EP1608359A4 - Particules a charge medicamenteuse ciblant les tumeurs - Google Patents

Particules a charge medicamenteuse ciblant les tumeurs

Info

Publication number
EP1608359A4
EP1608359A4 EP04758803A EP04758803A EP1608359A4 EP 1608359 A4 EP1608359 A4 EP 1608359A4 EP 04758803 A EP04758803 A EP 04758803A EP 04758803 A EP04758803 A EP 04758803A EP 1608359 A4 EP1608359 A4 EP 1608359A4
Authority
EP
European Patent Office
Prior art keywords
tumor
targeting drug
loaded particles
loaded
particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP04758803A
Other languages
German (de)
English (en)
Other versions
EP1608359A2 (fr
Inventor
Jessie L-S Au
M Guillaume Wientjes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP1608359A2 publication Critical patent/EP1608359A2/fr
Publication of EP1608359A4 publication Critical patent/EP1608359A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5052—Proteins, e.g. albumin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Epoxy Compounds (AREA)
EP04758803A 2003-04-03 2004-04-02 Particules a charge medicamenteuse ciblant les tumeurs Withdrawn EP1608359A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46082703P 2003-04-03 2003-04-03
US460827P 2003-04-03
PCT/US2004/010230 WO2004089291A2 (fr) 2003-04-03 2004-04-02 Particules a charge medicamenteuse ciblant les tumeurs

Publications (2)

Publication Number Publication Date
EP1608359A2 EP1608359A2 (fr) 2005-12-28
EP1608359A4 true EP1608359A4 (fr) 2011-08-17

Family

ID=33159807

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04758803A Withdrawn EP1608359A4 (fr) 2003-04-03 2004-04-02 Particules a charge medicamenteuse ciblant les tumeurs

Country Status (8)

Country Link
EP (1) EP1608359A4 (fr)
JP (1) JP4927535B2 (fr)
KR (1) KR100849911B1 (fr)
CN (2) CN102697737B (fr)
AU (1) AU2004228008B2 (fr)
CA (1) CA2520475C (fr)
IL (1) IL171185A (fr)
WO (1) WO2004089291A2 (fr)

Families Citing this family (59)

