (de) * | 2003-03-14 | 2008-05-15 | Merck & Co Inc | Bicyclische anilidspirohydantoine als cgrp- rezeptorantagonisten |
| TW200524601A (en) | 2003-12-05 | 2005-08-01 | Bristol Myers Squibb Co | Heterocyclic anti-migraine agents |
| TW200533398A (en) | 2004-03-29 | 2005-10-16 | Bristol Myers Squibb Co | Novel therapeutic agents for the treatment of migraine |
| US7659300B2 (en) * | 2004-09-08 | 2010-02-09 | Merck Sharp & Dohme Corp. | Monocyclic anilide spirolactam CGRP receptor antagonists |
| EP1794133B1 (fr) * | 2004-09-09 | 2011-12-14 | Merck Sharp & Dohme Corp. | Antagonistes des recepteurs cgrp d'aryle-spirolactame |
| CN101014345A (zh) | 2004-09-09 | 2007-08-08 | 默克公司 | 三环酰苯胺螺环内酰胺cgrp受体拮抗剂 |
| CA2579847A1 (fr) | 2004-09-13 | 2006-03-23 | Merck & Co., Inc. | Antagonistes des recepteurs du cgrp de spirolactame anilide bicyclique |
| US7750010B2 (en) * | 2004-09-13 | 2010-07-06 | Merck Sharp & Dohme Corp. | Tricyclic anilide spirohydantion CGRP receptor antagonists |
| US7384931B2 (en) | 2004-11-03 | 2008-06-10 | Bristol-Myers Squibb Company | Constrained compounds as CGRP-receptor antagonists |
| US7384930B2 (en) | 2004-11-03 | 2008-06-10 | Bristol-Myers Squibb Company | Constrained compounds as CGRP-receptor antagonists |
| US7449586B2 (en) | 2004-12-03 | 2008-11-11 | Bristol-Myers Squibb Company | Processes for the preparation of CGRP-receptor antagonists and intermediates thereof |
| US7834007B2 (en) | 2005-08-25 | 2010-11-16 | Bristol-Myers Squibb Company | CGRP antagonists |
| US8168592B2 (en) * | 2005-10-21 | 2012-05-01 | Amgen Inc. | CGRP peptide antagonists and conjugates |
| EP3069731A1 (fr) | 2005-11-14 | 2016-09-21 | Labrys Biologics Inc. | Antagonistes d'anticorps dirigés contre un peptide associé au gène de la calcitonine et procédés les utilisant |
| AU2006316644B2 (en) | 2005-11-18 | 2011-11-10 | Merck Sharp & Dohme Corp. | Spirohydantoin tricyclic CGRP receptor antagonists |
| JP2009515971A (ja) | 2005-11-18 | 2009-04-16 | メルク エンド カムパニー インコーポレーテッド | スピロヒダントインアリールｃｇｒｐ受容体アンタゴニスト |
| AU2006316642A1 (en) * | 2005-11-18 | 2007-05-31 | Merck Sharp & Dohme Corp. | Spirolactam tricyclic CGRP receptor antagonists |
| US8071771B2 (en) * | 2005-11-18 | 2011-12-06 | Merck Sharp & Dohme Corp. | Bicyclic spirohydantoin CGRP receptor antagonists |
| WO2007061677A2 (fr) * | 2005-11-18 | 2007-05-31 | Merck & Co., Inc. | Antagoniste du recepteur cgpr de spirolactam aryle |
| AU2007284994B2 (en) | 2006-05-09 | 2010-04-22 | Merck Sharp & Dohme Corp. | Substituted spirocyclic CGRP receptor antagonists |
| DE102006024024A1 (de) * | 2006-05-23 | 2007-11-29 | Bayer Healthcare Aktiengesellschaft | Substituierte Arylimidazolone und -triazolone sowie ihre Verwendung |
| DE602007006961D1 (de) * | 2006-07-21 | 2010-07-15 | Vertex Pharma | Cgrp-rezeptorantagonisten |
| US7951795B2 (en) * | 2006-12-08 | 2011-05-31 | Merck Sharp & Dohme Corp. | Constrained spirocyclic compounds as CGRP receptor antagonists |
| JP2010521457A (ja) * | 2007-03-12 | 2010-06-24 | メルク・シャープ・エンド・ドーム・コーポレイション | 単環式アニリドスピロラクタムｃｇｒｐ受容体アンタゴニスト |
| US8372859B2 (en) * | 2007-04-11 | 2013-02-12 | Merck, Sharp & Dohme Corp. | CGRP receptor antagonists with tertiary amide, sulfonamide, carbamate and urea end groups |
| AU2008241488A1 (en) * | 2007-04-16 | 2008-10-30 | Merck Sharp & Dohme Corp. | Bicyclic anilide heterocyclic CGRP receptor antagonists |
| WO2008130524A1 (fr) * | 2007-04-16 | 2008-10-30 | Merck & Co., Inc. | Antagonistes des récepteurs du cgrp aryl hétérocycliques |
| CA2689217C (fr) * | 2007-06-05 | 2016-02-16 | Merck & Co., Inc. | Antagonistes des recepteurs cgrp a base de carboxamide heterocyclique |
| WO2008153852A1 (fr) * | 2007-06-07 | 2008-12-18 | Merck & Co., Inc. | Antagonistes de récepteurs cgrp hétérocycliques de l'anilide tricyclique |
| RU2522493C2 (ru) | 2008-03-04 | 2014-07-20 | Пфайзер Лимитед | Способы лечения хронической боли |
| CA2735821A1 (fr) * | 2008-09-08 | 2010-03-11 | Merck Sharp & Dohme Corp. | Antagonistes du recepteur cgrp d'amide monocyclique |
| AU2009298752A1 (en) * | 2008-10-03 | 2010-04-08 | Merck Sharp & Dohme Corp. | CGRP receptor antagonists |
