EP1606264A4 - Antagonistes des recepteurs du cgrp d'anilide spirohydantoine monocyclique - Google Patents
Antagonistes des recepteurs du cgrp d'anilide spirohydantoine monocycliqueInfo
- Publication number
- EP1606264A4 EP1606264A4 EP04719323A EP04719323A EP1606264A4 EP 1606264 A4 EP1606264 A4 EP 1606264A4 EP 04719323 A EP04719323 A EP 04719323A EP 04719323 A EP04719323 A EP 04719323A EP 1606264 A4 EP1606264 A4 EP 1606264A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- antagonists
- spirohydantoin
- anilide
- monocyclic
- cgrp receptors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45494403P | 2003-03-14 | 2003-03-14 | |
| US454944P | 2003-03-14 | ||
| PCT/US2004/007678 WO2004083187A1 (fr) | 2003-03-14 | 2004-03-10 | Antagonistes des recepteurs du cgrp d'anilide spirohydantoine monocyclique |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| EP1606264A1 EP1606264A1 (fr) | 2005-12-21 |
| EP1606264A4 true EP1606264A4 (fr) | 2009-02-18 |
| EP1606264B1 EP1606264B1 (fr) | 2012-05-02 |
Family
ID=33029931
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP04719323A Expired - Lifetime EP1606264B1 (fr) | 2003-03-14 | 2004-03-10 | Antagonistes des recepteurs du cgrp d'anilide spirohydantoine monocyclique |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7192954B2 (fr) |
| EP (1) | EP1606264B1 (fr) |
| JP (1) | JP4673295B2 (fr) |
| AT (1) | ATE556060T1 (fr) |
| AU (1) | AU2004221891B2 (fr) |
| CA (1) | CA2518852A1 (fr) |
| WO (1) | WO2004083187A1 (fr) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7842808B2 (en) | 2002-06-05 | 2010-11-30 | Bristol-Myers Squibb Company | Anti-migraine spirocycles |
| US7220862B2 (en) | 2002-06-05 | 2007-05-22 | Bristol-Myers Squibb Company | Calcitonin gene related peptide receptor antagonists |
| JP4673294B2 (ja) * | 2003-03-14 | 2011-04-20 | メルク・シャープ・エンド・ドーム・コーポレイション | 二環式アニリドスピロヒダントインｃｇｒｐ受容体拮抗物質 |
| AU2004222328B2 (en) * | 2003-03-14 | 2009-10-08 | Merck Sharp & Dohme Corp. | Aryl spirohydantoin CGRP receptor antagonists |
| EP1606286B1 (fr) * | 2003-03-14 | 2011-05-11 | Merck Sharp & Dohme Corp. | Antagonistes benodiazepine spirohydantoin des recepteurs de cgrp |
| TW200524601A (en) | 2003-12-05 | 2005-08-01 | Bristol Myers Squibb Co | Heterocyclic anti-migraine agents |
| TW200533398A (en) | 2004-03-29 | 2005-10-16 | Bristol Myers Squibb Co | Novel therapeutic agents for the treatment of migraine |
| JP2008512460A (ja) * | 2004-09-08 | 2008-04-24 | メルク エンド カムパニー インコーポレーテッド | 単環式アニリドスピロラクタムｃｇｒｐ受容体拮抗薬 |
| JP2008512459A (ja) | 2004-09-09 | 2008-04-24 | メルク エンド カムパニー インコーポレーテッド | アリールスピロラクタムｃｇｒｐ受容体拮抗薬 |
| CA2579717A1 (fr) | 2004-09-09 | 2006-03-23 | Merck & Co., Inc. | Antagonistes des recepteurs cgrp sous forme de spirolactame d'anilide tricyclique |
| US8003792B2 (en) | 2004-09-13 | 2011-08-23 | Merck Sharp & Dohme Corp. | Bicyclic anilide spirolactam CGRP receptor antagonists |
| AU2005285083B2 (en) * | 2004-09-13 | 2011-03-10 | Merck Sharp & Dohme Corp. | Tricyclic anilide spirohydantoin CGRP receptor antagonists |
| US7384930B2 (en) | 2004-11-03 | 2008-06-10 | Bristol-Myers Squibb Company | Constrained compounds as CGRP-receptor antagonists |
| US7384931B2 (en) | 2004-11-03 | 2008-06-10 | Bristol-Myers Squibb Company | Constrained compounds as CGRP-receptor antagonists |
| US7449586B2 (en) | 2004-12-03 | 2008-11-11 | Bristol-Myers Squibb Company | Processes for the preparation of CGRP-receptor antagonists and intermediates thereof |
| US7834007B2 (en) | 2005-08-25 | 2010-11-16 | Bristol-Myers Squibb Company | CGRP antagonists |
| US8168592B2 (en) * | 2005-10-21 | 2012-05-01 | Amgen Inc. | CGRP peptide antagonists and conjugates |
| SI3045182T1 (en) * | 2005-11-14 | 2018-08-31 | Teva Pharmaceuticals International Gmbh | An antibody to a peptide-associated peptide antagonist to calcitonin for treating a headache in aggregates |
| AU2006316645A1 (en) * | 2005-11-18 | 2007-05-31 | Merck Sharp & Dohme Corp. | Bicyclic spirohydantoin CGRP receptor antagonists |