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JP2007526322A (ja) * 2004-03-02 2007-09-13 マサチューセッツ インスティテュート オブ テクノロジー ナノセル薬物送達系
ES2557988T3 (es) * 2005-03-31 2016-02-01 Lidds Ab Método para tratar enfermedades de próstata basado en el suministro local de principios activos
BRPI0600285C1 (pt) * 2006-01-13 2011-10-11 Brz Biotecnologia Ltda compostos farmacêuticos contendo nanopartìculas úteis para tratamento de lesões reestenóticas
JP2007277217A (ja) * 2006-03-17 2007-10-25 Fujifilm Corp 薬剤を均一に封入した生分解性マトリックス
US8414526B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids
US8425459B2 (en) 2006-11-20 2013-04-23 Lutonix, Inc. Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent
EP2092942A1 (fr) * 2006-11-20 2009-08-26 Lutonix, Inc. Revêtements de libération de médicament pour dispositifs médicaux
US9737640B2 (en) 2006-11-20 2017-08-22 Lutonix, Inc. Drug releasing coatings for medical devices
US9700704B2 (en) 2006-11-20 2017-07-11 Lutonix, Inc. Drug releasing coatings for balloon catheters
US8414910B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US8414909B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US20080276935A1 (en) 2006-11-20 2008-11-13 Lixiao Wang Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs
EP2074988B1 (fr) 2007-12-28 2018-03-14 Industrial Technology Research Institute Composition à libération prolongée et son procédé de fabrication
US9161943B2 (en) 2007-12-31 2015-10-20 Industrial Technology Research Institute Sustained release composition and manufacturing method thereof
WO2009116556A1 (fr) * 2008-03-19 2009-09-24 富士フイルム株式会社 Composition pharmaceutique pour injection
US8613951B2 (en) 2008-06-16 2013-12-24 Bind Therapeutics, Inc. Therapeutic polymeric nanoparticles with mTor inhibitors and methods of making and using same
JP2012501965A (ja) 2008-06-16 2012-01-26 バインド バイオサイエンシズ インコーポレイテッド 薬剤を装填したポリマーナノ粒子及びその製造方法と使用方法
ES2721850T3 (es) 2008-06-16 2019-08-05 Pfizer Nanopartículas poliméricas terapéuticas que comprenden alcaloides vinca y procedimientos de fabricación y uso de las mismas
WO2010068866A2 (fr) 2008-12-12 2010-06-17 Bind Biosciences Particules thérapeutiques pour administration parentérale, et procédés de fabrication et d'utilisation associés
US20100216804A1 (en) 2008-12-15 2010-08-26 Zale Stephen E Long Circulating Nanoparticles for Sustained Release of Therapeutic Agents
US8357401B2 (en) 2009-12-11 2013-01-22 Bind Biosciences, Inc. Stable formulations for lyophilizing therapeutic particles
ES2780156T3 (es) 2009-12-15 2020-08-24 Pfizer Composiciones terapéuticas de nanopartículas poliméricas con alta temperatura de transición vítrea o copolímeros de alto peso molecular
KR101314579B1 (ko) * 2011-04-07 2013-10-10 광주과학기술원 파크리탁셀이 선적된 고분자 나노입자 및 그 제조방법
JP2013053103A (ja) * 2011-09-05 2013-03-21 Ltt Bio-Pharma Co Ltd 薬物を封入した肝臓集積性ナノ粒子
WO2013124867A1 (fr) * 2012-02-21 2013-08-29 Amrita Vishwa Vidyapeetham University Polymer - polymer or polymer - protein core - shell nano medicine loaded with multiple drug molecules
MX356097B (es) 2012-09-17 2018-05-14 Pfizer Inc Star Proceso para la preparacion de nanoparticulas terapeuticas.
US10143700B2 (en) 2013-02-19 2018-12-04 Amrita Vishwa Vidyapeetham Nanoparticle formulations for delivering multiple therapeutic agents
ES2640648T3 (es) 2013-09-16 2017-11-03 Astrazeneca Ab Nanopartículas poliméricas terapéuticas y métodos para su fabricación y uso
MA39734B1 (fr) 2014-03-14 2019-07-31 Pfizer Nanoparticules thérapeutiques comportant un agent thérapeutique, et leurs procédés de fabrication et d'utilisation
WO2016111913A1 (fr) * 2015-01-05 2016-07-14 Boston Scientific Scimed, Inc. Microsphère biodégradable éluant un médicament pour le traitement de tumeurs solides
GB201505527D0 (en) 2015-03-31 2015-05-13 Jmedtech Pte Ltd Composition
EP3302423B1 (fr) 2015-06-04 2022-05-25 Crititech, Inc. Système de production de particules et dispositif de collecte de particules
US20170128424A1 (en) * 2015-11-11 2017-05-11 Qrono, Inc. Sustained release pharmaceutical compositions and methods of use
BR112018069628A2 (pt) 2016-04-04 2019-02-12 Crititech, Inc. métodos para tratamento de tumor sólido
CN106075535B (zh) * 2016-06-14 2019-04-02 武汉纺织大学 一种医用敷料及其制备方法
WO2018011040A1 (fr) * 2016-07-13 2018-01-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Microparticules de plga chargées de fluoroquinolone pour le traitement de maladies respiratoires.
US10993919B2 (en) 2016-10-04 2021-05-04 University Of Florida Research Foundation, Inc. Chondroprotective nanoparticles for the treatment of osteoarthritis
CN107049984A (zh) * 2017-03-14 2017-08-18 武汉理工大学 一种载紫杉醇聚乳酸‑羟基乙酸微球的制备方法
KR102024273B1 (ko) * 2017-03-27 2019-11-04 주식회사 피에프디 약물 작용 관리 장치 및 방법
EP3615145B1 (fr) 2017-06-09 2024-05-15 Crititech, Inc. Compositions pour utilisation dans le traitement des kystes épithéliaux par injection intrakystique de particules antinéoplasiques
WO2018231908A1 (fr) 2017-06-14 2018-12-20 Crititech, Inc. Méthodes de traitement de troubles pulmonaires
KR20250057947A (ko) 2017-10-03 2025-04-29 크리티테크, 인크. 암의 치료를 위한 면역치료제의 전신 전달과 조합된 항신생물성 입자의 국소 전달
WO2019071245A1 (fr) 2017-10-06 2019-04-11 Foundry Therapeutics, Inc. Dépôts implantables pour la libération régulée d'analgésiques pour traiter une douleur postopératoire associée à une chirurgie orthopédique, et dispositifs, systèmes et procédés associés
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GB201800912D0 (en) * 2018-01-19 2018-03-07 Ucl Business Plc Compositions for the treatment of a disease of the urinary tract and treatment of a disease involving the intracellular delivery of the particle
EP3793536A1 (fr) 2018-05-12 2021-03-24 Foundry Therapeutics, Inc. Dépôts implantabes pour la libération contrôlée d'agents thérapeutiques
WO2019231499A1 (fr) * 2018-05-31 2019-12-05 Crititech, Inc. Utilisation d'agents antinéoplasiques pour stimuler le système immunitaire pour le traitement du cancer
US12303619B2 (en) 2018-08-28 2025-05-20 Foundry Therapeutics, Inc. Polymer implants
WO2020072090A1 (fr) * 2018-10-03 2020-04-09 Crititech, Inc. Utilisation d'agents antinéoplasiques pour stimuler le système immunitaire pour la production de structures lymphoïdes tertiaires (tls)
EP3750523A1 (fr) * 2019-06-13 2020-12-16 CAPNOMED GmbH Système de distribution de substances actives
EP3750524A1 (fr) * 2019-06-13 2020-12-16 CAPNOMED GmbH Administration retardée et modifiée de médicaments anti-cancer
EP3791865A1 (fr) * 2019-09-16 2021-03-17 CAPNOMED GmbH Système de distribution de substances actives avec distribution retardée
WO2022075318A1 (fr) * 2020-10-08 2022-04-14 学校法人関西医科大学 Marqueur d'évaluation reflétant l'efficacité d'une composition de traitement du cancer
US20240016774A1 (en) * 2020-10-14 2024-01-18 Foundry Therapeutics, Inc. Implantable depots for localized, sustained, controlled release of therapeutic agents to treat cancer and related conditions
US20240307220A1 (en) * 2021-03-05 2024-09-19 H. Lee Moffitt Cancer Center And Research Institute Inc. Combination Therapy to Treat Temperature Sensitive Mutant Tumors
CN115770224B (zh) * 2023-01-17 2023-04-18 中国人民解放军总医院第一医学中心 一种携载紫杉醇药物的丙烯酸微球及其制备方法
CN118649148B (zh) * 2024-05-30 2024-11-01 河南中医药大学第一附属医院 一种黄芪多糖复合纳米颗粒及其制备方法、应用
CN118948780B (zh) * 2024-08-07 2025-07-15 山东序列生物科技有限公司 一种罗西维林冻干制剂及其制备方法