| DE102008060967A1 (de) | 2008-12-06 | 2010-06-10 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Phenylsulfonyltriazolone und ihre Verwendung |
| DE102010001064A1 (de) * | 2009-03-18 | 2010-09-23 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 2-Acetamido-5-Aryl-1,2,4-triazolone und deren Verwendung |
| CN102740884A (zh) | 2009-08-28 | 2012-10-17 | 瑞纳神经科学公司 | 通过施用针对降钙素基因相关肽的拮抗性抗体来治疗内脏痛的方法 |
| UA109650C2 (xx) | 2010-02-27 | 2015-09-25 | Біс-арилзв'язані арилтриазолони та їх застосування | |
| DE102010040187A1 (de) | 2010-09-02 | 2012-03-08 | Bayer Schering Pharma Aktiengesellschaft | Substituierte N-Phenethyl-triazolonacetamide und ihre Verwendung |
| DE102010040924A1 (de) | 2010-09-16 | 2012-03-22 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Phenylacet- und Phenylpropanamide und ihre Verwendung |
| CN107827982B (zh) | 2011-05-20 | 2021-07-06 | H.伦德贝克公司 | 抗cgrp抗体和抗体片段用于在有需要的受试者中预防或抑制畏光或厌光的用途 |
| TWI705825B (zh) | 2011-05-20 | 2020-10-01 | 美商艾爾德生物控股有限責任公司 | 抗降血鈣素基因相關胜肽（ａｎｔｉ－ｃｇｒｐ）或抗降血鈣素基因相關胜肽受器（ａｎｔｉ－ｃｇｒｐ－ｒ）抗體或抗體片段治療或預防慢性及急性型腹瀉之用途 |
| PE20141787A1 (es) | 2011-05-20 | 2014-12-07 | Alderbio Holdings Llc | Composiciones anti-cgrp y uso de las mismas |
| US20170114122A1 (en) | 2015-10-23 | 2017-04-27 | Alderbio Holdings Llc | Regulation of glucose metabolism using anti-cgrp antibodies |
| AU2015230933B2 (en) | 2014-03-21 | 2020-08-13 | Teva Pharmaceuticals International Gmbh | Antagonist antibodies directed against calcitonin gene-related peptide and methods using same |
| US10556945B2 (en) | 2014-03-21 | 2020-02-11 | Teva Pharmaceuticals International Gmbh | Antagonist antibodies directed against calcitonin gene-related peptide and methods using same |
| SI3215498T1 (sl) | 2014-11-03 | 2018-11-30 | Bayer Pharma Aktiengesellschaft | Hidroksialkil-substituirani derivati feniltriazola in njihove uporabe |
| FR3030521B1 (fr) * | 2014-12-23 | 2019-07-26 | Galderma Research & Development | Nouveaux composes heterocycliques et leur utilisation en medecine ainsi qu'en cosmetique |
| US9988367B2 (en) | 2016-05-03 | 2018-06-05 | Bayer Pharma Aktiengesellschaft | Amide-substituted pyridinyltriazole derivatives and uses thereof |
| CN109952314A (zh) | 2016-09-23 | 2019-06-28 | 泰瓦制药国际有限公司 | 治疗难治性偏头痛 |
| EP3366286A1 (fr) | 2017-02-22 | 2018-08-29 | Johannes Keller | Composés destinés au traitement de septicémie |
| WO2020146527A1 (fr) | 2019-01-08 | 2020-07-16 | Alder Biopharmaceuticals, Inc. | Traitement aigu et traitement rapide de maux de tête à l'aide d'anticorps anti-cgrp |
| CA3077973A1 (fr) | 2020-04-06 | 2021-10-06 | H. Lundbeck A/S | Traitement du symptome le plus perturbant associe a la migraine au moyen d`anticorps anti-cgrp |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4772632A (en) * | 1987-02-24 | 1988-09-20 | The United States Of America As Represented By The Department Of Health And Human Services | Antineoplastic, system - L specific amino acid nitrogen mustards |
| JP3449084B2 (ja) * | 1995-12-25 | 2003-09-22 | 富士レビオ株式会社 | ヒダントイン誘導体 |
-
2004
- 2004-03-10 EP EP04719323A patent/EP1606264B1/fr not_active Expired - Lifetime
- 2004-03-10 AU AU2004221891A patent/AU2004221891B2/en not_active Ceased
- 2004-03-10 JP JP2006507138A patent/JP4673295B2/ja not_active Expired - Fee Related
- 2004-03-10 WO PCT/US2004/007678 patent/WO2004083187A1/fr not_active Ceased
- 2004-03-10 US US10/547,082 patent/US7192954B2/en not_active Expired - Lifetime
- 2004-03-10 AT AT04719323T patent/ATE556060T1/de active
- 2004-03-10 CA CA002518852A patent/CA2518852A1/fr not_active Abandoned
Non-Patent Citations (1)
| Title |
|---|
| No further relevant documents disclosed * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1606264A1 (fr) | 2005-12-21 |
| JP4673295B2 (ja) | 2011-04-20 |
| EP1606264B1 (fr) | 2012-05-02 |
| CA2518852A1 (fr) | 2004-09-30 |
| JP2006520387A (ja) | 2006-09-07 |
| AU2004221891B2 (en) | 2009-11-19 |
| ATE556060T1 (de) | 2012-05-15 |
| US7192954B2 (en) | 2007-03-20 |
| US20060148779A1 (en) | 2006-07-06 |
| AU2004221891A1 (en) | 2004-09-30 |
| WO2004083187A1 (fr) | 2004-09-30 |
Similar Documents
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