| US7968540B2 (en) | 2005-11-18 | 2011-06-28 | Merck Sharp & Dohme Corp. | Spirohydantoin tricyclic CGRP receptor antagonists |
| EP1951042B1 (fr) * | 2005-11-18 | 2012-10-10 | Merck Sharp & Dohme Corp. | Antagonistes du récepteur cgrp spirolactame tricycliques |
| EP1954135B1 (fr) * | 2005-11-18 | 2012-10-10 | Merck Sharp & Dohme Corp. | Antagonistes du récepteur cgrp spirolactame-aryle |
| CA2629406A1 (fr) | 2005-11-18 | 2007-05-31 | Merck & Co., Inc. | Antagonistes du recepteur cgrp de spirohydatoin aryle |
| WO2007133491A1 (fr) * | 2006-05-09 | 2007-11-22 | Merck & Co., Inc. | Antagonistes de récepteurs cgrp monocycliques substitués |
| DE102006024024A1 (de) * | 2006-05-23 | 2007-11-29 | Bayer Healthcare Aktiengesellschaft | Substituierte Arylimidazolone und -triazolone sowie ihre Verwendung |
| JP5511379B2 (ja) * | 2006-07-21 | 2014-06-04 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ｃｇｒｐレセプターアンタゴニスト |
| US7951795B2 (en) * | 2006-12-08 | 2011-05-31 | Merck Sharp & Dohme Corp. | Constrained spirocyclic compounds as CGRP receptor antagonists |
| JP2010521457A (ja) | 2007-03-12 | 2010-06-24 | メルク・シャープ・エンド・ドーム・コーポレイション | 単環式アニリドスピロラクタムｃｇｒｐ受容体アンタゴニスト |
| US8372859B2 (en) * | 2007-04-11 | 2013-02-12 | Merck, Sharp & Dohme Corp. | CGRP receptor antagonists with tertiary amide, sulfonamide, carbamate and urea end groups |
| CA2683745A1 (fr) * | 2007-04-16 | 2008-10-30 | Merck & Co., Inc. | Antagonistes des recepteurs cgrp heterocycliques d'anilide bicyclique |
| WO2008130524A1 (fr) * | 2007-04-16 | 2008-10-30 | Merck & Co., Inc. | Antagonistes des récepteurs du cgrp aryl hétérocycliques |
| CA2689217C (fr) * | 2007-06-05 | 2016-02-16 | Merck & Co., Inc. | Antagonistes des recepteurs cgrp a base de carboxamide heterocyclique |
| US8163752B2 (en) * | 2007-06-07 | 2012-04-24 | Merck, Sharp & Dohme Corp. | Tricyclic anilide heterocyclic CGRP receptor antagonists |
| KR101304150B1 (ko) | 2008-03-04 | 2013-09-05 | 라브리스 바이올로직스 인코포레이티드 | 만성 통증의 치료 방법 |
| EP2331101A4 (fr) * | 2008-09-08 | 2012-08-29 | Merck Sharp & Dohme | Antagonistes du récepteur cgrp d'amide monocyclique |
| JP2012504625A (ja) * | 2008-10-03 | 2012-02-23 | メルク・シャープ・エンド・ドーム・コーポレイション | Ｃｇｒｐ受容体アンタゴニスト |
| DE102008060967A1 (de) | 2008-12-06 | 2010-06-10 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Phenylsulfonyltriazolone und ihre Verwendung |
| DE102010001064A1 (de) * | 2009-03-18 | 2010-09-23 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 2-Acetamido-5-Aryl-1,2,4-triazolone und deren Verwendung |
| BR112012004464B8 (pt) | 2009-08-28 | 2021-05-25 | Labrys Biologics Inc | uso de um anticorpo antagonista anti-cgrp para preparar uma composição farmacêutica para tratar e/ou prevenir dor visceral e/ou um ou mais sintomas de dor visceral, em que a dor visceral está associada á cistite intersticial (ic), e dita composição farmacêutica |
| ES2635340T3 (es) | 2010-02-27 | 2017-10-03 | Bayer Intellectual Property Gmbh | Ariltriazolonas ligadas a bis-arilo y su uso |
| DE102010040187A1 (de) | 2010-09-02 | 2012-03-08 | Bayer Schering Pharma Aktiengesellschaft | Substituierte N-Phenethyl-triazolonacetamide und ihre Verwendung |
| DE102010040924A1 (de) | 2010-09-16 | 2012-03-22 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Phenylacet- und Phenylpropanamide und ihre Verwendung |
| EA033109B1 (ru) | 2011-05-20 | 2019-08-30 | Олдербайо Холдингз Ллк | Способы ингибирования, профилактики или лечения диареи и/или поддержания соответствующих уровней электролитов и жидкости в толстой кишке субъекта, подвергающегося связанному с диареей состоянию, с помощью антитела против cgrp или фрагмента антитела против cgrp |
| CN108014334B (zh) | 2011-05-20 | 2021-11-30 | H.伦德贝克公司 | 抗cgrp抗体和抗体片段用于在有需要的受试者中预防或抑制畏光或厌光的用途 |
| PT3495392T (pt) | 2011-05-20 | 2021-09-22 | H Lundbeck As | Composições anti-cgrp e a sua utilização |