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US20020013298A1 (en) * 1996-12-02 2002-01-31 William L. Hunter Compositions and methods for treating or preventing inflammatory diseases

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US20020013298A1 (en) * 1996-12-02 2002-01-31 William L. Hunter Compositions and methods for treating or preventing inflammatory diseases
WO1999021908A1 (fr) * 1997-10-29 1999-05-06 Angiotech Pharmaceuticals, Inc. Systemes polymeres de liberation de medicaments et utilisation de ces systemes

Also Published As

Publication number Publication date
CN1816331A (zh) 2006-08-09
AU2004228008B2 (en) 2008-11-06
JP4927535B2 (ja) 2012-05-09
JP2006522148A (ja) 2006-09-28
KR20060006911A (ko) 2006-01-20
CN102697737A (zh) 2012-10-03
CN1816331B (zh) 2012-08-08
WO2004089291A3 (fr) 2005-04-21
CN102697737B (zh) 2014-03-19
WO2004089291A2 (fr) 2004-10-21
KR100849911B1 (ko) 2008-08-04
CA2520475C (fr) 2012-10-09
CA2520475A1 (fr) 2004-10-21
IL171185A (en) 2013-07-31
AU2009200463A1 (en) 2009-03-05
AU2004228008A1 (en) 2004-10-21
EP1608359A2 (fr) 2005-12-28

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