| US20170114122A1 (en) | 2015-10-23 | 2017-04-27 | Alderbio Holdings Llc | Regulation of glucose metabolism using anti-cgrp antibodies |
| US10556945B2 (en) | 2014-03-21 | 2020-02-11 | Teva Pharmaceuticals International Gmbh | Antagonist antibodies directed against calcitonin gene-related peptide and methods using same |
| MX378344B (es) | 2014-03-21 | 2025-03-10 | Teva Pharmaceuticals Int Gmbh | Anticuerpos antagonistas dirigidos contra el peptido relacionado con el gen de calcitonina y metodos que usan los mismos. |
| US20170313665A1 (en) | 2014-11-03 | 2017-11-02 | Bayer Pharma Aktiengesellschaft | Hydroxyalkyl-substituted phenyltriazole derivatives and uses thereof |
| FR3030521B1 (fr) | 2014-12-23 | 2019-07-26 | Galderma Research & Development | Nouveaux composes heterocycliques et leur utilisation en medecine ainsi qu'en cosmetique |
| US9988367B2 (en) | 2016-05-03 | 2018-06-05 | Bayer Pharma Aktiengesellschaft | Amide-substituted pyridinyltriazole derivatives and uses thereof |
| SMT202600087T1 (it) | 2016-09-23 | 2026-03-09 | Teva Pharmaceuticals Int Gmbh | Trattamento dell’emicrania refrattaria |
| EP3366286A1 (fr) | 2017-02-22 | 2018-08-29 | Johannes Keller | Composés destinés au traitement de septicémie |
| CR20210373A (es) | 2019-01-08 | 2021-08-19 | H Lundbeck As | Tratamiento agudo y tratamiento rápido de la cefalea usando anticuerpos anti-cgrp |
| GEAP202515803A (en) | 2019-05-02 | 2025-06-10 | H Lundbeck As | Treatment of headache using anti-cgrp antibodies |
| KR20210124867A (ko) | 2020-04-06 | 2021-10-15 | 하. 룬드벡 아크티에셀스카브 | 항-cgrp 항체를 사용하는 편두통 관련 성가심 증상 (mbs) 의 치료 |
| AU2022324472A1 (en) * | 2021-08-05 | 2024-02-15 | 4E Therapeutics, Inc. | Methods of treating migraine with mnk inhibitors |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4772632A (en) * | 1987-02-24 | 1988-09-20 | The United States Of America As Represented By The Department Of Health And Human Services | Antineoplastic, system - L specific amino acid nitrogen mustards |
| JP3449084B2 (ja) * | 1995-12-25 | 2003-09-22 | 富士レビオ株式会社 | ヒダントイン誘導体 |
-
2004
- 2004-03-10 EP EP04719323A patent/EP1606264B1/fr not_active Expired - Lifetime
- 2004-03-10 WO PCT/US2004/007678 patent/WO2004083187A1/fr not_active Ceased
- 2004-03-10 AU AU2004221891A patent/AU2004221891B2/en not_active Ceased
- 2004-03-10 AT AT04719323T patent/ATE556060T1/de active
- 2004-03-10 US US10/547,082 patent/US7192954B2/en not_active Expired - Lifetime
- 2004-03-10 CA CA002518852A patent/CA2518852A1/fr not_active Abandoned
- 2004-03-10 JP JP2006507138A patent/JP4673295B2/ja not_active Expired - Fee Related
Non-Patent Citations (1)
| Title |
|---|
| No further relevant documents disclosed * |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2518852A1 (fr) | 2004-09-30 |
| JP4673295B2 (ja) | 2011-04-20 |
| WO2004083187A1 (fr) | 2004-09-30 |
| US20060148779A1 (en) | 2006-07-06 |
| EP1606264A1 (fr) | 2005-12-21 |
| US7192954B2 (en) | 2007-03-20 |
| AU2004221891B2 (en) | 2009-11-19 |
| ATE556060T1 (de) | 2012-05-15 |
| AU2004221891A1 (en) | 2004-09-30 |
| EP1606264B1 (fr) | 2012-05-02 |
| JP2006520387A (ja) | 2006-09-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE556060T1 (de) | Monocyclische anilidspirohydantoine als cgrp- rezeptorantagonisten | |
| EP1606286A4 (fr) | Antagonistes benodiazepine spirohydantoin des recepteurs de cgrp | |
| EP1608627A4 (fr) | Antagonistes des recepteurs du cgrp spirohydantoine anilides bicycliques | |
| ATE535514T1 (de) | Carboxamid-spirohydantoin-cgrp-rezeptor- antagonisten | |
| EP1605936A4 (fr) | Antagonistes du recepteur cgrp d'aryl spirohydantoine | |
| JO2355B1 (en) | Hereditary calcitonin polypeptide receptor antagonists | |
| DE602005020655D1 (de) | Carboxamid-spirolactam-cgrp-rezeptor-antagonisten | |
| NO20072435L (no) | CGRP-reseptorantagonister | |
| EP1615914A4 (fr) | Antagonistes des recepteurs de cgrp | |
| EP1797073A4 (fr) | Antagonistes des recepteurs du cgrp de spirolactame anilide bicyclique | |
| EP1641423A4 (fr) | Antagonistes du recepteur du cgrp de | |
| WO2006029153A3 (fr) | Antagonistes de recepteurs cgrp d'anilide spirolactame monocyclique | |
| WO2005000807A3 (fr) | Antagonistes du recepteur cgrp de benzodiazepine | |
| EP1794133A4 (fr) | Antagonistes des recepteurs cgrp d'aryle-spirolactame | |
| ATE537170T1 (de) | Cgrp-rezeptorantagonisten | |
| EP1793827A4 (fr) | Antagonistes des recepteurs cgrp sous forme de spirolactame d'anilide tricyclique | |
| EP1794146A4 (fr) | Antagoniste des recepteurs cgrp spirohydantoin anilide tricyclique | |
| ATE503755T1 (de) | Cgrp-rezeptorantagonisten | |
| EP1802372A4 (fr) | Antagonistes des recepteurs du cgrp) | |
| ATE466853T1 (de) | Cgrp-rezeptorantagonisten |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| 17P | Request for examination filed |
Effective date: 20051014 |
|
| AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR |
|
| AX | Request for extension of the european patent |
Extension state: AL LT LV MK |
|
| RAX | Requested extension states of the european patent have changed |
Extension state: LV Payment date: 20051014 Extension state: LT Payment date: 20051014 |
|
| A4 | Supplementary search report drawn up and despatched |
Effective date: 20090121 |
|
| 17Q | First examination report despatched |
Effective date: 20091026 |
|
| RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: MERCK SHARP & DOHME CORP. |
|
| GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
| GRAS | Grant fee paid |
Free format text: ORIGINAL CODE: EPIDOSNIGR3 |
|
| GRAA | (expected) grant |
Free format text: ORIGINAL CODE: 0009210 |
|
| AK | Designated contracting states |
Kind code of ref document: B1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR |
|
| AX | Request for extension of the european patent |
Extension state: LT LV |
|
| REG | Reference to a national code |
Ref country code: GB Ref legal event code: FG4D |
|
| REG | Reference to a national code |
Ref country code: CH Ref legal event code: EP Ref country code: AT Ref legal event code: REF Ref document number: 556060 Country of ref document: AT Kind code of ref document: T Effective date: 20120515 |
|
| REG | Reference to a national code |
Ref country code: IE Ref legal event code: FG4D |
|
| REG | Reference to a national code |
Ref country code: CH Ref legal event code: NV Representative=s name: MARKS & CLERK (LUXEMBOURG) LLP |
|
| REG | Reference to a national code |
Ref country code: DE Ref legal event code: R096 Ref document number: 602004037612 Country of ref document: DE Effective date: 20120628 |
|
| REG | Reference to a national code |
Ref country code: CH Ref legal event code: PFUS Owner name: SCHERING CORPORATION, US Free format text: FORMER OWNER: MERCK SHARP + DOHME CORP., US Ref country code: CH Ref legal event code: PFA Owner name: MERCK SHARP & DOHME CORP. Free format text: SCHERING CORPORATION#2000 GALLOPING HILL ROAD#KENILWORTH, NJ 07033 (US) -TRANSFER TO- MERCK SHARP & DOHME CORP.#126 EAST LINCOLN AVENUE#RAHWAY, NEW JERSEY 07065 (US) |
|
| RAP2 | Party data changed (patent owner data changed or rights of a patent transferred) |
Owner name: SCHERING CORPORATION |
|
| REG | Reference to a national code |
Ref country code: NL Ref legal event code: T3 |
|
| RAP2 | Party data changed (patent owner data changed or rights of a patent transferred) |
Owner name: MERCK SHARP & DOHME CORP. |
|
| REG | Reference to a national code |
Ref country code: GB Ref legal event code: 732E Free format text: REGISTERED BETWEEN 20120802 AND 20120808 |
|
| REG | Reference to a national code |
Ref country code: NL Ref legal event code: SD Effective date: 20120828 |
|
| REG | Reference to a national code |
Ref country code: NL Ref legal event code: TD Effective date: 20120924 |
|
| REG | Reference to a national code |
Ref country code: LT Ref legal event code: MG9D Effective date: 20120502 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: PL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20120502 Ref country code: SE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20120502 Ref country code: FI Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20120502 Ref country code: CY Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20120502 |
|
| REG | Reference to a national code |
Ref country code: AT Ref legal event code: MK05 Ref document number: 556060 Country of ref document: AT Kind code of ref document: T Effective date: 20120502 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: SI Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20120502 Ref country code: GR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20120803 Ref country code: PT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20120903 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: BE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20120502 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: RO Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20120502 Ref country code: EE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20120502 Ref country code: CZ Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20120502 Ref country code: DK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20120502 Ref country code: SK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20120502 Ref country code: AT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20120502 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: IT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20120502 |
|
| PLBE | No opposition filed within time limit |
Free format text: ORIGINAL CODE: 0009261 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT |
|
| REG | Reference to a national code |
Ref country code: DE Ref legal event code: R082 Ref document number: 602004037612 Country of ref document: DE Representative=s name: ABITZ & PARTNER, DE |
|
| 26N | No opposition filed |
Effective date: 20130205 |
|
| REG | Reference to a national code |
Ref country code: FR Ref legal event code: TP Owner name: SCHERING CORPORATION, US Effective date: 20130318 Ref country code: FR Ref legal event code: CD Owner name: SCHERING CORPORATION, US Effective date: 20130319 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: ES Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20120813 |
|
| PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: CH Payment date: 20130129 Year of fee payment: 10 |
|
| REG | Reference to a national code |
Ref country code: DE Ref legal event code: R082 Ref document number: 602004037612 Country of ref document: DE Representative=s name: ABITZ & PARTNER, DE Effective date: 20130514 Ref country code: DE Ref legal event code: R082 Ref document number: 602004037612 Country of ref document: DE Representative=s name: ABITZ & PARTNER, DE Effective date: 20130327 Ref country code: DE Ref legal event code: R081 Ref document number: 602004037612 Country of ref document: DE Owner name: MERCK SHARP & DOHME CORP., US Free format text: FORMER OWNER: SCHERING CORPORATION, RAHWAY, US Effective date: 20130514 Ref country code: DE Ref legal event code: R081 Ref document number: 602004037612 Country of ref document: DE Owner name: MERCK SHARP & DOHME CORP., US Free format text: FORMER OWNER: MERCK SHARP & DOHME CORP., RAHWAY, US Effective date: 20130327 Ref country code: DE Ref legal event code: R081 Ref document number: 602004037612 Country of ref document: DE Owner name: MERCK SHARP & DOHME CORP., US Free format text: FORMER OWNER: MERCK & CO., INC., WHITEHOUSE STATION, US Effective date: 20120507 Ref country code: DE Ref legal event code: R081 Ref document number: 602004037612 Country of ref document: DE Owner name: MERCK SHARP & DOHME CORP., RAHWAY, US Free format text: FORMER OWNER: MERCK SHARP & DOHME CORP., RAHWAY, N.J., US Effective date: 20130327 Ref country code: DE Ref legal event code: R081 Ref document number: 602004037612 Country of ref document: DE Owner name: MERCK SHARP & DOHME CORP., RAHWAY, US Free format text: FORMER OWNER: SCHERING CORPORATION, RAHWAY, US Effective date: 20130514 Ref country code: DE Ref legal event code: R081 Ref document number: 602004037612 Country of ref document: DE Owner name: MERCK SHARP & DOHME CORP., RAHWAY, US Free format text: FORMER OWNER: MERCK & CO., INC., WHITEHOUSE STATION, N.J., US Effective date: 20120507 Ref country code: DE Ref legal event code: R082 Ref document number: 602004037612 Country of ref document: DE Representative=s name: ABITZ & PARTNER PATENTANWAELTE MBB, DE Effective date: 20130327 Ref country code: DE Ref legal event code: R082 Ref document number: 602004037612 Country of ref document: DE Representative=s name: ABITZ & PARTNER PATENTANWAELTE MBB, DE Effective date: 20130514 |
|
| REG | Reference to a national code |
Ref country code: DE Ref legal event code: R097 Ref document number: 602004037612 Country of ref document: DE Effective date: 20130205 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: BG Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20120802 |
|
| PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: NL Payment date: 20130312 Year of fee payment: 10 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: MC Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20130331 |
|
| REG | Reference to a national code |
Ref country code: IE Ref legal event code: MM4A |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: IE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20130310 |
|
| REG | Reference to a national code |
Ref country code: NL Ref legal event code: V1 Effective date: 20141001 |
|
| REG | Reference to a national code |
Ref country code: CH Ref legal event code: PL |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: CH Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20140331 Ref country code: LI Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20140331 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: NL Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20141001 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: TR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20120502 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: HU Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO Effective date: 20040310 Ref country code: LU Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20130310 |
|
| REG | Reference to a national code |
Ref country code: FR Ref legal event code: PLFP Year of fee payment: 13 |
|
| REG | Reference to a national code |
Ref country code: FR Ref legal event code: PLFP Year of fee payment: 14 |
|
| REG | Reference to a national code |
Ref country code: FR Ref legal event code: PLFP Year of fee payment: 15 |
|
| REG | Reference to a national code |
Ref country code: DE Ref legal event code: R081 Ref document number: 602004037612 Country of ref document: DE Owner name: MERCK SHARP & DOHME LLC, RAHWAY, US Free format text: FORMER OWNER: MERCK SHARP & DOHME CORP., RAHWAY, N.J., US |
|
| REG | Reference to a national code |
Ref country code: GB Ref legal event code: 732E Free format text: REGISTERED BETWEEN 20220908 AND 20220914 |
|
| PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: FR Payment date: 20230209 Year of fee payment: 20 |
|
| PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: GB Payment date: 20230208 Year of fee payment: 20 Ref country code: DE Payment date: 20230210 Year of fee payment: 20 |
|
| REG | Reference to a national code |
Ref country code: DE Ref legal event code: R071 Ref document number: 602004037612 Country of ref document: DE |
|
| REG | Reference to a national code |
Ref country code: GB Ref legal event code: PE20 Expiry date: 20240309 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: GB Free format text: LAPSE BECAUSE OF EXPIRATION OF PROTECTION Effective date: 20240309 |